Clinical trials: Migraine Headache
Patent Foramen Ovale
Precutaneous High Risk Patent Foramen Ovale to Treat Migraine Headaches
The foramen ovale, a kind of physiologic channel in the interatrial septum in the heart at embryonic stage, is closed normally at 5-7 months after birth.
- Trial name
- NCT02777359
- Testing
- the transcatheter closure of PFO
- Where
- China
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Migraine, Common Migraine
A Study of the Efficacy and Safety of Two Doses of Topiramate Compared to Placebo and Propranolol in the Prevention of Migraine
The purpose of this study is to evaluate the safety and efficacy of two doses of topiramate (100 and 200 mg daily) versus placebo and propranolol in the prevention of migraine.
- Conditions
- Migraine, Common Migraine, Classic Migraine, Headache
- Trial name
- NCT00236561
- Testing
- topiramate, propranolol
- Volunteers
- 786 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Migraine Disorders, Migraine With Aura
Continue or Stop Applying Wet Cupping (Al-Hijamah) in Migraine
This study evaluates the short and long-term effects of application of Wet Cupping Therapy (WCT) in the treatment of migraine headaches in adults.Half of the participants will continue WCT application and the other half will not.
- Conditions
- Migraine Disorders, Migraine With Aura, Migraine Without Aura
- Trial name
- NCT03479060
- Testing
- Wet Cupping
- Where
- Turkey (Türkiye)
- Volunteers
- 109 people
- Sponsor
- Karabuk University
Migraine Headache
Cefaliv® Compared to Neosaldina® in the Treatment of Migraine Attacks
This study evaluates the non-inferiority of Cefaliv® compared to Neosaldina® in the treatment of migraine attack in two hundred and sixteen adults of both sexes with age between eighteen and sixty five years old.
- Trial name
- NCT02706015
- Where
- Brazil
- Sponsor
- Ache Laboratorios Farmaceuticos S.A.
Chronic Migraine, Fibromyalgia
Study of Low-dose Naltrexone in Chronic Migraine With Fibromyalgia
This research aims to look at the effect of low-dose naltrexone on the severity and frequency of attacks in people with chronic migraine with or without new daily persistent headache and fibromyalgia.
- Conditions
- Chronic Migraine, Fibromyalgia, New Daily Persistent Headache
- Trial name
- NCT05536050
- Testing
- Migraine diary and Questionnaires
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Thomas Jefferson University
Migraine
Migraine Prevention Using ActiPatch
Chronic pain is now widely understood to be due to central sensitization, which leads to exaggerated pain perception. Migraine is no exception, since it is well known that sensitization of the trigeminovascular pain pathway can…
- Trial name
- PSWT (NCT03166046)
- Testing
- Pulsed Shortwave Therapy
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- BioElectronics Corporation
Migraine, Patent Foramen Ovale
GORE® CARDIOFORM Septal Occluder Migraine Clinical Study
Multi-center, prospective, randomized, placebo- and sham-controlled study to evaluate the GORE® CARDIOFORM Septal Occluder for migraine headache relief
- Conditions
- Migraine, Patent Foramen Ovale, PFO - Patent Foramen Ovale
- Trial name
- RELIEF (NCT04100135)
- Testing
- Actual device PFO closure, Thienopyridine (clopidogrel or prasugrel)
- Where
- 15 sites in United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- W.L.Gore & Associates
Migraine
Study to Assess Effectiveness of Oral Atogepant in Adult Participants For Prevention of Migraine in the United Kingdom
Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound.
- Trial name
- PRACTICE (NCT07690215)
- Volunteers
- 200 people
- Sponsor
- AbbVie
Persian Gulf Syndrome
Treatment Study of Carnosine Versus Placebo in Gulf War Illness (GWI)
The purpose of this study is to perform a randomized double-blind, placebo-controlled, 12 week study of the effects of carnosine on cognitive, psychometric, autonomic, and muscle strength outcomes in 100 GWI subjects.
- Trial name
- NCT00810368
- Testing
- Carnosine
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Georgetown University
Chronic Migraine
Post-marketing Clinical Follow-up for Long-term Use of Intranasal Kinetic Oscillation in Subjects With Chronic Migraine
An non controlled, long term, multi center investigation
- Trial name
- NCT05843721
- Testing
- KOS (Intranasal kinetic oscillation stimulation)
- Where
- 12 sites in Germany, Israel and 2 more
- Volunteers
- 98 people
- Sponsor
- Chordate Medical
Migraine With Aura
Study of the Safety and Effectiveness of NXN-188 for the Acute Treatment of Migraine Attacks With Aura
The following study is being conducted to explore the safety and effectiveness of a new chemical entity called NXN-188 in subjects with a history of migraine with aura.
- Trial name
- NCT00877838
- Testing
- NXN-188
- Where
- Denmark
- Volunteers
- 40 people
- Sponsor
- Danish Headache Center
Headache, Migraine
Headache Inducing Effect of Cromakalim in Migraine Patients
To investigate the role of KATP channels on the cerebral hemodynamic in migraine patients.
- Trial name
- NCT03228355
- Testing
- Levcromakalim, Saline
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Danish Headache Center
Migraine
Zonisamide Versus Topiramate in Migraine
Investigators aim to compare the effect of zonisamide versus topiramate in migraine by assessing the absolute reduction in MMD in each group, the percentage of patients who achieved ≥ 50% reduction in the monthly headache days…
- Trial name
- NCT06347497
- Testing
- Zonisamide 50 MG, Topiramate 50 MG
- Where
- Egypt
- Volunteers
- 600 people
- Sponsor
- Kafrelsheikh University
Headache Disorders, Tension-Type Headache
An Open Internet-based Survey and Natural Language Processing Project Analysing Written Monologues by Headache Patients
Headache disorders are among the most prevalent medical conditions worldwide. The diagnosis of headache disorders is based on medical history taking.
- Conditions
- Headache Disorders, Tension-Type Headache, Migraine Disorders, Cluster Headache
- Trial name
- NLPH-OPEN (NCT05153876)
- Testing
- Questionnaires
- Where
- Belgium
- Volunteers
- 1,150 people
- Sponsor
- University Hospital, Ghent
Vestibular Migraine, Dizziness
Chinese Real-world Study of Treatment of Vestibular Migraine
Vestibular migraine is a phenotype of migraine, characterized by more prominent vertigo symptoms compared to headache. Treatments for VM are mainly divided into two categories: acute treatment and preventive treatment.
- Conditions
- Vestibular Migraine, Dizziness, Vertigo
- Trial name
- NCT07203248
- Testing
- CGRP R Inhibitor; CGRP Inhibitor, none-CGRP
- Volunteers
- 2,000 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Migraine; Status
Effect of Acupressure in Migraine: Single-blinded, Randomized, Controlled Clinical Trial
Background : Migraine is one of the most complex, prevalent, debilitating neurologic disorder in the world. In clinical experience, there are limitation over western medicine for migraine, especially some extra adverse effects.
- Trial name
- NCT04429048
- Testing
- Acupressure elastic band (Sea-Band), General elastic band (no bud)
- Where
- Taiwan
- Volunteers
- 17 people
- Sponsor
- National Taiwan University Hospital
Chronic Migraine, Migraine Disorders
Osteopathic Manipulative Treatment and Migraine Headaches
In this study the investigators hypothesize, that Osteopathic Manipulative Therapy (OMT) will reduce migraine disability and severity scores when compared to standard of care including prophylactic pharmacological agents with…
- Conditions
- Chronic Migraine, Migraine Disorders, Headache Disorders, Headache, Migraine
- Trial name
- NCT04976985
- Testing
- Osteopathic Manipulative Therapy (OMT), Standard of care
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- St. Luke's Hospital, Pennsylvania
Migraine With and Without Aura
Low-Dose Naltrexone and Acetaminophen Combination and Sumatriptan in the Acute Treatment of Migraine With Nausea
This proof-of-concept study compares side-by-side low-dose naltrexone and acetaminophen combination to sumatriptan in the acute treatment of migraine.
- Trial name
- NCT03185143
- Testing
- Naltrexone and Acetaminophen Combination, Sumatriptan 100 mg
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- Allodynic Therapeutics, Inc
Migraine
The Identification and Characterization of Autonomic Dysfunction in Migraineurs With and Without Auras
This is a study to compare subject response and symptoms resulting from administration of three clinical assessments. The 3 assessments are 1. passive upright tilt table testing, 2.
- Trial name
- NCT01080287
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- The Cleveland Clinic
Chronic Migraine
Cannabis for Chronic Headaches in Adolescents: the CAN-CHA Trial
Chronic headaches are a major cause of disability among adolescents. Cannabis products have supported the management of headaches in adults and may play a role in pediatric chronic pain.
- Trial name
- CAN-CHA (NCT05337033)
- Testing
- MPL-001
- Where
- 3 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of Manitoba