Clinical trials: Microparticles
Fibromuscular Dysplasia
Pathophysiological Mechanisms of Fibromuscular Dysplasia
Fibromuscular dysplasia is an non inflammatory non atherosclerotic obstructive arterial disease affecting mid-size arteries. It is considered as a rare vascular disease of unknown origin.
- Trial name
- MeDyA (NCT01935752)
- Testing
- blood samples, vascular echotracking
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
COVID-19
Role of Microparticles in Covid-19 Infection
Among the distinctive features of Covid-19, numerous reports have stressed the importance of vascular damages associated with coagulopathy onset.
- Trial name
- MICO (NCT04448743)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 189 people, healthy volunteers welcome
- Sponsor
- University Hospital, Strasbourg, France
Psoriasis With Cell-derived Microparticles
The Difference of Microparticles in Patients With Psoriasis Vulgaris Who Received Stelara(Ustekinumab)
Background: Psoriasis, a common inflammatory disease, is associated with atherosclerotic vascular diseases, including stroke, myocardial infarction, and impaired microcirculations, among which circulating microparticles play an…
- Trial name
- NCT02693470
- Testing
- Ustekinumab
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
HIV,
Microparticles, Vector of Genetic Information During HIV Infection
The aim of the investigators study is to demonstrate in healthy subjects and a cohort of patients infected with HIV, the presence of miRNAs in circulating peripheral blood microparticles (MPs).
- Trial name
- NCT01687452
- Testing
- Blood samples
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Vascular Complications, Vascular Stiffness
Cardiovascular Effects of Chronic Snus Use
The current study proposes to investigate the effects of chronic snus use on the blood vessels. Several cardiovascular endpoints are measured using various methods in healthy daily snus users as well as in healthy matched…
- Conditions
- Vascular Complications, Vascular Stiffness, Tobacco Dependence
- Trial name
- CHROS (NCT02564289)
- Where
- Sweden
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Umeå University
Osteoarthritis, Hip
Intraarticular Gold Microparticles for Hip Osteoarthritis
In a pilot study, the investigators recently showed that intraarticular metallic gold microparticles reduce knee osteoarthritis pain for up to two years and found associated significant proteomic changes in serum and synovial…
- Trial name
- NCT06186115
- Testing
- Gold
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Knee Osteoarthritis
Intraarticular Gold Microparticles for Knee Osteoarthritis
The investigators have shown in three pilot studies that intra-articular metallic gold microparticles can reduce knee osteoarthritis pain for up to two years.
- Trial name
- NCT07202390
- Testing
- 20 mg metallic gold microparticles (72.000 particles, 20-40 µm) will be injected into the knee joint using 2 mL hyaluronic acid., Intervention
- Volunteers
- 240 people
- Sponsor
- Northern Orthopaedic Division, Denmark
HIV Infections
Safety of and Immune Response to a Combination HIV Vaccine Regimen in HIV Uninfected Adults
To prevent HIV infection, a vaccine that produces strong HIV-specific humoral (B-cell) and cellular (T-cell) immune system responses is desirable.
- Trial name
- NCT00073216
- Testing
- Clade B gag DNA/PLG and env DNA/PLG Microparticles, Clade B Recombinant, Oligomeric gp140/MF59 Adjuvant
- Where
- 4 sites in United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Oxygen, Hyperoxemia
Cerebral Hemodynamic Effects of Oxygen and Antioxidants (CHEOXANT)
This study is called CHE-OX-ANT (Cerebral Hemodynamic Effects of Oxygen and Antioxidants). It is a single-center, academic research project led by the Department of Intensive Care at Erasme Hospital (Université Libre de…
- Conditions
- Oxygen, Hyperoxemia, Antioxidant, Cerebral Autoregulation
- Trial name
- CHEOXANT (NCT07369232)
- Testing
- Oxygen, Vitamin C (Ascorbic Acid)
- Where
- Belgium
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Erasme University Hospital
Non ST Segment Elevation Acute Coronary Syndrome
Study of Effects of Ticagrelor on Microparticles and Micro-RNA in NSTE-ACS
The aim of the study is to learn more about the pathophysiology of acute coronary syndrome (ACS) and to evaluate the mechanisms responsible of the action and benefits of ticagrelor.
- Trial name
- TIGER-M (NCT02071966)
- Testing
- Ticagrelor, Clopidogrel
- Where
- Italy
- Volunteers
- 55 people
- Sponsor
- Catholic University of the Sacred Heart
Achilles Tendinopathy
A Study to Investigate the Safety, Tolerability and Preliminary Efficacy of NGI226 Microparticles in Patients With Achilles Tendinopathy
The purpose of this study is to measure local and systemic safety and tolerability as well as improvement of Achilles tendon mechanical properties after a single peritendon injection of NGI226 MP in comparison to placebo MP in…
- Trial name
- NCT05592990
- Testing
- NGI226
- Where
- 7 sites in United States, France and 1 more
- Volunteers
- 45 people
- Sponsor
- Novartis Pharmaceuticals
Allergic Reaction
Is There an Allergy to Pure Metallic Gold Microparticles?
The investigators hypothesize gold is inert and thereby there is no pure-gold allergy. The primary aim of this study is to measure the prevalence of allergy to metallic pure gold microparticles and allergy to GSTS.
- Trial name
- NCT05284253
- Testing
- Gold microparticles, Gold thiosulphate
- Volunteers
- 60 people
- Sponsor
- Northern Orthopaedic Division, Denmark
Sickle Cell Disease
Pathophysiology of Acute Pain in Patients With Sickle Cell Disease
Background: Sickle Cell Disease (SCD) is a blood disorder that occurs mainly in people of African descent. Researchers want to learn more about the painful attacks and complications associated with SCD.
- Trial name
- NCT03049475
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Breast Cancer, Chemotherapeutic Toxicity
Neurovascular Changes Induced by Chemotherapy
The purpose of the present study was to test the hypothesis that doxorubicin and cyclophosphamide adjuvant chemotherapy (CHT) acutely induces neurovascular and hemodynamic changes in patients with breast cancer.
- Trial name
- NCT03339804
- Testing
- Chemotherapy
- Where
- Brazil
- Volunteers
- 16 people
- Sponsor
- University of Sao Paulo General Hospital
Atopic Dermatitis
Exploratory Study of the Cutaneous Penetration of Biodegradable Polymeric Microparticles in Atopic Dermatitis
This proof of concept study aims to assess in patients suffering from atopic dermatitis if polymeric microparticles reach the pilosebaceous follicles of inflamed skin.
- Trial name
- MicroIskin (NCT02369432)
- Testing
- Biodegradable and biocompatible polymeric microparticles containing a fluorochrome applied to the skin followed by a skin biopsy
- Where
- France
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Sickle Cell Disease
MACS Study - Microparticles and Coagulation in Sickle Cell Disease
Sickle cell disease (SCD) is an inherited disorder of the red blood cell. It is now the commonest genetic disorder in the UK and of childhood stroke, with up to 40% of children having a stroke (clinical or picked up on a scan) by…
- Trial name
- MACS (NCT01242878)
- Where
- 3 sites in United Kingdom
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- University College, London
Facial Acne Vulgaris
A Study to Evaluate Sebacia Microparticles in Patients With Inflammatory Acne Vulgaris
This study is proposed to evaluate Sebacia Microparticle treatment in patients with facial inflammatory acne vulgaris.
- Trial name
- NCT02758041
- Testing
- Sebacia Microparticles
- Where
- 3 sites in Denmark, Switzerland
- Volunteers
- 85 people
- Sponsor
- Sebacia, Inc.
Myeloproliferative Neoplasm
Role of the Circulating Procoagulants Microparticles in the Hypercoagulability of MNP Ph1-
Patients with myeloproliferative neoplasms Philadelphia chromosome negative (MPNsPh1-) such as Essential thrombocytosis (ET), Polycythemia vera (PV) and Primary Myelofibrosis (PMF) have a higher risk of arterial or deep-vein…
- Trial name
- MICROP-SMP (NCT02862366)
- Testing
- Blood sampling
- Where
- 3 sites in France
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Lille Catholic University
Acute Lymphoblastic Leukemia
Role of the Microparticles and of Tissue Factor in the Pro-thrombotic Phenotype and the Thromboembolic Complications During the Acute Lymphoblastic Leukemia in Children.
Acute lymphoblastic leukemia is the most common malignancy of the child. Current therapeutic strategies allow healing of over 80% of children. However these treatments are associated with toxicity, with a mortality of 1-2%.
- Trial name
- THROMBLEUKEMIA (NCT02862652)
- Testing
- Blood sample
- Where
- France
- Volunteers
- 24 people
- Sponsor
- CHU de Reims
Sleep Apnea, Obstructive
Microparticles in Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is independently associated with cardiovascular diseases, including myocardial infarction and stroke.
- Trial name
- BioSAS (NCT03438149)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- University Hospital, Angers