Clinical trials: Mild Traumatic Brain Injury (mTBI)
Traumatic Brain Injury
Defining Axonal Injury in Children With Mild Traumatic Brain Injury
To measure Axonal Injury in children with mild traumatic brain injury enrolled in an Emergency Department using Diffusion Tensor Imaging, a type of MRI and biomarkers.
- Trial name
- NCT01922531
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Concussion, Mild Traumatic Brain Injury
Implementation of an Evidence-Based Educational Resource for Children With Mild Traumatic Brain Injury
The goal of this prospective, observational study is to (1) collaborate with our stakeholders to identify essential mTBI-information from existing evidence-based materials to develop a Post-mTBI Educational Resource for children…
- Trial name
- POCKIT (NCT07414303)
- Testing
- Post-mTBI Educational Resource
- Where
- 3 sites in United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Baylor Research Institute
Mild Traumatic Brain Injury, Post Traumatic Stress Disorder
Neuromodulation and Neurorehabilitation for mTBI
This study will determine (i) the magnitude of immediate and sustained effects of a current clinical standard interactive computer attention processing training (APT) when combined with intermittent theta burst stimulation…
- Trial name
- NCT03819608
- Testing
- real iTBS, real APT
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- Northwestern University
Brain Concussion
Enhanced Screening for Early Treatment Targets After MTBI
The study will examine whether enhancing screening-informed follow-up letters will improve (i) family physician compliance with best practice guidelines for managing persistent symptoms following concussion, and (ii) clinical…
- Trial name
- NCT03221218
- Testing
- Enhanced screening-informed follow up letter
- Where
- Canada
- Volunteers
- 150 people
- Sponsor
- University of British Columbia
MTBI - Mild Traumatic Brain Injury
Imaging of Injury Mechanism and Interaction of Intestinal Bacteria in Children With Mild Traumatic Brain Injury
Traumatic brain injury (TBI) is the leading cause of disability in children and young adults. Children with moderate to severe TBI are typically at risk of poor functional outcome in terms of neurocognitive impairment and…
- Trial name
- NCT05090007
- Testing
- magnetic resonance image, gut microbiota
- Where
- China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Persistent Post Concussion Syndrome, Mild Traumatic Brain Injury
Targeting Neuroplasticity for Persistent Post-Concussive Cognitive Symptoms
This project investigates an innovative combination of non-invasive neuromodulation (transcranial direct current stimulation - tDCS) and cognitive training as a novel treatment approach aimed at improving function in individuals…
- Trial name
- NCT07246993
- Testing
- Active tDCS
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Minnesota
Traumatic Brain Injury
Broad-spectrum Cognitive Remediation: Effects of a Brain Plasticity-based Program in Mild Traumatic Brain Injury
The primary objective of this study is to evaluate the effects of plasticity-based, adaptive cognitive remediation on the cognitive abilities, functional status and quality of life of soldiers and veterans diagnosed with…
- Trial name
- BRAVE (NCT01640158)
- Testing
- Computerized Plasticity-based Adaptive Cognitive Training, Commercially available computerized training
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Posit Science Corporation
Brain Concussion
LED Therapy for the Treatment of Concussive Brain Injury
A double blind randomized trial of light-emitting diode (LED) therapy for patients suffering from mild traumatic brain injury (mTBI).
- Trial name
- NCT02383472
- Testing
- MedX Health Console model 1100
- Where
- 2 sites in United States
- Volunteers
- 53 people
- Sponsor
- Boston Children's Hospital
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
Contributions of mTBI to Neurodegeneration Due to Chronic Traumatic Encephalopathy (CTE) and Alzheimer's Disease (AD)
This is a research study that aims to examine whether Veterans with mild Traumatic Brain Injuries are at risk for dementia by studying their memory, brain wave activity, brain structure and proteins that can be elevated after…
- Conditions
- Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury, Mild Cognitive Impairment
- Trial name
- NCT04124029
- Testing
- No Intervention is used for this study but all subjects will be asked to complete electroencephalogram (EEG) testing and an MRI scan., No intervention is used for this study but all subjects will be asked to complete a venous blood draw procedure and a lumbar puncture procedure.
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury
Olfactory Function in Patients With Acute Mild Traumatic Brain Injury
In this project the investigators aim to evaluate olfactory and non-olfactory function in patients within the first 24h following a mild traumatic brain injury (acute mTBI) and compare their results to a group of age and sex…
- Trial name
- NCT02977728
- Testing
- Olfactory Evaluation
- Volunteers
- 42 people
- Sponsor
- Hôpital de Viege
Concussion
Pathology in the Brain After mTBI - A Multimodal MRI Study
The purpose is to use Diffusion Kurtosis Imaging (DKI), Diffusion Tensor Imaging (DTI) and resting state functional MRI to examine tissue damage in the brains of people who have had a concussion, both acute and 3 months after the…
- Trial name
- NCT01936792
- Where
- Denmark
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Traumatic Brain Injury (TBI), Chronic Traumatic Encephalopathy (CTE)
The Effects of Fish Oil Supplementation on the Brain Health of Collegiate Football Athletes
Determine if the daily docosahexaenoic acid (DHA)/eicosapentaenoic acid (EPA) supplement will reduce serum levels of biomarkers of sub-concussion injuries over a course of American football season among collegiate football…
- Trial name
- NCT04796207
- Testing
- Fish Oil (DPA+EPA 2:1 ratio) Capsules, High Oleic Safflower Oil Capsules
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Mild Traumatic Brain Injury, Post-Concussive Syndrome
Hyperbaric Oxygen Therapy (HBO2T) for Post-Concussive Symptoms (PSC) After Mild Traumatic Brain Injury (mTBI)
The goal of this research is to serve as a demonstration project to determine the tolerability of individuals with persistent post-concussive symptoms from combat-related mild TBI (traumatic brain injury), identify dose-finding…
- Trial name
- HBOT (NCT01220713)
- Testing
- Hyperbaric Oxygen Therapy
- Where
- 3 sites in United States
- Volunteers
- 60 people
- Sponsor
- Virginia Commonwealth University
Traumatic Brain Injury, Vestibular Deficits
Traditional Balance vs Vibrotactile Feedback Training for Vestibular Rehabilitation
The goal of this clinical research study at RIC is to determine the value and benefit of the SK multimodal balance training system through independent clinical evaluations.
- Trial name
- NCT01672658
- Testing
- Sensory Kinetics Balance System, Traditional Vestibular Rehabilitation
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Shirley Ryan AbilityLab
Traumatic Brain Injury
Neurofeedback Technology (GZNT) for Persistent Post-Concussive Symptoms in Soldiers
A new technology called Global Z-Score Neurofeedback Technology (GZNT) has been identified that can overcome an existing barrier to the use of neurofeedback as a treatment technique in a military setting.
- Trial name
- GZNT (NCT02509689)
- Testing
- Global Z-Score Neurofeedback Training
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- The Defense and Veterans Brain Injury Center
Traumatic Intracranial Hemorrhage, Traumatic Brain Injury
No Cases of Delayed Intracranial Hemorrhage (d-ICH) Among Patients With Mild Traumatic Brain Injury (mTBI) on Oral Anticoagulation Therapy
Abstract Purpose Patients with anticoagulation therapy has a higher risk of developing traumatic Intracranial Hemorrhage (tICH).
- Trial name
- NCT05609734
- Testing
- no intervention, only observational retrospective study
- Where
- Sweden
- Volunteers
- 249 people
- Sponsor
- Umeå University
Brain Concussion
Sleep After Adolescent Concussion
The purpose of this research study is to learn more about how sleep changes as teens recover from concussions. We also want to learn if we can improve sleep in teens who have concussions.
- Trial name
- NCT03781076
- Testing
- Sleep Intervention
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Children's Hospital Medical Center, Cincinnati
MTBI - Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
Rapid Diagnosis and Prognosis Recognition of Imaging and Biomarkers in Mild to Moderate Traumatic Brain Injury
The investigators will carry out multi-center and large sample research based on the Chinese population, screen the optimal diagnostic and prognosis recognition biomarkers and analyze the diagnostic critical cutoff values in…
- Trial name
- NCT05108909
- Testing
- MRI, CT, and serum biomarkers
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Traumatic Brain Injury, Concussion, Mild
Rapid Biochemical Diagnostics of Traumatic Brain Injury
The objective of the study is to confirm the clinical relevance of the novel biomarker for traumatic brain injury (TBI) detection.
- Conditions
- Traumatic Brain Injury, Concussion, Mild, Bone Fracture
- Trial name
- NCT03306563
- Testing
- Sample collection
- Where
- 3 sites in Finland
- Volunteers
- 68 people, healthy volunteers welcome
- Sponsor
- Medicortex Finland Oy
Alcohol Use Disorder, Mild Traumatic Brain Injury
Pilot rTMS for AUD+mTBI
This is a pilot randomized controlled trial (RCT) for Veteran participants with alcohol use disorder co-occurring with mild traumatic brain injury and/or post-traumatic stress disorder.
- Conditions
- Alcohol Use Disorder, Mild Traumatic Brain Injury, Post-traumatic Stress Disorder
- Trial name
- TMS_AUD+mTBI (NCT03995173)
- Testing
- repetitive transcranial magnetic stimulation
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- VA Office of Research and Development