Clinical trials: Midazolam
Healthy Participants
Study of BLU-808 in Healthy Adult Participants
This is a 3-part study. Parts 1 and 2 are randomized, double-blind, placebo-controlled investigations of single ascending doses (SAD) (Part 1) and multiple ascending doses (MAD) (Part 2) of orally administered BLU-808 in healthy…
- Trial name
- NCT06948032
- Testing
- BLU-808, Midazolam
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Blueprint Medicines Corporation
Overweight Subject, Healthy Subjects
A Drug-Drug Interaction Study of HDM1002 and Metformin, Empagliflozin, Midazolam, Valsartan, and Warfarin
The purpose of this study is to characterize the drug-drug intereaction of HDM1002 and metformin, empagliflozin, midazolam, valsartan, and warfarin in overweight/obese adult subjects.
- Trial name
- NCT07331389
- Testing
- Metformin, Empagliflozin, Midazolam
- Where
- China
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.
Healthy Participants
Study of How Mitapivat Affects Midazolam Blood Levels in Healthy Participants
The primary purpose of this study is to assess the effect of mitapivat on the single oral dose pharmacokinetics (PK) of midazolam in healthy participants.
- Trial name
- NCT06648824
- Testing
- Mitapivat, Midazolam
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Agios Pharmaceuticals, Inc.
Healthy
Drug-Drug Interaction Study of Qualaquin and Midazolam
This is an open label non-randomized single sequence, single group two way drug interaction study in healthy adult volunteers to determine the extent to which quinine, an inducer of cytochrome p450 CYP 3A4, affects the…
- Trial name
- NCT00785486
- Testing
- Midazolam Alone, Qualaquin (quinine) alone steady state, Midazolam and Qualaquin at steady state
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Mutual Pharmaceutical Company, Inc.
Tonsillitis
Comparison of Dexmedetomidine and Midazolam for Prevention of Emergence Delirium in Children
Emergence delirium is a common complication in children after anesthesia. The incidence of emergence delirium is reported upto 50%.
- Trial name
- NCT03337672
- Testing
- Dexmedetomidine, Midazolam
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Eunah Cho, MD
Atherosclerosis
Pharmacokinetic Interaction of Darapladib and CYP 3A4 in Healthy Subjects
This study will determine the effect of single and repeat administration of darapladib, a novel, selective, orally active inhibitor of lipoprotein associated phospholipase A2 (Lp-PLA2) currently under clinical development on the…
- Trial name
- NCT01873339
- Testing
- Darapladib, Midazolam
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Healthy
Pharmacokinetic Interaction Between SSP-004184 (SPD602) and Midazolam in Healthy Adult Subjects
A Study to Evaluate the Pharmacokinetic Interaction Between SSP-004184 and Midazolam in Healthy Adult Subjects
- Trial name
- NCT01989169
- Testing
- Midazolam, SSP-004184SS
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Shire
Dental Anxiety
Comparison of Triazolam and Midazolam for Anxiolysis During Dental Treatment in the Pediatric Patient
This study will evaluate the perceptions of the effects of two anxiolytic medications commonly used during dental treatment in patients weighing 40 kilograms or more.
- Trial name
- NCT03360123
- Testing
- Midazolam Hydrochloride 2Mg/mL Syrup, Triazolam 0.125 MG
- Where
- United States
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Healthy Participants
A Study to Investigate the Pharmacokinetics of Midazolam After Repeated Doses of Camizestrant (AZD9833) and to Investigate the Pharmacokinetics of Camizestrant When Administered Alone and in Combination With Carbamazepine in Healthy Post-Menopausal Female Participants
This study will be conducted in order to determine the effect of repeated oral doses of camizestrant on the pharmacokinetics (PK) of midazolam and to determine the effect of repeated oral titrated doses of carbamazepine on the PK…
- Trial name
- NCT06547164
- Testing
- Midazolam, Camizestrant, Carbamazepine
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- AstraZeneca
Healthy
Pharmacokinetic Study of Intranasal Esketamine and Its Effects on the Pharmacokinetics of Orally-Administered Midazolam and Bupropion in Healthy Participants
The primary purpose of this study is to evaluate the induction potential of repeated administration of intranasal esketamine on cytochrome P450 (CYP) 3A4 and CYP2B6 activity in healthy participants using orally administered…
- Trial name
- NCT02568176
- Testing
- Midazolam, Esketamine, Bupropion
- Where
- Belgium
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Invasive Aspergillosis
Evaluation of the Potential for Cytochrome P450 3A4 Inhibition by F901318 Using Oral Midazolam as a Probe
Open label evaluation of potential interaction of F901318 with cytochrome P450 3A4 using midazolam as a probe. Twenty healthy male subjects will participate
- Trial name
- NCT02680808
- Testing
- Midazolam with F901318
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- F2G Ltd
Drug Interaction Potentiation
Open-label, Single Center, Non-randomized, Fixed Sequence Phase 1 Drug-drug Interaction Study With LEO 32731 and Midazolam
This is a single center, non-randomized, open-label, fixed sequence study to investigate the effect of multiple oral dosing of LEO 32731 (up-titrated), on CYP3A activity in healthy male subjects using midazolam as a probe CYP3A…
- Trial name
- NCT03126578
- Testing
- LEO 32731, Midazolam
- Where
- Germany
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- LEO Pharma
Healthy Volunteers
Phase 1 Bioavailability Study of MELT-100 (Midazolam and Ketamine Sublingual) and IV Midazolam or Ketamine
Comparative Bioavailability study testing MELT-100 (midazolam and ketamine sublingual tablet) and IV midazolam or ketamine in healthy volunteers
- Trial name
- NCT04485702
- Testing
- Midazolam injection, Ketamine Injectable Product, MELT-100
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Melt Pharmaceuticals
Vesicoureteral Reflux
Midazolam Effect in Children Undergoing Voiding Cystourethrogram (VCUG)
The purpose of this research is to validate the common administration of oral midazolam to children prior to voiding cystourethrogram (VCUG) to see if this will significantly decrease children's anxiety and make the experience…
- Trial name
- NCT00894465
- Testing
- midazolam
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Disorders of Gallbladder, Biliary Tract and Pancrease
Efficacy and Safety Profiles of Combination Sedation Propofol With Midazolam and Meperidine.
The purpose of this study is to compare efficacy and safety of combination of propofol and midazolam with meperidine versus midazolam and meperidine for ambulatory ERCP
- Trial name
- ERCP (NCT01709422)
- Testing
- Propofol, Midazolam, Meperidine
- Where
- Thailand
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Prince of Songkla University
Midazolam Overdose
Measurement of Midazolam Levels in Follicular Fluid
To determine the impact of Midazolam levels in follicular fluid on morpho-kinetics and morpho-genetics. The reason to measure Midazolam levels in larger size follicles in this study is to maximize the chances to get a mature…
- Trial name
- NCT03049293
- Testing
- Midazolam
- Where
- United Arab Emirates
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Healthy
Drug-drug Interaction Study of Evobrutinib With Midazolam in Healthy Participants
The study will investigate the effect of single dose and multiple doses of M2951 on midazolam Pharmacokinetics (PK) in healthy participants.
- Trial name
- NCT04697511
- Testing
- Midazolam, M2951
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany
Healthy Participants
Assess the Drug Interactions of BBT-877 and Midazolam, Itraconazole, and Esomeprazole in Healthy Adult Subjects
Study to determine the effect of multiple-dose BBT-877 on the single-dose pharmacokinetics of midazolam, the safety and tolerability of a single dose of BBT-877 administered alone and with multiple doses of itraconazole, and the…
- Trial name
- NCT04138836
- Testing
- BBT-877, Midazolam, Itraconazole
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bridge Biotherapeutics, Inc.
Epilepsy
Pharmacodynamics of Nasal and Buccal Midazolam Using EEG
Approximately 3 million individuals suffer from epilepsy in America alone and about 200,000 new cases of epilepsy in America are diagnosed each year (Epilepsy Foundation, 2005).
- Trial name
- nMDZ-EEG (NCT01316445)
- Testing
- nasal Midazolam
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Columbia University
Inguinal Hernia
Comparison of Dexmedetomidine and Midazolam for Intra-op Sedation in TIVA in Children Undergoing Inguinal Hernia Repair
To compare dexmedetomidine and midazolam for intra-op sedation in TIVA in children undergoing inguinal hernia repair. The results of the study if found significant will guide the anesthetist in appropriate choice and dose of…
- Trial name
- NCT05337085
- Testing
- Dexmedetomidine, Midazolam
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Sheikh Zayed Medical College