Clinical trials: Microparticles
Malignant Pleural Effusion,, Malignant Ascites
Safety and Effectiveness Study of Tumor Cell-derived Microparticles to Treat Malignant Ascites and Pleural Effusion
Malignant ascites and pleural effusion are common symptoms in patients with advanced cancer. Currently, the management of malignant ascites and pleural effusion is a considerable clinical challenge.
- Trial name
- NCT01854866
- Testing
- Drug-packaging microparticles
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Huazhong University of Science and Technology
Carbon Monoxide Poisoning
Microparticles Blood Level in Acute Carbon Monoxide Poisoning
The goal of this pilot, clinical, experimental, biological and prospective study with uso of biological material (venous blood sampling), in patient with acute carbon monoxide (CO) intoxication and in a group of healthy…
- Trial name
- COMPs (NCT05591300)
- Testing
- Microparticles research
- Where
- Italy
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Azienda Ospedaliero Universitaria Maggiore della Carita
Graft Versus Host Disease, Leukemia
Donor Lymphocytes to Prevent Graft-Versus-Host Disease in Patients With Chronic Myeloid Leukemia
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy used to kill cancer cells. Sometimes the transplanted cells can be rejected by the body's normal tissues.
- Trial name
- NCT00004878
- Testing
- therapeutic allogeneic lymphocytes, cytarabine, fludarabine phosphate
- Sponsor
- Jonsson Comprehensive Cancer Center
Peritoneal Carcinomatosis
Intraperitoneal Paclitaxel-loaded TPM for Treatment of Peritoneal Carcinomatosis
A first-in-human, unblinded, phase I trial of Paclitaxel-loaded tumor penetrating microparticles (TPM) in peritoneal carcinomatosis patients who are not eligible for standard-of-care therapeutic interventions.
- Trial name
- NCT05159050
- Testing
- Paclitaxel-loaded tumor penetrating microparticles
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Carlos Chan
Pancreatic Cancer
CT-guided Percutaneous Radionuclide Therapy With 32P Microparticles in Patients With Non-progressive Locally Advanced Pancreatic Cancer
Pancreatic ductal adenocarcinoma is a highly lethal cancer, and approximately 40% of patients present with non-metastatic locally advanced pancreatic cancer (LAPC) that is not suitable for surgical resection.
- Trial name
- PANCOSIL (NCT07595835)
- Testing
- CT-guided percutaneous intratumoural implantation of the OncoSil™ device
- Where
- Netherlands
- Volunteers
- 20 people
- Sponsor
- M.R. Meijerink
Decompression Sickness, Endothelial Dysfunction
Exercise and Repetitive Diving
SCUBA diving frequently involves repetitive exposures over multiple days. The goal of this study was to see how exercise impacts microparticles (MPs), endothelial function, and venous gas emboli (VGE) over a series of dives.
- Conditions
- Decompression Sickness, Endothelial Dysfunction, Neutrophil Activation, Venous Gas Emboli
- Trial name
- NCT02118207
- Testing
- Aerobic running exercise
- Where
- 2 sites in United States, Croatia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Split
Decompression Sickness, Dysbarism
Microparticles in Scuba Divers With Decompression Sickness
The investigators hypothesize that membrane microparticles (MPs) are liberated into the blood stream in response to decompression stress and that certain MPs characteristics initiate inflammatory responses that contribute to the…
- Trial name
- NCT01587209
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- University of Pennsylvania
Degenerative Aortic Valve Stenosis
The Effect of Transaortic Valve Replacement on the Endothelial Integrity and Function
Degenerative aortic valve stenosis (AVS) is the leading cause of aortic valve morbidity with a prevalence of 2-7% at ages above 65 years, with ever-increasing incidence especially in the 8th decades.
- Trial name
- NCT01993485
- Where
- Germany
- Volunteers
- 61 people
- Sponsor
- Heinrich-Heine University, Duesseldorf
Benign Prostatic Hyperplasia
Comparison of Glue with Microparticles in Prostatic Artery Embolization
Prostatic artery embolisation (PAE) is an alternative treatment to surgery for benign prostatic hyperplasia (BPH). It has been practised since 2012 and numerous publications have proved not only its safety but also its efficacy.
- Trial name
- EMBOLICOL (NCT06678308)
- Testing
- Embolisation with Magic Glue®, Embolisation with Embosphere®
- Where
- France
- Volunteers
- 96 people
- Sponsor
- Almaviva Sante
Decompression Sickness, SCUBA Diving
High Intensity Cycling Before SCUBA Diving Reduces Post-decompression Microparticle Production and Neutrophil Activation
The purpose of this study is to determine the impact of high intensity,anaerobic exercise, in the form of cycling, on SCUBA diving.
- Trial name
- NCT02064361
- Testing
- High intensity exercise
- Where
- 2 sites in United States, Croatia
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of Split
Liver Cirrhosis, Portal Hypertension
Microparticles in Cirrhosis and Portal Hypertension
research on interactions between portal hypertension and microparticles
- Trial name
- MicroCir (NCT02859610)
- Testing
- research on interactions between portal hypertension and microparticles
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Atypical Hemolytic Uremic Syndrome, Thrombotic Thrombocytopenic Purpura
The Role of Microparticles as a Biomarker
The investigators propose to characterize MPs in aHUS and TTP both at the onset and throughout treatment. The investigators believe that the number, size, and cell origin of MPs will differ between these two diseases.
- Conditions
- Atypical Hemolytic Uremic Syndrome, Thrombotic Thrombocytopenic Purpura, Microparticles, Microangiopathic Hemolytic Anemia
- Trial name
- NCT02626663
- Where
- United States
- Sponsor
- University of Rochester
Endothelium, Hydroxymethylglutaryl-CoA Reductase Inhibitors
Single Dose of Atorvastatin and Circulating Endothelial Microparticles
Healthy subjects take single dose of 80mg atorvastatin, then measured their circulating endothelial microparticles and flow-mediated vasodilation in the brachial artery by ultrasound at different time points.
- Trial name
- NCT02023892
- Testing
- atorvastatin
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Healthy
Circulating Endothelial Compartment During Normal and Pathological Aging
This part of the project aims to describe changes in markers of vascular competence (Endothelial Microparticles Platelet (EMP), Circulating endothelial cells (CEC) and Circulating endothelial progenitors (EPC)) at different ages…
- Trial name
- VIMOPEIL (NCT01038700)
- Where
- France
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Locally Advanced Pancreatic Cancer, Adenocarcinoma, Pancreas
Safety and Efficacy of Clopidogrel in Locally Advanced and Metastatic Pancreatic Adenocarcinoma Treated With Chemotherapy
Clopidogrel has been shown to slow down tumor progression in orthoptic pancreatic murine tumor. In a pilot study, the rate of microparticles was correlated with response rate of pancreatic adenocarcinoma.
- Conditions
- Locally Advanced Pancreatic Cancer, Adenocarcinoma, Pancreas, Metastatic Pancreatic Cancer
- Trial name
- PANCREADOGREL (NCT02404363)
- Testing
- Clopidogrel
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Colorectal Carcinoma
Microparticles in Peritoneal Carcinomatosis of Colorectal Origin
Peritoneal carcinomatosis (PC), a tumoral tumor of the peritoneum, is a frequent metastatic localization of colorectal cancer (CRC, 13%).
- Trial name
- MICROCOL (NCT03969784)
- Testing
- blood draw, tumoral biopsy tissus
- Where
- France
- Volunteers
- 41 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Scleroderma, Pulmonary Hypertension
Endothelial Biomarkers of Systemic Sclerosis-associated Pulmonary Hypertension
Systemic sclerosis (SSc, AKA scleroderma) is an autoimmune condition characterized by endothelial damage and progressive fibrosis of the skin and internal organs.
- Trial name
- BOSS-PH (NCT03459716)
- Testing
- No intervention
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans