Clinical trials: Middle Aged Patients
Bipolar II Disorder
add-on Low Dose Memantine in Middle-to-old Aged Bipolar II Disorder Patients
The investigators hypothesized that add-on memantine (MM) 5 mg/day may reduce chronic inflammation, and subsequently improve neuro-progression process and cognitive function in middle-to-old aged bipolar II disorder (BP-II)…
- Trial name
- NCT04035798
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- National Cheng-Kung University Hospital
Cognitive Disorders
EGb 761® (Tanakan®) Effectiveness in the Treatment of Patients of Middle Age and Younger With Psycho-emotional Symptoms, Added to Cognitive Disorders
The purpose of this study is to determine the effectiveness of EGb 761® (Tanakan®) in Russian patients of middle age and younger, suffering from psycho-emotional symptoms added to cognitive disorders based on the improvement of…
- Trial name
- TAYPES (NCT02321475)
- Testing
- EGb761®
- Where
- 2 sites in Russia
- Volunteers
- 54 people
- Sponsor
- Ipsen
Depression
Preventing the Return of Depression in Elderly Patients
The purpose of this study is to compare the effectiveness of two doses of nortriptyline in elderly patients whose depression returned after stopping treatment. Nortriptyline is an antidepressant.
- Trial name
- NCT00000377
- Testing
- Nortriptyline
- Sponsor
- University of Pittsburgh
Cancer Pain
Efficacy of Biofeedback-Based Serious Game for Pain Alleviation in Middle-Aged and Older Ovarian Cancer Patients: A Randomized Controlled Trial
Consistent pain affects most middle-aged and older ovarian cancer patients. Non-pharmacological pain interventions, such as serious games, offer a promising approach to alleviating this pain by providing an effective sense of…
- Trial name
- NCT06612489
- Testing
- biofeedback based dynamic-difficulty game, fixed difficulty game
- Where
- China
- Volunteers
- 52 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Traumatic Injury
Ketogenic Feeding for Muscle Preservation After Trauma
The purpose of this study is to determine whether a ketogenic diet, provided as tube feeding, compared with a standard hospital tube feeding, is safe and feasible and helps preserve muscle mass and improve metabolic health in…
- Trial name
- KETO TRAUMA (NCT07827820)
- Testing
- Ketogenic feeding, Standard feeding
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Alabama at Birmingham
Dental Caries, Caries,Dental
Caries Prevalence, Experience and Risk Related Factors Among Early Middle-aged Patients Attending Cairo University
Dental caries, a widespread oral health issue, results from a complex interplay of factors including behavior, hygiene, diet, and socio-demographic aspects.
- Trial name
- NCT06365281
- Where
- Egypt
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Cairo University
Effect of Age on Mortality, ICU Mortality
Impact of Age on Mortality in Critically Ill Adult Patients in Nepal- a Single Center Retrospective Study of 5 Years.
Rationale: Age is often considered a strong factor that determines the outcomes in critically ill patients. In a resource limited low middle income country (LMIC) like Nepal, the age factor is often considered when making…
- Conditions
- Effect of Age on Mortality, ICU Mortality, Age
- Trial name
- NCT06888206
- Where
- Nepal
- Volunteers
- 8,189 people
- Sponsor
- Tribhuvan University Teaching Hospital, Institute Of Medicine.
Hormone Deficiency
Outcomes of Adipose Derived Mesenchymal Stem Cells on Sexual Hormone Deficiency
The purpose of this study is to evaluate the safety and effectiveness of adipose derived mesenchymal stem cells (AD-MSCs) therapy on sexual hormone deficiency in the middle-aged patients
- Trial name
- MSCSHD (NCT03346967)
- Testing
- adipose-derived mesenchymal stem cells
- Where
- Vietnam
- Volunteers
- 30 people
- Sponsor
- Vinmec Research Institute of Stem Cell and Gene Technology
Anesthesia; Adverse Effect
Neurotoxicity of Anesthesia in Middle Aged Patients
for the last 20 years, the increasing reports from non-human studies have raised suspicion that general anesthetics may cause neurotoxic changes in the developing brain that lead to adverse neurodevelopmental outcomes later in…
- Trial name
- NCT04275531
- Testing
- Anesthesia Agent
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Tanta University
Ovarian Cancer
The Effectiveness of an Online Support Group in Enhancing Recovery Identity and Health-Related Quality of Life
Background Ovarian cancer poses challenges for middle-aged and older patients, impacting physical and self-conceptual aspects. A research gap exists on the impact of online support groups (SPs) on identity synthesis and…
- Trial name
- NCT06145295
- Testing
- mobile online support group (experiment group), offline support group (control group)
- Where
- China
- Volunteers
- 68 people
- Sponsor
- Shanghai Jiao Tong University School of Medicine
Early Onset Alzheimer Disease, Alzheimer Disease
Sleep Apnea in Early to Mid-Stage Alzheimer's Disease
Obstructive sleep apnea (OSA) is much more common in the elderly than in the young; the latest studies show prevalence between 45% and 62% in individuals over 60.
- Conditions
- Early Onset Alzheimer Disease, Alzheimer Disease, Obstructive Sleep Apnea Syndromes
- Trial name
- AZAP (NCT01400542)
- Testing
- CPAP Treatment, No treatment
- Where
- France
- Volunteers
- 22 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Knee Pain Chronic
Arthroscopic Versus Conservative Treatment of Degenerative Meniscal Tear in Middle Aged Patients in Regard to Pain & Knee Function
The study is prospective comparative study, conducted in Erbil teaching hospital on 60 patients, their age ranging between 40 and 60 years.
- Trial name
- NCT04313569
- Testing
- Arthroscopic menisctomy
- Where
- Iraq
- Volunteers
- 60 people
- Sponsor
- Hawler Medical University
Functional Impairment, Frailty
A Partnered Evaluation to Improve the Identification and Management of Functional Impairment and Frailty Among Older Veterans in Primary Care Settings
Maintaining functional status, or the ability to perform daily activities, is central to older adults' quality of life, health, and ability to remain independent.
- Trial name
- NCT06404970
- Testing
- Screening intervention, Standard bundle of implementation strategies, Enhanced bundle of implementation strategies
- Where
- United States
- Volunteers
- 10,000 people
- Sponsor
- VA Office of Research and Development
Hip Fractures
Hip Fracture in Individuals Under 60 Years of Age
This study prospectively analyses and describes a cohort of non-elderly hip fracture patients at four orthopaedic departments in two Scandinavian countries regarding epidemiology, treatment, Patient Reported Outcome Measures…
- Trial name
- HFU-60 (NCT03848195)
- Where
- 4 sites in Denmark, Sweden
- Volunteers
- 218 people
- Sponsor
- Lund University
Preoperative Anxiety
The Effectiveness of Warm Hand Bath in Improving Anxiety
Patients undergoing surgery often experience anxiety before the procedure. The aim of this study is to investigate the effectiveness of warm water baths in reducing preoperative anxiety levels in middle-aged and elderly patients…
- Trial name
- NCT06041672
- Testing
- Warm Water Hand Baths
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Cathay General Hospital
Caries,Dental, Caries Root
Coronal and Radicular Caries Prevalence and Related Risk Factor in Diabetic Patient
This study aims to investigate the prevalence and risk factors of coronal and radicular caries in middle-aged individuals with Type 2 diabetes.
- Conditions
- Caries,Dental, Caries Root, Diabetes Mellitus, Type 2
- Trial name
- NCT06701565
- Volunteers
- 265 people
- Sponsor
- Cairo University
Degenerative Meniscal Tear
Surgical or Exercise Therapy on Patients With Degenerative Meniscus Tears
This study is conducted as a collaboration between NAR, Orthopedic Department, Oslo University Hospital,Ullevaal, Hjelp24Nimi Oslo, Martina Hansens Hospital Norway, and University of Southern Denmark, Odense, Denmark.
- Trial name
- OMEX (NCT01002794)
- Testing
- Arthroscopic partial menisectomy, Supervised neuromuscular and strength training
- Where
- Norway
- Volunteers
- 140 people
- Sponsor
- Oslo University Hospital
Middle Aged Patients, Sevoflurane
Minimal Alveolar Concentration of Sevoflurane Inducing Isoelectric Electroencephalogram
Sevoflurane can abolish movement or adrenergic response to noxious stimulus. In order to investigate the effect of sevoflurane on cerebral electrical activity, we determined the MAC of sevoflurane inducing isoelectric…
- Conditions
- Middle Aged Patients, Sevoflurane, General Anesthesia
- Trial name
- NCT01662622
- Testing
- Sevoflurane
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Huazhong University of Science and Technology
Type 2 Diabetes Mellitus (T2DM)
Effects of a Multimodal Exercise Program on Physical Performance and Muscle Function in Middle-aged Patients With T2DM
Background Middle-aged adults with type 2 diabetes mellitus (T2DM), especially in Asian populations, are at increased risk of sarcopenia, reduced muscle function, and decline in physical performance.
- Trial name
- NCT07255222
- Testing
- A Multimodal Exercise Intervention
- Where
- Taiwan
- Volunteers
- 66 people
- Sponsor
- Chung Shan Medical University
Heart Failure
Balance and Executive Function in Middle-age and Older Patients With Heart Failure in Post-Acute Care Program
This trial is a single-center clinical trial in Taiwan with an expected enrollment of 60 people in Taiwan. The purpose of this trial is to compare the performance of middle-aged and elderly patients with subacute heart failure…
- Trial name
- NCT06463496
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chang Chia-Jung