Clinical trials: Mild Hypertension
Mild to Moderate Hypertension
Evaluation of Drug-drug Interaction Between LCZ696 and Sildenafil in Subjects With Mild to Moderate Hypertension
This study was conducted to investigate the potential for a pharmacokinetic drug-drug interaction in support of the co-administration of LCZ696 and sildenafil.
- Trial name
- NCT01601470
- Testing
- LCZ696, Sildenafil
- Where
- Germany
- Volunteers
- 28 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension
A Trial Comparing MICARDIS® (Telmisartan) and COZAAR® / LORZAAR® (Losartan) in Patients With Mild-to-Moderate Hypertension Using Ambulatory Blood Pressure Monitoring (ABPM)
The primary aim of the trial is to compare the influence of MICARDIS® (telmisartan) and COZAAR® / LORZAAR® (losartan) in lowering ambulatory diastolic blood pressure (DBP) during the last 6 hours of the 24-hour dosing interval as…
- Trial name
- TOPAS (NCT02200653)
- Testing
- High dose of MICARDIS®, once daily, Low dose of MICARDIS®, once daily, Low dose of COZAAR® / LORZAAR®, once daily
- Volunteers
- 387 people
- Sponsor
- Boehringer Ingelheim
Essential Hypertension
A Valsartan 80 Mg-Referenced, Therapeutic Exploratory Clinical Study to Evaluate the Antihypertensive Efficacy of Fimasartan 30 mg During 24 Hours in Patients With Mild to Moderate Essential Hypertension
The purpose of this study is to Evaluate the Antihypertensive efficacy of Fimasartan 30 mg during 24 hours in Patients with Mild to Moderate Essential Hypertension
- Trial name
- NCT01878201
- Testing
- Fimasartan, Valsartan
- Where
- South Korea
- Volunteers
- 75 people
- Sponsor
- Boryung Pharmaceutical Co., Ltd
Diabetes Mellitus
Comparison of Pharmacodynamic Effects of Sotagliflozin and Empagliflozin in T2DM Patients With Mild to Moderate Hypertension
Primary Objective: To compare the metabolic and gastrointestinal pharmacodynamic (PD) effects of an 8 weeks treatment with sotagliflozin once daily (QD) to an 8 weeks treatment to empagliflozin QD in mild or moderate hypertensive…
- Trial name
- NCT03462069
- Testing
- Sotagliflozin (SAR439954), Empagliflozin
- Where
- Germany
- Volunteers
- 41 people
- Sponsor
- Sanofi
Pregnancy; Pre-eclampsia, Mild
Role of Placental Growth Factor (PlGF) in the Management of Non-Severe Preeclampsia
Preeclampsia is an important disease that develops during pregnancy and it is one of the main contributors to maternal and fetal complications. The only known definitive treatment is delivery.
- Trial name
- MAP (NCT02373839)
- Testing
- Measurement of PlGF
- Where
- Spain
- Volunteers
- 300 people
- Sponsor
- Fetal Medicine Research Center, Spain
Hypertension, Mild Cognitive Impairment
CAndesartan vs LIsinopril Effects on the BRain
The aim of this study is to conduct a 1-year double blind randomized control trial comparing candesartan to lisinopril in 140 individuals with hypertension and executive mild cognitive impairment in their effects on executive…
- Trial name
- CALIBREX (NCT01984164)
- Testing
- Candesartan, Lisinopril
- Where
- United States
- Volunteers
- 176 people
- Sponsor
- Emory University
Hypertension
Compare Effectiveness of Eplerenone vs Atenolol in Reversing the Remodelling Resistance Arteries in Subjects With HT
To investigate the impact of antihypertensive therapy with the selective mineralocorticoid receptor blocker, eplerenone, on small resistance artery remodeling, compared to the effect of equivalent blood pressure control achieved…
- Trial name
- NCT00147563
- Testing
- Eplerenone
- Where
- Canada
- Volunteers
- 34 people
- Sponsor
- Pfizer
Hypertension
Chronic Hypertension and Pregnancy (CHAP) Project
The purpose of this study is to evaluate whether a blood pressure treatment strategy during pregnancy to achieve targets that are recommended for non-pregnant reproductive-age adults (<140/90 mmHg) compared ACOG- recommended…
- Trial name
- CHAP (NCT02299414)
- Testing
- Anti-hypertensive therapy, No anti-hypertensive therapy (unless BP is severe)
- Where
- 72 sites in United States
- Volunteers
- 2,408 people
- Sponsor
- University of Alabama at Birmingham
Blood Pressure, Hypertension
Bioavailability of Hesperidine and Narirutin From Orange Juice to Identify Metabotypes in Hypertension
Flavonoids are polyphenolic compound mainly found in fruits and vegetables with numerous beneficial health effects as protection against cardiovascular diseases by an antihypertensive effect.
- Trial name
- FLAVOTIP (NCT04234100)
- Testing
- Orange juice rich in hesperidin and narirutin
- Where
- Spain
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Technological Centre of Nutrition and Health, Spain
Hypertension
The First-in-Human Study of GW906 Injection
This study is a randomized, double-blind, placebo-controlled, single-dose, dose-escalation trial to evaluate the safety, tolerability, pharmacokinetics, and pharmacodynamics of GW906 in healthy subjects and subjects with mild…
- Trial name
- NCT07884461
- Testing
- GW906 injection
- Where
- China
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Shenzhen Salubris Pharmaceuticals Co., Ltd.
Glaucoma, Open-Angle
Open-Angle Glaucoma Subjects With Cataract Treated With Cataract Surgery Plus One iStent and One iStent Supra
Open Angle Glaucoma Subjects with Cataract treated with Cataract Surgery plus one trabecular micro-bypass stent and one suprachoroidal stent
- Trial name
- NCT03255785
- Testing
- Cataract surgery plus one iStent and one iStent Supra implanted
- Where
- Armenia
- Volunteers
- 15 people
- Sponsor
- Glaukos Corporation
Ocular Hypertension, Open Angle-glaucoma
A 28 Day Study of ONO-9054 Ophthalmic Solution in Subjects With Ocular Hypertension (OHT) or Open-angle Glaucoma (OAG)
The primary objectives of this study are to compare the safety, tolerability, and mean change from baseline in diurnal intraocular pressure (IOP) of ONO-9054 30 µg/mL (0.003%) to latanoprost 0.005% following ocular instillation…
- Trial name
- NCT02083289
- Testing
- ONO-9054, Latanoprost
- Where
- 12 sites in United States
- Volunteers
- 123 people
- Sponsor
- Ono Pharmaceutical Co., Ltd.
Hypertension, Ankle Edema
Assessment of Aliskiren/Amlodipine and Amlodipine on Ankle Foot Volume (AFV) in Patients With Hypertension
The purpose of the present study was to evaluate the addition of aliskiren, to amlodipine can attenuate ankle edema formation in hypertensive patients.
- Trial name
- NCT01080768
- Testing
- Aliskiren/amlodipine, Amlodipine
- Where
- 9 sites in Netherlands
- Volunteers
- 31 people
- Sponsor
- Novartis Pharmaceuticals
Hypertension
First-in-Human Study of VB0004 in Healthy Subjects and to Patients With Mild to Moderate Hypertension With Low Cardiovascular Risk
This will be a single center, Phase I/IB, randomized, double-blind, placebo-controlled, sequential SAD/MAD/FE study, with a patients arm.
- Trial name
- NCT04925050
- Testing
- VB0004
- Where
- 3 sites in Australia
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Syneos Health
Mild Hypertension
A Study in People With Mild Hypertension
The primary objective of this study is to test the hypothesis that LY518674, administered for 6 weeks to patients with mild hypertension, reduces Systolic Blood Pressure, compared with placebo.
- Trial name
- NCT00374855
- Testing
- PPAR alpha, Hydrochlorothiazide
- Where
- 10 sites in Sweden
- Volunteers
- 153 people
- Sponsor
- Eli Lilly and Company
Hypertension, Cardiovascular Disease
Safety and Efficacy Study of Angiotensin Therapeutic Vaccine in Subjects With Mild to Moderate Hypertension
Angiotensin Therapeutic Vaccine (ATV), which contains the novel adjuvant, CoVaccine HT™ , is being developed for the treatment of high blood pressure (hypertension), a major risk factor for serious diseases such as heart attacks…
- Trial name
- NCT00702221
- Testing
- Angiotensin Therapeutic Vaccine plus CoVaccine HT™ adjuvant, CoVaccine HT™ adjuvant
- Where
- 12 sites in United Kingdom
- Volunteers
- 20 people
- Sponsor
- BTG International Inc.
Hypertension
Study of Co-administration of Olmesartan Medoxomil Plus Amlodipine in Patients With Mild to Severe Hypertension
This study assesses the efficacy and safety of co-administration of olmesartan medoxomil plus amlodipine in mild to severe hypertensive patients older than 18 years of age
- Trial name
- NCT00185133
- Testing
- Olmesartan medoxomil, Amlodipine
- Where
- 139 sites in United States
- Volunteers
- 1,900 people
- Sponsor
- Daiichi Sankyo
Cardiovascular Diseases, Hypertension
Effect of an Extract From the Wine Industry on Blood Pressure (HYPERGRAPES)
By-products from the wine industry pose serious problems of management, both from an economic and environmental point of view. Although traditionally the use of by-products of the wine sector has been limited to the production of…
- Trial name
- HYPERGRAPES (NCT04992936)
- Testing
- Extract from the wine industry
- Where
- Spain
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Fundació Eurecat
Diabetes Mellitus, Type 2, Essential Hypertension
Lacidipine In Mild To Moderate Essential Hypertension Patients With Type 2 Diabetes In Korea
This study was designed to evaluate the anti-hypertensive efficacy of lacidipine in hypertensives with Type 2 diabetes and effectiveness on endothelial cell function in Korean population.
- Trial name
- NCT00328965
- Testing
- Lacidipine
- Sponsor
- GlaxoSmithKline
Hypertension
Study to Evaluate Symptoms in Patients Treated With Nebivolol or Metoprolol Extended-release (ER) for Hypertension
The purpose of this study was to compare the tolerability of nebivolol to metoprolol ER in a general population of patients with mild to moderate hypertension receiving hydrochlorothiazide (HCTZ)
- Trial name
- NCT00547300
- Testing
- Metoprolol ER, Nebivolol
- Where
- 24 sites in United States
- Volunteers
- 49 people
- Sponsor
- Forest Laboratories