Clinical trials: Microvascular Perfusion
Hypertension
Effects of Nebivolol on Skeletal Muscle During Exercise in Hypertensive Patients
The purpose of this study is to determine if Nebivolol improves microvascular perfusion in skeletal muscle during exercise in hypertensive patients and whether this improvement is accompanied by reduction in vascular oxidative…
- Trial name
- NCT01501929
- Testing
- Metoprolol succinate, Nebivolol, Non-invasive measurement of Cardiac Output (CO)
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Free Tissue Flaps
Detection of Flap Ischemia Using Interstitial Glucose Monitor
A simple device that objectively assesses flap perfusion - either as a stand-alone tool or an adjunct to the current monitoring method - would be a tremendous improvement in detection of early postoperative flap ischemia and, in…
- Trial name
- NCT02604069
- Testing
- Continuous Glucose Monitor
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Hamilton Health Sciences Corporation
Circulatory; Change
Evaluating A Non-Invasive Tissue Perfusion Monitor
The Pedra perfusion system will be used to assess changes in perfusion in response to physiological stimuli. It will be compared to other standard diagnostics.
- Trial name
- NCT04630704
- Testing
- Pedra
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Pedra Technology, PTE LTD
Metabolic Syndrome
Effects of Exercise and GLP-1 Agonism on Muscle Microvascular Perfusion and Insulin Action in Adults With Metabolic Syndrome
The primary objective of this study is to examine whether exercise training alone, liraglutide treatment alone or exercise training plus liraglutide treatment increases cardiac and skeletal muscle microvascular blood volume…
- Trial name
- ZQL008 (NCT04575844)
- Testing
- Liraglutide, Exercise training, Liraglutide + Exercise training
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Microvascular Disease, Microvascular Complications
Comparison of Differencens in VO2-max, Perfusion of the Heart and Brain and Cognitive Performance Between Patients with Type 2 Diabetes and Healthy Age Matched Controls.
In the aging population, ischemic heart disease, stroke and dementia are increasingly prevalent. Diagnosis and treatment of the former two i.e., large-vessel coronary heart disease and endovascular thrombectomy of the brain in…
- Conditions
- Microvascular Disease, Microvascular Complications, Dementia, Diabetes Mellitus Type 2
- Trial name
- SVAT (NCT06628297)
- Testing
- PET
- Where
- Denmark
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
Sickle Cell Disease
Microvessels and Heart Problems in Sickle Cell Disease
Background: Small blood vessels (microvessels) in many different organs are affected by diseases such as diabetes and atherosclerosis. These microvessels may also be abnormal in people who have sickle cell disease.
- Trial name
- NCT01602809
- Where
- United States
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
NIRS, Tissue Oxygenation
CHECK-NIRS2D-Study
The study investigates how external, physiological, and behavioral factors influence the measurement of regional tissue oxygenation using two-dimensional near-infrared spectroscopy (NIRS) imaging in healthy volunteers.
- Conditions
- NIRS, Tissue Oxygenation, Microvascular Perfusion, Vascular Occlusion Test
- Trial name
- NCT07854431
- Where
- Germany
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Heinrich-Heine University, Duesseldorf
Coronary Microvascular Disease, Coronary Artery Disease
A Non-invasive Index of Microciculatory Resistance
Coronary artery microvascular disease (CMVD) lacks reliable and non-invasive quantitative diagnosis methods. Improving coronary microcirculation has become one of the main goals of coronary heart disease treatment.
- Trial name
- NCT04554004
- Testing
- CCTA, CT-MPI, DSA, FFR
- Where
- China
- Volunteers
- 295 people, healthy volunteers welcome
- Sponsor
- First People's Hospital of Hangzhou
Microvascular Disease, Microvascular Complications
Test of Reproducibility of [15O]H20-PET Assessment of Brain Perfusion
In the aging population, ischemic heart disease, stroke and dementia are increasingly prevalent. Diagnosis and treatment of the former two i.e., large-vessel coronary heart disease and endovascular thrombectomy of the brain in…
- Conditions
- Microvascular Disease, Microvascular Complications, Diabetes Mellitus Type 2, Cerebral Hypoperfusion
- Trial name
- SVAT (NCT06624267)
- Testing
- PET
- Where
- Denmark
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University Hospital Bispebjerg and Frederiksberg
End Stage Heart Failure
Impact of LVAD Implantation on Micro- and Macrovascular Function
End stage heart failure is characterized by a critical inability of the heart to meet the organism's blood demand even under resting conditions.
- Trial name
- LVAD (NCT02174133)
- Where
- Germany
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Klinik für Kardiologie, Pneumologie und Angiologie
Type 2 Diabetes
Myocardial Perfusion in Type 2 Diabetes
The investigators aimed to evaluate microvascular circulation with novel method: real-time myocardial contrast echocardiography in patients with type 2 diabetes and normal coronary arteries.
- Trial name
- NCT01043965
- Testing
- Metformin
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Vascular Stiffness, Insulin Sensitivity
Effect of Hyperglycemia on Microvascular Perfusion in Healthy Adults
The investigators are studying the effects of Hyperglycemia on vascular function and insulin sensitivity on healthy adults
- Trial name
- EJB050 (NCT03520569)
- Testing
- Octreotide, Insulin, Dextrose 20% solution
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Chest Pain, Sickle Cell Anemia
Effects of Nitric Oxide and Nitroglycerin in Patients With Sickle Cell Anemia
Sickle cell anemia is the most common genetic disease affecting African-Americans. About 1 in every 1000 African-Americans has the disease and 1 in every 12 carry the genes that could be passed on to their children.
- Trial name
- NCT00001716
- Testing
- Nitric Oxide, Nitroglycerin
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Stroke, Epilepsy
Coronary and Cerebral Microvascular Dysfunction in Neurological Diseases
Neurological and cardiovascular diseases are increasing in relative and absolute terms globally, and pose a major burden in terms of morbidity, mortality, quality of life and healthcare costs.
- Conditions
- Stroke, Epilepsy, Transient Global Amnesia (TGA)
- Trial name
- G-HeBra (NCT07009990)
- Where
- Germany
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Biological Aging
Effects of Phytonutrients Upon Muscle Perfusion in Response to Feeding
This is a random order cross over design trial to evaluate the efficacy of select nutritional ingredients on enhancing muscle perfusion in response to an acute meal stimulus.
- Trial name
- NCT03213340
- Testing
- Catechin Cohort 1, Curcuminoid Cohort 2, Flavonoid Cohort 3
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition