Clinical trials: Mild Cognitive Disorder
Cognitive Impairment
Effect of Technology on Cognitive Function in Elderly
Cognitive technology therapies, including interactive video gaming, computer soft wares and mobile technology, have been used to implement cognitive training and rehabilitation programs.
- Trial name
- cogntion (NCT06378606)
- Testing
- cognitive therapy
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nourhan Hesham Ali
Mild Traumatic Brain Injury, Internet-Delivered Cognitive Behavioural Therapy
Internet Delivered Cognitive Behavioural Therapy for Persons With Mild Traumatic Brain Injury
Background: Individuals with neurological conditions (stemming from brain injury or stroke) can experience high levels of emotional distress leading to decreased quality of life and increased health care costs.
- Conditions
- Mild Traumatic Brain Injury, Internet-Delivered Cognitive Behavioural Therapy, Depression, Anxiety
- Trial name
- NCT04561011
- Testing
- Internet-delivered Cognitive Behavioural Therapy(ICBT)
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Alzheimer's Disease
ADNI: Alzheimer's Disease Neuroimaging Initiative
The purpose of this study is to examine how brain imaging technology can be used with other tests to measure the progression of mild cognitive impairment (MCI) and early Alzheimer's disease (AD).
- Trial name
- NCT00106899
- Testing
- Magnetic Resonance Imaging (MRI), Positron Emission Tomography (PET), Lumbar Puncture (LP)
- Where
- 59 sites in United States, Canada
- Volunteers
- 818 people, healthy volunteers welcome
- Sponsor
- Alzheimer's Disease Cooperative Study (ADCS)
Alzheimer s Disease, Mild Cognitive Impairment (MCI)
Chinese University-Alzheimer's Disease With Vascular and Other Co-pathology: Towards Actionable Neuro-Cognitive-Omic Evaluations (CU-ADVANCE)
Population aging is transforming the epidemiological landscape of the Asia-Pacific region at an unprecedented pace. By 2050, more than one quarter of the region's population will be aged over 60, with 36.7% of countries projected…
- Trial name
- NCT07917182
- Where
- China
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Alzheimer Disease, Alzheimer's Disease (Incl Subtypes)
Amyloid Prediction in Early Stage Alzheimer's Disease Through Speech Phenotyping - PAST Extension
The primary objective of the study is to evaluate whether a set of algorithms analysing acoustic and linguistic patterns of speech can detect amyloid-specific cognitive impairment in early stage Alzheimer's disease, based on…
- Conditions
- Alzheimer Disease, Alzheimer's Disease (Incl Subtypes), Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease
- Trial name
- PAST-US (NCT04937959)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Novoic Limited
Memory Disorders
AIT-082 Phase 1B Study
AIT-082 is a novel small molecule that crosses the blood-brain barrier to enhance nerve function by increasing levels of neurotrophic growth factors and encouraging nerve sprouting in the brain.
- Trial name
- NCT00000180
- Testing
- AIT-082
- Where
- 4 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute on Aging (NIA)
Alzheimer's Disease
Imaging Inflammation in Alzheimer's Disease
This study is being done to learn about inflammation and amyloid in Alzheimer's disease. A type of brain scan called a PET scan is used measure 1) inflammation and 2) abnormal accumulation of a the amount of a certain protein…
- Trial name
- NCT02831283
- Testing
- 11C-PBR28, 18F-Florbetaben, Lumbar puncture (optional)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Patrick Lao
Mild Cognitive Impairment, Alzheimer Disease
Spatial Navigation for the Early Detection of Alzheimer's Disease.
Alzheimer's Disease (AD) is the most common form of dementia and may contribute to 60-70 % of all cases. An early, accurate diagnosis of AD will become increasingly important with disease-modifying therapies.
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Healthy Aging
- Trial name
- ALLO-task (NCT06385951)
- Testing
- Procedure for patients, Procedure for healthy controls
- Where
- Belgium
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Healthy, Alzheimer Disease
A Study to Measure CSF Proteins in Elderly Healthy Volunteers and Volunteers With Mild Cognitive Impairment or Alzheimer's Disease
The purpose of this study is to investigate changes of cerebral spinal fluid (CSF) proteins over time using continuous CSF sampling for 36 hours in elderly healthy volunteers and volunteers with mild cognitive impairment or…
- Trial name
- NCT01436188
- Testing
- Standard CSR sampling procedure, Alternate frequency CSR sampling procedure, Standard frequent CSR sampling procedure with 800 mg ibuprofen
- Where
- 3 sites in Belgium, Netherlands
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Janssen Research & Development, LLC
Mild Cognitive Impairment
The Relationship Between Metamemory and Memory in Old Age
The purpose of this research is to explore the relationship of metamemory and memory of elders and to evaluate the effectiveness of a metamemory cognitive intervention on elders with mild cognitive impairment and low memory…
- Trial name
- M&Mresearch (NCT02113345)
- Testing
- Metamemory Cognitive Intervention
- Where
- Hong Kong
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dementia, Mild Cognitive Impairment
Dual-Task Training for People With Mild Cognitive Impairment and Mild Dementia
Evidence shows that people with dementia have a higher prevalence of sleep disturbance, cognitive decline, behavioral disturbance, and experience motor dysfunction. These symptoms are interrelated.
- Conditions
- Dementia, Mild Cognitive Impairment, Older Adult
- Trial name
- DTT (NCT06348810)
- Testing
- Dual-task training, Cognitive training, Motor training
- Where
- Indonesia
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Taipei Medical University
Mild Cognitive Impairment
Effects of Thai Dance With Twenty-five Squares in Elderly With Mild Cognitive Impairment
The objective of this study was to determine the effects of Thai dance with twenty-five squares on cerebrovascular and cognitive function in elderly with mild cognitive impairment
- Trial name
- NCT06236646
- Testing
- Thai dance with twenty-five squares (TDT), Control (CON)
- Where
- 2 sites in Thailand
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Mild Cognitive Impairment (MCI), Dementia
An Insole and Ankle Device for Monitoring Cognitive Decline in Individuals at Risk for Alzheimer's Disease and/or Alzheimer's Disease Related Dementias (AD/ADRD)
This study tests an innovative system and service for collecting objective, consistent, and in-community gait parameters suitable for use as AD/ADRD biomarkers.
- Trial name
- NCT07127133
- Testing
- Insole and ankle device
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- HealthPartners Institute
Alzheimer Disease, Amyloid Angiopathy
Comparison of OCTA Factors in Patients With or Without Amyloid Pathology: A Prospective Study
To compare alternation of retinal microcirculation within the macula and optic disc in patients with dementia, mild cognitive impairment (MCI), and cognitively healthy subjects who had positive amyloid biomarkers (Aβ +) or not…
- Conditions
- Alzheimer Disease, Amyloid Angiopathy, Macular Ischemia, Dementia
- Trial name
- NCT05475158
- Where
- South Korea
- Volunteers
- 117 people, healthy volunteers welcome
- Sponsor
- Pusan National University Hospital
Alzheimer's Disease
[18F]MK-3328 as a Possible Novel Positron Emission Tomography (PET) Tracer for the Detection of Brain Amyloid Plaques (MK-3328-002)
The purpose of this study is to evaluate radiolabeled [18F]MK-3328 as a PET tracer for estimating the regional distribution and extent of amyloid plaques in participants suffering from amnestic mild cognitive impairment (aMCI)…
- Trial name
- NCT01385033
- Testing
- [18F]MK-3328
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Merck Sharp & Dohme LLC
Subjective Cognitive Decline, Alzheimer Dementia
Davos Alzheimer's Collaborative Healthcare System Preparedness to Increase Cognitive Assessment Rates for Older Adults
In this study the investigators explore a pragmatic strategy to increase cognitive screening rates in the community. The investigators will compare the monetary value of different combinations of SCD questionnaires, digital…
- Trial name
- NCT06191952
- Testing
- Cognigram, Subjective cognitive decline questionnaire (SCD-Q), blood-based biomarkers
- Where
- Germany
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Ludwig-Maximilians - University of Munich
Mild Cognitive Impairment, Alzheimer Disease
TREAD: Time Restricted Eating Intervention for Alzheimer's Disease
The goal of this clinical trial is to learn if restricting the time of eating to allow for prolonged fasting at night may reduce sleep disturbances, cognitive decay, and pathology in patients diagnosed with Mild Cognitive…
- Conditions
- Mild Cognitive Impairment, Alzheimer Disease, Alzheimer's Disease
- Trial name
- TREAD (NCT06548191)
- Testing
- Time-restricted eating
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Mental Health (Depression), Mental Health and General Well-being
Thrive at Home: A Virtual Reality Social Intervention for Older Adults
The goal of this clinical trial is to evaluate whether a virtual reality (VR) based social platform can improve mental health and social connection for older adults who receive in-home care.
- Conditions
- Mental Health (Depression), Mental Health and General Well-being, Loneliness, Well Being
- Trial name
- Thrive at Home (NCT07835568)
- Testing
- Full Virtual Reality Social Intervention, Abbreviated Virtual Reality Social Intervention
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of California, Santa Barbara
Alzheimers Disease, Mild Cognitive Impairment
Non-expensive and Widely Available Tests as Diagnostic Tools in Dementia and Their Ability to Predict Disease Progression
Alzheimers disease (AD) is the most common course of cognitive decline and thereby the course of more than half of all cases of dementia.
- Trial name
- DEMPROG (NCT01642420)
- Where
- Denmark
- Volunteers
- 115 people, healthy volunteers welcome
- Sponsor
- Zealand University Hospital
Alzheimer s Disease, Mild Cognitive Impairment
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
Background: About 5 million adults in the United States have age-related brain disorders. These include Alzheimer disease (AD), mild cognitive impairment (MCI), and other dementias.
- Conditions
- Alzheimer s Disease, Mild Cognitive Impairment, Healthy
- Trial name
- NCT07169630
- Testing
- 18F-PF974, 18F-florbetaben
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)