Clinical trials: Migraine With Aura
Migraine, Migraine Disorders
Real-world Effectiveness and Tolerability of Triptans-Ditans-Gepants (TRIDIGEP)
Migraine is the third most prevalent disease and the leading reason of years lived with disability in the most productive years of the life. Migraine associated disability can be alleviated by acute and preventive treatment.
- Conditions
- Migraine, Migraine Disorders, Migraine With Aura, Headache Disorders
- Trial name
- TRIDIGEP (NCT06267664)
- Testing
- Patients with migraine treated with triptans, Lasmiditan or Gepants
- Where
- Spain
- Volunteers
- 1,500 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Migraine With or Without Aura
An Acute Migraine Factorial Study
The study consists of a screening visit, out-patient treatment of a moderate or severe migraine attack with a single dose of the study medication within 8 weeks, and End-of-Study Visit 2-7 days after dosing.
- Trial name
- ANODYNE-1 (NCT06245902)
- Testing
- Naltrexone and Acetaminophen, Naltrexone and Acetaminophen-High Dose, Naltrexone Alone (regular dose)
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Allodynic Therapeutics, Inc
Migraine Disorders, Migraine With Aura
The FreMRI Study: Advanced MRI on Migraine Patients Treated With Fremanezumab
The goal of this open-label, single-blind, controlled-trial is to evaluate brain changes evaluated with diffusion Magnetic Resonance Imaging (MRI) and functional MRI in patients with high-frequency episodic migraine and chronic…
- Conditions
- Migraine Disorders, Migraine With Aura, Migraine Without Aura, Brain Diseases
- Trial name
- FreMRI (NCT06244823)
- Testing
- Fremanezumab Prefilled Syringe
- Where
- Spain
- Volunteers
- 87 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Migraine
Mindfulness and Mechanisms of Pain Processing in Adults With Migraines
Although many adults with migraines use non-pharmacological treatment options, there is a lack of research on the use of many mind/body techniques specifically for headache.
- Trial name
- NCT02695498
- Testing
- Mindfulness Based Stress Reduction, Migraine/stress Education
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Wake Forest University Health Sciences
Migraine, Migraine With Aura
A Randomized, Double-Blind, Parallel Group, Placebo-Controlled Study to Assess STS101 in the Acute Treatment of Migraine
Study STS101-007 is a randomized, double-blind, parallel group, placebo-controlled, multicenter study to evaluate the efficacy, safety, and tolerability of single doses of STS101 (dihydroergotamine nasal powder) in the acute…
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura
- Trial name
- SUMMIT (NCT04940390)
- Testing
- Dihydroergotamine
- Where
- 127 sites in United States
- Volunteers
- 1,591 people
- Sponsor
- Satsuma Pharmaceuticals, Inc.
Migraine Without Aura
Effect of Levcromakalim in Individuals With Migraine Pretreated With Erenumab
An outstanding scientific question, that merits further investigation, is whether dilation of intracranial arteries is implicated in the pathogenesis of cephalic pain in migraine.
- Trial name
- COLLIDE (NCT05889442)
- Testing
- Levcromakalim
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Danish Headache Center
Migraine Without Aura
Effect of Sildenafil in Individuals With Migraine Pretreated With Erenumab
An outstanding scientific question, that merits further investigation, is whether dilation of intracranial arteries is implicated in the pathogenesis of cephalic pain in migraine.
- Trial name
- COMPETE (NCT05889455)
- Testing
- Sildenafil
- Where
- Denmark
- Volunteers
- 16 people
- Sponsor
- Danish Headache Center
Migraine, Episodic Migraine
Transnasal Cooling for Migraine
This is a prospective, double-blind, sham-controlled, randomized study to assess the safety, tolerability, and optimal dose of the COOLSTAT Transnasal Thermal Regulating Device for acute treatment of migraine.
- Conditions
- Migraine, Episodic Migraine, Migraine With Aura, Migraine Without Aura
- Trial name
- NCT04936061
- Testing
- CoolStat active device
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- CoolTech LLC
Acute Migraine With or Without Aura
Study to Assess the Safety and Efficacy of ONZETRA® Xsail® for the Acute Treatment of Episodic Migraine With or Without Aura in Adolescents
This study will be conducted to evaluate the safety and efficacy of sumatriptan nasal powder (AVP-825) compared to placebo in the acute treatment of migraine in adolescent participants, 12 through 17 years of age.
- Trial name
- NCT03338920
- Testing
- sumatriptan nasal powder
- Where
- 40 sites in United States
- Volunteers
- 159 people
- Sponsor
- Currax Pharmaceuticals
Migraine, Migraine With Aura
A Study to Evaluate the Safety of STS101 in the Acute Treatment of Migraine
Study STS101-003 is a multi-center, multiple dose (PRN), open-label, 12-month study to evaluate the safety and tolerability of STS101 (dihydroergotamine nasal powder) in the acute treatment of migraine.
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura
- Trial name
- ASCEND (NCT04406649)
- Testing
- Dihydroergotamine
- Where
- 44 sites in United States
- Volunteers
- 482 people
- Sponsor
- Satsuma Pharmaceuticals, Inc.
Migraine, Migraine With Aura
A Randomized, Double-Blind, Placebo-Controlled Study to Evaluate STS101 in the Acute Treatment of Migraine
Study STS101-002 is a randomized, double-blind, parallel group, placebo-controlled, multicenter study to evaluate the efficacy, safety, and tolerability of single doses of STS101 (dihydroergotamine nasal powder) in the acute…
- Conditions
- Migraine, Migraine With Aura, Migraine Without Aura
- Trial name
- EMERGE (NCT03901482)
- Testing
- Dihydroergotamine
- Where
- 117 sites in United States
- Volunteers
- 1,201 people
- Sponsor
- Satsuma Pharmaceuticals, Inc.
Migraine With Aura, Migraine Without Aura
Digital Treatment for Migraines - a Feasibility Study
An individualised internet-based treatment from a biopsychosocial perspective for patients with migraines in primary care has been developed within the Vastra Gotaland region in 2019.
- Trial name
- NCT05018572
- Testing
- I AM
- Where
- Sweden
- Volunteers
- 29 people
- Sponsor
- Vastra Gotaland Region
Headache, Migraine, Aura
Migraine Inducing Effect of Levcromakalim in Patients With Migraine With Aura
To investigate the migraine inducing effect of levcromakalim in patients with migraine with aura.
- Trial name
- NCT04905654
- Testing
- Levcromakalim, Saline
- Where
- Denmark
- Volunteers
- 35 people
- Sponsor
- Danish Headache Center
Headache, Migraine With Aura
The Involvement of ATP Sensitive Potassium Channel in Migraine Aura and Migraine Pain.
The aim of the present study to investigate whether Opening of KATP channels causes migraine pain by activation of meningeal nociceptors and ascending trigeminal nociceptive pathways.
- Conditions
- Headache, Migraine With Aura, Migraine Without Aura
- Trial name
- NCT05565001
- Testing
- Levcromakalim
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Danish Headache Center
Migraine Without Aura
Migraine STImulation Crisis of Migraine
Migraine is a neurovascular disease whose prevalence is estimated at almost 20% of the adult population. Currently, there is no treatment for migraine.
- Trial name
- MISTIC (NCT04568252)
- Testing
- Wristband with millimeter wave emission.
- Where
- 6 sites in France
- Volunteers
- 140 people
- Sponsor
- Remedee SA
Migraine, Migraine Disorders
Integrative Migraine Pain Alleviation Through Chiropractic Therapy
This pilot study evaluates the addition of chiropractic treatment to conventional neurological care in the treatment of migraine headaches in adult women.
- Conditions
- Migraine, Migraine Disorders, Migraine With Aura, Migraine Without Aura
- Trial name
- IMPACT (NCT03177616)
- Testing
- Chiropractic Treatment
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Harvard University Faculty of Medicine
Migraine, With or Without Aura
Safety and Efficacy Study in Adult Subjects With Acute Migraines
The purpose of this study is to compare the efficacy of BHV-3000 (rimegepant) versus placebo in subjects with Acute Migraines
- Trial name
- NCT03235479
- Testing
- Rimegepant
- Where
- 50 sites in United States
- Volunteers
- 1,485 people
- Sponsor
- Pfizer
Migraine, With or Without Aura
Safety and Efficacy in Adult Subjects With Acute Migraines
The purpose of this study is to compare the efficacy of BHV-3000 (rimegepant) versus placebo in subjects with Acute Migraines
- Trial name
- NCT03237845
- Testing
- Rimegepant
- Where
- 50 sites in United States
- Volunteers
- 1,499 people
- Sponsor
- Pfizer
Migraine, With or Without Aura
Open Label Safety Study in Acute Treatment of Migraine
The purpose of this study is to evaluate safety and tolerability of BHV-3000 (rimegepant).
- Trial name
- NCT03266588
- Testing
- Rimegepant
- Where
- 98 sites in United States
- Volunteers
- 3,019 people
- Sponsor
- Pfizer
Migraine, With or Without Aura
Trial in Adult Subjects With Acute Migraines
The purpose of this study is to compare the efficacy of BHV-3000 (rimegepant ODT) versus placebo in subjects with Acute Migraines.
- Trial name
- NCT03461757
- Testing
- Rimegepant
- Where
- 69 sites in United States
- Volunteers
- 1,811 people
- Sponsor
- Pfizer