Clinical trials: Migraine Disease
Headache Migraine Chronic
Spectacle Tints and Thin-Films for Migraine
Nearly all migraine sufferers report sensitivity to light during a headache and a significant proportion of sufferers report light sensitivity between attacks. Light is also a common trigger for migraine headaches.
- Trial name
- NCT02720211
- Testing
- Gray tinted spectacle lenses, Thin-Film spectacle lenses
- Where
- 4 sites in United States
- Volunteers
- 10 people
- Sponsor
- University of Utah
Familial Hemiplegic Migraine
Calcitonin Gene Related Peptide-Induced Headache in Patients With Familial Hemiplegic Migraine Type 1 and 2.
The aim of the present study is to explore functional consequences of migraine gene mutations on their responses to Calcitonin Gene Related Peptide (CGRP)infusion.
- Trial name
- NCT00358839
- Testing
- CGRP
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
Consistency of Response With Rimegepant in Acute Treatment of Migraine
This is a non-interventional, prospective study that will enroll participants with migraine in the United Kingdom currently in use of rimegepant to acutely treat migraine attacks.
- Trial name
- CORRELATE-UK (NCT06898047)
- Testing
- Rimegepant for acute migraine treatment
- Where
- United Kingdom
- Volunteers
- 250 people
- Sponsor
- Pfizer
Photophobia, Traumatic Brain Injury
Objectively Diagnose and Monitor Treatment of Light Sensitivity
The purpose of this project is to provide a new framework for diagnosing and monitoring treatment of light sensitivity and headache by objective measurement of facial features, pupil responses, retinal electrical responses and…
- Conditions
- Photophobia, Traumatic Brain Injury, Migraine
- Trial name
- NCT03694626
- Testing
- Pupillography, Ocular Coherence Tomography (OCT), Wrist-watch sensor device
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Migraine Headaches
Study to Determine the Efficacy and Safety of ELS-M11 in Acute Migraine
This is a Phase 1/ Phase 2, 12-week, multi-center, randomized, double-blind, cross-over, placebo-controlled study to evaluate the efficacy and safety of ELS-M11 compared to placebo in 50 male and female subjects, aged 18 to 65…
- Trial name
- NCT02057315
- Testing
- ELS-M11
- Where
- 2 sites in United States
- Volunteers
- 48 people
- Sponsor
- Achelios Therapeutics
Headache, Migraine
Influence of Main Psychological and Social Factors on Primary Headaches
This study aims to describe the psychological and social characteristics of patients suffering from primary headache and monitored in Neurology department of Besançon University Hospital
- Trial name
- CEPHAPSY (NCT03577548)
- Testing
- Auto- questionnaires
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Headache, Migraine
Headache Inducing Effect of Levcromakalim in Migraine With Aura Patients
To investigate the role of KATP channels in migraine with aura patients.
- Conditions
- Headache, Migraine, Aura
- Trial name
- NCT04012047
- Testing
- Levcromakalim, Saline
- Where
- Denmark
- Volunteers
- 17 people
- Sponsor
- Danish Headache Center
Migraine Disorders
Potential Osteocatabolic Effect Caused by Anti-CGRP mAbs in Migraine Patients Treated With Anti-CGRP mAbs - an Observational Pilot Project With Prospectively Collected Health Related Data
Background: To gain insight on the osteoanabolic activity of anti-CGRP mAbs in patients with migraine as this was not yet specifically investigated in registration or post-approval clinical studies, however, being…
- Trial name
- NCT06035458
- Testing
- Diagnostic radiology
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Ente Ospedaliero Cantonale, Bellinzona
Migraine
MLD10 in the Prevention of Migraine in Adults
This is a double-blind, placebo-controlled, randomized, multi-center study. Subjects agreeing to participate in the study and meet the entry criteria assessed at the screening visit, will begin a 28 day baseline period to confirm…
- Trial name
- NCT02322333
- Testing
- MLD10
- Where
- 9 sites in United States
- Volunteers
- 157 people
- Sponsor
- Pharmalyte Solutions LLC
Migraine
A Dual Intervention in Migraine Treatment: Tens and Exercise
The aim of this clinical trial was to investigate the effects of TENS and exercise training on pain and disability in women diagnosed with migraine.
- Trial name
- NCT07125820
- Testing
- Experimental Group, control group
- Where
- Turkey (Türkiye)
- Volunteers
- 38 people
- Sponsor
- Suleyman Demirel University
Migraine
Positron Emission Tomography (PET) Study of Brain Calcitonin Gene-Related Peptide (CGRP) Receptor Occupancy After Telcagepant Administration (MK-0974-067)
The purpose of this study is to determine the receptor occupancy (RO) associated with telcagepant (MK-0974) administration based on displacement of [11C]MK-4232 from the CGRP receptors in the brain using PET.
- Trial name
- NCT01315847
- Testing
- telcagepant, [11C]MK-4232
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Migraine
Study to Evaluate the Efficacy and Safety of Erenumab (AMG 334) in Migraine Prevention
The primary objective of the study was to evaluate the effect of erenumab compared to placebo on the change from baseline in monthly migraine days.
- Trial name
- STRIVE (NCT02456740)
- Testing
- Erenumab
- Where
- 129 sites in United States, Austria and 11 more
- Volunteers
- 955 people
- Sponsor
- Amgen
Headache, Migraine
Study of Intramuscular Ropivacaine Injections for Treatment of Pediatric Headache
Objective: To determine if lower paracervical intramuscular ropivacaine injection is an effective treatment for pediatric headache in an emergency department setting.
- Trial name
- NCT00680823
- Testing
- Ropivacaine, Normal saline
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Robert Hickey
Migraine
Efficacy of Smartphone Based Digital Application in Improving Headache Related Parameters in Patients With Migraine
Migraine is a common headache disorder and affects 1 in 5 adults during their lifetime. It is a disorder which leads to significantly impaired quality of life, absence from work, loss of productivity in workplace and reduced…
- Trial name
- NCT04984720
- Testing
- Smartphone based digital application
- Where
- India
- Volunteers
- 403 people
- Sponsor
- All India Institute of Medical Sciences
Migraine Disorders, Brain, rTMS Stimulation
Prospective Exploratory Study on rTMS for Migraine Under the Guidance of MEG
Using magnetoencephalography to locate and regulate targets in migraine patients, repeating transcranial magnetic stimulation to physically regulate targets, and evaluating the safety and effectiveness of this treatment method…
- Trial name
- NCT06796725
- Testing
- rTMS, Sibelium
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Ruijin Hospital
Migraine, Episodic Migraine
Real-world Prospective Study on the Use of Anti-CGRP Drugs in Migraine
The goal of this observational study is to evaluate clinical differences in patients who received preventive treatment with medication targeting calcitonin gene-related peptide (CGRP) or its receptor: monoclonal antibodies…
- Conditions
- Migraine, Episodic Migraine, Chronic Migraine, Headache
- Trial name
- EUREkA (NCT07159750)
- Testing
- CGRP antibody or gepant
- Where
- 26 sites in United States, Argentina and 11 more
- Volunteers
- 700 people
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Migraine
Biological Profiles of Neuropeptides, Neurotrophins and miRNA in Migraine
There are still no reliable biomarkers for migraine; the diagnosis is based on symptomatology, and the pathogenesis remains largely a mystery.
- Trial name
- BioM (NCT07832032)
- Testing
- Rimegepant 75 MG
- Where
- Norway
- Volunteers
- 60 people
- Sponsor
- Nordlandssykehuset HF
Migraine
Retinal Nerve Fiber Layer Thickness Changes in Migraine: A Meta-Analysis of Case-control Studies
Optical coherence tomography (OCT) is a non-invasive retinal imaging technology that can provide high-resolution cross-sectional images of the peripapillary retinal nerve fiber layer (RNFL) and measure its thickness.
- Trial name
- NCT02196532
- Testing
- Device: Optical coherence tomography
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Yifan Feng
Episodic Migraine Headache
Craniocervical Flexion Training for Reducing Migraine Headaches and Disability
Migraine, a leading cause of disability globally, necessitates effective interventions beyond pharmacotherapy due to the associated risks.
- Trial name
- NCT06751732
- Testing
- Craniocervical Flexion Training (CCFT), Diaphragm Respiratory Training, Cervical Mobilization and Traction
- Where
- Pakistan
- Volunteers
- 38 people
- Sponsor
- Riphah International University
Migraine
Metoclopramide for Migraine: A Dose Finding Study
Metoclopramide is an effective intravenous treatment for acute migraine attacks, but we do not know the best dose to administer. This study compares three different doses of metoclorpamide.
- Trial name
- MDFS (NCT00682734)
- Testing
- metoclopramide, Diphenhydramine 25mg
- Where
- United States
- Volunteers
- 349 people
- Sponsor
- Montefiore Medical Center
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