Clinical trials: Microvascular Disease
STEMI (ST Elevation MI)
Inhibition of Late Sodium Current (INa) to Prevent Coronary MICROvascular Dysfunction in Patients Presenting With ST-Elevation Myocardial Infarction and Multivessel Disease: INaMICRON Study
This is a Phase IIb, multicentric, prospective, randomized (1:1 ratio), open label, and no profit study, with the aim of evaluating the efficacy of late INa current inhibition to improve coronary microcirculation in patients…
- Trial name
- INaMICRON (NCT07380919)
- Testing
- Ranolazine
- Where
- 3 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Federico II University
Type 2 Diabetes
Myocardial Perfusion in Type 2 Diabetes
The investigators aimed to evaluate microvascular circulation with novel method: real-time myocardial contrast echocardiography in patients with type 2 diabetes and normal coronary arteries.
- Trial name
- NCT01043965
- Testing
- Metformin
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Ovarian Cancer
Contrast-Enhanced Ultrasonography in Diagnosing Early-Stage Ovarian Cancer in Patients With an Adnexal Mass Undergoing Surgery to Remove the Ovary
RATIONALE: New diagnostic procedures, such as contrast-enhanced ultrasonography, may be an effective method of finding ovarian cancer.
- Trial name
- NCT00626873
- Testing
- Definity, medical chart review
- Where
- 3 sites in United States
- Volunteers
- 67 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Hypertrophic Cardiomyopathy (HCM)
Perfusion Abnormalities in Hypertrophic Cardiomyopathy
The purpose of this study is to investigate whether myocardial microvascular perfusion in patients with hypertrophic cardiomyopathy improved after initiation of cardiac myosin inhibitor therapy.
- Trial name
- NCT06599229
- Testing
- myocardial contrast echo
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Virginia
Ischemic Heart Disease, Coronary Microvascular Disease
MCG for Suspected INOCA Confirmed by Thermodilution-Derived CFR
This study will be an observational registry to investigate the ability of magnetocardiography (MCG) in determining the presence of myocardial ischemia with the absence of obstructive coronary artery disease, by using an invasive…
- Conditions
- Ischemic Heart Disease, Coronary Microvascular Disease, Angina
- Trial name
- MICRO(T) (NCT06139094)
- Testing
- CardioFlux Magnetocardiography
- Where
- 4 sites in United States
- Volunteers
- 48 people
- Sponsor
- Genetesis Inc.
Heart Failure With Preserved Ejection Fraction, Microvascular Dysfunction
Empagliflozin for Peripheral Microvascular Dysfunction in Heart Failure With Preserved Ejection Fraction
The goal of this low-intervention clinical trial is to learn about the effect of the drug Empagliflozin in patients with heart failure with preserved ejection fraction.
- Trial name
- NCT06046612
- Testing
- Participants receive 10mg Empaglifozin once daily on prescription from their treating physician. This is not an intervention in this trial, but part of their normal HFpEF treatment
- Where
- Netherlands
- Volunteers
- 48 people
- Sponsor
- Maastricht University Medical Center
Metabolic Syndrome, Coronary Microvascular Dysfunction
Vericiguat in Patients With Metabolic Syndrome and Coronary Vascular Dysfunction
Coronary vascular dysfunction is one of the "final common pathways" for the impact of multiple cardiovascular risk factors. The investigators will conduct a randomized, double-blind placebo-controlled study in individuals with…
- Trial name
- NCT05711719
- Testing
- Vericiguat
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Johns Hopkins University
Hypertension, Insulin Resistance
Role of AT1-receptor Blockers in Insulin-induced Vasodilation.
In this study we hypothesize that blocking the angiotensin II AT1-receptor improves the insulin-induced microvascular dilatation. Objectives: 1.
- Conditions
- Hypertension, Insulin Resistance, Microcirculation
- Trial name
- NCT00742066
- Testing
- Irbesartan, Felodipine
- Where
- Netherlands
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Insulin Resistance, Microvascular Disease
The Vascular Effects of Vildagliptin in Insulin Resistant Individuals
Animal models have demonstrated that incretins have a glucose-independent effect on vascular perfusion, and there is limited evidence that incretins may enhance endothelial function in healthy subjects.
- Trial name
- NCT01122641
- Testing
- Vildagliptin
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Microvascular Coronary Artery Disease
Additive Value of Physiology Coronary in Clinical Practice
The important evidence of coronary microcirculation for the management of patients with coronary artery disease is only increasing.
- Trial name
- PRINCIPE (NCT04560829)
- Where
- France
- Volunteers
- 150 people
- Sponsor
- University Hospital, Grenoble
Diabetic Neuropathy, Painful, Diabetic Neuralgia
Study for Safety and Effectiveness of RWJ-333369 (Carsibamate) for the Treatment of Diabetic Peripheral Neuropathy (DPN).
The purpose of this study is to evaluate the safety, effectiveness, and tolerability of 200 mg of RWJ-333369 given twice daily by mouth compared with placebo in the treatment of Diabetic Peripheral Neuropathy (DPN).
- Conditions
- Diabetic Neuropathy, Painful, Diabetic Neuralgia, Diabetic Polyneuropathy, Diabetic Mononeuropathy
- Trial name
- NCT00501202
- Testing
- RWJ-333369 (carisbamate)
- Volunteers
- 132 people
- Sponsor
- SK Life Science, Inc.
HCC
Artificial Intelligence and Hepatocellular Carcinoma
To identify new relevant biomarkers for HCC patients and their risk of recurrence. Radiomics data and computer-vision data will be explored for their ability to predict the presence of particular pathological signs of…
- Trial name
- ARTIHCC (NCT05637788)
- Testing
- CT Scan Radiomics Features Extraction
- Where
- Italy
- Volunteers
- 535 people
- Sponsor
- Humanitas Clinical and Research Center
Stable Angina, Coronary Artery Disease
Impact of Rotational Atherectomy on Coronary Microcirculation
The purpose of this observational study is to compare the impact of rotational atherectomy to conventional stenting and to investigate how it may affect coronary microcirculation in patients with calcified coronary artery lesions…
- Trial name
- MICRO-ROTA (NCT05771961)
- Testing
- coronary pressure/temperature sensor-tipped guidewire, Angiography-derived index of microcirculatory resistance (IMRangio)
- Where
- Lithuania
- Volunteers
- 300 people
- Sponsor
- Lithuanian University of Health Sciences
Sickle Cell Disease
TRF-1101 Assessment in Sickle Cell Disease
This study is designed to assess the safety, tolerability, and activity of TRF-1101 on microvascular blood flow, vascular endothelial injury, and vasoocclusive pain associated with sickle cell disease.
- Trial name
- NCT00773890
- Testing
- TRF-1101
- Where
- 6 sites in United States
- Volunteers
- 80 people
- Sponsor
- TRF Pharma, Inc
Coronary Artery Disease
Effects of Cangrelor on MIcRovAscular Disfunction During Elective Percutaneous CORonary Intervention
Dual Antiplatelet Therapy represents the main therapy for patients presenting with chronic coronary syndromes and undergoing elective PCI.
- Trial name
- MIRACOR (NCT06089577)
- Testing
- Cangrelor 50 MG
- Where
- 2 sites in Italy
- Volunteers
- 80 people
- Sponsor
- Federico II University
Cardiovascular Diseases
The Effects of Aerobic Exercise in Microvascular Endothelium Function in Patients With Cardiovascular Diseases
This study evaluates the effects of different volumes of aerobic exercise training in cardiovascular parameters of patients with cardiovascular diseases enrolled in a cardiac rehabilitation program.
- Trial name
- NCT02514564
- Testing
- Exercise, Sedentarism
- Where
- Brazil
- Volunteers
- 115 people
- Sponsor
- Instituto Nacional de Cardiologia de Laranjeiras
Coronary Microvascular Disease, Coronary Artery Disease
A Non-invasive Index of Microciculatory Resistance
Coronary artery microvascular disease (CMVD) lacks reliable and non-invasive quantitative diagnosis methods. Improving coronary microcirculation has become one of the main goals of coronary heart disease treatment.
- Trial name
- NCT04554004
- Testing
- CCTA, CT-MPI, DSA, FFR
- Where
- China
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Hangzhou
Type 2 Diabetes
The Effect of 4 Weeks of L-Citrulline Supplementation on Macro- and Microvascular Function in Type 2 Diabetes
The purpose of this study is to examine the effect of 4 weeks of Citrulline supplementation on macro- and microvascular function during acute hyperglycemia in middle-aged and older adults with type 2 diabetes.
- Trial name
- NCT06016478
- Testing
- L-citrulline
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Texas Tech University
Cardiac Allograft Vasculopathy, Endothelial Dysfunction
Determining the Association of Microvascular Disease as Assessed by PET and Graft Injury by Donor Derived Cell Free DNA
The goal of this research study is to understand if a blood test in people who have had heart transplants can detect and predict the following: Blockages in the small blood vessels of the heart.
- Conditions
- Cardiac Allograft Vasculopathy, Endothelial Dysfunction, Microvascular Coronary Artery Disease
- Trial name
- DEPICT (NCT05756088)
- Testing
- Blood draw to measure the levels of dd-cf DNA
- Where
- United States
- Sponsor
- Yale University