Clinical trials: Migraine Headache With Intractable Migraine
Chronic Migraine Without Aura, Intractable, Migraine With Typical Aura
Treatment of Chronic Migraine Headaches.
The purpose of the study is assessment of the safety and efficacy of the De-Novo therapy in the treatment of craniofacial neuralgia and migraine headaches.This is an open-label study of simultaneous administration of combination…
- Conditions
- Chronic Migraine Without Aura, Intractable, Migraine With Typical Aura, Migraine Disorders
- Trial name
- Migraine (NCT03220113)
- Testing
- Dexamethasone, Lidocaine, Thiamine cohort
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Corona Doctors Medical Clinics, Inc.
Chronic Migraine, Headache, Refractory Migraine
Occipital Nerve Stimulation in Chronic Migraine
The goal of this clinical trial is to compare two different types of occipital nerve stimulation (BurstDR (dorsal root) microdosing versus Tonic) in chronic refractory migraine.
- Trial name
- NCT07087678
- Testing
- Prodigy internal pulse generator occipital nerve stimulator
- Volunteers
- 40 people
- Sponsor
- University College, London
Migraine
Treatment for Migraines With an Implantable Device
The purpose of this study is to evaluate the safety and effectiveness of an implantable device for difficult to treat migraine. There are a significant number of patients who have drug refractory migraine and alternative…
- Trial name
- NCT00286078
- Testing
- Precision
- Where
- 15 sites in United States
- Volunteers
- 179 people
- Sponsor
- Boston Scientific Corporation
Refractory Chronic Migraine
A Feasibility Clinical Trial to Evaluate High Frequency Spinal Cord Stimulation for the Treatment of Patients With Chronic Migraine
The purpose of this study is to assess short- and long-term safety, tolerability and efficacy of cervical High Frequency Spinal Cord Stimulation (HF-SCS) in patients suffering from chronic migraine refractory to conventional…
- Trial name
- rCM HF-SCS (NCT01653340)
- Testing
- Senza™, High Frequency Spinal Cord Stimulator for Refractory Chronic Migraine
- Where
- Italy
- Volunteers
- 18 people
- Sponsor
- University of Roma La Sapienza
Chronic Pain
Home-based Transcranial Stimulation in the Treatment of Patients With Refractory Chronic Pain
Refractory chronic pain represents a serious and limiting health condition which does not respond to standard pharmacological therapy.
- Trial name
- NCT05099406
- Testing
- Transcranial electrical stimulation
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- University of Santiago de Compostela
Migraine
Psychological and Biological Markers of Refractory Migraine
The term "refractory" migraine describes a particularly aggressive form of the disease in which the patient does not benefit from any of the preventive therapies with the various classes of drugs available, including treatment…
- Trial name
- NCT05046119
- Where
- Italy
- Volunteers
- 80 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Migraine
Clinical Experience With Transcutaneous Supraorbital Nerve Stimulation in Refractory Migraine
Migraine is included in the top-ten disabling diseases and conditions among the Western populations. Non-invasive neurostimulation (t-SMS), including the Cefaly® device, for the treatment of various types of pain is a relatively…
- Trial name
- NCT03125525
- Testing
- Cefaly device
- Volunteers
- 37 people
- Sponsor
- Corfu Headache Clinic
High Frequency Episodic Migraine and Chronic Migraine
TI-001 (Intranasal Oxytocin) for Treatment of High Frequency Episodic Migraine and Chronic Migraine
This study evaluates the use of oxytocin, given as a nasal spray, for treatment of high frequency episodic migraine and chronic migraine.
- Trial name
- NCT01839149
- Testing
- TI-001
- Where
- 6 sites in Australia, Chile and 1 more
- Volunteers
- 240 people
- Sponsor
- Trigemina, Inc
Chronic Migraine, Cluster Headache
Intra-arterial Sphenopalatine Ganglion Block for Patients With Refractory Headache
The purpose of this study is to evaluate the safety and efficacy of intra-arterial (IA) delivery of Dexamethasone and Ketorolac into the arteries supplying the sphenopalatine ganglion (SPG) - a collection of neurons that plays an…
- Conditions
- Chronic Migraine, Cluster Headache, Trigeminal Neuralgia
- Trial name
- NCT04353505
- Testing
- Ketorolac, Dexamethasone
- Where
- United States
- Sponsor
- Weill Medical College of Cornell University
Migraine, Chronic Migraine Headache
Bilateral Embolization of the Middle Meningeal Arteries for Refractory Chronic Migraine
This study is to test the safety and feasibility of a procedure called embolization of the middle meningeal arteries (MMA), using a product called Onyx. Embolization creates a plug in the arteries.
- Conditions
- Migraine, Chronic Migraine Headache, Refractory Migraine
- Trial name
- MMAE-Migraine (NCT07223008)
- Testing
- embolization of middle meningeal arteries
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Johns Hopkins University
Chronic Migraine
A Two-Arm Study Evaluation H.P. Acthar Injection Gel in Treatment of Chronic Migraines
This small study is to investigate the efficacy of Acthar in the treatment of chronic migraine in patients who have failed multiple treatments, including Botox (which is defined as having <30% reduction from baseline in the…
- Trial name
- NCT01813591
- Testing
- H.P. Acthar Gel
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- Dent Neuroscience Research Center
Migraine Headache With Intractable Migraine
Ketamine for Refractory Chronic Migraine: a Pilot Study
Ketamine is a drug used for anesthesia but at low doses it is a very effective pain reliever in several chronic conditions. Preliminary studies have shown that ketamine might be effective for patients with refractory chronic…
- Trial name
- NCT03896256
- Testing
- ketamine infusion
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Thomas Jefferson University
Migraine, Aura
MIST II PFO-Migraine Trial With BioSTAR® Bioabsorbable Septal Repair Implant
The objective of the study is to investigate the safety and effectiveness of PFO closure with the BioSTAR Septal Repair Implant System in a population of patients that have refractory migraine (with aura) and who have failed…
- Conditions
- Migraine, Aura, Patent Foramen Ovale
- Trial name
- NCT00283738
- Testing
- BioSTAR Septal Repair Implant System
- Where
- 2 sites in United States
- Volunteers
- 610 people
- Sponsor
- NMT Medical
Refractory Chronic Migraine
Treatment of Chronic Migraine With Erenumab Alone or as an Add on Therapy
Treatment of chronic migraineurs who have failed more than 3 preventive drugs with Erenumab alone, to reduce frequency of monthly migraine days or as an add on therapy
- Trial name
- NCT04152434
- Testing
- Erenumab Auto-Injector
- Where
- Canada
- Volunteers
- 158 people
- Sponsor
- Clinique des Céphalées de Montréal