Clinical trials: Mild Moderate
Depression and/or Anxiety in the Mild-to-moderate Range, Cognitive Behavioral Therapy
Internet-Based Cognitive Behavioural Therapy (iCBT) for Anxiety and Depression in Singapore
Cognitive-behavioural therapy (CBT) has a robust evidence base for treating anxiety disorders and depression, including transdiagnostic CBT. Internet-based CBT (iCBT) offers a new approach to delivering these therapies.
- Trial name
- NCT07532551
- Testing
- Internet-delivered cognitive behavioural therapy (iCBT)
- Where
- 3 sites in Singapore
- Volunteers
- 390 people
- Sponsor
- National University of Singapore
Depression, Suicide and Self-harm
Telehealth Behavioral Activation for Teens
Behavioral activation is one such empirically supported intervention. Derived from cognitive-behavioral therapy, a well-established treatment for depression, behavioral activation uses psychoeducation and skill-building to…
- Conditions
- Depression, Suicide and Self-harm, Depression in Adolescence, Depression Mild
- Trial name
- NCT06273995
- Testing
- Behavioral Activation
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- Baylor College of Medicine
Mild to Moderate Hypertension
Phase II Clinical Study of HRS-9563 in Patients With Mild to Moderate Hypertension
This study aims to evaluate the efficacy and safety of HRS-9563 in patients with mild to moderate hypertension, and to explore its appropriate dosage.
- Trial name
- NCT07297797
- Testing
- HRS-9563 Injection, sodium chloride injection
- Where
- China
- Volunteers
- 238 people
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Oral Frailty, Mild Cognitive Impairment (MCI)
Oral Motor and Cognitive Dual-Task Training (OMCDT) Program for Improving Oral and Cognitive Functions Among People With Oral Frailty
The goal of this clinical trial is to proposes a novel Oral Motor and Cognitive Dual-Task Training (OMCDT) program that combines both oral motor exercises and cognitive tasks to improve brain and oral function at the same time.
- Conditions
- Oral Frailty, Mild Cognitive Impairment (MCI), Moderate Cognitive Impairment
- Trial name
- OMCDT (NCT07733726)
- Testing
- Oral Motor and Cognitive Dual-Task Training (OMCDT), Oral motor exercise
- Where
- Hong Kong
- Volunteers
- 66 people
- Sponsor
- The Hong Kong Polytechnic University
Intellectual Disability, Mild to Moderate
Body Awareness Training for Motor Skills and Activity Performance in Children With Intellectual Disabilities
We tested whether adding a simple, structured Body Awareness Training (BAT) program to conventional physiotherapy improves motor skills, everyday activity performance, and participation (goal achievement and satisfaction) in…
- Trial name
- BAT-MAP-ID (NCT07729163)
- Testing
- Body Awareness Training and Conventional Physiotherapy, Conventional Physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 41 people
- Sponsor
- Cyprus International University
Mental Health, Depression and/or Anxiety in the Mild-to-moderate Range
Effect of a Programme Including an AI-enhanced Mobile Application on the Mental Well- Being of Young Adolescents in Hong Kong
Study Aim and Methods (≈250 words) It aims to evaluate the effectiveness, user perceptions, and applicability of the e-CAMP intervention in improving mental well-being and reducing depressive symptoms among adolescents aged 11-15…
- Trial name
- AI-eCAMP_RCT (NCT07704996)
- Testing
- Control Group :health talk and usual care by school, mobile app group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tung Wah College
Depression and/or Anxiety in the Mild-to-moderate Range, Stress (Psychology)
SanaMente: A Peer-Led Program to Reduce Health Disparities in Rural Latino/a Communities
The goal of this clinical trial is to evaluate the feasibility, acceptability, and preliminary effectiveness of the SanaMente peer-led mental health and lifestyle program for rural Latino/a adults with chronic medical conditions…
- Conditions
- Depression and/or Anxiety in the Mild-to-moderate Range, Stress (Psychology), Chronic Medical Illness
- Trial name
- SanaMente (NCT07705776)
- Testing
- SanaMente
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Boulder
Healthy Participants, Participants With Mild Hepatic Impairment
A Phase I Clinical Trial to Evaluate the Pharmacokinetic and Safety of Ammoxetine Hydrochloride Enteric-Coated Tablets in Participants With Mild Hepatic Impairment, Moderate Hepatic Impairment, and Normal Liver Function
Use these resources to provide understandable information about this study to patients, families, and health care providers:This study is a multi-center, non-randomized, open-label, parallel-group, multiple-dose Phase I clinical…
- Conditions
- Healthy Participants, Participants With Mild Hepatic Impairment, Participants With Moderate Hepatic Impairment
- Trial name
- NCT07694843
- Testing
- ammoxetine hydrochloride enteric-coated tablets
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- CSPC ZhongQi Pharmaceutical Technology Co., Ltd.
Colorectal Cancer, Colorectal Neoplasms
Early Detection of Advanced Adenomas and Colorectal Cancer
This study aims to develop a highly sensitive, specific, and cost-effective blood assay for early detection of colorectal adenomas and cancer, using advanced machine learning and state-of-the-art biological analyses.
- Conditions
- Colorectal Cancer, Colorectal Neoplasms, Colorectal Polyp, Colorectal Adenocarcinoma
- Trial name
- AACRC (NCT06342440)
- Testing
- DENEB
- Where
- 6 sites in United States, China and 3 more
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- City of Hope Medical Center
Depression Mild, Depression
fMRI Neurofeedback With Matter Neuroscience App
Study will utilize an app, Matter Neuroscience, designed to help users with depression understand positive emotions and the neurotransmitters that create them.
- Conditions
- Depression Mild, Depression, Depression Moderate
- Trial name
- NCT06735885
- Testing
- Matter Neuroscience App, Stock Photos, No Home Training
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Stanford University
Brain Injury, Chronic, Intellectual Disability, Mild to Moderate
The (Cost)Effectiveness of a Social Robot for Persons With Problems in Daily Structure and Planning in Disability Care
The goal of this multiple baseline single case study is to study the (cost)effectiveness of a social robot in reducing professional caregiver support and promoting independence for individuals in long-term disability care…
- Conditions
- Brain Injury, Chronic, Intellectual Disability, Mild to Moderate, Autism Spectrum Disorder, Down Syndrome
- Trial name
- NCT06592404
- Testing
- Robot Tessa
- Where
- 4 sites in Netherlands
- Volunteers
- 32 people
- Sponsor
- Academy Het Dorp
Mild to Moderate Asthma
A Study of CDX-622 in Participants With Mild to Moderate Asthma
This is a study to determine the safety, pharmacodynamics (PD), and pharmacokinetics (PK) of CDX-622 in adults with mild to moderate asthma.
- Trial name
- NCT07330778
- Testing
- CDX-622
- Where
- 4 sites in United States
- Volunteers
- 12 people
- Sponsor
- Celldex Therapeutics
Mild to Moderate Dehydration
Nitrous Oxide for Analgesia During Nasogastric Tube Placement in Young Children
Since nitrous oxide/oxygen mixture is effective to reduce pain and anxiety induced by various painful procedures in children, the investigators hypothesized that its inhalation would reduce pain during nasogastric tube placement…
- Trial name
- SONGER (NCT04008628)
- Testing
- Nitrous Oxide
- Where
- 4 sites in France
- Volunteers
- 23 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Mild to Moderate Atopic Dermatitis
Observational Study to Evaluate Use of Elidel® in South and East Asian Pediatric Patients With Atopic Dermatitis.
Elidel® is indicated for the short-term treatment and long-term management of signs and symptoms of atopic dermatitis (AD) in infants (3 to 23 months), children (2 to 11 years), adolescents (12 to 17 years), and adults.
- Trial name
- Elidel-SEA (NCT06052995)
- Testing
- Elidel 1% Topical Cream
- Where
- 9 sites in Malaysia, Taiwan and 1 more
- Volunteers
- 130 people
- Sponsor
- BGP Products Operations GmbH, a Viatris company
Mild-to-moderate Depression, Neural Activity
Probiotics for Depressive Symptomatology and Neural Activity.
This study aims to investigate the acute and chronic effects of 16-week probiotic supplementation (Ecologic® Barrier) on depressive symptoms and neural activity in those with mild-to-moderate depression.
- Conditions
- Mild-to-moderate Depression, Neural Activity, Executive Function (Cognition)
- Trial name
- PRODAN (NCT07667530)
- Testing
- Ecologic® Barrier
- Where
- United Kingdom
- Volunteers
- 76 people
- Sponsor
- University of Reading
Mild and Moderate Atopic Dermatitis Patients, Atopic Dermatitis (AD)
Clinical Trial of an Ointment in Patients With Mild and Moderate Atopic Dermatitis
Atopic dermatitis (AD) is a chronic skin disorder, which negatively impacts up to 20% children and 3% adults in the world. The main AD treatments aim to regress clinical manifestations, improve and restore skin lesions.
- Trial name
- NCT07653386
- Testing
- S.formosum-containing ointment, commercial moisturizer
- Where
- Vietnam
- Volunteers
- 90 people
- Sponsor
- VinUniversity
Depressive Disorder (Per DSM-V Criteria, Mild-to-moderate), Acute Coronary Syndrome (ACS)
Efficacy of Transcutaneous Auricular Vagus Nerve Stimulation on Alleviating Major Depressive Disorder in Patients With Acute Coronary Syndrome After Percutaneous Coronary Intervention:A Prospective, Double-Blind,Randomized Controlled Study
This is a randomized, controlled study. ACS follow- up patients aged 18 to 80 years old with hemodynamic stability, who are 14 days to 1 year after PCI, are screened through the HAMD score and the HAMA score.
- Conditions
- Depressive Disorder (Per DSM-V Criteria, Mild-to-moderate), Acute Coronary Syndrome (ACS), Percutaneous Coronary Intervention (PCI), Depressive Disorder
- Trial name
- NCT07454070
- Testing
- Transcutaneous Auricular Vagus Nerve Stimulation (taVNS) Intervention
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Jing Han
Intellectual Disability, Mild to Moderate
Adaptive Mixed Reality for Students With Intellectual Disabilities
This study design investigates the empirical efficacy of an Adaptive Mixed Reality Learning Environment (AMRLE) tailored for educable adolescents and young adults (aged 10-20) diagnosed with mild-to-moderate intellectual…
- Trial name
- AMRLE (NCT07647926)
- Testing
- Adaptive Mixed Reality Learning Environment (AMRLE)
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- King Salman Center for Disability Research
Undergoing Nonemergent Cardiac Surgery, Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure)
SvO2 Trigger in Transfusion Strategy After Cardiac Surgery
Current international guidelines suggest a restrictive transfusion strategy, setting that Hb level at 7 g/dl is a reasonable threshold.
- Conditions
- Undergoing Nonemergent Cardiac Surgery, Central Venous Catheter on the Superior Vena Cava (to Perform ScVO2 Measure), Anemia (<9g/dL) Requiring Blood Transfusion, Hemodynamic and Respiratory Stability
- Trial name
- ReTSEACS (NCT02761564)
- Testing
- Red blood cell tranfusion, ScvO2 measure
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Montpellier
Ulcerative Colitis Chronic Mild, Ulcerative Colitis Chronic Moderate
R-3750 in Patients With Mild to Moderate Ulcerative Colitis
The goal of this study is to determine the safety and tolerability of orally taken probiotic (R-3750) in patients with mild to moderate ulcerative colitis.
- Conditions
- Ulcerative Colitis Chronic Mild, Ulcerative Colitis Chronic Moderate, Ulcerative Colitis Chronic, Ulcerative Colitis
- Trial name
- NCT05666960
- Testing
- R-3750
- Where
- 5 sites in United States
- Volunteers
- 36 people
- Sponsor
- Rise Therapeutics LLC