Clinical trials: Microvascular Function
Gestational Diabetes, Oxidative Stress
Role of NADPH Oxidase in Microvascular Dysfunction Following GDM
The purpose of this investigation is to examine NADPH oxidase as a source of reactive oxygen species contributing to aberrant microvascular function in otherwise healthy women with a history of GDM.
- Conditions
- Gestational Diabetes, Oxidative Stress, Vascular Endothelial Function
- Trial name
- NCT05946798
- Testing
- Acetylcholine, Insulin aspart
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
Stroke, Vascular Diseases
Passive Limb Movement Study
Stroke survivors have compromised vascular function which may contribute to secondary stroke risk, cardiovascular disease, and may limit their exercise tolerance.
- Conditions
- Stroke, Vascular Diseases, Ischemic
- Trial name
- PLM (NCT05935670)
- Testing
- Ischemic Conditioning
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Obesity, Vascular Dysfunction
DNA Methylation and Vascular Function
The main objective is to examine DNA hypomethylation as an underlying mechanism for the increased production of inflammatory cytokines and the impaired vascular function in obese individuals and as a potential target for…
- Trial name
- NCT03527420
- Testing
- Exercise training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Illinois at Chicago
Microvascular Dysfunction
Cheese Consumption and Human Microvascular Function
Increased dairy intake is associated with improved measures of blood vessel health. Dairy cheese, however, is often high in sodium. Dietary sodium can impair blood vessel function.
- Trial name
- NCT03376555
- Testing
- Low sodium no cheese, Low sodium cheese, High sodium no cheese
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Lacy Alexander
Chronic Kidney Diseases
Skeletal Muscle Oxygenation in Patients With Chronic Kidney Disease Stage 2, 3 and 4
Endothelial dysfunction occurs early in chronic kidney disease (CKD) and is associated with target organ damage, progression of renal injury, cardiovascular events, and mortality.
- Trial name
- NCT05250167
- Where
- Greece
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Aristotle University Of Thessaloniki
Stroke, Epilepsy
Coronary and Cerebral Microvascular Dysfunction in Neurological Diseases
Neurological and cardiovascular diseases are increasing in relative and absolute terms globally, and pose a major burden in terms of morbidity, mortality, quality of life and healthcare costs.
- Conditions
- Stroke, Epilepsy, Transient Global Amnesia (TGA)
- Trial name
- G-HeBra (NCT07009990)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Endothelial Dysfunction, Hyperhomocysteinemia
Effects of Oral Supplementation With Creatine on Systemic Microvascular Endothelial Function in Vegetarian Individuals
The present study aims at investigating the effects of the oral supplementation with creatine on the systemic microvascular reactivity and plasma levels of homocysteine in vegetarian individuals of the vegan type.
- Trial name
- NCT02961972
- Testing
- monohydrate and micronized creatine
- Where
- Brazil
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Insulin Resistance, Microvascular Disease
The Vascular Effects of Vildagliptin in Insulin Resistant Individuals
Animal models have demonstrated that incretins have a glucose-independent effect on vascular perfusion, and there is limited evidence that incretins may enhance endothelial function in healthy subjects.
- Trial name
- NCT01122641
- Testing
- Vildagliptin
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Royal Devon and Exeter NHS Foundation Trust
Ageing, Blood Flow Restriction
Comparing Vascular Responses to Resistance Exercise with and Without Blood Flow Restriction in Young and Older Adults
Aging leads to declines in functional capacity and effort tolerance. Muscle strength remains stable from ages 25 to 50 but declines significantly after age 60, affecting activities like stair climbing and walking, reducing…
- Trial name
- HOLD TIGHT (NCT06596304)
- Testing
- Low intensity-resistance training with lower limb blood flow restriction, High Intensity Resistance Training
- Where
- 2 sites in Portugal
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL
Diabetes Mellitus
Microvascular Response in Diabetes Mellitus
Vascular and neurological mechanisms are both likely to be involved in foot ulcer. We recently reported on the hand an original transient pressure-induced vasodilation (PIV) during a 5 mmHg/min increase of pressure strain using…
- Trial name
- NCT00160927
- Testing
- local heating, iontophoresis, actylcholine
- Where
- France
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Obstructive Sleep Apnoea, Obesity
Peripheral Vascular Function in Obstructive Sleep Apnoea
Peripheral vascular function is impaired in people with obstructive sleep apnoea who are untreated compared with age-, weight- and sex-matched healthy controls.
- Trial name
- NCT01619748
- Where
- 2 sites in United Kingdom
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust
Coronary Microvascular Disease, Cardiac Pacemaker Syndrome
The Effects of Trans Venous Cardiac Pacing on Coronary Microvascular Function and Hemodynamics
The study will examine role of transvenous pacing on coronary microcirculation.
- Trial name
- NCT03917251
- Testing
- Coronary flow and pressure measurement in patients with ventricular pacing
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Nebraska
Prediabetes, Obese
Inflammation Inhibition in Prediabetic Humans
Prediabetes, characterized by elevated fasting blood sugar or exaggerated blood sugar response to sugar ingestion, effects over 79 million adult Americans and is a precursor to the development of Type 2 diabetes.
- Trial name
- INCITE (NCT01977417)
- Testing
- Salsalate
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Gary L. Pierce
Aging, Lipemia
Effects of Nicotinamide Riboside on Metabolism and Vascular Function
The purpose of this study is to determine the effects of Nicotinamide Riboside (NR) supplementation on metabolism and vascular function following high-fat meal.
- Trial name
- NCT03501433
- Testing
- Nicotinamide riboside chloride (Niagen)
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Iowa State University
Gestational Diabetes, Vascular Endothelial Function
Oxidative Stress in Microvascular Dysfunction Following Gestational Diabetes
The purpose of this investigation is to examine the role of oxidative stress in aberrant microvascular function in otherwise healthy women with a history of GDM.
- Trial name
- NCT05946785
- Testing
- Acetylcholine, insulin aspart
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Anna Stanhewicz, PhD
TBI
Non-invasive Measurement of Cerebrovascular Reactivity After Traumatic Brain Injury
The investigators will longitudinally measure cerebrovascular reactivity (CVR) by functional near-infrared spectroscopy (fNIRS) in acute (≤3 days from injury), subacute, and chronic phases after TBI as a biomarker of TCVI as…
- Trial name
- NCT02990078
- Testing
- Sildenafil citrate, Functional Near Infared Spectroscopy, Hypercapnia Challenge
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Pediatric Hypertension, Primary Hypertension
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Children With Newly Diagnosed Hypertension
Childhood hypertension is associated with early endothelial dysfunction and an increased risk of future cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial…
- Conditions
- Pediatric Hypertension, Primary Hypertension, Endothelial Dysfunction
- Trial name
- HYPER-endoEV-c (NCT07728643)
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Severe Sepsis, Critical Illness
Ultrasound Measurement of Reactive Hyperemia in Critical Care
The investigators hypothesize that doctors and nurses can undergo a brief period of training and then use ultrasound to accurately measure blood flow in a forearm artery after a brief period when this flow is interrupted with a…
- Trial name
- URHC (NCT01726595)
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Vascular Remodeling, Sedentary Behavior
Effect of Training Intensity on Microvascular Function
The aim of this trial is to investigate the effect of aerobic training intensity on muscle vascular function: continuous versus interval.
- Conditions
- Vascular Remodeling, Sedentary Behavior, Hemodynamic Rebound
- Trial name
- NCT07237854
- Testing
- Percutaneous muscle biopsies of the vastus lateralis (quadriceps), Measurement of the maximal oxygen uptake (VO2max), Non-Invasive Cardiac Output Measurement (Innocor)
- Where
- Belgium
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Université Libre de Bruxelles
Arterial Hypertension, Erectile Dysfunction
Effects of Sildenafil on Penile Vascular Function in Hypertensive Men With Erectile Dysfunction
The study will evaluate the effects of a chronic 30-day treatment with sildenafil citrate on penile and systemic microvascular function as well as in blood pressure.
- Trial name
- NCT02620995
- Testing
- sildenafil citrate, comparator group
- Where
- Brazil
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil