Clinical trials: Mild Traumatic Injury
PTSD, Concussion, Mild
SMART-CPT for PTSD/Concussion Implementation
The clinical implementation trial will evaluate effectiveness and feasibility, acceptability, appropriateness, barriers, and facilitators of implementing SMART-CPT, a treatment targeting the two primary factors leading to poor…
- Trial name
- NCT06995612
- Testing
- SMART-CPT, CPT
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- San Diego Veterans Healthcare System
Posttraumatic Stress Disorder, Traumatic Brain Injury
Mild Traumatic Brain Injury and Post-Traumatic Stress Disorder
Background: Some people who have a traumatic brain injury (TBI) recover completely. Others, however, develop post-traumatic stress disorder (PTSD), with anxiety and depression.
- Trial name
- NCT01547819
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institutes of Health Clinical Center (CC)
Spinal Cord Injury
Treatment of Mild to Moderate Depression Symptoms in Patients With Spinal Cord Injury
This study was initially designed to test the efficacy of Venlafaxine HCl in reducing incidence of the onset of major depression after a new spinal cord injury (SCI).
- Trial name
- NCT00735670
- Testing
- Venlafaxine HCl
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan
Mild Traumatic Brain Injury
Mobilizing Early Management of Mental Health Complications After Mild Traumatic Brain Injury
Mental health problems frequently complicate recovery from mild traumatic brain injury (mTBI) but are under-recognized and under-treated.
- Trial name
- M4 (NCT04704037)
- Testing
- Guideline implementation tool, Generic information about concussion management
- Where
- 9 sites in Canada
- Volunteers
- 537 people
- Sponsor
- University of British Columbia
Concussion, Mild
Poly-omic Predictors of Symptom Duration and Recovery for Adolescent Concussion
The purpose of this study is to identify changes in salivary micro ribonucleic acid (miRNA) levels that are predictive of symptom duration and character following mild traumatic brain injury (mTBI) in children.
- Trial name
- NCT04582682
- Where
- 5 sites in United States
- Volunteers
- 750 people
- Sponsor
- Milton S. Hershey Medical Center
Traumatic Brain Injury
Non-invasive Deep Brain Stimulation to Improve Spatial Navigation Abilities in Individuals Following Traumatic Brain Injury
Impairments in spatial memory and spatial navigation are commonly reported amongst patients presenting post-traumatic brain injury (TBI).
- Trial name
- NCT07271524
- Testing
- Transcranial electric stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 25 people
- Sponsor
- Friedhelm Hummel
Traumatic Brain Injury
Plasticity of Deep Brain Structures in Mild Cognitive Impairment and Healthy Aging
Acute and chronic cognitive impairment (TBI and MCI) is one of the most common problems in the growing and aging society of the 21st century. At an individual level, not all brain structures are affected with the same rate.
- Trial name
- PlasMA (NCT06822283)
- Testing
- transcranial electric stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 19 people
- Sponsor
- Friedhelm Hummel
Concussion, Mild
Non-invasive Brain Stimulation and Injury Risk Biomechanics
The goal of this clinical trial is to test the effects of repetitive transcranial magnetic stimulation (theta burst stimulation) on movement biomechanics (jump landing) among individuals with and without a concussion history.
- Trial name
- NCT06093295
- Testing
- Repetitive Transcranial Magnetic Stimulation (Theta Burst Stimulation)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Georgia
Fatigue, Traumatic Brain Injury
Service Member Fatigue and Lack of Motivation Following Concussion
Background: Many service members have reported feeling tired, a loss of motivation, mood changes, and problems working with others after they have a concussion during deployment.
- Trial name
- NCT01496586
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Growth Hormone Treatment, Growth Hormone Deficiency
Growth Hormone Deficiency in Mild Traumatic Brain Injury
The goal of this randomized control trial is to test if growth hormone therapy is a safe and effective treatment for patients suffering from growth hormone deficiency and persistent post-concussion symptoms.
- Conditions
- Growth Hormone Treatment, Growth Hormone Deficiency, Concussion, Mild, Concussion Post Syndrome
- Trial name
- NCT05660356
- Testing
- Growth Hormone
- Volunteers
- 20 people
- Sponsor
- University of Calgary
Brain Injury Traumatic Mild, Post-traumatic Stress Disorder
Brain Health & Wellness Classes for Veterans With Traumatic Brain Injury
This study is testing the usefulness of two types of Brain Health \& Wellness classes for Veterans with a history of concussion to improve mental health.
- Trial name
- NCT06150196
- Testing
- Mindfulness-based Stress Reduction class, Brain Health Education class
- Where
- United States
- Volunteers
- 117 people
- Sponsor
- East Bay Institute for Research and Education
Brain Concussion, Mild Traumatic Brain Injury
Neuromodulation and Neuroimaging in Older Children With Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) often causes persistent motor and cognitive deficits in children resulting in functional limitations.
- Conditions
- Brain Concussion, Mild Traumatic Brain Injury, Motor Disorders, Cognitive Impairment
- Trial name
- CI-tDCS (NCT05762796)
- Testing
- tDCS in Youth with mild traumatic brain injury
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- State University of New York at Buffalo
Mild Traumatic Brain Injury, Brain Concussion
Testing mTBI in Athletes
This study will assess the effectiveness of a portable goggle system in the diagnosis of mild traumatic brain injury (mTBI) in athletes.
- Trial name
- NCT02486003
- Where
- United States
- Volunteers
- 329 people, healthy volunteers welcome
- Sponsor
- University of Miami
Tetraplegia, Hypothermia
Effect of Heat Exposure on Cognition in Persons With Tetraplegia
The ability to maintain normal body temperature (Tcore) is impaired in persons with tetraplegia: subnormal Tcore and vulnerability to hypothermia (<95 F) have been documented in this population after exposure to even mild…
- Conditions
- Tetraplegia, Hypothermia, Mild Cognitive Impairment
- Trial name
- NCT02488824
- Testing
- Warm Temperature
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Concussion, Brain
Objective Concussion Assessment Using MRI and Metabolomics
Mild traumatic brain injury (mTBI), also referred to as concussions, affect millions of people around the world and can cause harmful long term effects.
- Trial name
- NCT05993351
- Testing
- Magnetic resonance imaging (MRI), Urine and saliva samples, Questionnaires
- Where
- Canada
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- St. Joseph's Healthcare Hamilton
Concussion
Speech Analysis as a Diagnostic Tool for Mild Traumatic Brain Injury
The waveform assessment of an athlete's speech production has a high probability of showing abnormalities after brain injury (concussions) which could be used not only for diagnosis of the concussion, but for recovery of the…
- Trial name
- NCT02069795
- Testing
- Voice recording
- Volunteers
- 50 people
- Sponsor
- Forte Sports Medicine and Orthopedics
Sleep Architecture, Mild Traumatic Brain Injury
Evaluation of Cognitive Behavioral Therapy for Insomnia (CBT-I) in Individuals With Mild Traumatic Brain Injury (mTBI)
This study will employ cognitive behavioral therapy for insomnia (CBT-I) among individuals with mild traumatic brain injury (mTBI) who experience sleep disturbances.
- Conditions
- Sleep Architecture, Mild Traumatic Brain Injury, Sleep, Sleep and Circadian Problems
- Trial name
- NCT07385105
- Testing
- Cognitive behavioral Therapy for insomnia (CBT-I)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- University of Missouri-Columbia
Concussion, Brain, Mild Traumatic Brain Injury
Oculogica Portable EyeBOX Study
The objective of this study is to assess the accuracy of a portable version of the EyeBOX device, an eye-tracking based diagnostic, in comparison to a clinical reference standard of concussion.
- Trial name
- RESTLESS (NCT05047003)
- Testing
- EyeBOX Model EBX-4 (Portable version)
- Where
- 4 sites in United States
- Volunteers
- 100 people
- Sponsor
- Oculogica, Inc.
Post Traumatic Stress Disorder, Mild Traumatic Brain Injury, Concussion
Rehabilitation of Executive Functioning in Veterans With PTSD and Mild TBI
One of the most pressing concerns within the VA currently is the provision of interventions that address the cognitive as well as emotional problems faced by Veterans with concurrent mild TBI and PTSD.
- Trial name
- NCT01921179
- Testing
- GOALS (Goal-Oriented Attentional Regulation), EDU (Brain Health Education)
- Where
- 2 sites in United States
- Volunteers
- 76 people
- Sponsor
- VA Office of Research and Development
Grade 1 Anterior Cruciate Ligament Injury
EFFECTIVENESS OF ECCENTRIC HAMSTRING CONTRACTIONS WITH PHYSIOTHERAPY TRAINING ON SPORTS PERFORMANCE AND QUALITY OF LIFE IN YOUNG MALE FOOTBALL PLAYERS WITH NON-CONTACT GRADE 1 ACL INJURY
The overall aim of the study is to evaluate the impact of eccentric hamstring contractions on sports performance in young male football players with non-contact grade 1 Anterior Cruciate Ligament injuries.
- Trial name
- NCT07115316
- Testing
- Exercises
- Where
- United Arab Emirates
- Volunteers
- 180 people
- Sponsor
- Emirates Health Services (EHS)