Clinical trials: Mifepristone
Invasive Breast Cancer, Ductal Carcinoma in Situ
Preoperative Testing of the Anti-Progesterone Mifepristone in Early Stage Breast Cancer
The primary objective of this study is to identify the group of women with early stage breast cancer most likely to benefit from treatment with the selective progesterone receptor modulator (SPRM) mifepristone.
- Trial name
- NCT01138553
- Testing
- Mifepristone
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, San Diego
Menstrual Regulation
Introducing Mifepristone-Misoprostol for Menstrual Regulation in Public Sector Facilities in Bangladesh
This open-label study is being conducted to determine whether a mifepristone-misoprostol regimen for uterine evacuation which consists of 200 mg mifepristone followed 24 hours later by 800 mcg buccal misoprostol is acceptable to…
- Trial name
- NCT01798017
- Testing
- Mifepristone and misoprostol
- Where
- 8 sites in Bangladesh
- Volunteers
- 1,738 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Borderline Personality Disorder
Preliminary Trial of the Effect of Glucocorticoid Receptor Antagonist on Borderline Personality Disorder (BPD)
Participants will be randomized to either Mifepristone 600mg once daily for seven days or Placebo tablet once daily for seven days. Rating scales, vital signs, cortisol levels will be collected for evaluation.
- Trial name
- NCT01212588
- Testing
- mifepristone
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Indiana University
Major Depressive Disorder, Psychotic Disorders
An International Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depression
Corlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. Under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress…
- Trial name
- NCT00128505
- Testing
- Mifepristone
- Where
- 19 sites in Bulgaria, Croatia and 2 more
- Volunteers
- 104 people
- Sponsor
- Corcept Therapeutics
Adenomyosis, Mifepristone
Long-term Use of Mifepristone in the Treatment of Adenomyosis
The design was a prospective, randomized, positive-control, parallel-group, multicenter clinical trial. The study included a randomized, parallel-group treatment for 24 weeks in 140 subjects from eight hospitals in seven cities…
- Trial name
- LUOMITTOA (NCT05151016)
- Testing
- mifepristone, Triptorelin Acetate
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Early Pregnancy Failure, Miscarriage
MiMi: A Randomized Trial of Mifepristone and Misoprostol for Treatment of Early Pregnancy Failure
The purpose of this study is to compare two combinations of drugs (mifepristone and misoprostol versus placebo and misoprostol) used for medical treatment for early pregnancy failure.
- Conditions
- Early Pregnancy Failure, Miscarriage, Fetal Demise, Anembryonic Pregnancy
- Trial name
- MiMi (NCT00468299)
- Testing
- Mifepristone and misoprostol
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Boston University
Induced Vaginal Delivery
Mifepristone for Labor Induction
The purpose of this trial is to explore mifepristone as an option for induction of labor at term by evaluating the efficacy of mifepristone use for cervical preparation.
- Trial name
- MiLI (NCT05097326)
- Testing
- Mifepristone, Misoprostol
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Stanford University
Early Pregnancy Failure
Comparing Two Medical Treatments for Early Pregnancy Failure.
This study aims to compare whether a combination of two drugs (Mifepristone and misoprostol) are superior compared to using only one of these drugs (Misoprostol) as medical treatment for a miscarriage.
- Trial name
- Triple M (NCT03212352)
- Testing
- Mifepristone, Misoprostol
- Where
- 13 sites in Netherlands
- Volunteers
- 342 people
- Sponsor
- Radboud University Medical Center
Abortion Seekers
Mifepristone at Same Time Multicenter Study
This is a multicenter, randomized study. 564 healthy women, age 18 years or older, with an intrauterine pregnancy, and requesting a medical abortion, will be recruited to participate in this prospective clinical trial.
- Trial name
- MAST (NCT00269568)
- Testing
- mifepristone and misoprostol
- Where
- 4 sites in United States
- Volunteers
- 1,128 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Pregnancy, Unwanted
Blocking Mifepristone Action With Progesterone
Double-blind randomized trial to evaluate the potential impact of progesterone treatment on early pregnancies exposed to mifepristone.
- Trial name
- NCT03774745
- Testing
- Mifepristone 200 MG, micronized Progesterone
- Where
- 3 sites in United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Abortion, Induced
A Randomized Trial of Buccal Compared to Oral Misoprostol Following Mifepristone for Medical Abortion up to 63 Days LMP
This open-label, randomized study will compare the efficacy, safety, and acceptability of mifepristone 200 mg followed in 24-36 hours either by buccal (i.e., in the cheeks) or oral misoprostol 800 mcg for termination of pregnancy…
- Trial name
- NCT00386867
- Testing
- 800 mcg misoprostol via oral or buccal administration
- Where
- 8 sites in United States
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Central Serous Chorioretinopathy
Short-Term Oral Mifepristone for Central Serous Chorioretinopathy
The goal of the study is to assess the efficacy and safety of mifepristone 300 or 900-mg once-daily dosing by mouth for 4 weeks in patients with central serous chorioretinopathy.
- Trial name
- STOMP-CSC (NCT02354170)
- Testing
- Mifepristone
- Where
- 2 sites in United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Roger Goldberg, M.D., MBA
Medical Abortion
Acceptability and Feasibility of Medical Abortion in Singapore
To test the hypothesis that a regimen of 200 mg oral mifepristone, with the option of home administration, followed by 800 μg buccal misoprostol 24 hours later for abortion through 70 days LMP will be feasible and acceptable in…
- Trial name
- NCT02985229
- Testing
- Mifepristone, Misoprostol
- Where
- 2 sites in Singapore
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Depressive Disorder, Major
A United States Extension Study of Corlux for Recurrent Psychotic Symptoms in Psychotic Major Depression
Corlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. Under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress…
- Trial name
- NCT00208156
- Testing
- Mifepristone
- Where
- 13 sites in United States
- Volunteers
- 87 people
- Sponsor
- Corcept Therapeutics
Abortion in Second Trimester
Mifepristone and Misoprostol for Mid-trimester Termination of Pregnancy in Armenia
The primary goal of this study is to examine the efficacy and feasibility of a mifepristone combined with misoprostol medical abortion regimen in terminating pregnancies 13-22 weeks in Armenia.
- Trial name
- NCT01766388
- Where
- 2 sites in Armenia
- Volunteers
- 120 people
- Sponsor
- Gynuity Health Projects
Treatment-resistant PTSD
REVERSE: Improving Treatment-resistant Post Traumatic Stress Disorder (PTSD) with Glucocorticoid Receptor (GR) Antagonism
Rationale: Post-traumatic stress disorder (PTSD) is a psychiatric disorder that can develop in people who have experienced or witnessed a traumatic event.
- Trial name
- REVERSE (NCT06689254)
- Testing
- Mifepristone 1200 mg daily
- Where
- Netherlands
- Volunteers
- 60 people
- Sponsor
- Christiaan Vinkers
Abortion, Induced
Value of Mifepristone in Cervical Preparation Prior to Dilation and Evacuation 19-24 Weeks
A common practice for preparation for surgical abortion after 19 weeks gestation is the placement of multiple sets of osmostic dilators 1-2 days prior to the procedure.
- Trial name
- NCT01615731
- Testing
- Mifepristone, Hygroscopic cervical dilators, Misoprostol
- Where
- 2 sites in United States
- Volunteers
- 50 people
- Sponsor
- Stanford University
Other Abortion
Mifepristone and Misoprostol for Mid-trimester Termination of Pregnancy in Ukraine
The goal of this study is to examine the effectiveness and feasibility of a mifepristone-misoprostol medical abortion regimen in terminating pregnancies 13-22 weeks in Ukraine.
- Trial name
- NCT02415894
- Where
- 3 sites in Ukraine
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Medical Abortion
Mifepristone and Two Doses of Misoprostol for Abortion at 11&12 Weeks
This study seeks to evaluate the efficacy, side effect profile and acceptability of a medical abortion regimen with mifepristone and two doses of 800 mcg misoprostol buccally at 71-77 and 78-84 days of gestation to further expand…
- Trial name
- NCT05119439
- Testing
- Mifepristone + 2 doses of misoprostol 800 mcg
- Where
- 6 sites in United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Surgical Abortion
Cervical Preparation for Surgical Abortion at 12-14 Weeks: a Prospective, Randomized, Evaluator-blinded, Multicenter, Controlled Comparison Between Mifepristone, Misoprostol and Their Combination
More than 100 000 surgical abortions are annually performed in France. About four in ten women will have an abortion in their life.
- Trial name
- NCT01795599
- Testing
- Mifegyne ®, Gymiso®
- Where
- France
- Volunteers
- 198 people
- Sponsor
- Assistance Publique Hopitaux De Marseille