Clinical trials: Mild Hypertension
Essential Hypertension, Healthy Volunteers
Phase 1 Clinical Study of MWX401 Injection in Chinese Healthy Participants and Participants With Mild Hypertension
This is a single-center, randomized, double-blind, placebo-controlled, single ascending-dose phase 1 clinical study, aimed at evaluating the safety, tolerability, PK, PD and immunogenicity of single subcutaneous administration of…
- Trial name
- NCT07803835
- Testing
- MWX401 1, MWX401 2, MWX401 3
- Where
- China
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Shanghai Minwei Biotechnology Co., Ltd
Hypertension
Efficacy of Irbesartan/Hydrochlorothiazide Versus Valsartan/Hydrochlorothiazide in Mild to Moderate Hypertension
The primary objective is to compare the efficacy of irbesartan/hydrochlorothiazide 300/25mg against valsartan/hydrochlorothiazide 160/25mg in reducing mean systolic blood pressure (SBP) as measured by home blood pressure…
- Trial name
- COSIMA2 (NCT00500604)
- Testing
- Irbesartan/hydrochlorothiazide, Valsartan/hydrochlorothiazide, Hydrochlorothiazide
- Where
- 14 sites in Egypt, Hong Kong and 12 more
- Volunteers
- 1,617 people
- Sponsor
- Sanofi
Blood Pressure
The Effects of Milk Proteins on Blood Pressure
The primary purpose of the study is to demonstrate a blood pressure lowering effect of CasiGold and CasiMax in subjects with high-normal blood pressure or mild hypertension.
- Trial name
- NCT00471263
- Testing
- Casigold, Casimax
- Where
- Netherlands
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- TNO
Hypertension, Oedema
A Clinical Study Comparing Ankle Swelling Caused by Two Different Blood Pressure Medications, Levamlodipine and Amlodipine, in Post-menopausal Women With Mild High Blood Pressure.
High blood pressure is often treated with a medication called Amlodipine, but it can cause uncomfortable ankle swelling, especially in women.
- Trial name
- TERESA (NCT07618806)
- Testing
- Amlodipine
- Volunteers
- 344 people
- Sponsor
- Zentiva, k.s.
Hypertension
Telmisartan Effectiveness on Left Ventricular Mass Reduction (TELMAR) as Assessed by MRI, in Patients With Mild to Moderate Hypertension
The primary objective was to show that telmisartan is not inferior to metoprolol succinate in respect of the percentage change from baseline in LVMI(H) after a 6.5 months treatment period.
- Trial name
- NCT02242812
- Testing
- Telmisartan, Metoprolol succinate
- Volunteers
- 24 people
- Sponsor
- Boehringer Ingelheim
Hypertension
L-arginine Treatment in Mild Hypertension
Essential Hypertension is characterized by endothelial dysfunction due to reduced nitric oxide (NO) bioavailability. Impairment in nitric oxide-mediated vasodilatation in human brachial, coronary, and renal arteries has been…
- Trial name
- LAHN (NCT02894723)
- Testing
- L-arginine, syrup
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Meir Medical Center
Mild Cognitive Impairment
Candesartan's Effects on Alzheimer's Disease And Related Biomarkers
This study is intended to investigate the safety of candesartan, a blood pressure medication, in non-hypertensive individuals who have mild cognitive impairment (MCI) due to Alzheimer's disease and its effect on disease…
- Trial name
- CEDAR (NCT02646982)
- Testing
- Candesartan
- Where
- 2 sites in United States
- Volunteers
- 77 people
- Sponsor
- Emory University
Essential Hypertension
Efficacy and Safety of Valsartan/Amlodipine in Patients With Mild to Moderate Essential Hypertension
This study assessed the efficacy and safety of the valsartan/amlodipine 160/5 mg single-pill combination in patients with uncomplicated essential hypertension not adequately controlled (MSDBP ≥90 mmHg and <110 mmHg) on valsartan…
- Trial name
- NCT01001572
- Testing
- Valsartan/amlodipine 160/5 mg, Valsartan 160 mg
- Volunteers
- 932 people
- Sponsor
- Novartis
Hypertension, Dyslipidemia
Duowell® vs. Telmisartan Monotherapy in Mild Dyslipidemia Patients With Hypertension
This study is to evaluate effect and safety on central blood pressure with Duowell compared to telmisartan monotherapy in mild dyslipidemia patients with hypertension during 16 weeks.
- Trial name
- NCT03267329
- Testing
- Duowell®, Telmisartan
- Where
- South Korea
- Volunteers
- 80 people
- Sponsor
- Yuhan Corporation
Hypertension
An Efficacy and Safety Study Evaluating the Fixed-Dose Combination of Candesartan Plus Amlodipine in Participants With Mild/Moderate Essential Hypertension
The purpose of this study is to evaluate the efficacy and safety of TCV-116CCB (candesartan cilexetil and amlodipine besylate fixed-dose combination) in Chinese participants with mild to moderate hypertension who do not reach…
- Trial name
- NCT02969265
- Testing
- Amlodipine, TCV-116CCB
- Where
- 25 sites in China
- Sponsor
- Takeda
Hypertension
Comparative Effects of Mild and Moderate Aerobic Exercises on BP, VO2 and HR in Hypertensive Patients
World Health Organization, when systolic blood pressure is equal to or above 130 mm Hg and/or a diastolic blood pressure equal to or above 85 mm Hg , the blood pressure is considered to be raised or high is called hypertension."…
- Trial name
- NCT05409456
- Testing
- mild aerobic exercise, moderate aerobic exercise
- Where
- Pakistan
- Volunteers
- 28 people
- Sponsor
- Riphah International University
Aging, Mild Cognitive Impairment
bpMedManage: Digital Technology to Support Adherence to Hypertension Medications
The purpose of the bpMedManage study is to rigorously test the efficacy of a smartphone technology to help improve high blood pressure medication adherence among older adults with mild cognitive impairment (MCI) in a 16-week…
- Conditions
- Aging, Mild Cognitive Impairment, Hypertension
- Trial name
- NCT06307574
- Testing
- bpMedManage
- Where
- 2 sites in United States
- Volunteers
- 100 people
- Sponsor
- University of Arizona
Hypertension
Pharmacokinetic and Pharmacodynamic Profiles of Aliskiren in Japanese Patients With Mild to Moderate Essential Hypertension
This study will evaluate the pharmacokinetic profile, the effect of rennin inhibition and the relationship among pharmacokinetics, renin-angiotensin system (RAS) biomarkers, and blood pressure lowering effects of oral doses of…
- Trial name
- NCT00424541
- Testing
- SPP100 (aliskiren)
- Where
- Japan
- Volunteers
- 34 people
- Sponsor
- Novartis
Hypertension
Using Telmisartan Alone or Combination of Telmisartan -HCTZ in the Treatment of Mild to Moderate Essential Hypertension
The aim of this therapeutic observation is to demonstrate the efficacy and safety of telmisartan or telmisartan and HCTZ in the treatment of patients with mild-to-moderate essential hypertension under normal conditions of use…
- Trial name
- NCT00638911
- Volunteers
- 33,247 people
- Sponsor
- Boehringer Ingelheim
Hypertension
Study to Compare the Effect of Valsartan vs Atenolol on Pro-thrombotic State in Hypertensive Patients.
A study to compare the effects of Diovan or Atenolol taken for 12 weeks on platelet function of patients who have mild to moderately severe hypertension
- Trial name
- NCT00171756
- Testing
- valsartan/atenolol
- Where
- Switzerland
- Volunteers
- 92 people
- Sponsor
- Novartis
Chronic Kidney Disease, Hypertension
A Study in Male and Female Participants (After Menopause) With Mild to Moderate High Blood Pressure to Learn How Safe the Study Treatment BAY3283142 is, How it Affects the Body and How it Moves Into, Through and Out of the Body After Taking Single and Multiple Doses
Researchers are looking for a better way to treat people who have chronic kidney disease (CKD), a progressive decrease in the kidneys' ability to work properly.
- Trial name
- NCT05491642
- Testing
- BAY3283142
- Where
- 4 sites in Bulgaria, Germany
- Volunteers
- 56 people
- Sponsor
- Bayer
Hypertension
The Effect of Hibiscus Sabdariffa L. Tea on Blood Pressure
The goal of this study is to find out whether the plant compounds present in Hibiscus sabdariffa, a plant commonly used in herbal tea blends and other beverages, will have a beneficial effect on blood pressure in people with…
- Trial name
- NCT00175110
- Testing
- herbal therapy/botanical therapy (Hibiscus sabdariffa)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Tufts University
Hypertension
A Study to Evaluate Efficacy and Safety of ALN-AGT01 in Patients With Mild To-Moderate Hypertension
The purpose of this study is to evaluate the effect of ALN-AGT01 on systolic and diastolic blood pressure and to characterize the pharmacodynamic (PD) effects and safety of ALN-AGT01.
- Trial name
- KARDIA-1 (NCT04936035)
- Testing
- ALN-AGT01
- Where
- 75 sites in United States, Canada and 3 more
- Volunteers
- 394 people
- Sponsor
- Alnylam Pharmaceuticals
Hypertension
COREG MR Versus TOPROL-XL On The Lipid Profile Of Normolipidemic Or Mildly Dyslipidemic Patients With Hypertension
This study was designed to determine whether treatment with COREG MR is more effective at maintaining a better lipid profile than treatment with TOPROL-XL for hypertension.
- Trial name
- NCT00273052
- Testing
- Carvedilol Phosphate modified release formulation, metoprolol succinate
- Where
- 120 sites in United States, Canada and 1 more
- Volunteers
- 514 people
- Sponsor
- GlaxoSmithKline
Hypertension
Effects of the DASH vs. the Mediterranean Diet Combined With Salt Restriction on Blood Pressure Levels in Adults
Non-pharmacological measures should serve as the first-line treatment in individuals with high normal blood pressure (BP) levels or grade 1 hypertension and low-moderate cardiovascular disease risk.
- Trial name
- NCT05669404
- Testing
- Salt Restriction Group (SRG), DASH Diet combined with salt restriction Group (DDG), Mediterranean Diet combined with salt restriction Group (MDG)
- Where
- Greece
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Hippocration General Hospital