Clinical trials: Migraine Disorders
Migraine Disorders
Sofusa System With Sumatriptan (KC5010) Phase 1 Dose Escalation Safety and PK Study (KCC-SMT-002)
Study KCC-SMT-002, is a Phase 1, single-site, open-label, non-randomized, crossover, flexible dose design study to investigate the pharmacokinetic (PK) and safety comparing the Sofusa™ system with sumatriptan (KC5010) to Imitrex®…
- Trial name
- KCC-SMT-002 (NCT03229798)
- Testing
- Sumatriptan Succinate Oral Tablet, Transdermal delivery of sumatriptan succinate
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Sorrento Therapeutics, Inc.
Migraine
Topical Intra-Oral Ketoprofen for Migraine Prevention
Intra-Oral Topical Ketoprofen gel, applied to a branch of the trigeminal nerve, has been shown to prevent migraines when used once daily for 3 months in open label studies.
- Trial name
- NCT01211795
- Testing
- topical intraoral ketoprofen gel
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Behar, Caren, M.D.
Migraine
Migraine is Associated With Altered Mechanical Pain Sensitivity. This Study Investigates Mechanical Pain Sensitivity, Headache Burden, and Quality of Life in Episodic and Chronic Migraine, Comparing Pressure Algometry and Algopeg® and Assessing Mechanosensitivity of Peripheral Nerves.
Migraine is one of the most prevalent neurological disorders and is associated with a substantial individual and societal burden.
- Trial name
- MechSens_Migra (NCT07559565)
- Testing
- pressure pain algometry
- Where
- Austria
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Bernhard Taxer
Migraine
"Completeness of Response" Following Treatment With Treximet™ for Migraine
Many clinical trials may not fully explore criteria that are important to some migraine patients' definition of "complete response." This study offers the opportunity to evaluate the effectiveness of Treximet™ when non-standard…
- Trial name
- NCT00893737
- Testing
- sumatriptan succinate 85 mg/naproxen sodium 500 mg (Treximet)
- Where
- 8 sites in United States
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Cady, Roger, M.D.
Migraine Without Aura
PACAP27 Headache Properties in Migraine Without Aura Patients
Pituitary adenylate cyclase-activating polypeptide (PACAP) is a signaling molecule, localized in sensory and parasympathetic perivascular nerves fibres.
- Trial name
- NCT03471039
- Testing
- PACAP27, Saline
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Migraine
Melatonin for Migraine Prevention
The circadian system with its centre in the hypothalamus is involved in migraine pathophysiology. Whether it plays a pivotal role is not clarified.
- Trial name
- MMP (NCT00849511)
- Testing
- melatonin
- Where
- 2 sites in Norway
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Nordlandssykehuset HF
Headache
Ketamine for Acute Migraine in the Emergency Department
This research study will be a prospective, randomized, double-blind, placebo-controlled trial. Because ketamine has yet to be directly studied as treatment for acute migraine headache in the emergency department, the research…
- Trial name
- NCT02697071
- Testing
- Ketamine, Normal Saline
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Carilion Clinic
Migraine Disorders
A Pharmacokinetic Study to Evaluate TREXIMET in Adolescents With Migraine and Healthy Subjects Administered at Three Doses.
This is a pharmacokinetic (PK) study designed to investigate a combination product containing sumatriptan succinate and naproxen sodium administered at 3 single doses (10mg sumatriptan/60mg naproxen sodium, 30mg sumatriptan/180mg…
- Trial name
- NCT00989625
- Testing
- This is a pharmacokinetic study (Treximet)
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Migraine With and Without Aura, Chronic Migraine
Migraine and Body Composition
This research is being done to look at the association between migraine and obesity.
- Conditions
- Migraine With and Without Aura, Chronic Migraine, Healthy Controls
- Trial name
- NCT01720862
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Sleep Bruxism, Tension Headache
Treatment Sleep Bruxism With the Luco Hybrid OSA Appliance
To determine the effectiveness of the Luco Hybrid OSA Appliance in the treatment of sleep bruxism and to aid in the treatment of associated tension/migraine type headaches in adults.
- Conditions
- Sleep Bruxism, Tension Headache, Migraine Headache
- Trial name
- LucoHybrid (NCT02882880)
- Testing
- The Luco Hybrid OSA Appliance
- Where
- Canada
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Luco Hybrid OSA Appliance Inc.
Chronic Daily Headache, Chronic Migraine
Analysis of Headache Chronification With Imaging, Deep Phenotyping, and Proteomics
Study is aimed at determining why some patients with episodic headache proceed to chronic daily or near daily headaches. The Investigators seek to discover differences in brain anatomy and function, composition of cerebrospinal…
- Trial name
- NCT03231241
- Where
- United States
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- Stanford University
Migraine Disorders
Defining the Sympathetic Skin Response of Migraineurs in the Facial Area
The aim of this study is to define the sympathetic skin response of migraineurs in the facial area. This will be achieved by exposing healthy volunteers and migraine patients to various stress stimuli (pain, visual stimulation…
- Trial name
- NCT03772860
- Testing
- Pain stimulation, Visual stimulation, Auditory stimulation
- Where
- Israel
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Hillel Yaffe Medical Center
Migraine
Study of Oral Lasmiditan in Participants With Normal and Impaired Renal Function
This is a multi-center, open-label, non-randomized, parallel-group, adaptive, single dose study. This study will enroll up to 32 participants using an adaptive design that can include up to 3 groups of 8 participants with…
- Trial name
- NCT03009162
- Testing
- Lasmiditan
- Where
- 2 sites in Canada
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Migraine, Magnesium, Pediatric
Serum Magnesium Level and Pediatric Migraine
Aim: The purpose of this study is to compare serum magnesium levels between patients with migraine and a control group and to examine the relationship between the frequency and duration of attacks in patients with migraine and…
- Trial name
- Migraine (NCT06274255)
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mersin University
Cystitis, Interstitial, Dysmenorrhea
Chronic Pain Risk Associated With Menstrual Period Pain
The purpose of this study is to determine if some women with dysmenorrhea (painful periods) are at higher future risk of developing chronic pelvic pain (CPP) and if oral contraceptives (OC) can be used to reverse this chronic…
- Conditions
- Cystitis, Interstitial, Dysmenorrhea, Migraine Disorders, Pelvic Pain
- Trial name
- CRAMPP (NCT02214550)
- Testing
- cyclic microgestin 1/20, continuous microgestin 1/20
- Where
- United States
- Volunteers
- 353 people, healthy volunteers welcome
- Sponsor
- Endeavor Health
Migraine
Puberty, Sex Hormones and Pain Sensitivity in Adolescents With Migraine
The purpose of this research study is to investigate the relationships between sex hormone levels and experimental pain sensitivity and migraine severity will be examined.
- Trial name
- IHS (NCT05738213)
- Testing
- Thermal stimuli, Pressure stimuli, Pain ratings
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Hypertension, Heart Failure
LSFG-SKIN, Laser Speckle Flowgraphy
The purpose of this project is to quantify normal and abnormal skin blood flow regionally in different areas of the body(face, extremities, over burns and wounds) at baseline and over time in response to treatment or…
- Conditions
- Hypertension, Heart Failure, Vascular Ischemia, Burns
- Trial name
- NCT03660618
- Testing
- laser speckle flowgraphy
- Where
- United States
- Volunteers
- 1 people, healthy volunteers welcome
- Sponsor
- Randy Kardon
Headache, Migraine
Carbon Monoxide's Headache Inducing Characteristics and Effects on the Cerebral Arteries and Blood Flow
In this study the investigators will research the hypothesis that the gas carbon monoxide induces headache and increases the blood flow velocity in the middle cerebral artery.
- Trial name
- NCT02066558
- Testing
- Carbon monoxide
- Where
- Denmark
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Danish Headache Center
Healthy
A Study to Compare Two Different Formulations of Lasmiditan in Healthy Participants
The main purpose of this study is to compare the amount of lasmiditan that gets into the blood stream and how long it takes the body to get rid of it, when given as a oral-disintegrating (OD) tablet compared to immediate-release…
- Trial name
- NCT04881747
- Testing
- Lasmiditan
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Migraine in Children
Uric Acid Levels and Migraine in Children
Migraine is recognized as one of the most prevalent neurological disorders. The exact pathophysiological mechanisms underlying migraine have not yet been fully elucidated.
- Trial name
- NCT06966037
- Where
- Turkey (Türkiye)
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Aysen Orman