Clinical trials: Microvascular Angina
Metabolic Syndrome X
Effects of High-fat and Low-fat Diet on the Gut
Rationale: The prevalence of the metabolic syndrome is strongly increasing in developed countries. The role of the small intestine seems important in the development of the metabolic syndrome.
- Trial name
- NCT00561626
- Testing
- high fat diet followed by low fat diet, low fat diet followed by high fat diet
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Obstructive Sleep Apnea, Metabolic Syndrome X
Obstructive Sleep Apnea (OSA) and Metabolic Syndrome: Role of Oxidative Stress
The purpose of this study is to define the mechanism(s) through which Obstructive Sleep Apnea/Hypopnea (OSAH) promotes abnormal metabolic processes which characterize the metabolic syndrome.
- Trial name
- NCT00177892
- Testing
- sleep disruption, sleep with and without positive pressure
- Where
- United States
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Hyperlipidemias, Metabolic Syndrome X
Effect of Vegetable Oils for Use by the Snack Food Industry on Plasma Lipid Levels and Inflammatory Markers
The current study is designed to assess the effect of a conventional cooking oil (hydrogenated oil) and a reformulated fat low in trans fatty acids on cardiovascular disease risk factors.
- Conditions
- Hyperlipidemias, Metabolic Syndrome X, Cardiovascular Diseases
- Trial name
- NCT00175071
- Testing
- Comparison of cooking oils
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tufts University
Healthy, Metabolic Syndrome X
Investigation of Genetic Risk of Metabolic Syndrome in Company Employee (NGK Study)
The metabolic syndrome is a highly prevalent disorder, which causes atherosclerotic cardiovascular disease and is closely associated with insulin resistance.
- Conditions
- Healthy, Metabolic Syndrome X, Hyperlipidemia, Hypertension
- Trial name
- NCT00408824
- Where
- Japan
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Nagoya University
Spinal Muscular Atrophy, Fragile X Syndrome
Early Check: Expanded Screening in Newborns
Early Check provides voluntary screening of newborns for a selected panel of conditions. The study has three main objectives: 1) develop and implement an approach to identify affected infants, 2) address the impact on infants and…
- Conditions
- Spinal Muscular Atrophy, Fragile X Syndrome, Fragile X - Premutation, Duchenne Muscular Dystrophy
- Trial name
- NCT03655223
- Testing
- Confirmatory Testing
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- RTI International
Diabetes Mellitus, Steroid Diabetes
Sitagliptin Prophylaxis for Glucocorticoid-Induced Impairment of Glucose Metabolism in Males With the Metabolic Syndrome
The investigators will assess whether the DPP-inhibitor sitagliptin will ameliorate glucocorticoid-induced impairment of glucose metabolism and beta-cell dysfunction and thus could be used as a prophylaxis for…
- Conditions
- Diabetes Mellitus, Steroid Diabetes, Glucocorticoid-induced Diabetes, Beta-cell Function
- Trial name
- SPHINX (NCT00721552)
- Testing
- Sitagliptin 100 mg, Prednisolone 30 mg
- Where
- Netherlands
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Amsterdam UMC, location VUmc
Obesity, Overweight
Impact of Almond Supplementation on Body Composition in Overweight/Obese Minority Adults
The purpose of this study is to determine whether introducing almonds into the diet of overweight and obese Blacks and Hispanics improves body composition, decreases liver fat, and lowers cardiovascular disease profile.
- Conditions
- Obesity, Overweight, Fatty Liver, Metabolic Syndrome X
- Trial name
- NCT02347007
- Testing
- Almond, Cereal Bar
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Columbia University
Microvascular Angina, Microvascular Coronary Artery Disease
EUROpean Coronary microCirculatory Resistance and Absolute Flow Trial
Rationale: coronary microvascular disease is a relatively 'new' entity within the field of cardiology. The investigators are able to investigate the microcirculation by measurements performed in the catheterization laboratory.
- Conditions
- Microvascular Angina, Microvascular Coronary Artery Disease, Coronary Vasospasm, Microvascular Resistance
- Trial name
- EURO-ccraft (NCT04598308)
- Testing
- absolute flow and resistance measurements
- Where
- Netherlands
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Catharina Ziekenhuis Eindhoven
Glucose Intolerance, Hyperinsulinemia
Health Effects of Liposuction in Overweight Women With Elevated Insulin Levels, Impaired Glucose Tolerance and/or Type 2 Diabetes
This study is for women who have already decided to undergo liposuction at Georgetown University Medical Center in Washington, D.C.
- Conditions
- Glucose Intolerance, Hyperinsulinemia, Diabetes Mellitus, Non Insulin Dependent, Obesity
- Trial name
- NCT00005760
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Metabolic Syndrome X
Clinical Trial of Anti-oxidant Astaxanthin in Insulin-resistant Subjects
Astaxanthin is a natural compound, present in many foodstuffs and available as a nutritional supplement that has been shown to have beneficial effects on many of the features of insulin resistance/glucose intolerance, at least in…
- Trial name
- Astaxanthin (NCT03310359)
- Testing
- Astaxanthin
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Atherosclerosis, Congestive Heart Failure
Dallas Heart Study 2: Return Clinic Visit for the Dallas Heart Study Cohort
The Dallas Heart Study (DHS-1) is a large, multi-ethnic, population-based epidemiological study designed to identify determinants of atherosclerotic heart disease (ASHD) in a representative United States (US) urban environment.
- Conditions
- Atherosclerosis, Congestive Heart Failure, Left Ventricular Hypertrophy, Diabetes Mellitus
- Trial name
- NCT00344903
- Where
- United States
- Volunteers
- 3,400 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Metabolic Syndrome X, Liver Diseases
Effects of Macronutrients on Hepatic Lipids, Plasma Triglycerides, and Insulin Sensitivity
The purpose of this study is to assess how the macronutrient composition of the diet effects lipid and glucose metabolism intrahepatic lipids insulin sensitivity in healthy lean subjects and in subjects with a high metabolic risk…
- Trial name
- MACRONUTR (NCT00523562)
- Testing
- diet intervention
- Where
- Switzerland
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Lausanne
Metabolic Syndrome X
Study of Chronic Degenerative Diseases
The prevalence of obesity and type 2 diabetes mellitus (DM) in children have been increasing in parallel at an alarming rate. In particular, the increasing prevalence of type 2 DM is attributable to genetic factors, clinical…
- Trial name
- NCT02495961
- Where
- Mexico
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Asociación Científica Latina A.C.
Metabolic Syndrome X
Efficacy Study Regarding the Beneficial Effects of Omega-3 Fatty Acids on Cardiometabolic Health
Fish oil supplements (which are rich in omega-3 fatty acids) have been shown to provide cardiometabolic benefits to individuals of all ages.
- Trial name
- FOHS (NCT02042274)
- Testing
- Fish oil supplement
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Guelph
Coronary Microvascular Disease, Coronary Artery Disease
A Non-invasive Index of Microciculatory Resistance
Coronary artery microvascular disease (CMVD) lacks reliable and non-invasive quantitative diagnosis methods. Improving coronary microcirculation has become one of the main goals of coronary heart disease treatment.
- Trial name
- NCT04554004
- Testing
- CCTA, CT-MPI, DSA, FFR
- Where
- China
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Hangzhou
Metabolic Syndrome X
Inflammation and the Metabolic Syndrome in Humans
People who are overweight are at increased risk of heart disease. Being overweight and having heart disease are linked in that both involve inflammation.
- Trial name
- LPS (NCT00954824)
- Testing
- Endotoxin (LPS)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Metabolic Syndrome X
Effect of Exercise Training on the Function of the High Density Lipoprotein (HDL)-Cholesterol, Endothelial Function and Endothelial Progenitor Cells in Patients With Metabolic Syndrome(HERMET-Study)
The purpose of the present study is to characterize the quality of HDL-Cholesterol in patients with metabolic syndrome and reduced blood HDL-Cholesterol levels and to examine the effect of exercise training on the…
- Trial name
- HERMET (NCT00515476)
- Testing
- physical exercise
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Hannover Medical School
Metabolic Syndrome X
Mechanisms of Cerebrovascular Control
The objective of this study is to identify insulin-specific cerebral blood flow (CBF) control mechanisms, and establish cerebrovascular responsive baseline in younger (18-45 yrs) metabolic syndrome adults (MetSyn) who are at…
- Trial name
- NCT02936687
- Testing
- NOS Inhibition, ET-1 Inhibition, 3 Tesla MRI
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Insulin Resistance, Metabolic Syndrome X
Individual Metabolism and Physiology Signature Study
To determine if consumption of different diet plans that both are nutritionally-adequate and provide energy to maintain body weight, alters fasting insulin concentrations, shifts other common clinical markers of metabolic disease…
- Conditions
- Insulin Resistance, Metabolic Syndrome X, Obesity
- Trial name
- iMAPS (NCT02298725)
- Testing
- DGA Diet Plan, NHANES Diet Plan
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- USDA, Western Human Nutrition Research Center
Cardiovascular Disease, Metabolic Syndrome X
Inflammatory Profiles of Children at High Risk for Atherosclerosis
The purpose of this study is to evaluate levels of inflammatory mediators in children at risk for cardiovascular disease due to family history.
- Conditions
- Cardiovascular Disease, Metabolic Syndrome X, Hypercholesterolemia, Inflammation
- Trial name
- NCT00115232
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital