Clinical trials: Mild Obstructive Sleep Apnea
Obstructive Sleep Apnea (Mild, Moderate, Severe) as Per Polysomnography
Intranasal Mometasone in Children With Obstructive Sleep Apnea Due to Adenotonsillar Hypertrophy
Obstructive sleep apnea (OSA) in children is a disorder of breathing during sleep characterized by prolonged partial upper airway obstruction and/or intermittent complete obstruction (obstructive apnea) that disrupts normal…
- Trial name
- Nasonex OSA (NCT01671852)
- Testing
- Mometasone furoate nasal spray
- Where
- Canada
- Sponsor
- Children's & Women's Health Centre of British Columbia
Mild Obstructive Sleep Apnea, Snoring
Study to Examine the Effect of Silicone Mouth Tape on Snoring and Mild Sleep Apnea.
Snoring is a common problem caused by vibration of tissues in the throat region during sleep. Although snoring is sometimes dismissed as a minor nuisance rather than a medical disorder, several studies indicate that snoring can…
- Trial name
- MTASSA (NCT06587256)
- Testing
- Mouth Tape
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Johns Hopkins University
Obstructive Sleep Apnea
Orofacial Myofunctional Therapy and Positive Airway Pressure-CPAP Trial for Mild-to-Moderate Obstructive Sleep Apnea
The goal of this clinical trial is to evaluate the isolated and combined effects of orofacial myofunctional therapy (OMT) and continuous positive airway pressure (CPAP) in adults with mild-to-moderate obstructive sleep apnea.
- Trial name
- OMPACT-OSA (NCT07539870)
- Testing
- Orofacial Myofunctional Therapy, Continuous Positive Airway Pressure, Standard of Care Sleep-Hygiene and Lifestyle Counseling
- Volunteers
- 168 people
- Sponsor
- Saint-Joseph University
Sleep Apnea, Obstructive
Effect of Adenotonsillectomy on Quality of Life in Children With Mild Obstructive Sleep Apnea
In children, enlarged adenoids and/or tonsils are the most common cause of obstructive sleep apnea (OSA), which is temporary blockage of breathing during sleep.
- Trial name
- NCT01539278
- Testing
- Adenotonsillectomy, Observation alone / no intervention
- Where
- United States
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Eastern Virginia Medical School
Sleep Disorder, Sleep Apnea Syndromes
Respiratory Rehabilitation in Obstructive Sleep Apneas
The Obstructive Sleep Apnea is characterized by obstruction of the upper airway during sleep (for at least 10 sec), with repeated breathing pauses, accompanied by oxygen desaturation in the blood and by sleep interruption with…
- Trial name
- OSA20 (NCT04412941)
- Testing
- Myofunctional exercises, The rules of sleep hygiene
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- Università degli Studi 'G. d'Annunzio' Chieti e Pescara
Obstructive Sleep Apnea, Healthy Subjects
Study to Evaluate the Respiratory Safety of Lemborexant in Adult and Elderly Healthy Subjects and Adult and Elderly Subjects With Mild Obstructive Sleep Apnea
This study will be conducted to determine whether lemborexant as compared to placebo decreases the peripheral oxygen saturation during total sleep time in healthy adult and elderly participants after a single dose of treatment…
- Trial name
- NCT03471871
- Testing
- Lemborexant 10 mg, Lemborexant 25 mg
- Where
- 11 sites in United States
- Volunteers
- 146 people, healthy volunteers welcome
- Sponsor
- Eisai Inc.
Sleep Apnea, Dyslipidaemia
Effect of Nasal CPAP on Lipid Profile in Patients With Dyslipidaemia and Sleep Apnea
OBJECTIVES Main objective: To assess if six months of treatment with CPAP, associated with conventional treatment, improves the lipid profile of patients with dyslipidemia and mild-moderate apnea-hypopnea syndrome (OSA).
- Trial name
- NCT02557412
- Testing
- Continuous positive airway pressure, Intensive lifestyle intervention, Conventional treatment
- Where
- Spain
- Sponsor
- Hospital Universitario La Paz
Snoring, Obstructive Sleep Apnea
Safety, and Tolerability of the ZENS Device (PLUTO)
The primary objective of the PLUTO study is to evaluate the safety and tolerability of the ZENS transcutaneous nerve stimulator device in primary snorers and those with mild obstructive sleep apnea.
- Trial name
- NCT04063917
- Testing
- ZENS
- Where
- 2 sites in Canada
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Zennea Technologies Inc.
Patients with Mild Obstructive Sleep Apnea Hypopnea
A Clinical Pharmacology Study of TS-142 in Patients with Obstructive Sleep Apnea Hypopnea.
A study to evaluate the respiratory safety of TS-142 in patients with mild obstructive sleep apnea hypopnea.
- Trial name
- NCT04746105
- Testing
- TS-142
- Where
- Japan
- Volunteers
- 46 people
- Sponsor
- Taisho Pharmaceutical Co., Ltd.
Sleep Apnea, Obstructive, Otorhinolaryngologic Diseases
Randomized Control Trials of Surgery for Pediatric OSA
Randomized study on pediatric OSA with 2 groups: mild-moderate OSA and severe OSA. Mild-moderate are randomized to either expectancy or ATE. Severe are randomized to either ATE or APP. Pediatric age span of 2 until 4,9 years.
- Conditions
- Sleep Apnea, Obstructive, Otorhinolaryngologic Diseases, Pediatric Disorder
- Trial name
- NCT02315911
- Testing
- ATE, APP
- Where
- Sweden
- Volunteers
- 143 people
- Sponsor
- Karolinska University Hospital
Sleep Apnea, Snoring
Substantial Equivalence of iSlpr™ and SomnoDent® Classic in the Treatment of Snoring and Mild to Moderate Sleep Apnoea.
The study is a thirty three week, prospective, open-label, randomized, parallel-group non-inferiority study. The study aims to investigate the Substantial Equivalence of a novel mandibular device called iSlpr™, produced by…
- Trial name
- NCT04250584
- Testing
- iSlpr™, SomnoDent® Classic
- Volunteers
- 66 people
- Sponsor
- BioAnalytics Holdings Pty Ltd
Obstructive Sleep Apnea of Adult, Myofunctional Therapy
Myofunctional Therapy in Patients With Mild-moderate Sleep Apnea
The main objective of this study is to compare the change in the apnea-hypopnea index (AHI) in patients with mild to moderate sleep apnea without daytime sleepiness after 12 months of myofunctional therapy exercises with respect…
- Trial name
- NCT04169984
- Testing
- Myofunctional Therapy
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Obstructive Sleep Apnea
Somnodent vs Herbst in Mild and Moderate OSA Patients
Obstructive sleep apnea (OSA) is a common chronic sleep disorder that often requires lifelong care. The prevalence in the Netherlands is estimated around 300.000 patients.
- Trial name
- COSH (NCT02724865)
- Testing
- Somnodent® (Oral appliance therapy), Herbst® (Oral appliance therapy)
- Where
- Netherlands
- Volunteers
- 140 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Apnea, Obstructive Sleep, Obstructive Sleep Apnea
OSA-18 in Children With Mild Obstructive Sleep Apnea: Can it be a Helpful Decision Making Tool?
The concept is a novel research idea that incorporates the potential impact of patient quality of life (QOL) on decision-making for treatment of mild obstructive sleep apnea (OSA).
- Trial name
- OSA-18 (NCT05911646)
- Testing
- OSA-18 Survey, Decisional Conflict (DCS)
- Where
- United States
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- Connecticut Children's Medical Center
High Flow Nasal Cannula, Obstructive Sleep Apnea
High Flow Nasal Cannula and Conventional Oxygen Therapy in the Postoperative Management of Patients With Mild to Moderate Obstructive Sleep Apnea
This study aims to compare the effectiveness of conventional oxygen therapy oxygen and high-flow nasal cannula therapy on oxygen saturation (SpO2), measuring number of SpO2 drop >4% of base line oxygen saturation (o2 desaturation…
- Trial name
- NCT06306651
- Testing
- High flow nasal cannula therapy group, Conventional oxygen therapy group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Ain Shams University
Obstructive Sleep Apnea
Nasal Budesonide in Children With Rhinitis and/or Mild Obstructive Sleep Apnea Syndrome
-Intranasal budesonide therapy may lead to improved symptoms and sleep study findings in children with mild obstructive sleep apnea with and without allergic rhinitis that would not be treated with T\&A.
- Trial name
- NCT00560586
- Testing
- Budesonide
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- University of Louisville
Obstructive Sleep Apnea, Gastroesophageal Reflux
Proton Pump Inhibitor Therapy for Mild to Moderate Obstructive Sleep Apnea
Obstructive Sleep Apnea (OSA) is common in modern society, affecting up to 5% of working middle-aged adults in the United States. Obesity is the number one risk factor for the development of OSA.
- Trial name
- NCT00211614
- Testing
- Lansoprazole
- Where
- United States
- Sponsor
- MetroHealth Medical Center
Mild Cognitive Impairment (MCI)
Effect of Intranasal Negative Pressure Therapy on Cognitive Function in Patients With Mild Cognitive Impairment and Obstructive Sleep Apnea
This study is a randomized controlled trial with two phases: pre-trial and formal trial. The pre-trial will include 5 participants to observe the 4-week adherence (≥4 hours/night) and safety (adverse event rate) of the iNAP…
- Trial name
- NCT07353359
- Testing
- Intranasal Negative Pressure
- Where
- China
- Volunteers
- 65 people
- Sponsor
- Xuanwu Hospital, Beijing
Obstructive Sleep Apnea
OROPHARYNGEAL MYOFUNCTIONAL THERAPY IN OBSTRUCTIVE SLEEP APNEA
Obstructive Sleep Apnea (OSA) is a prevalent nocturnal breathing disorder among the general population. Oropharyngeal myofunctional therapy (OMT) is an alternative conservative treatment used to improve OSA, associated health…
- Trial name
- NCT06681974
- Testing
- CONTROL:Information form with hygienic-dietary measures or sleep hygiene guidelines is provided and explained., EXPERIMENTAL: program of exercises that will be composed of 4 blocks
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Instituto de Investigación Marqués de Valdecilla
Obstructive Sleep Apnea Syndrome
Safety and Efficacy of Eszopiclone With Mild to Moderate Obstructive Sleep Apnea Syndrome (OSAS)
The purpose of this study is to evaluate the hypnotic efficacy of ezopiclone in subjects with mild to moderate OSAS.
- Trial name
- NCT00685269
- Testing
- Eszopiclone
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Sumitomo Pharma America, Inc.