Clinical trials: Microparticles
Venous Thromboembolism, Pulmonary Thromboembolisms
Time of Treatment With LMWH in Cancer Patients With Thromboembolic Disease
Cancer is the most important acquired risk factor of thromboembolisms. More than 20% of all episodes of venous thromboembolism (VT) or pulmonary thromboembolisms (PT) are cancer related.
- Conditions
- Venous Thromboembolism, Pulmonary Thromboembolisms, Cancer
- Trial name
- NCT03134820
- Volunteers
- 352 people
- Sponsor
- Delos Clinical
Heart Failure, High-intensity Interval Training
High-Intensity Interval Training Recuperates Capacity of Endogenous Thrombin Generation in Patients With Heart Failure
Consumptive coagulopathy is associated with increased mortality in patients with heart failure (HF). Physical activity influences the risk of major vascular thrombotic events.
- Trial name
- NCT04033523
- Testing
- HIIT
- Volunteers
- 76 people
- Sponsor
- Chang Gung Memorial Hospital
Hernia, Ventral Hernia
A Study of Fibrin Sealant Plus Silver Microparticles to Prevent Incisional Hernias Following Abdominal Surgery
Incisional hernias are a frequent consequence of abdominal surgery. Current clinical efforts are primarily focused on improving repair materials and surgical techniques to correct these hernias instead of the optimal solution…
- Conditions
- Hernia, Ventral Hernia, Abdominal Hernia
- Trial name
- HiP_1 (NCT02584153)
- Testing
- Fibrin Sealant, Silver Microparticles
- Sponsor
- Hobart Harris
Cardiac Sudden Death, Hypoxia Brain
New Biomarkers of Neurological Outcome After a Sudden Cardiac Death
The aim of the project is to establish the value of circulating microparticles as a new biomarker for neurological prognosis of patients recovered from sudden cardiac death who remain comatose.
- Conditions
- Cardiac Sudden Death, Hypoxia Brain, Cell Membrane Microparticles, Biomarkers
- Trial name
- NCT03962361
- Testing
- Concentration of circulating microparticles.
- Where
- Spain
- Volunteers
- 84 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Intestinal Obstruction, Carcinoma
Efficacy and Safety of Lanreotide Microparticles as Palliative Treatment in Peritoneal Carcinomatosis
The purpose of this study is to determine whether lanreotide 30mg microparticles are effective in the relief of clinical symptoms due to small bowel obstruction in inoperable patients with peritoneal carcinomatosis.
- Conditions
- Intestinal Obstruction, Carcinoma, Peritoneal Neoplasms
- Trial name
- NCT00216372
- Testing
- Lanreotide (microparticle formulation)
- Where
- 53 sites in Belgium, France and 1 more
- Volunteers
- 80 people
- Sponsor
- Ipsen
Atherosclerosis, Inflammation
Nutraceutical Combination in Patients With Low-grade Systemic Inflammation
The investigators tested if a nutraceutical combination with red yeast rice, berberine and policosanol (NC) can significantly modify inflammation, lipid profile and markers of endothelial injury (endothelial microparticles) in…
- Conditions
- Atherosclerosis, Inflammation, Hypercholesterolemia
- Trial name
- NCT02422927
- Testing
- Nutraceutical Combination, Standard of Care
- Volunteers
- 100 people
- Sponsor
- University Of Perugia
Atrial Fibrillation
Microparticles Circulating Plasma Concentration in Atrial Fibrillation After Percutaneous Occluding of the Left Atrium
The aim of the study is to compare levels of differnts types of microparticles circulating before and after percutaneous occluding of the left atrium by patients with atrial fibrillation and patients control.
- Trial name
- MICROPLUG (NCT03361202)
- Testing
- blood sampling
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Institut Mutualiste Montsouris
Acne Vulgaris
Multiple Arm Study of Sebacia Microparticles in the Treatment of Acne Vulgaris
Prospective, multicenter study with multiple arms to examine the safety and effectiveness of the Sebacia Acne Treatment System for the treatment of acne vulgaris.
- Trial name
- NCT02219074
- Testing
- Sebacia microparticle and laser treatment, Vehicle and laser treatment
- Where
- 2 sites in Poland
- Volunteers
- 350 people
- Sponsor
- Sebacia, Inc.
Myocardial Infarction, Reperfusion Injury
Role of Adiponectin and Endothelial Progenitor Cells in Reperfusion Injury in Patients With Acute Myocardial Infarction
There is experimental evidence that low levels of adiponectin are associated with more reperfusion injury. In addition experimental studies have demonstrated that endothelial progenitor cells may have a favorable effect on…
- Trial name
- R²ACE (NCT01414452)
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Universiteit Antwerpen
Diabetes Mellitus, Type 1
Effects of Aspirin Treatment on Fibrin Network Formation in Patients With Type 1 Diabetes
The fibrin network is an important component of an arterial thrombus and its structure influences the degradation of the formed clot.
- Trial name
- NCT01397513
- Testing
- Aspirin
- Where
- Sweden
- Volunteers
- 48 people
- Sponsor
- Karolinska Institutet
Pulmonary Hypertension
Effect of Endothelin-1 Receptor Blockade on Circulating Endothelial Microparticles Levels in Patients With Pulmonary Hypertension
Pulmonary hypertension is a progressive and life threatening condition. It is characterized by severe remodeling of the pulmonary vessel wall, obstructive plexiform lesions, multi-focal thrombosis, and enhanced vasoconstriction.
- Trial name
- NCT00675051
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of California, San Francisco
Systemic Inflammatory Response Syndrome
Endothelial Microparticles as a Biomarker for Diagnosis and Prognosis in Early Sepsis
Sepsis is a major global health problem, leading to substantial morbidity and mortality despite medical care. The initial diagnosis of sepsis is a clinical challenge, as it is based on nonspecific systemic criteria.
- Trial name
- NCT01998139
- Where
- 2 sites in United States, Qatar
- Volunteers
- 137 people
- Sponsor
- Weill Medical College of Cornell University
Pancreatic Cancer, Gastric Cancer
Kinetics of Microparticles Under Chemotherapy in Patients With Gastric or Pancreatic Cancer
Microparticles have recently emerged as a thrombotic risk marker with a potential role in determining which patients are at greatest risk for developing thrombosis.
- Trial name
- DOMICA (NCT03471468)
- Testing
- kinetics of microparticles under chemotherapy
- Where
- France
- Volunteers
- 3 people
- Sponsor
- Poitiers University Hospital
Childhood Obesity, Bariatric Surgery Candidate
Validation of Circulating Endothelial Cells and Microparticles in Youth
Identification and validation of early chronic disease biomarkers in children is of paramount importance especially in the burgeoning arena of pediatric obesity research.
- Trial name
- NCT01508598
- Where
- United States
- Volunteers
- 390 people
- Sponsor
- University of Minnesota
Aortic Valve Stenosis
Microparticles in Severe Aortic Stenosis
Microparticles are small cell fragments that can induce fat plaques, calcification and formation of thrombus. They can be released through multiple stimulations, but also the high flow of blood through partially obstructed aortic…
- Trial name
- NCT02193035
- Testing
- Microparticle levels
- Where
- Brazil
- Volunteers
- 15 people
- Sponsor
- InCor Heart Institute
Peripheral Vascular Diseases
Microparticles and the Risk of Re-stenosis Following Balloon Angioplasty in Patients With Peripheral Arterial Disease
Although microparticles have been well-documented as mediators of inflammation and coagulation in various cardio-vascular disease events, it is currently not known how Percutaneous Transluminal Angioplasty (PTA) for peripheral…
- Trial name
- NCT01422343
- Testing
- percutaneous transluminal angioplasty femoro-popliteal
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Hemophilia A, Hemophilia B
Global Hemostatic Methods in Hemophilia and Von Willebrand's Disease
Patients with hemophilia who have the same level of deficient factor(s) may express different severity of clinical presentation and bleeding tendency.
- Conditions
- Hemophilia A, Hemophilia B, Von Willebrand's Disease
- Trial name
- GHMHW (NCT02061033)
- Where
- Sweden
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Karolinska University Hospital
Cardiovascular Disease
Dietary Intervention and Vascular Function
It is well established that diet plays an important role in both the development and progression of heart disease. Different types of dietary fat have varying effects on heart disease risk factors.
- Trial name
- DIVAS (NCT01478958)
- Testing
- SFA diet, MUFA diet, n-6 PUFA diet
- Where
- 2 sites in United Kingdom
- Volunteers
- 202 people
- Sponsor
- University of Reading
Aging
Effect of Aging on Haemostasis Parameters
Aging is an independent risk factor, without any clear explanation. The primary aim of the study is to depict the effect of aging on the coagulation fibrinolysis parameters and microparticles.
- Trial name
- NCT00299624
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Hopital Lariboisière
Bronchiolitis Obliterans
Microparticles and Bronchiolitis Obliterans Syndrome
The main long-term complication of lung transplantation is chronic lung allograft dysfunction (CLAD). Bronchiolitis obliterans syndrome (BOS) is the most frequent presentation of CLAD.
- Trial name
- MIBO (NCT02458274)
- Testing
- Dosage of Microparticles (MPs) in broncho-alveolar lavage fluid (BALF)
- Where
- France
- Volunteers
- 60 people
- Sponsor
- University Hospital, Strasbourg, France