Clinical trials: Mild Traumatic Brain Injury (mTBI)
Mild Traumatic Brain Injury, Posttraumatic Stress Disorder
Improving Cognitive Rehabilitation Outcomes
Posttraumatic stress disorder (PTSD) and mild TBI (mTBI) frequently co-occur in post-9/11 Veterans, and together are associated with worse cognitive performance, mental health, everyday functioning, community integration, quality…
- Trial name
- NCT07055633
- Testing
- CCT+MBLT, CCT+ION
- Where
- 2 sites in United States
- Volunteers
- 144 people
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury
Standardized Instruments to Provide Diagnostic and Prognostic Information in Mild Traumatic Brain Injury (mTBI)
This study will establish the capability of a suite of conventional tests and the Neurolign Dx_100 I-PAS goggle system to reliably and objectively detect mTBI in an acute setting when comparing individuals with mTBI to controls…
- Trial name
- NCT04372797
- Testing
- Diagnostic test
- Where
- 3 sites in United States
- Volunteers
- 161 people
- Sponsor
- Carey Balaban
Traumatic Brain Injury
Effects of LEDs on Memory in TBI Patients
The purpose of the study is to investigate whether transcranial, high-intensity LED placed on the scalp can improve working memory in people who have sustained a concussion with lingering effects or a mild brain injury.
- Trial name
- LED (NCT01598532)
- Testing
- MedX Health Phototherapy (light therapy)
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Spaulding Rehabilitation Hospital
Acute Concussion Syndrome
Pilot Clinical Investigation Evaluating the Safety and Performance of RGn550 in Treating Sportspeople Suffering From Acute Concussion Syndrome
This is a controlled investigation, with randomization of the patients, which aims at evaluating the safety and performance of device RGn550 in treating sportspeople suffering from acute concussion syndrome.
- Trial name
- RECOVERY (NCT05647304)
- Testing
- RGn550 5 Hz-PWM, RGn550 10 Hz-PWM
- Where
- France
- Volunteers
- 50 people
- Sponsor
- REGEnLIFE SAS
Traumatic Brain Injury
Growth Hormone or Sildenafil as Therapies for Fatigue in Mild- Traumatic-brain-injury (MTBI)
The overall goal is to determine whether perceptual or performance fatigue can be reduced in MTBI patients with and without growth hormone (GH) deficiency by treating them in a crossover fashion based upon GH status.
- Trial name
- NCT02114775
- Testing
- Growth Hormone, Sildenafil
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- The University of Texas Medical Branch, Galveston
Concussion
Pathology in the Brain After mTBI - A Multimodal MRI Study
The purpose is to use Diffusion Kurtosis Imaging (DKI), Diffusion Tensor Imaging (DTI) and resting state functional MRI to examine tissue damage in the brains of people who have had a concussion, both acute and 3 months after the…
- Trial name
- NCT01936792
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Traumatic Brain Injury With Brief Loss of Consciousness, Traumatic Brain Injury With No Loss of Consciousness
The Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain Injury
The objective of this trial is to evaluate the effectiveness of cognitive rehabilitation in OIF/OEF service members with a history of mild traumatic brain injury and persistent (3-24 months post injury) cognitive complaints.
- Trial name
- SCORE (NCT01339806)
- Testing
- Cognitive Rehab, Brainworks, Informational Handout/Provider Visits
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Brooke Army Medical Center
Sleep Architecture, Mild Traumatic Brain Injury
Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI)
This study will employ cognitive behavioral therapy for insomnia (CBT-I) among individuals with mild traumatic brain injury (mTBI) who experience sleep disturbances.
- Conditions
- Sleep Architecture, Mild Traumatic Brain Injury, Sleep, Sleep and Circadian Problems
- Trial name
- NCT07385105
- Testing
- Cognitive behavioral Therapy for insomnia (CBT-I)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Missouri-Columbia
Concussion, Brain
Postural Control in Children and Adolescents After Suffering From a Concussion
Sport-related concussions occur during different types of sport and are still an underestimated brain injury. Especially children are affected due to their lacking movement control and thereby at higher risk of situations leading…
- Trial name
- NCT03575741
- Testing
- Balance Tests
- Where
- Austria
- Sponsor
- Universitaet Innsbruck
Brain Concussion, Brain Trauma
Remotely Supervised tDCS+ for Complex Attention in mTBI (Cognetric)
The proposed study will evaluate a new approach to cognitive rehabilitation of mTBI using a brain stimulation technique called "Remotely Supervised Transcranial Direct Current Stimulation combined with Cognitive Training"…
- Conditions
- Brain Concussion, Brain Trauma, Attention Concentration Difficulty, Brain Injuries
- Trial name
- COGNETRIC (NCT06413173)
- Testing
- Active tDCS and Cognitive Training Intervention
- Where
- 2 sites in United States
- Volunteers
- 160 people
- Sponsor
- United States Naval Medical Center, San Diego
Mild Traumatic Brain Injury
Pro-2-Cool Device Clinical Study
This study is being conducted to quantify the clinical safety and efficacy of head and neck cooling when applied up to 8 days after mild traumatic brain injury (mTBI) among adolescents participating in sporting activities.
- Trial name
- NCT03511339
- Testing
- TecTraum device
- Where
- 5 sites in United States
- Volunteers
- 174 people
- Sponsor
- TecTraum Inc.
Mild Traumatic Brain Injury
Change in Connectivity After mTBI Depending on Cognitive Reserve
The purpose of this study is to investigate the role of cognitive reserve in change in connectivity in the brain (measured with functional magnetic resonance imaging, fMRI) and how this is related to symptoms and symptom…
- Trial name
- NCT05593172
- Where
- Sweden
- Volunteers
- 30 people
- Sponsor
- Danderyd Hospital
Brain Injuries, Traumatic, Concussion, Mild
Objective Brain Function Assessment of mTBI/Concussion
This study (Part 3) is designed to build a database including EEG, neurocognitive performance, clinical symptoms, history and other relevant data, which will be used to derive a multimodal EEG based algorithm for the…
- Conditions
- Brain Injuries, Traumatic, Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- CAS13-25 (NCT03963804)
- Testing
- BrainScope Ahead 300iP
- Where
- 4 sites in United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- BrainScope Company, Inc.
Brain Concussion
Enhanced Problem-Solving Training
Mild traumatic brain injury (mTBI) is among the most common injuries sustained by Veterans of Operations Enduring and Iraqi Freedom.
- Trial name
- E-PST (NCT03759223)
- Testing
- Enhanced Problem-Solving Training (E-PST), Healthy Living Messages (HLM), Enhanced Problem-Solving Training (E-PST) (non-randomized)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- VA Office of Research and Development
Post-Concussion Symptoms, Insomnia
Neurotechnology Following Traumatic Brain Injury
This two-part study seeks to improve symptoms such as pain and sleep problems after concussion, or mild traumatic brain injury (mTBI).
- Conditions
- Post-Concussion Symptoms, Insomnia, Pain, Chronic, Depressive Symptoms
- Trial name
- Cereset (NCT03649958)
- Testing
- HIRREM-SOP or Cereset, Cereset 2x
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Brain State Technologies, LLC
Concussion, Traumatic Brain Injury
Concussion Device Audiological Measures
Significant morbidity, mortality, and related costs are caused by traumatic brain injury (TBI). A simple, effective, and lightweight device worn by athletes or war fighters in the field, designed to mitigate TBI resulting from…
- Trial name
- NCT02262507
- Testing
- Device Wearing
- Volunteers
- 410 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion, Mild
Australian University of California San Francisco (UCSF) Concussion in Athletes (AUSSIE-2)
Analysis of cardiac induced brain forces using cranial accelerometry has been shown to diagnose concussion in high school athletes.
- Trial name
- AUSSIE-2 (NCT05771051)
- Testing
- Headpulse measurements
- Where
- United States
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Traumatic Brain Injuries, TBI (Traumatic Brain Injury)
Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI)
The primary goal of this study is to evaluate the effectiveness of an integrated therapeutic model - combining VR and standard psychotherapy in improving executive function and hyperarousal adults impacted with mTBI.
- Conditions
- Traumatic Brain Injuries, TBI (Traumatic Brain Injury), MTBI - Mild Traumatic Brain Injury, mTBI
- Trial name
- ReVIVE (NCT07890337)
- Testing
- Virtual Reality, Standard Psychotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Traumatic Brain Injury, Fatigue
Brain and Gut Plasticity in Mild TBI or Post-acute COVID Syndrome Following Growth Hormone Therapy
Patients with a history of mild traumatic brain injury (mTBI) or post acute sequelae of SARS-CoV-2 (PASC) and abnormal growth hormone secretion, as measured by glucagon stimulation test, will be treated with replacement growth…
- Conditions
- Traumatic Brain Injury, Fatigue, Cognitive Impairment, COVID-19
- Trial name
- NCT03554265
- Testing
- Somatropin
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- The University of Texas Medical Branch, Galveston
Mild Traumatic Brain Injury
A Prospective Study of Brain Network Activation (BNA) Changes in High School Athletes Following Concussion
The main purpose of this study is to prospectively examine changes in Brain Network Activation(BNA)following concussion in high school athletes.
- Trial name
- NCT01673464
- Where
- United States
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- ElMindA Ltd