Clinical trials: Mild Traumatic Brain Injury
Persistent Post-concussive Syndrome, Concussion Post Syndrome
Hyperbaric Oxygen Effects on Persistent Post-concussive Symptoms
Persistent post-concussive symptoms (PPCS) are a source of significant burden among a subset of patients with concussion with prevalence rates previously reported between 11 - 82% based on timing of assessment, diagnostic…
- Trial name
- HOINPCS (NCT05173818)
- Testing
- Hyperbaric oxygen at 1.5 ATA
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Essentia Health
Concussion
Does Oral Micronized Progesterone Shorten Time of Symptoms From Concussion
Concussions are a common injury among athletes in the United States. The annual incidence of sports and recreational related traumatic brain injuries in the United States is 1.6 to 3.8 million, and the likelihood of an athlete in…
- Trial name
- NCT01809639
- Testing
- Progesterone
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Wake Forest University Health Sciences
Concussion, Mild, Concussion, Brain
Concussion Prevention in Female Soccer Athletes
The purpose of the study is to monitor longitudinal changes in brain structure and function between the preseason and postseason, in a population of soccer playing athletes wearing the Device and compared to a similar population…
- Trial name
- NCT03014492
- Testing
- Q Collar
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion, Brain
Developing an Implementation Strategy for Post-concussion Communication With Low Health Literacy Parents in the Emergency Department
Investigators will conduct a hybrid implementation-effectiveness evaluation of an educational intervention that supports communication with families post-concussion in the emergency department.
- Trial name
- NCT04112914
- Testing
- Post-concussion education for families
- Where
- United States
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Seattle Children's Hospital
Dizziness, Brain Injury
Vestibular Consequences of Blast-related Mild Traumatic Brain Injury (TBI)
The purpose of this project is to determine the effects of mild traumatic brain injury and blast exposure on the inner ear balance and central nervous systems.
- Trial name
- NCT01021137
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment, Alzheimer's Disease
Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Memory deficits are common after traumatic brain injuries (TBI) and are characteristic of various forms of dementia, such as Alzheimer's disease and its common precursor mild cognitive impairment (MCI).
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Traumatic Brain Injury
- Trial name
- NCT00714571
- Testing
- Mnemonic strategy training (MST), Repeated exposure (XP), Subtracting Cues training
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury (TBI)
Managing Mild Traumatic Brain Injury Related Headaches With Repetitive Transcranial Magnetic Stimulation
Persistent headache is one of the most common debilitating symptoms in military personnel suffering from mild traumatic brain injury (MTBI).
- Trial name
- NCT03314584
- Testing
- Transcranial Magnetic Stimulation, Magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- VA Office of Research and Development
Healthy Athlete
Movement Assessment for Concussion Management
Previous work in the area of concussion management has focused heavily on neuro-cognitive testing. In addition to routine neuro-cognitive testing through Immediate Post-Concussion Assessment and Cognitive Testing (ImPACT),this…
- Trial name
- NCT02776904
- Testing
- Immediate Post-concussion Assessment and Cognitive Testing, Gait with single and dual task, Y-Balance test
- Where
- United States
- Volunteers
- 327 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Concussion
Q-collar and Brain Injury Biomarkers
Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). A simple, effective, and lightweight device worn by athletes or war fighters in the field, designed to mitigate TBI resulting from…
- Trial name
- NCT02271451
- Testing
- Q collar
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Post-Traumatic Headache
Prazosin for Post-Concussive Headaches
Mild traumatic brain injury (mTBI) caused by blast effects of explosive devices has been called the "signature injury" of soldiers who served in the Iraq and Afghanistan conflicts.
- Trial name
- NCT02965027
- Testing
- Prazosin
- Where
- 2 sites in United States
- Volunteers
- 89 people
- Sponsor
- Seattle Institute for Biomedical and Clinical Research
Concussion
Smart Phone Application for Postconcussion Symptom Reduction
The proposed study will address a very important issue for the VA both currently and in the future -- the high percentage of OIF/OEF/OND Veterans who have been medically diagnosed with a mild traumatic brain injury (mild TBI) and…
- Trial name
- NCT02501642
- Testing
- Concussion Coach, Treatment as usual
- Where
- 2 sites in United States
- Volunteers
- 479 people
- Sponsor
- VA Office of Research and Development
Concussion, Mild, Post-Concussion Symptoms
Bright Light Therapy for Treatment of Sleep Problems Following Mild Traumatic Brain Injury
The purpose of the research study is to understand the effectiveness of a six-week course of light exposure on cognitive functioning, mood, activity, and sleep in people that have suffered a head injury leading to a concussion.
- Conditions
- Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
- Trial name
- NCT02374918
- Testing
- mTBI wavelength-1 bright light, mTBI wavelength-2 bright light, HC wavelength-1 bright light
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Traumatic Brain Injury
Study to Evaluate the Efficacy and Safety of Armodafinil as Treatment for Patients With Excessive Sleepiness Associated With Mild or Moderate Closed Traumatic Brain Injury
The primary objective of the study is to determine whether armodafinil treatment is more effective than placebo treatment in patients with excessive sleepiness associated with mild or moderate closed traumatic brain injury (TBI).
- Trial name
- NCT00893789
- Testing
- Armodafinil
- Where
- 73 sites in United States, Germany and 2 more
- Volunteers
- 117 people
- Sponsor
- Cephalon, Inc.
Traumatic Brain Injury
Transforming Research and Clinical Knowledge in TBI Pilot
The global aim of this proposal is to test and refine Common Data Elements (CDEs), neuroimaging standards, and best practices for genetics and proteomics in Traumatic Brain Injury (TBI) studies.
- Trial name
- NCT01565551
- Testing
- N/A (Observational Study)
- Where
- 4 sites in United States
- Volunteers
- 650 people
- Sponsor
- University of California, San Francisco
Dementia
Prazosin and Cerebrospinal Fluid (CSF) Biomarkers in Mild Traumatic Brain Injury (mTBI)
Mild traumatic brain injury (mTBI) from explosions is the "signature injury" of Veterans who have deployed to the wars in Afghanistan and Iraq.
- Trial name
- PoND (NCT03221751)
- Testing
- prazosin hydrochloride
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Post-traumatic Stress Disorder
Mission Connect Mild Traumatic Brain Injury (TBI) Integrated Clinical Protocol
The purpose of this study is to improve the ability to diagnose problems after mild traumatic brain injury (MTBI) and to test a drug that may improve the outcome from these injuries.
- Trial name
- NCT01013870
- Testing
- Atorvastatin
- Where
- 2 sites in United States
- Volunteers
- 52 people
- Sponsor
- Baylor College of Medicine
Traumatic Brain Injury
TBI MR Study 3 Houston Methodist
This hypothesis-generating feasibility study to determine potential associations between a broad range of clinical neurological symptoms and Magnetic Resonance Image (MRI), data, and clinical findings involved in mild traumatic…
- Trial name
- NCT02218216
- Testing
- MRI Diagnostic
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- GE Healthcare
Concussion Mild
Yoga and Female Concussion
Most research on the impact of mild Traumatic Brain Injury/Concussions have been deficit-based and focused on the impairments induced by the injury. Research shows that trauma doesn't always have negative effects.
- Trial name
- NCT07170488
- Testing
- Yoga, Yoga for wait list control
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- University of Pittsburgh
Post Traumatic Stress Disorder, Mild Traumatic Brain Injury, Concussion
Rehabilitation of Executive Functioning in Veterans With PTSD and Mild TBI
One of the most pressing concerns within the VA currently is the provision of interventions that address the cognitive as well as emotional problems faced by Veterans with concurrent mild TBI and PTSD.
- Trial name
- NCT01921179
- Testing
- GOALS (Goal-Oriented Attentional Regulation), EDU (Brain Health Education)
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- VA Office of Research and Development
Concussion, Mild Traumatic Brain Injury
Clinical Trial of a Rehabilitation Game - SuperBetter
Today's hospitals need innovative solutions to help patients transition from our care to self-management at home. The vast majority of the patients seen in Dodd Rehabilitation Hospital and associated clinics leave our care with…
- Conditions
- Concussion, Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
- Trial name
- SuperBetter (NCT01398566)
- Testing
- SuperBetter play
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ohio State University