Clinical trials: Migraine
Migraine With Aura
Tonabersat in the Prophylaxis of Migraine With Aura
Overall trial objectives: 1. Can treatment with tonabersat reduce the number of days with aura and/or migraine headache in patients with migraine with aura 2.
- Trial name
- NCT00332007
- Testing
- Tonabersat
- Where
- Denmark
- Volunteers
- 39 people
- Sponsor
- Minster Research Ltd
Migraine, Headache
Comparing the Safety and Effectiveness of Topiramate With the Safety and Effectiveness of Amitriptyline in Preventing Migraine Headaches
The purpose of this study is to compare the effectiveness and safety of two treatment regimens in preventing migraines. The antidepressant amitriptyline has been used successfully to prevent migraine headaches.
- Trial name
- NCT00210821
- Testing
- topiramate
- Volunteers
- 347 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Migraine
Post-marketing Clinical Trial of Elexir(Trigeminal Nerve Electrical Stimulator) for the Acute Treatment of Migraine
The purpose of this study is to evaluate the efficacy and safety of treating migraine in the acute phase by applying the acute mode (program 1) of Elexir (trigeminal nerve electrical stimulator) to patients with migraine.
- Trial name
- NCT06170411
- Testing
- Elexir (program1)
- Where
- 2 sites in South Korea
- Volunteers
- 100 people
- Sponsor
- Nu Eyne Co., Ltd.
Headache Disorders, Secondary, Post-Dural Puncture Headache
Association Between Chronic Headache and Back Pain With Childbirth
This study uses a single questionnaire to evaluate two separate primary outcomes: 1. To identify association between chronic headache in women who have given birth to children as compared to a control group of women who have…
- Conditions
- Headache Disorders, Secondary, Post-Dural Puncture Headache, Migraine Disorders, Back Pain
- Trial name
- NCT04091321
- Where
- United States
- Volunteers
- 1,112 people
- Sponsor
- Stanford University
Migraine Disorders
Sumatriptan and Naratriptan Pregnancy Registry
Anti-migraine drugs, including triptans, are not indicated for use in pregnancy. However, the peak prevalence of migraine is in women of childbearing age.
- Trial name
- NCT01059604
- Testing
- Sumatriptan, Naratriptan, Sumatriptan-naproxen combination
- Volunteers
- 868 people
- Sponsor
- GlaxoSmithKline
Migraine Without Aura
Investigation of Serotonin Receptor Binding in the Migraine Brain Using Positron Emission Tomography
Migraine affects 16% of the world population and is one of the most disabling of all disorders. It is a complex brain disorder characterized primarily by recurrent headache attacks.
- Trial name
- NCT02309606
- Testing
- PET scan with 5-HT receptor ligands
- Where
- Denmark
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Menstrual Migraine
Fremanezumab for the Prevention of Menstrually-related Migraine Attacks
The goal of this observational study is to compare, in real-world clinical practice, the effect of fremanezumab on menstrual migraine to the effect of fremanezumab on non-perimenstrual attacks.
- Trial name
- FROMM (NCT06659120)
- Testing
- Fremanezumab
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Vestibular Migraine
Acupuncture for Prophylaxis of Vestibular Migraine
With its high incidence rate and low diagnosis rate, vestibular migraine (VM) can seriously affect patients' quality of life. Current treatment of VM mainly contain rescue treatment and prophylaxis, both of which are often…
- Trial name
- NCT04664088
- Testing
- Acupuncture, Venlafaxine
- Where
- China
- Volunteers
- 72 people
- Sponsor
- Affiliated Hospital of Jiaxing University
Migraine With Aura, Migraine Without Aura
A Phase I Study to Study the PK and Safety of Single Doses of STS101, DHE Injection and Nasal Spray in Healthy Subjects
Single-center, single-dose, open-label, 2-part, 3-period crossover (in each part), pharmacokinetic and safety study.
- Conditions
- Migraine With Aura, Migraine Without Aura, Migraine
- Trial name
- NCT03874832
- Testing
- Dihydroergotamine
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Satsuma Pharmaceuticals, Inc.
Migraine
A Trial of Eptinezumab in Participants With Migraine and Insufficient Response to Anti-CGRP Medications
The main goal of this trial is to learn whether eptinezumab improves migraine symptoms and quality of life of participants with migraine who did not perceive a sufficient improvement during previous treatment with therapies…
- Trial name
- NCT06701526
- Testing
- Eptinezumab
- Where
- 21 sites in United States
- Volunteers
- 164 people
- Sponsor
- H. Lundbeck A/S
Migraine
Greater Occipital Nerve Block Versus Pulse Radiofrequency in Migraine
The aim of the study is to evaluate the clinical efficacy of the repeated greater occipital nerve(GON) blokcs with GON pulse radiofreaquency (PRF)
- Trial name
- GON-B/PRF (NCT06345326)
- Testing
- Greater occipital nerve block
- Where
- Turkey (Türkiye)
- Volunteers
- 68 people
- Sponsor
- Adiyaman University Research Hospital
Migraine, With or Without Aura
Long-term Safety of BR005-036C Tablets in the Acute Treatment of Migraine in Adults
The purpose of this study is to evaluate the long-term safety of BR005-036C tablets in the acute treatment of migraines
- Trial name
- NCT07835152
- Testing
- BR005-036C
- Where
- 81 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Brise Pharmaceuticals Co., Ltd.
Migraine With Aura, Migraine Without Aura
Can DFN-15 Terminate Migraine With Allodynia?
The majority of migraineurs seeking secondary or tertiary medical care develop cutaneous allodynia during the course of migraine, a sensory abnormality mediated by sensitization of central trigeminovascular neurons in the spinal…
- Conditions
- Migraine With Aura, Migraine Without Aura, Allodynia
- Trial name
- NCT03472378
- Testing
- DFN-15
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Hartford Hospital
Pain, Head Pain
Aromatherapy Massage in Migraine Attacks
The aim of the study was to determine the effect of aromatherapy massage on the pain severity and quality of life in patients diagnosed with migraine in addition to medical treatment during an acute migraine attack.
- Conditions
- Pain, Head Pain, Quality of Life
- Trial name
- NCT04151576
- Testing
- aromatherapy massage
- Volunteers
- 83 people
- Sponsor
- Biruni University
Episodic Migraine
The Effect of Daylight Saving Time Transitions on Sleep and Migraine Headaches.
A prospective study that investigates the impact of circadian rhythm disturbances due to daylight saving time transitions on migraine patients.
- Trial name
- DST (NCT05742191)
- Testing
- Daylight Savings time transitions
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- OSF Healthcare System
Migraine
Efficacy of OnabotulinumtoxinA in Migraine
Population studies estimate that patients who have episodic migraine transition to chronic migraine at a rate of about 2.5% per year. CM is a devastating disorder associated to severe disability.
- Trial name
- NCT04578782
- Testing
- OnabotulinumtoxinA
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine, Migraine Headache
Neuromodulation During the Prodrome to Prevent Disabling Migraine Attacks in Youth
Background \& Rationale: One in ten Canadian youth have migraine, a disabling neurological disease that is more common in females and characterized by moderate-severe disabling headaches.
- Trial name
- NCT07772427
- Testing
- Active Remote Electrical Neuromodulation
- Where
- Canada
- Volunteers
- 30 people
- Sponsor
- University of Calgary
Migraine Disorders
Potential Osteocatabolic Effect Caused by Anti-CGRP mAbs in Migraine Patients Treated With Anti-CGRP mAbs - an Observational Pilot Project With Prospectively Collected Health Related Data
Background: To gain insight on the osteoanabolic activity of anti-CGRP mAbs in patients with migraine as this was not yet specifically investigated in registration or post-approval clinical studies, however, being…
- Trial name
- NCT06035458
- Testing
- Diagnostic radiology
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Headache, Migraine
Headache Inducing Effect of NN414 in Migraine Patients
To investigate the role of KATP channels on the cerebral hemodynamic in migraine patients.
- Trial name
- NCT04744129
- Testing
- NN414, Saline
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Danish Headache Center
Migraine, Cluster Headache
Pain Biomarker Study
This study investigates molecular and physical biomarkers of headaches in order to better understand mechanisms of these diseases. There are 3 main parts: 1.
- Conditions
- Migraine, Cluster Headache, Trigeminal Autonomic Cephalgia, Hemicrania Continua
- Trial name
- PBS (NCT03511846)
- Testing
- Oral capsaicin, Topical capsaicin, Intranasal capsaicin
- Where
- United States
- Volunteers
- 371 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston