Clinical trials: Mifepristone
Major Depressive Disorder, Psychotic Disorders
A United States Study of Corlux for Psychotic Symptoms in Psychotic Major Depression
Corlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. Under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress…
- Trial name
- NCT00130676
- Testing
- Mifepristone
- Where
- 23 sites in United States
- Volunteers
- 257 people
- Sponsor
- Corcept Therapeutics
Uterine Fibroid, Vaginal Bleeding.
Efficacy Study of Vaginal Mifepristone to Treat Uterine Fibroids
The purpose of this study is to evaluate the effect of daily dosage of vaginally mifepristone on reduction of uterine fibroids size and the symptoms associated with uterine fibroids.
- Trial name
- NCT00881140
- Testing
- mifepristone vaginal tablets
- Where
- 2 sites in Israel
- Volunteers
- 30 people
- Sponsor
- BioPro Medical Ltd
Abortion, First Trimester
Acceptability and Feasibility of a Simplified Medical Abortion Regimen in Georgia
This study examined the acceptability and feasibility of using a simplified regimen of medical abortion in the eastern and western regions of the country of Georgia.
- Trial name
- NCT02398838
- Testing
- Home administration of 200 mg mifepristone, Home or clinic administration of 400 mcg buccal misoprostol
- Where
- 4 sites in Georgia
- Volunteers
- 622 people
- Sponsor
- Gynuity Health Projects
Anembryonic Pregnancy, Gestation Abnormality
Mifepristone and Misoprostol for Fetal Demise
This is a pilot clinical trial to evaluate whether the medical management of early pregnancy failure with mifepristone and misoprostol is an effective and acceptable treatment.
- Conditions
- Anembryonic Pregnancy, Gestation Abnormality, Intrauterine Fetal Demise Term
- Trial name
- MIMID (NCT00177372)
- Testing
- mifepristone/misoprostol
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Breast Cancer, Ovarian Epithelial Cancer Recurrent
Mifepristone and Eribulin in Patients With Metastatic Triple Negative Breast Cancer or Other Specified Solid Tumors
This is a study to assess the safety of the combination of mifepristone and eribulin in patients with metastatic or locally advanced unresectable breast or other specified solid tumors, and determine preliminary efficacy of the…
- Conditions
- Breast Cancer, Ovarian Epithelial Cancer Recurrent, Sarcoma, Non-small Cell Lung Cancer
- Trial name
- NCT02014337
- Testing
- Mifepristone and Eribulin in combination
- Where
- 11 sites in United States
- Volunteers
- 37 people
- Sponsor
- Corcept Therapeutics
Type 2 Diabetes Mellitus, Insulin Resistance
Efficacy of Mifepristone in Males With Type 2 Diabetes Mellitus
Randomized, double blind, placebo-controlled clinical trial examining the efficacy and safety of mifepristone 600 mg daily in male subjects with type 2 diabetes mellitus, not associated with Cushing's syndrome
- Trial name
- NCT03052400
- Testing
- Mifepristone 600 mg daily
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Charles Drew University of Medicine and Science
Early Pregnancy
Comparison of the Effectiveness of Treatment With Mifepristone and Misoprostol at the Same Time Compared to the Administration of Drugs at a 48-hour Interval for Medical Abortion.
Medical termination of pregnancy is a common and safe alternative to surgical termination of pregnancy(8). The current protocol in the investigators unit includes oral administration of Mifepristone 600 mg and oral Misoprostol…
- Trial name
- NCT03440866
- Testing
- Administration of drugs concomitantly.
- Where
- Israel
- Volunteers
- 250 people
- Sponsor
- HaEmek Medical Center, Israel
Uterine Fibroids
The Effect of Mifepristone on Uterine Fibroids and Breast Tissue
Uterine fibroids are a benign but common condition among women in reproductive age. It is one of the most common reasons for hysterectomy since it often causes bleeding problems sometimes leading to anemia.
- Trial name
- NCT00579475
- Testing
- Mifegyne
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Karolinska Institutet
Hepatitis C Virus Infection
Antiviral Activity and Safety of 3 Different Doses of Mifepristone in Hepatitis C Infected Patients
Hepatitis C virus (HCV) infects approximately 170 million people worldwide. The current standard- of- care therapy of chronic HCV infection is a regimen of subcutaneously administered (pegylated)-interferon-α and ribavirin for 24…
- Trial name
- NCT00255177
- Testing
- VGX-410 (Mifepristone)
- Where
- 4 sites in United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- VGX Pharmaceuticals, LLC
Abortion, First Trimester
Acceptability and Feasibility of Medical Abortion Using Mifepristone and Buccal Misoprostol
This study examined the acceptability and feasibility of introducing a mifepristone-misoprostol regimen of medical abortion into abortion services in two private clinics in Puerto Rico; 2 clinics in Baku, Azerbaijan; 3 clinics in…
- Trial name
- NCT00386282
- Testing
- mifepristone-misoprostol treatment
- Where
- 11 sites in Armenia, Azerbaijan and 2 more
- Volunteers
- 1,250 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Cushing's Syndrome
Prospective, Open-Label, Multicenter, International Study of Mifepristone for Symptomatic Treatment of Cushing's Syndrome Caused by Ectopic Adrenal Corticotrophin Hormone (ACTH) Secretion
This study will evaluate whether the drug mifepristone can improve the symptoms of Cushing's syndrome in people with ectopic adrenal corticotrophin hormone (ACTH) secretion.
- Trial name
- NCT00422201
- Testing
- Mifepristone
- Where
- 15 sites in United States, France and 3 more
- Volunteers
- 18 people
- Sponsor
- HRA Pharma
Cushing's Syndrome
Retrospective Chart Review Study of Korlym for the Treatment of ACTH Independent Cushing's Syndrome
Chart review study to collect patient data from medical charts of patients who have been treated with Korlym® for the treatment of ACTH independent adrenal Cushing's Syndrome.
- Trial name
- RE-KLAIM (NCT02663609)
- Testing
- No intervention
- Volunteers
- 24 people
- Sponsor
- Corcept Therapeutics
Medical Termination of Pregnancy
Efficacy of Mifepristone - Prostaglandin Analogue Combination in Medical Termination of Pregnancy Beyond 7 Weeks of Amenorrhea
This study is a non-interventional prospective, multicenter, longitudinal study conducted in France, among a representative sample of public and/or private birth control centers.
- Trial name
- NCT02614781
- Where
- France
- Volunteers
- 892 people
- Sponsor
- Nordic Pharma SAS
Abortion, Induced
Cervical Preparation Before Dilation and Evacuation
The purpose of this research study is to compare three different ways of opening a woman's cervix before her second-trimester surgical abortion.
- Trial name
- NCT01751087
- Testing
- Mifepristone, misoprostol, Osmotic dilators
- Where
- 7 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Planned Parenthood League of Massachusetts
Adenomyosis
Evaluation of Therapeutic Effect and Safety of Mifepristone in the Treatment of Adenomyosis
This clinical trial is designed to study the effectiveness and safety of mifepristone in the treatment of symptomatic adenomyosis with multi center, random, double blind and controlled clinical trials.
- Trial name
- ETESRTA (NCT03520439)
- Testing
- Mifepristone
- Where
- China
- Volunteers
- 134 people
- Sponsor
- xinmei zhang
Legally Induced Abortion Without Mention of Complication
Mifepristone Versus Osmotic Dilators in Conjunction With Misoprostol for Cervical Preparation Prior to D&E at 14-19 Weeks
Dilation and evacuation (D\&E) is a common surgical procedure in the U.S. Adequate pre-operative preparation of the uterine cervix is an important part of preventing complications of the procedure.
- Trial name
- NCT02679092
- Testing
- Misoprostol, Mifepristone, Hygroscopic cervical dilators
- Where
- United States
- Sponsor
- Stanford University
Abortion, Induced
Mifepristone Plus Misoprostol Versus Misoprostol Alone for 2nd Trimester Abortion (14 - 21 Weeks Last Menstrual Period (LMP))
The primary goal of this study is to determine the clinical advantage of pre-treatment with mifepristone in second trimester misoprostol induction abortion.
- Trial name
- NCT00969982
- Testing
- mifepristone+misoprostol
- Where
- 2 sites in Moldova, Tunisia
- Volunteers
- 238 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Post Traumatic Stress Disorder (PTSD)
A Clinical Trial for Post Traumatic Stress Disorder
he purpose of this study is to test whether a medication, called mifepristone (commonly known as the ³Morning-After-Pill²), can help to prevent emotional problems after someone has survived a traumatic experience.
- Trial name
- MATTER (NCT00554177)
- Testing
- Medicane (mifepristone)
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Antonia New
Induced Abortion, First Trimester Abortion
Study of Clinic-based Versus Self-use of Medical Abortion Pills
The goal of the study is to determine whether important clinical outcomes differ among women who access a combined medical abortion regimen from a pharmacy when compared with those who access it from a facility.
- Conditions
- Induced Abortion, First Trimester Abortion, Misoprostol, Mifepristone
- Trial name
- MOC (NCT03727308)
- Testing
- Medical abortion pills sourced from pharmacies, Medical abortion pills sourced from health clinics
- Where
- 2 sites in Cambodia, Ghana
- Volunteers
- 4,196 people, healthy volunteers welcome
- Sponsor
- Ipas
Medical Abortion
Medical Abortion at Gestational Age of 8 to ≤9 Weeks Versus >9 to ≤12 Weeks
The purpose of this study is to assess the effectiveness, safety, and acceptability of home-administered medical abortion at gestational age of 8 to ≤9 weeks versus >9 to ≤12 weeks among a cohort of women in Mexico City.
- Trial name
- NCT02745093
- Testing
- Mifepristone, Misoprostol
- Where
- 3 sites in Mexico
- Volunteers
- 648 people
- Sponsor
- Ibis Reproductive Health