Clinical trials: Migraine
Familial Hemiplegic Migraine Type 1 and 2, Healthy Volunteers
Glyceryl-Trinitrate-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2
The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to GTN infusion.
- Trial name
- NCT00257985
- Testing
- GTN
- Where
- Denmark
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine in Children, Migraine With Aura
Mindfulness for Adolescents for CM and HFEM
Chronic Migraine (CM) and High Frequency Episodic Migraine (HFEM) without Aura affect adolescents' lives in terms of reduced health, reduced ability to perform daily chores and reduced quality of life.
- Trial name
- MINDKIDS (NCT04968093)
- Testing
- Mindfulness-based therapy.
- Where
- Italy
- Volunteers
- 37 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Chronic Migraine
Neurophysiological, Biomolecular and Psychological Aspects of Erenumab Treatment in Chronic Migraine
Monoclonal antibodies (mABs) targeting calcitonin gene-related peptide (CGRP) proved effective in the preventive treatment of episodic and chronic migraine as well as in difficult-to-treat patients such as those who had…
- Trial name
- NCT04361721
- Testing
- Erenumab
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine, Pain
Nitrous Oxide for Acute Migraine Pain in the Emergency Room (ED)
BACKGROUND Migraine headaches account for 8-18% of all headaches seen in pediatric emergency rooms. Standard treatment includes IV pain medications, anti-emetics, and IV fluids.
- Trial name
- NCT01287052
- Testing
- Nitrous Oxide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Migraine
Abortive Effect of an Ear Insufflator on Migraine
Evaluate the effectiveness of air insufflation in aborting (stopping) an acute episode of migraine and compare it with a placebo effect of using the same procedure but without active insufflation.
- Trial name
- NCT02614378
- Testing
- air insufflation
- Where
- 2 sites in United States
- Volunteers
- 58 people
- Sponsor
- Carrick Institute for Graduate Studies
Headache, Migraine
The Effect of Adenosine on Cranial Hemodynamic, Headache and Migraine Induction Properties.
Adenosine is a nucleoside that plays a role in both vascular and nociceptive systems, and it has been proposed that adenosine may cause headache in particularly sensitive subjects.
- Trial name
- NCT04577443
- Testing
- Adenosine, Saline
- Where
- Denmark
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
Study for Prevent Chronification Migraine Through Prediction of Response to Treatment With Anti-CGRP Antibodies
Being able to predict each patients response to a specific treatment can mean a significant improvement in socioeconomic costs, but above all in their quality of life.
- Trial name
- PREDI-CGRP (NCT06459648)
- Testing
- Headache record, Scales, Monoclonal antibody anti-CGRP
- Where
- 7 sites in Spain
- Volunteers
- 350 people
- Sponsor
- Fundación de Investigación Biomédica - Hospital Universitario de La Princesa
Migraine
Investigation of Safety and Efficacy of ABP-450 for Migraine Prevention in Adults
This Phase 2 trial will evaluate the efficacy and safety of ABP-450 for migraine prevention in adults who suffer from six or more migraine days per month.
- Trial name
- NCT04845178
- Testing
- ABP-450
- Where
- 62 sites in United States, Australia and 1 more
- Volunteers
- 797 people
- Sponsor
- AEON Biopharma, Inc.
Migraine
Comparison of Patient-reported Outcomes for Rimegepant and Triptans in the 2023 US National Health and Wellness Survey
This is a cross-sectional study using the cross-sectional 2023 National Health and Wellness Survey (NHWS) data from the US, with a large and nationally representative population (N=75,007).
- Trial name
- NCT06680206
- Testing
- Rimegepant, Triptans
- Where
- United States
- Volunteers
- 1,395 people
- Sponsor
- Pfizer
Vestibular Migraine
Comparison of Propranolol and Venlafaxine in Treatment of Vestibular Migraine
The presented study aims to compare effectivity of propranolol with effectivity of venlafaxine in escalating dose in subjects with vestibular migraine (VM) over a period of 12 weeks.
- Trial name
- NCT02350985
- Testing
- Propranolol, Venlafaxine
- Where
- Turkey (Türkiye)
- Volunteers
- 73 people
- Sponsor
- Haseki Training and Research Hospital
Migraine
Intra-Nasal Mechanical Stimulation (INMEST) as a Potential Preventative Treatment for Migraine
This is a prospective, randomized, open-label, delayed-start clinical investigation evaluating the safety and efficacy of the Walther System, a Class IIa investigational medical device delivering intra-nasal mechanical…
- Trial name
- A-MI-01 (NCT07279623)
- Testing
- INMEST-treatment
- Where
- Sweden
- Volunteers
- 110 people
- Sponsor
- Abilion Medical Systems AB
Chronic Migraine Headache
Efficacy of Ultrasound-Guided Combined Greater Occipital Nerve Block and Greater Auricular Nerve Block Versus Greater Occipital Nerve Block Alone in the Management of Chronic Migraine
Migraine is one of the most prevalent neurological disorders worldwide and remains a leading cause of disability, particularly among individuals of working age.
- Trial name
- NCT07763678
- Testing
- greater occipital nerve block, Greater Auricular Nerve Block
- Volunteers
- 80 people
- Sponsor
- Assiut University
Headache, Migraine
0.5% Bupivacaine Lower Cervical Intramuscular Injection vs IV Medications for Headache Treatment
Headache is a frequent chief complaint among patients presenting to the Emergency Department (ED), accounting for 2.1 million visits annually in the United States.
- Conditions
- Headache, Migraine, Tension Headache, Occipital Neuralgia
- Trial name
- NCT06937385
- Testing
- 0.5% Bupivacaine HCl, standard IV treatment for headache
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- HCA Florida North Florida Hospital
Migraine
RELAXaHEAD for Headache Patients (Phase III)
This study is a fully powered, remote randomized control trial to evaluate RELAXaHEAD in people with migraine.
- Trial name
- NCT06077838
- Testing
- RELAXaHEAD Smartphone App Version 1, RELAXaHEAD Smartphone App Version 2
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- NYU Langone Health
Migraine Headache, Migraine Without Aura
Investigation of Vascular Inflammation in Migraine Using Molecular Nano-imaging and Black Blood Imaging MRI
The investigators aim to investigate inflammation of cranial and meningeal arteries during pharmacologically induced migraine attacks, using ultrasmall superparamagnetic iron oxide (USPIO) nanoparticles and black blood imaging…
- Trial name
- NCT02549898
- Testing
- Feraheme, Cilostazol, USPIO-MRI
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- Danish Headache Center
Migraine
Study to Determine Safety and Efficacy of B244 in Subjects With Episodic Migraine
This is a prospective, randomized, vehicle-controlled, double-blind, multi-center study assessing the safety, tolerability, and efficacy of B244 delivered as an intranasal spray for preventive treatment in subjects with episodic…
- Trial name
- NCT03488563
- Testing
- B244, Vehicle
- Where
- 22 sites in United States
- Volunteers
- 313 people, healthy volunteers welcome
- Sponsor
- AOBiome LLC
Intractable Chronic Migraine
Peripheral Nerve Stimulation Registry for Intractable Migraine Headache
The purpose of this study is to evaluate the long-term safety and performance of neurostimulation for the treatment of intractable chronic migraine as well as to detect infrequent complications or problems only apparent in…
- Trial name
- Relief (NCT02227758)
- Where
- 18 sites in Belgium, Germany and 4 more
- Volunteers
- 112 people
- Sponsor
- Abbott Medical Devices
Episodic Migraine, Prophylaxis
The Role of Left Prefrontal Transcranial Magnetic Stimulation in Episodic Migraine Prophylaxis
The aim of the study was to examine the prophylactic role of repetitive transcranial magnetic stimulation (rTMS) on the frequency, and severity of migraine attacks in episodic migraineurs who failed medical treatment.
- Trial name
- NCT04031781
- Testing
- repetitive transcranial magnetic stimulation (rTMS) 100% motor threshold, repetitive transcranial magnetic stimulation (rTMS) 50% motor threshold
- Volunteers
- 33 people
- Sponsor
- Ain Shams University
Migraine, Obesity
Diet and Migraine Study
The purpose of this study is to look at two different diets (a low carbohydrate diet and a low fat diet) for migraine prevention in overweight or obese persons with migraine.
- Trial name
- NCT01859052
- Testing
- Low carbohydrate diet, Low calorie low fat diet, AHA diet recommendations
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Chronic Headache, Chronic Headache Disorder
The Impact of Greater Occipital Nerve and Stellate Ganglion Block Treatments on Sleep in Chronic Headache Management
This study aims to evaluate the effect of Greater Occipital Nerve and Stellate Ganglion block treatments on sleep in patients with chronic headaches.
- Conditions
- Chronic Headache, Chronic Headache Disorder, Migraine
- Trial name
- NCT06646081
- Testing
- Greater Occipital Nerve Block, Stellate Ganglion Block
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people
- Sponsor
- Ankara Etlik City Hospital