Clinical trials: Mild Cognitive Impairment
Alzheimer Disease, Cognitive Dysfunction
A Study to Evaluate the Safety and Tolerability of SAGE-718 in Participants With Mild Cognitive Impairment or Mild Dementia Due to Alzheimer's Disease (AD)
The primary purpose of this study is to evaluate the safety and tolerability of SAGE-718 and its effects on cognitive and neuropsychiatric symptoms in participants with mild cognitive impairment (MCI) or mild dementia due to…
- Conditions
- Alzheimer Disease, Cognitive Dysfunction, Mild Dementia
- Trial name
- NCT04602624
- Testing
- SAGE-718
- Where
- 10 sites in United States
- Volunteers
- 26 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Alzheimer Disease, Mild Cognitive Impairment
Flortaucipir PET Imaging in the Preclinical, Prodromal and Dementia Phases of Alzheimer's Disease
A Phase 1 study designed to evaluate imaging characteristics of flortaucipir in the preclinical, prodromal and dementia phases of Alzheimer's disease.
- Trial name
- NCT04468347
- Testing
- Flortaucipir F18, Brain PET scan
- Volunteers
- 89 people, healthy volunteers welcome
- Sponsor
- Avid Radiopharmaceuticals
MCI
Accexible Speech Analysis for MCI Detection and Monitoring in Colombia
Mild Cognitive Impairment (MCI) is frequently underdiagnosed due to its subtle clinical presentation. This study evaluates the diagnostic performance of AcceXible, a speech analysis-based machine learning platform, compared to…
- Trial name
- NCT07553117
- Testing
- Accexible
- Where
- Colombia
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Accexible
Insomnia, Mild Cognitive Impairment
SleepSMART for Veterans With Insomnia and Mild Cognitive Impairment
Insomnia is a transdiagnostic health problem affecting the physical, cognitive, emotional, and social functioning of Veterans. Importantly, chronic insomnia may be a modifiable risk factor for progression to serious health…
- Trial name
- SleepSMART (NCT07397182)
- Testing
- Cognitive BehavioralTherapy for Insomnia (CBT-I), SleepSMART
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment
Exploratory Trial in Healthy Adults With Mild Cognitive Impairment,16-week Intervention With Mitocholine™
To evaluate the effect of 16-weeks consumption of Mitocholine on Executive Function and Homocysteine levels in a population experiencing Mild Cognitive Impairment.
- Trial name
- NCT05690724
- Where
- Ireland
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mitocholine Ltd
Mild Cognitive Impairment (MCI)
Levetiracetam and Memory Function in Amnestic Mild Cognitive Impairment (MCI)
This research is being done to find out if daily use of the drug levetiracetam can improve memory function in individuals with memory problems like those associated with Mild Cognitive Impairment (MCI) and Alzheimer's disease…
- Trial name
- NCT01044758
- Testing
- Levetiracetam 62.5mg, Levetiracetam 125mg, Levetiracetam 250mg
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Traumatic Brain Injury
Non-invasive Deep Brain Stimulation to Improve Spatial Navigation Abilities in Individuals Following Traumatic Brain Injury
Impairments in spatial memory and spatial navigation are commonly reported amongst patients presenting post-traumatic brain injury (TBI).
- Trial name
- NCT07271524
- Testing
- Transcranial electric stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 25 people
- Sponsor
- Friedhelm Hummel
Mild Cognitive Impairment
The Influence of Multi-domain Cognitive Training on Large-scale Structural and Functional Brain Networks in MCI
The purpose of this study is to integrate advanced computational techniques and multimodal neuroimaging methods to examine the potential effects of long-term, multi-domain, online, computerized cognitive training on large-scale…
- Trial name
- NCT03883308
- Testing
- Multi-domain cognitive training, Cross-word puzzle training
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Primary Aldosteronism, Cognitive Dysfunction
The Association Between Primary Aldosteronism and Cognitive Dysfunction
The goal of this observational study is to learn about the prevalence, progression, and influencing factors of cognitive impairment in patients with primary aldosteronism (PA). The main questions it aims to answer are: 1.
- Conditions
- Primary Aldosteronism, Cognitive Dysfunction, Mild Cognitive Impairment (MCI), Dementia
- Trial name
- PACD (NCT07304674)
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Xinjiang Medical University
Type 2 Diabetes, Mild Cognitive Impairment
Transcutaneous Auricular Vagus Nerve Stimulation in Type 2 Diabetes With Mild Cognitive Impairment
This study is a 24-week, single-center, randomized, double-blind, sham-controlled, parallel-group clinical trial. A total of 38 patients with type 2 diabetes and mild cognitive impairment were enrolled and randomly assigned in a…
- Trial name
- NCT07642518
- Testing
- active transcutaneous auricular vagus nerve stimulation
- Volunteers
- 38 people
- Sponsor
- The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment
Effect of Striatal Temporal Interference Stimulation on Language Processing in Neurodegenerative Diseases
The purpose of this study is to investigate the immediate effects of non-invasive temporal interference stimulation (TIS) targeting the striatum on sentence processing and brain connectivity in patients with neurodegenerative…
- Conditions
- Mild Cognitive Impairment (MCI) Amnestic, Lewy Body Disease With Mild Cognitive Impairment, Parkinson's Disease With Mild Cognitive Impairment
- Trial name
- NCT07449117
- Testing
- Active Temporal Interference Stimulation (TIS)
- Where
- Czechia
- Volunteers
- 70 people
- Sponsor
- Masaryk University
Mild Cognitive Impairment, Normal Aging
An Observational Study Using Multimodal Sensors to Measure Cognitive Health in Adults and Distinguish Mild Cognitive Impairment From Normal Aging
The primary objectives are to develop and validate a classifier using multimodal passive sensor data and metrics derived from normal iPhone and Apple Watch usage to distinguish individuals with normal cognition from those with…
- Trial name
- Intuition (NCT05058950)
- Where
- United States
- Volunteers
- 22,720 people, healthy volunteers welcome
- Sponsor
- Biogen
Cognitive Dysfunction, Mild Cognitive Impairment
Improving the Referral of Patients With Suspected Cognitive Impairment and Early Dementia
The goal of this interventional study is to implement and evaluate the adhesion to two types of interventional strategies for assessing cognitive function, at Family Health Units (FHU), providing primary care clinicians (PCCs)…
- Trial name
- DemRefImprov (NCT05890313)
- Testing
- Mini Mental State Examination, Montreal Cognitive Assessment, Brain on Track (version BOT.0.0.0 03.03.2023)
- Where
- Portugal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Universidade do Porto
Mild Cognitive Impairment, Amnestic Mild Cognitive Impairment - aMCI
Cognitive Outcomes of Brain Stimulation As a Later-in-Life Treatment
This is a pilot study being done to attempt to improve episodic memory problems in persons with mild cognitive impairment (MCI).
- Trial name
- COBALT (NCT05564715)
- Testing
- NeuroElectric StarStim
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Texas Southwestern Medical Center
Mild Cognitive Impairment (MCI)
Sensory Integration Training for Older Adults With Mild Cognitive Impairment
This study aims to investigate the effects of sensory integration training on cognitive functions, quality of life, and social participation in older adults with Mild Cognitive Impairment (MCI)
- Trial name
- NCT07466615
- Testing
- Aerobic Exercise, Sensory Integration Training
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Akdeniz University
Periodontal Diseases, Oral Halitosis
The Effect of Regular Home Use of Dual-light Antibacterial Photodynamic Therapy (aPDT) or the Use of a Powered Toothbrush in Older Individuals With Periodontitis and Mild Cognitive Impairment.
Objective: To compare three different oral hygiene regimens regarding plaque index (PI), bleeding on probing (BOP), the number of deepened periodontal pockets ≥4 mm (PPD), oral halitosis, and changes in oral health-related…
- Trial name
- e-DENT II (NCT07166224)
- Testing
- Oral-B Powered toothbrush, Dual-Light aPDT Treatment - Lumoral
- Where
- 2 sites in Sweden
- Volunteers
- 90 people
- Sponsor
- Blekinge Institute of Technology
Hypertension, Cognitive Decline
Remote Monitoring and Virtual Collaborative Care For Hypertension Control To Prevent Cognitive Decline
This purpose of this study is to examine an aggressive method of blood pressure control that involves home blood pressure monitoring and management of medications by a team of clinical pharmacists in coordination with a primary…
- Trial name
- vCCC (NCT04585880)
- Testing
- Virtual Collaborative Care Clinic
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- University of Kansas Medical Center
Mild Cognitive Impairment
Enhancing Cognitive Control in Mild Cognitive Impairment Via Non-invasive Brain Stimulation
The overall goal of this project is to improve cognitive control abilities in adults with mild cognitive impairment (MCI) through a form of non-invasive brain stimulation, transcranial alternating current stimulation (tACS).
- Trial name
- NCT04647032
- Testing
- Transcranial alternating current stimulation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Mild Cognitive Impairment
Auditory Stimulation of Slow Wave Sleep and Memory in Mild Cognitive Impairment and Older Adults
This study will evaluate the ability of sounds played during slow wave sleep using a phase locked loop algorithm to enhance slow wave sleep and memory in cognitively healthy older adults and in those with amnestic mild cognitive…
- Trial name
- NCT02608840
- Testing
- Auditory stimulation during sleep
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Aging, Mild Cognitive Impairment
bpMedManage: Digital Technology to Support Adherence to Hypertension Medications
The purpose of the bpMedManage study is to rigorously test the efficacy of a smartphone technology to help improve high blood pressure medication adherence among older adults with mild cognitive impairment (MCI) in a 16-week…
- Conditions
- Aging, Mild Cognitive Impairment, Hypertension
- Trial name
- NCT06307574
- Testing
- bpMedManage
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Arizona