Clinical trials: Mifepristone
Fallopian Tube Cancer, Ovarian Cancer
Mifepristone in Treating Patients With Recurrent or Persistent Ovarian Epithelial, Primary Peritoneal, or Fallopian Tube Cancer
RATIONALE: Progesterone can cause the growth of ovarian epithelial cancer , primary peritoneal cancer, or fallopian tube cancer.
- Conditions
- Fallopian Tube Cancer, Ovarian Cancer, Primary Peritoneal Cavity Cancer
- Trial name
- NCT00459290
- Testing
- mifepristone
- Where
- 22 sites in United States
- Volunteers
- 24 people
- Sponsor
- Gynecologic Oncology Group
Uterine Fibroids
Mifepristone for Treatment of Uterine Fibroids
The objectives of this study are to estimate the efficacy and safety of the daily administration of mifepristone 5 mg versus 10 mg for three months for the treatment of uterine fibroids.
- Trial name
- Mifemyo (NCT00712595)
- Testing
- Mifepristone
- Where
- Cuba
- Volunteers
- 200 people
- Sponsor
- Mediterranea Medica S. L.
Missed Abortion, Pregnancy
Mifepristone and Misoprostol Versus Misoprostol Alone for Missed Abortion: A Randomized-controlled Trial
The purpose of the proposed study is to compare - in a randomized, placebo-controlled, double-blinded trial - a combination of mifepristone and misoprostol to misoprostol used alone for missed abortion.
- Trial name
- NCT02342002
- Testing
- Mifepristone, Misoprostol
- Where
- 4 sites in Argentina, Gabon and 2 more
- Volunteers
- 416 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Complete Abortion
Comparing Two Regimens for Medical Abortion: Mifepristone + Misoprostol Versus Misoprostol Alone
This double blinded, placebo-controlled randomized trial will compare the safety, efficacy and acceptability of two medical abortion regimens up to 63 days since last Menstrual Period (LMP) in Tunisia and Vietnam.
- Trial name
- NCT01387256
- Testing
- medical abortion
- Where
- 2 sites in Tunisia, Vietnam
- Volunteers
- 441 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Leiomyoma
Trial of Mifepristone for Fibroids
The purpose of this trial is to determine if low-dose mifepristone benefits women with symptomatic fibroids.
- Trial name
- NCT00133705
- Testing
- Mifepristone, Inert Capsule
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- University of Rochester
Drug Interaction Potentiation, Healthy
Mifepristone Drug-Drug Interaction Study With CYP3A Inhibitor
This is a Phase 1, single-center, fixed-sequence, open label, drug-drug interaction study of the effect of multiple daily doses of oral itraconazole 200 mg, a strong inhibitor of CYP3A, given with mifepristone 900 mg QD, in…
- Trial name
- NCT03259542
- Testing
- Mifepristone 300 MG, Itraconazole 100 MG
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
Complete Uterine Evacuation After Use of Study Drugs
Medical Abortion With Mifepristone + Misoprostol (13 - 22 Weeks)
A double-blind randomized controlled trial to compare a shorter interval between the administration of mifepristone and misoprostol (simultaneous administration compared to 24hours from administration of mifepristone to receipt…
- Trial name
- NCT01768299
- Testing
- Mifepristone, Misoprostol
- Where
- 3 sites in Vietnam
- Volunteers
- 504 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Cushing's Syndrome
An Extension Study of CORLUX in the Treatment of Endogenous Cushing's Syndrome
Participants in study C-1073-400 (NCT00569582) will be invited to participate in this extension study to examine the long term safety of mifepristone in the treatment of the signs and symptoms of endogenous Cushing's syndrome.
- Trial name
- NCT00936741
- Testing
- mifepristone
- Where
- 15 sites in United States
- Volunteers
- 30 people
- Sponsor
- Corcept Therapeutics
Legally Induced Abortion Without Mention of Complication
A Comparison of Sublingual and Buccal Misoprostol Regimens After Mifepristone for Mid-trimester Abortion
The primary goal of this study is to directly compare repeat doses of sublingual and buccal routes of 400 mcg misoprostol following mifepristone for second trimester abortion in order to determine if sublingual route confers an…
- Trial name
- NCT02708446
- Testing
- Mifepristone, Buccal misoprostol, Sublingual misoprostol
- Where
- 4 sites in Armenia, Nepal and 2 more
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Weight-Gain Prevention
A Two-Week Study of the Efficacy and Safety of Mifepristone in the Prevention of Olanzapine-Induced Weight Gain
This is a two-week study testing the efficacy and safety of mifepristone in the prevention of olanzapine-induced weight gain in healthy male volunteers by measuring changes in body weight and BMI.
- Trial name
- NCT00455442
- Testing
- Mifepristone
- Where
- India
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- Corcept Therapeutics
Medical Abortion, Complete or Unspecified, Without Complication
Second Trimester Medical Abortion
The use of Mifepristone, an antiprogesterone, and Misoprostol together, has been shown to make the medial abortion process more efficient and reduce the induction-to-abortion interval by almost 50%.
- Trial name
- RAPM (NCT04160221)
- Testing
- 12 hours interval, 24 hours interval
- Where
- Israel
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Sheba Medical Center
Second Trimester Abortion
Pilot Study of an Ambulatory Medical Abortion Service at 13-18 Weeks of Gestation in Colombia
This pilot study seeks to evaluate the safety, acceptability and feasibility of a shortened outpatient procedure for medical abortion at 13-18 weeks gestation.
- Trial name
- NCT04063904
- Testing
- Mifepristone, Misoprostol
- Where
- Colombia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Alcohol Dependence, Alcohol Use Disorders
Mifepristone Treatment of Alcohol Use Disorder
This is an 8-week, randomized, double-blind, placebo-controlled, 2 arm, parallel groups, study of 1-week of treatment with mifepristone (0, 1200 mg/d) given in conjunction with 8 weeks of manual-guided counseling, and a follow-up…
- Conditions
- Alcohol Dependence, Alcohol Use Disorders, Alcohol Abuse, Alcoholism
- Trial name
- NCT02179749
- Testing
- Mifepristone 1200 mg daily, Standardized behavioral therapy
- Where
- United States
- Volunteers
- 103 people
- Sponsor
- The Scripps Research Institute
Fetal Death
Mifepristone-misoprostol vs. Misoprostol Alone for Second Trimester Fetal Death
The primary aim of this trial is to compare the efficacy of mifepristone-misoprostol versus misoprostol alone for treatment of intrauterine fetal demise between 14 and 28 weeks LMP.
- Trial name
- NCT02633761
- Testing
- Mifepristone, Misoprostol 200mcg
- Where
- 3 sites in Mexico, Vietnam
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Uterine Fibroids
Mifepristone 10 or 5 mg for 6 Months to Treat Uterine Fibroids
The objectives of this study are to estimate the efficacy and safety of the daily administration for 6 months of 5 mg versus 10 mg.
- Trial name
- Mifemyo_2 (NCT00886873)
- Testing
- Mifepristone
- Where
- Cuba
- Volunteers
- 100 people
- Sponsor
- Mediterranea Medica S. L.
Cervical Preparation
Mifepristone Versus Osmotic Dilator Insertion for Cervical Preparation Prior to Surgical Abortion at 15-18 Weeks
In this study the investigators plan to compare mifepristone and misoprostol use to osmotic dilator use for cervical preparation for 15-18 week surgical abortion.
- Trial name
- SaMi2 (NCT01436279)
- Testing
- Mifepristone, osmotic dilators
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Boston University
Induced Abortion
Expansion Study of a Simplified Regimen of Medical Abortion Thru 63 Last Menstrual Period (LMP) in Tunisia
This open-label study is being conducted to determine whether national expansion of a 400 mcg of sublingual misoprostol (i.e., under the tongue) taken 24 hours following administration of mifepristone 200 mg is effective and…
- Trial name
- NCT01173003
- Testing
- Mifepristone, misoprostol
- Where
- Tunisia
- Volunteers
- 688 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Major Depressive Disorder, Psychotic Disorders
A United States Study of the Safety and Tolerability of Corlux for Psychotic Symptoms in Psychotic Major Depression
Corlux (mifepristone) is a new medication that modulates the body's use of a hormone called cortisol. Under normal conditions, cortisol and other hormones are created by the body in response to physical and emotional stress…
- Trial name
- NCT00128479
- Testing
- mifepristone, mifepristone 600 mg, mifepristone 1200 mg
- Where
- 44 sites in United States
- Volunteers
- 443 people
- Sponsor
- Corcept Therapeutics
Medication Abortion, Health Knowledge Attitudes and Practice
Patient Agreement Form and Medication Abortion Knowledge
This study evaluates whether exposure to the U.S. Food and Drug Administration (FDA)-required Patient Agreement Form (PAF) for mifepristone improves patient knowledge about medication abortion.
- Conditions
- Medication Abortion, Health Knowledge Attitudes and Practice, Pregnant People
- Trial name
- NCT07604675
- Testing
- Patient Agreement Form (PAF)
- Where
- 5 sites in United States
- Volunteers
- 637 people
- Sponsor
- University of California, San Francisco
Abortion, Induced, Abortion, Second Trimester
Mifepristone and Mid-Trimester Termination of Pregnancy
Mid-second trimester medical terminations of pregnancy require admission to the hospital for the length of time it takes a woman to abort.
- Trial name
- NCT00382538
- Testing
- Addition of mifepristone 200 mg 24 hours before induction
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Boston University