Clinical trials: Migraine, completed
Episodic Migraine
Study of Sustained Benefit of AMG334 in Adult Episodic Migraine Patients
The purpose of this study is to compare the sustained long-term benefit between two treatment paradigms of migraine prophylactic agents (erenumab versus a control arm of oral prophylactics) in episodic migraine patients who have…
- Trial name
- NCT03927144
- Testing
- AMG334, Oral Prophylactic
- Where
- 112 sites in United States, Argentina and 16 more
- Volunteers
- 621 people
- Sponsor
- Amgen
Central Sensitisation, Migraine
Presence of Signs of Central Sensitization in Episodic and Chronic Migraine
Nowadays migraine is conceptualized as a continuum, with at the one hand episodic migraine (EM) and at the other hand chronic migraine (CM) (1).
- Trial name
- CENSENMI (NCT05162664)
- Testing
- Pressure pain thresholds, Thermal detection and pain thresholds, Temporal summation
- Where
- Belgium
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University Ghent
Chronic Migraine, Headache
Mesotherapy in the Treatment of Chronic Migraine
Mesotherapy is a type of injection frequently used in clinics. It is a treatment procedure that involves the injection of some drugs under the skin or into the skin.
- Trial name
- NCT06118190
- Testing
- Lidocain
- Where
- Turkey (Türkiye)
- Volunteers
- 27 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Migraine
A Study Evaluating the Effectiveness of PEA Compared to Placebo for Reducing Pain Severity and Duration of Migraines.
This is a double-blind randomised controlled study to evaluate the effectiveness of orally-dosed Palmitoylethanolamide (PEA) compared to placebo for reducing pain severity and duration of migraines in otherwise healthy…
- Trial name
- NCT05046522
- Testing
- Palmitoylethanolamide sold as Levagen +
- Where
- Australia
- Volunteers
- 80 people
- Sponsor
- RDC Clinical Pty Ltd
Migraine Without Aura
Effect of Levcromakalim in Individuals With Migraine Pretreated With Erenumab
An outstanding scientific question, that merits further investigation, is whether dilation of intracranial arteries is implicated in the pathogenesis of cephalic pain in migraine.
- Trial name
- COLLIDE (NCT05889442)
- Testing
- Levcromakalim
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Danish Headache Center
Migraine Without Aura
Effect of Sildenafil in Individuals With Migraine Pretreated With Erenumab
An outstanding scientific question, that merits further investigation, is whether dilation of intracranial arteries is implicated in the pathogenesis of cephalic pain in migraine.
- Trial name
- COMPETE (NCT05889455)
- Testing
- Sildenafil
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Danish Headache Center
Migraine Disorders, Headache, Migraine
Effectiveness of Onabotulinumtoxin A (Botox) in Pediatric Patients Experiencing Migraines: A Study in the Pediatric Pain Population
The purpose of the research is to examine the outcomes of pediatric patients receiving Botulinum toxin type A (Botox ®) for the treatment of migraine.
- Conditions
- Migraine Disorders, Headache, Migraine, Pediatrics
- Trial name
- NCT03055767
- Testing
- OnabotulinumtoxinA
- Where
- 2 sites in United States
- Volunteers
- 17 people
- Sponsor
- University of California, Irvine
Migraine
Bilateral DLPC tDCS in Drug-resistant Migraine
The goal of this clinical trial is to study and describe the effects of bilateral tDCS applied to dorso-lateral-prefrontal cortex (DLPC) in patients with drug-resistant migraine in terms of reduction in frequency of pain, impact…
- Trial name
- NCT06079801
- Testing
- Transcranial direct current stimulation (tDCS), anti-CGRP-mAbs
- Where
- Spain
- Volunteers
- 36 people
- Sponsor
- Clínica de Intervención en Neurociencias
Migraine Headache
Psilocybin for the Treatment of Migraine Headache
The purpose of this study is to investigate the effects of oral psilocybin in migraine headache. Subjects will each receive a dose of placebo and a dose of psilocybin approximately 14 days apart.
- Trial name
- NCT03341689
- Testing
- High Dose Psilocybin, Low Dose Psilocybin
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- Yale University
Migraine Disorders, COVID-19 Pandemic
The Impact of nCoV-2019 on Children With Migraine
Executive functions, anxiety and their relation to social participation and quality of life among children with Migraine during COVID-19 Backgrounds: Among children, especially adolescents, migraine stands out as one of the most…
- Trial name
- NCT06077006
- Testing
- questionnaires Only
- Where
- Israel
- Volunteers
- 150 people
- Sponsor
- Bnai Zion Medical Center
Migraine
Multimechanistic Treatment Over Time of Migraine Symptoms (MOVEMENT)
MOVEMENT (Multimechanistic Treatment over Time of Migraine Symptoms) is a Phase 3 study to evaluate the long-term safety of chronic intermittent use of AXS-07 and to assess the effect of AXS-07 on migraine symptoms following…
- Trial name
- NCT04068051
- Testing
- AXS-07
- Where
- 51 sites in United States
- Volunteers
- 706 people
- Sponsor
- Axsome Therapeutics, Inc.
Migraine in Children, Migraine
A Study in Children and Young People With Migraine to Learn What the Body Does to Eptinezumab
The purpose of the study is to investigate how the body absorbs, distributes, and get rid of eptinezumab when given directly into a vein.
- Trial name
- NCT04537429
- Testing
- Eptinezumab
- Where
- 9 sites in United States
- Volunteers
- 28 people
- Sponsor
- H. Lundbeck A/S
Headache Disorders, Primary, Prevalence
Headache in Undergraduate Students and Biopsychosocial Status
The primary aim of this study was to determine the prevalence of headache in undergraduate students. The frequency, duration, localizations and symptoms of headache will be determined with the information obtained as a result of…
- Conditions
- Headache Disorders, Primary, Prevalence, Migraine, Student
- Trial name
- NCT05843760
- Testing
- personal information form, headache-specific questionnaires, Questionnaires for assessing biopsychosocial status
- Where
- Turkey (Türkiye)
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- şeyda öztürk
Migraine, Major Depressive Disorder
A Study to Evaluate the Efficacy and Safety of Fremanezumab for Preventive Treatment of Migraine in Patients With Major Depressive Disorder
The primary objective is to evaluate the efficacy of monthly 225 mg sc fremanezumab in adult participants with migraine and major depressive disorder (MDD) The secondary objectives are to evaluate the efficacy of monthly 225 mg…
- Trial name
- NCT04041284
- Testing
- Fremanezumab
- Where
- 64 sites in United States, Czechia and 11 more
- Volunteers
- 353 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Migraine
A Study to Evaluate the Efficacy and Safety of Eptinezumab for the Prevention of Migraine in Participants That Are Not Helped by Previous Preventive Treatments
Evaluation of eptinezumab in the prevention of migraine in participants with unsuccessful prior preventive treatments.
- Trial name
- DELIVER (NCT04418765)
- Testing
- Eptinezumab
- Where
- 138 sites in United States, Belgium and 15 more
- Volunteers
- 892 people
- Sponsor
- H. Lundbeck A/S
Chronic Migraine, Headache, Fibromyalgia Syndrome
Fibromyalgia Syndrome on Patients With Chronic Migraine
The aim of this study to evaluate the effects of fibromyalgia syndrome accompanying women with chronic migraine on pain, quality of life, sleep, anxiety and depression, central sensitization and functionality.
- Conditions
- Chronic Migraine, Headache, Fibromyalgia Syndrome, Chronic Pain Syndrome, Central Sensitisation
- Trial name
- NCT05381012
- Testing
- Allodynia, quality of life, sleep, anxiety and depression, disability, and central sensitization, Fibromyalgia syndrome
- Where
- Turkey (Türkiye)
- Volunteers
- 66 people
- Sponsor
- Istanbul University - Cerrahpasa
Chronic Migraine, Headache, Temporomandibular Joint Dysfunction
The Effect of Accompanying Temporomandibular Joint Dysfunction in Patients With Chronic Migraine
The aim of this clinical study to evaluate the effect of temporomandibular joint dysfunction accompanying patients with chronic migraine on pain, quality of life, sleep and functionality.
- Conditions
- Chronic Migraine, Headache, Temporomandibular Joint Dysfunction, Chronic Pain, Quality of Life
- Trial name
- NCT05381129
- Testing
- Detection of Pain, Quality of Life, Sleep and Functioning, Temporomandibular joint dysfunction
- Where
- Turkey (Türkiye)
- Volunteers
- 62 people
- Sponsor
- Istanbul University - Cerrahpasa
Migraine
Acute Treatment Trial in Adult Subjects With Migraines
The purpose of the study is to evaluate the safety and efficacy of three different intranasal dose levels of zavegepant (BHV-3500), relative to placebo, in the acute treatment of moderate to severe migraine.
- Trial name
- NCT03872453
- Testing
- Zavegepant, Intranasal Aptar Pharma Unit Dose System
- Where
- 82 sites in United States
- Volunteers
- 2,154 people
- Sponsor
- Pfizer
Nummular Headache, Migraine
Observational Prospective Study on the Presence of Typical Migraine Features in Nummular Headache Patients: The Numamig Study
Observational analytic study with prospective cohort design that aim to describe the presence of typical features of migraine in a cohort of nummular headache patients.
- Conditions
- Nummular Headache, Migraine, Headache Disorders, Primary
- Trial name
- NCT04299958
- Testing
- Patient diary
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Episodic Migraine
Atogepant for Prophylaxis of Migraine in Participants Who Failed Previous Oral Prophylactic Treatments.
This study will assess the safety, tolerability, and efficacy of Atogepant 60 mg compared with placebo in participants with episodic migraine and who have previously failed 2 to 4 classes of oral prophylactic treatments.
- Trial name
- ELEVATE (NCT04740827)
- Testing
- Atogepant 60 mg
- Where
- 114 sites in United States, Australia and 13 more
- Volunteers
- 315 people
- Sponsor
- Allergan