Clinical trials: Microvascular Angina, open to volunteers
Coronary Microvascular Disease
Coronary MicrovAscular Diseases Intervention With Compound Danshen Dropping Pills
Objective: To investigate the effect of Compound Danshen Dripping Pills （CDDP）on improving coronary flow reserve（CFR） in patients with coronary microvascular disease (CMVD) and to evaluate their efficacy and safety.
- Trial name
- MAID (NCT07885462)
- Testing
- Compound Danshen Dripping Pills
- Where
- China
- Volunteers
- 496 people
- Sponsor
- Qilu Hospital of Shandong University
Coronary Microvascular Dysfunction (CMD)
Multisensor Wireless Pressure Microcatheter For Microvascular Function Assessment In ANOCA/INOCA Patients: A Prospective, Multicenter, Single-Group Target Value Study
This study aims to evaluate the sensitivity and specificity of a multi-sensor wireless pressure microcatheter for the diagnosis of CMD in patients with ANOCA/INOCA, using quantitative myocardial perfusion imaging of cardiac…
- Trial name
- NCT07453381
- Where
- 5 sites in China
- Volunteers
- 114 people
- Sponsor
- Peking University Third Hospital
Hypertension, Blood Pressure Monitoring, Home
Home Blood Pressure Variability and Its Link to Arteriosclerosis and Metabolic Dysfunction in Hypertensive Patients
This observational study investigates the correlation between home blood pressure variability (BPV) and arteriosclerosis, alongside metabolic indicators, in hypertensive patients over a three-year period.
- Conditions
- Hypertension, Blood Pressure Monitoring, Home, Arteriosclerosis, Metabolic Syndrome X
- Trial name
- NCT06394934
- Testing
- Healthscan App
- Where
- 2 sites in South Korea
- Volunteers
- 4,188 people
- Sponsor
- Korea University Anam Hospital
Ventricular Tachycardia, Coronary Artery Disease
Coronary Flow During Rapid Heart Rates
The goal of this observational study is to learn about the factors which determine how well ventricular tachycardia (VT) is tolerated. The main questions it aims to answer are: 1.
- Conditions
- Ventricular Tachycardia, Coronary Artery Disease, Heart Failure, Coronary Microvascular Dysfunction
- Trial name
- VT flow (NCT05841199)
- Testing
- Pressure and flow measurement during simulated VT
- Where
- United Kingdom
- Volunteers
- 70 people
- Sponsor
- Imperial College London
Hypertrophic Cardiomyopathy
Coronary Sinus Reducer Objective Impact on SymptoMs, Ischaemia and miCrovascular Resistance in Non-obstructive Hypertrophic CardioMyopathy
Hypertrophic cardiomyopathy (HCM) is a common heart condition in which the heart muscle becomes abnormally thick. In non-obstructive HCM, blood flow out of the heart is not blocked, but many patients still experience chest pain…
- Trial name
- COSMIC-HCM (NCT07865364)
- Testing
- Coronary sinus reducer
- Where
- 8 sites in United Kingdom
- Volunteers
- 50 people
- Sponsor
- Imperial College London
Coronary Microvascular Dysfunction
Coronary Microvascular Disease (CMD) Registry
The purpose of this project is to provide appropriate administrative and technical supports for the warehousing and use of a database of patients with coronary microvascular disease (CMD).
- Trial name
- NCT05960474
- Testing
- Outcomes for Patients with CMD
- Where
- 3 sites in United States
- Volunteers
- 1,000 people
- Sponsor
- Medstar Health Research Institute
Hypertrophic, Ischemic
Coronary Artery Disease and Coronary Microvascular Disease in Cardiomyopathies Registry
Long-term prognostic value of macrovascular and microvascular coronary artery stenoses in each type of cardiomyopathy.
- Conditions
- Hypertrophic, Ischemic, Restrictive Cardiomyopathy, Dilated Cardiomyopathies
- Trial name
- 3CRegistry (NCT03479580)
- Testing
- Patients with a cardiomyopathy
- Where
- France
- Volunteers
- 1,600 people
- Sponsor
- University Hospital, Grenoble
Heart Failure, Microvascular Angina
Relationship Between Coronary Microvascular Dysfunction and Improvement of Left Ventricular Systolic Function in Patients With Heart Failure With Reduced Ejection Fraction Caused by Non-ischemic Etiology
This study aims to evaluate the incidence of coronary microvascular dysfunction (CMD) and its prognostic implication for the improvement of left ventricular function in patients who have been diagnosed with heart failure with…
- Conditions
- Heart Failure, Microvascular Angina, Non-ischemic Cardiomyopathy
- Trial name
- HFrEF-CMD (NCT06243653)
- Testing
- CMD test
- Where
- South Korea
- Volunteers
- 200 people
- Sponsor
- Samsung Medical Center
Safety Issues, Efficacy, Self
Lower Silesia Sinus Reducer Registry
Lower Silesia Sinus Reducer Registry is a , single-center, single-arm registry including patients with chronic disabling refractory angina pectoris (Canadian Cardiovascular Society [CCS] classes 2-4) despite maximally tolerated…
- Trial name
- LSSRR (NCT06288165)
- Testing
- Coronary Sinus Reducer Implantation
- Where
- 2 sites in Poland
- Volunteers
- 200 people
- Sponsor
- Miedziowe Centrum Zdrowia SA
ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD)
Invasive Evaluation and Phenotype-Guided Treatment of ANOCA in Women
This prospective single-center interventional study will include women with angina and non-obstructive coronary arteries. Participants will undergo a standardized invasive coronary assessment combining coronary physiology…
- Conditions
- ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD), Vasospastic Angina
- Trial name
- ANOCA-UY (NCT07593157)
- Testing
- Invasive Coronary Functional and Morphological Assessment, Pharmacological treatment will be individualized according to the invasive coronary phenotype identified. Treatment may include antianginal therapy, vasodilator therapy, endothelial function-targeted
- Where
- Uruguay
- Volunteers
- 50 people
- Sponsor
- Hospital de Clínicas Dr. Manuel Quintela
Coronary Microvascular Angina, Macitentan
Evaluation of the Efficacy of MACitentan in the Treatment of CoronaryMICrovascular Angina (MACMIC)
Coronary microvascular angina (MVA) significantly reduces quality of life and increases the risk of heart problems in patients with angina. Unfortunately, there are no effective treatments available yet.
- Trial name
- NCT06811831
- Testing
- Macitentan 10 mg tablet, once daily.
- Where
- China
- Volunteers
- 30 people
- Sponsor
- China-Japan Friendship Hospital
Microvascular Angina
Sex Difference of Coronary Microvascular Dysfunction in Patients With Non-obstructive Coronary Artery Disease
Sex difference of coronary microvascular dysfunction evaluated by coronary flow reserve will be assessed in patients with non-obstructive coronary artery disease
- Trial name
- NCT06076551
- Testing
- Adenosine stress echocardiography
- Where
- South Korea
- Volunteers
- 300 people
- Sponsor
- Korea University Anam Hospital
Coronary Microvascular Disease
Qishenyiqi Dripping Pill for Coronary Microvascular Disease
To investigate the efficacy and safety of Qishenyiqi in patients with microvascular angina pectoris. Long-term follow-up of 1 year will be performed to evaluate the effect of Qishenyiqi on coronary flow reserve and adverse…
- Trial name
- CMVD (NCT06699420)
- Testing
- Qishenyiqi dripping pills 1 bag, three times a day
- Where
- 3 sites in China
- Volunteers
- 162 people
- Sponsor
- Qilu Hospital of Shandong University
ANOCA - Angina With Non-obstructive Coronary Arteries, Coronary Microvascular Dysfunction (CMD)
Nebivolol ANOCA Treatment Randomized Trial
To determine the effectiveness of the beta-blocker nebivolol in controlling symptoms and improving the quality of life in patients with angina and coronary microvascular dysfunction.
- Trial name
- MOTORS (NCT06755801)
- Testing
- Nevibolol
- Volunteers
- 150 people
- Sponsor
- Spanish Society of Cardiology
Lynch Syndrome, Lynch Syndrome I
Lynch Syndrome X-Talk of Enteral Mucosa With Immune System
Lynch syndrome (OMIM #120435) is the most common dominantly inherited colorectal cancer syndrome with an estimated prevalence of 1:270 individuals.
- Conditions
- Lynch Syndrome, Lynch Syndrome I, Lynch Syndrome II, Lynch Syndrome I (Site-specific Colonic Cancer)
- Trial name
- LYNX-EYE (NCT06708429)
- Testing
- LYNX EYE (Lynch syndrome X-Talk of Enteral mucosa with Immune System)
- Where
- 5 sites in United States, Italy
- Volunteers
- 300 people
- Sponsor
- San Raffaele University
Myocardial Infarction, Gender
Barts-MINOCA Registry
The last 15 years the introduction of primary angioplasty has radically improved outcomes for acute myocardial infarction (AMI).
- Conditions
- Myocardial Infarction, Gender, Coronary Microvascular Disease
- Trial name
- NCT04440761
- Testing
- Observation only
- Where
- United Kingdom
- Volunteers
- 3,000 people
- Sponsor
- Queen Mary University of London
Angina, Non-obstructive Coronary Artery Disease
Imaging Coronary Microvascular Dysfunction (CMD) Study
Angina is a common clinical symptom of ischemic heart disease, affecting up to 11 million people in the United States alone, and 112 million people globally.
- Trial name
- NCT05634031
- Testing
- PET imaging, Coronary CT angiogram, Functional Angiography
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Coronary Artery Disease, Coronary Microvascular Dysfunction
The Effects of Tirzepatide in People With Overweight/Obesity and Coronary Artery Disease
The objective of this study is to investigate, as a proof-of-principle, long-term (52 weeks) effects of tirzepatide once-weekly vs.
- Conditions
- Coronary Artery Disease, Coronary Microvascular Dysfunction, Overweight or Obesity, Stable Angina Pectoris
- Trial name
- IDEAL-COR (NCT06606821)
- Testing
- Tirzepatide
- Where
- 3 sites in Denmark
- Volunteers
- 124 people
- Sponsor
- Tina Vilsbøll
Coronary Microvascular Disease
An Observational Study of Coronary Microvascular Disease of China
Non-obstructive coronary heart disease refers to patients with angina pectoris without significant narrowing of the epicardial vessels.
- Trial name
- CCMD (NCT06676137)
- Where
- China
- Volunteers
- 500 people
- Sponsor
- Henan Institute of Cardiovascular Epidemiology
Coronary Artery Disease, Angina (Stable)
Coronary Sinus Reducer Therapy for Persisting Angina
Refractory angina due to advanced obstructive coronary artery disease (CAD) remains a major clinical problem with limited evidence-based treatment options.
- Trial name
- REDUCE ANGINA (NCT07485985)
- Testing
- Coronary sinus reducer
- Volunteers
- 25 people
- Sponsor
- UMC Utrecht