Clinical trials: Microvascular Function
Microvascular Coronary Dysfunction
Cardiac Autonomic Function in Women with Microvascular Coronary Dysfunction
Microvascular coronary dysfunction (MCD) (abnormities in small blood vessels/arteries in heart) with symptoms of persistent chest pain impacts women.
- Trial name
- NCT01568177
- Testing
- Mental Stress Testing, Peripheral Arterial Tonometry (PAT) Testing, Heart Rate Variability (HRV)
- Where
- United States
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Obesity, Dyslipidemias
Evaluation of Systemic Microvascular Endothelial Function in Metabolically Healthy Obesity
Obesity is known to be a risk factor for cardiovascular disease (CVD), type 2 diabetes mellitus, gastrointestinal tract disease, respiratory problems (such as obstructive sleep apnea), joint and muscle problems, reproductive…
- Trial name
- NCT04233528
- Testing
- Evaluation of systemic skin microvascular endothelial function
- Where
- Brazil
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Microvascular Function
Cephalic Phase Insulin Secretion and Capillary Recruitment in Healthy Men
Forty healthy volunteers will undergo two nailfold-videocapillaroscopy exams with a 10-minute interval between them, after an 10-h overnight fast in a temperature controlled room.
- Trial name
- NCT01145027
- Testing
- Breakfast tray
- Where
- Brazil
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Aging
Heat, Microvascular Function and Aging
Vascular dysfunction is a common factor in many chronic debilitating diseases, contributing to morbidity and mortality. With the onset of chronic disease or exposure to stress, the vasculature displays an inability to adequately…
- Trial name
- NCT06633198
- Testing
- Passive Heating, L-NAME
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- William Hughes
Metabolic Syndrome
Acute Effects of Oral Carbohydrate and Fat Loads on Systemic Microvascular Endothelial Function in Healthy Individuals.
The present study was designed to evaluate vascular endothelial dysfunction resulting from the oral ingestion of high loads of sugar and fat meals in healthy individuals.
- Trial name
- NCT03515460
- Testing
- sugar oral load, fat oral load, sugar and fat oral load
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Obesity
Study About High Fat Meal and Postprandial Lipemia
The hypothesis of the proposed project is that after a fat overload, the postprandial response is different in both groups, suggesting that the LPP will present the most significant damage in endothelial vasomotion in obese…
- Trial name
- NCT01692327
- Testing
- High fat meal
- Where
- Brazil
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Hypertension
Does Ultraviolet Irradiation Reduce Platelet Reactivity and Improve Coronary Microvascular Function in Man?
Endothelium derived nitric oxide (NO) regulates vascular tone and blood pressure in man. NO also inhibits platelet aggregation and mediates a variety of beneficial anti-inflammatory and repair mechanisms.
- Trial name
- NCT01785511
- Testing
- UVA Radiation
- Where
- United Kingdom
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
Hypertension, Endothelial Function
Endothelial Extracellular Vesicles as Biomarkers of Endothelial Activation in Adults With Newly Diagnosed Hypertension
Hypertension is associated with endothelial dysfunction, an early event in the development of cardiovascular disease. Endothelial extracellular vesicles (EEVs) have emerged as promising biomarkers of endothelial activation and…
- Trial name
- HYPER-endoEV-a (NCT07728630)
- Where
- Croatia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Abdominal Obesity Metabolic Syndrome, Insulin Resistance
Aldosterone Antagonism and Microvascular Function
The prevalence of obesity and obesity-related complications is currently taking epidemic proportions. These complications increase the risk of type 2 diabetes and cardiovascular disease, which are important causes of morbidity…
- Conditions
- Abdominal Obesity Metabolic Syndrome, Insulin Resistance, Hypertension
- Trial name
- NCT01887119
- Testing
- Eplerenone
- Where
- Netherlands
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Hypertension,Essential
Peripheral Vascular Effects of Sulfhydryl-containing Antihypertensive Pharmacotherapy on Microvessels in Humans
High blood pressure can cause physical changes to the blood vessels of the body (remodeling). If a person who has high blood pressure also has a lot of blood vessel remodeling with their condition, they are more likely to have…
- Trial name
- H2SPharm (NCT03179163)
- Testing
- Captopril Pill, Enalapril Pill, Hydrochlorothiazide
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Penn State University
Endothelial Function
Evaluation of Systemic Microvascular Reactivity After Ingestion of an Energy Drink in Young Male Volunteers
Purpose: Energy drinks (EDs) are nonalcoholic beverages whose main ingredients are sugar, taurine, and caffeine. Their consumption is rising worldwide, with only few conflicting studies examining their vascular effects in young…
- Trial name
- NCT05575895
- Testing
- Ingestion of the energy drink (Red Bull®), Ingestion of mineral water
- Where
- 2 sites in Brazil
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Institute of Cardiology, Laranjeiras, Brazil
Healthy Subjects (HS), Cardiovascular Diseases (CVD)
Multi-organ Imaging of Microvascular and Metabolic Function
What if heart disease starts outside the heart? This research will study how to simultaneously assess brain and body physiology, how they are jointly related to heart function, and how their response to physical and mental stress…
- Trial name
- NCT07604207
- Testing
- 18F-FDG, Positron Emission Tomography (PET)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Type 2 Diabetes, Healthy Aging
Role of Autophagy in Type 2 Diabetes Microvascular Dysfunction
The goal of this clinical trial is to examine the role of autophagy on microvascular function in adults with Type 2 Diabetes. The main question it aims to answer are: Does presence of Type 2 Diabetes reduce autophagy and impair…
- Trial name
- NCT05593549
- Testing
- Trehalose
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Medical College of Wisconsin
Coronary Microvascular Dysfunction
Effect of Intact GLP-1 (7-36) and GLP-1 Metabolite (9-36) on Coronary and Peripheral Vascular Function in Adults
GLP-1 is an agent for treatment of type 2 diabetes and may have protective effects on the cardiovascular system. The mechanism is complex and there seems to be a dual function with intact GLP-1 (7-36), acting through the GLP-1…
- Trial name
- NCT02333591
- Testing
- GlucagonLikePeptide-1 (7-36), GlucagonLikePeptide-1 (9-36), Saline
- Where
- Denmark
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mette Zander
Diabetes Mellitus, Type 1
Effects of Low Intensity Aerobic Exercise on the Microvascular Endothelial Function of Patients With Type 1 Diabetes
Background: The aim of the present study was to evaluate the changes in the microvascular density and reactivity in patients with type 1 diabetes (T1D) resulting from low intensity chronic exercise training.
- Trial name
- NCT02441504
- Testing
- Low intensity Exercise
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Instituto Nacional de Cardiologia de Laranjeiras
COVID-19, Endothelial Function
Non-invasive Characterization of Systemic Microvascular Reactivity by Near-infrared Diffuse Optical Spectroscopy in COVID-19 Patients
The purpose of this study is to characterize microvascular reactivity on the forearm muscle using non-invasive near-infrared spectroscopy in critically ill COVID-19 patients, and to correlate its alterations with 28-day mortality…
- Trial name
- HEMOCOVID19 (NCT04689477)
- Testing
- Vascular occlusion test
- Where
- 8 sites in United States, Brazil and 2 more
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- Corporacion Parc Tauli
Physical Exertion
Acute Exercise and Microvascular Function
It is well recognized that chronic exercise protects against the development of cardiovascular diseases. However, the responses of vasculature to acute exercise (AE) are not well known and not consistent in literature.
- Trial name
- NCT02727439
- Testing
- Acute Exhausting Exercise (AE)
- Where
- Croatia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Josip Juraj Strossmayer University of Osijek
Hot Flashes, Menopause
Hot Flashes and Neurovascular Function in Women
Women who experience hot flashes are at greater risk for hypertension and other cardiovascular disease. Neurovascular control mechanisms are likely to play an important role in this relationship.
- Conditions
- Hot Flashes, Menopause, Vasomotor System; Labile
- Trial name
- NCT05193968
- Testing
- Sympathoexcitatory stressors, Sodium Nitroprusside, Acetylcholine
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Diabetes Mellitus, Type 2
Skin and Retina Microvascular Endothelial Function in Healthy, Insulin Resistant and Type 2 Diabetic Subjects
The purpose of this study is to investigate microvascular endothelial function in the retina of lean, obese, and type 2 diabetic subjects and to compare microvascular endothelial function in the retina with several other…
- Trial name
- NCT01241370
- Where
- Germany
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- ELAB-Logistics
Cardiovascular Disease, Endothelial Dysfunction
Elucidation and Monitoring Postprandial Endothelial Function
The primary aim of this study is to evaluate the effect of a high fat challenge on several measures of endothelial function. The secondary aim of this study is to elucidate the mechanism of postprandial endothelial dysfunction…
- Trial name
- EMPEF (NCT00766623)
- Testing
- high fat meal, control meal
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Wageningen University