Clinical trials: Mild Traumatic Injury
Mild Traumatic Brain Injury, Concussion, Mild
Trends in Cohabitation Status, Academic Achievement and Socio-economic Indicators After Mild Traumatic Brain Injury
Mild traumatic brain injury (mTBI) accounts for 70-90% of all diagnosed traumatic brain injuries (TBI) affecting approximately 50-300 per 100.000 individuals annually.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Mild, Academic Achievement, Specific Academic or Work Inhibition
- Trial name
- NCT03678077
- Testing
- Mild traumatic brain injury
- Where
- Denmark
- Volunteers
- 45,777 people
- Sponsor
- University of Copenhagen
Traumatic Brain Injuries, TBI (Traumatic Brain Injury)
Rehabilitation Through Virtual Immersion & Integrated Exposure for Mild Traumatic Brain Injury (ReVIVE for mTBI)
The primary goal of this study is to evaluate the effectiveness of an integrated therapeutic model - combining VR and standard psychotherapy in improving executive function and hyperarousal adults impacted with mTBI.
- Conditions
- Traumatic Brain Injuries, TBI (Traumatic Brain Injury), MTBI - Mild Traumatic Brain Injury, mTBI
- Trial name
- ReVIVE (NCT07890337)
- Testing
- Virtual Reality, Standard Psychotherapy
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Johns Hopkins University
Brain Concussion, Post-Concussion Symptoms
Perceptual-Cognitive Training After a Mild Traumatic Brain Injury: Towards a Sensitive Marker for Recovery
This study is part of a larger, multi-centered project done with the collaboration of University Of Victoria. This study holds three separate studies on the mild traumatic brain injured population and the use of…
- Conditions
- Brain Concussion, Post-Concussion Symptoms, Concussion
- Trial name
- NCT03213730
- Testing
- 3D-MOT Neurotracker, Visual Attention Intervention
- Where
- Canada
- Volunteers
- 63 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Mild Traumatic Brain Injury
VIDAS® TBI Real Life Performance in Subjects With Mild Traumatic Brain Injury (mTBI)
Decision Rules for an initial CT-scan in patients arriving to Emergency Department (ED) and presenting a mild traumatic brain injury could be optimized by the use of an objective parameter easily and rapidly measured.
- Trial name
- NCT06449183
- Testing
- VIDAS® TBI Test [GFAP and UCH-L1 assays]
- Where
- 5 sites in United States
- Volunteers
- 903 people
- Sponsor
- BioMérieux
Mild Traumatic Brain Injury, Concussion (Diagnosis)
Creatine Monohydrate for Mild Traumatic Brain Injury: a Randomised Controlled Pilot Study
Objectives: Approximately one-third of patients with concussion experience persistent symptoms that, in addition to causing serious discomfort, may lead to unemployment and other socioeconomic challenges.
- Trial name
- NCT06644131
- Testing
- Creatine Monohydrate
- Where
- Denmark
- Volunteers
- 34 people
- Sponsor
- University of Southern Denmark
Combat Posttraumatic Stess Disorder, Mild Traumatic Brain Injury
Lithium Augmentation for Hyperarousal Symptoms of Post Traumatic Stress Disorder: Pilot Study
The purpose of this study is to explore the effectiveness of adding lithium carbonate (lithium) to treatment for combat-related post traumatic stress disorder in combat veterans.
- Trial name
- NCT01754883
- Testing
- Lithium Carbonate
- Where
- United States
- Sponsor
- VA Eastern Colorado Health Care System
Insomnia Chronic, Mild Traumatic Brain Injury
Internet-guided Cognitive Behavioral Therapy for Insomnia in Military Service Members With History of TBI
This study aims to validate an established internet-guided cognitive behavioral therapy for insomnia (CBT-I) as an alternative program to traditional in-person therapy that may increase treatment availability and utilization…
- Trial name
- NCT04377009
- Testing
- Sleep Healthy Using the Internet (SHUTi), Education Control Program
- Where
- United States
- Volunteers
- 125 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Insomnia, Mild Traumatic Brain Injury
Behavioral Insomnia Treatment in Mild Traumatic Brain Injury
This is a single site, two-armed random controlled trials (RCT) comparing six sessions of Cognitive Behavioral Therapy for Insomnia (CBT-I) with four sessions of Brief Behavioral Therapy for Insomnia (BBT-I) in service members…
- Trial name
- NCT06551987
- Testing
- Cognitive Behavioral Therapy for Insomnia, Brief Behavioral Therapy for Insomnia
- Where
- United States
- Volunteers
- 160 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Sports Injury, Concussion, Mild
Turkish Translation of SportsConcussion Assesment Tool 6
Concussions, a significant type of sports injury caused by head, face, or neck trauma, are common in contact sports and require serious attention due to potential fatal consequences of mismanagement.
- Conditions
- Sports Injury, Concussion, Mild, Concussion, Brain, Concussion, Severe
- Trial name
- SCAT 6-tr (NCT06739785)
- Testing
- SCAT6-tr
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ordu University
Traumatic Brain Injury
CONcussion Treatment After Combat Trauma (CONTACT)
This study compares the effects of Individualized Scheduled Telephone Support (ISTS) and Usual Care (UC) for service members with Mild Traumatic Brain Injury (mTBI). A total of 400 service members will participate in this study.
- Trial name
- CONTACT (NCT01387490)
- Testing
- Individualized Scheduled Telephone Support (ISTS), Usual Care (UC)
- Where
- 4 sites in United States
- Volunteers
- 366 people
- Sponsor
- INTRuST, Post-Traumatic Stress Disorder - Traumatic Brain Injury Clinical Consortium
Mild Traumatic Brain Injury, Concussion
Advancement of Vestibular Intervention Via Portable Electrical Stimulator (VIPES)
The goal is to assess the potential benefit of stochastic galvanic vestibular stimulation (sGVS) in improving patient performance with respect to balance, gait, and/or overall vestibular function for individuals with known…
- Trial name
- NCT07466589
- Testing
- Stochastic Galvanic Vestibular Stimulation (sGVS)
- Where
- United States
- Volunteers
- 32 people
- Sponsor
- Vivonics, Inc.
Mild Traumatic Brain Injury, Post Concussion Syndrome
Non-invasive Stimulation of the Glymphatic System for Slowing Cognitive Decline
The purpose of this research is to demonstrate that mild stimulation of a nerve (trigeminal nerve) in the head can modulate blood flow in the brain.
- Trial name
- NCT07044596
- Testing
- Functional near-infrared spectroscopy (fNIRS), V1 stimulation electrodes, Magnetic Resonance Imaging (MRI)
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Traumatic Brain Injury
Evaluation of Biomarker Kinetics After Mild Brain Injury Trauma
The primary objective of the clinical trial is to evaluate the effect of time on levels of Ubiquitin C-terminal Hydrolase-L1 (UCH-L1) and Glial Fibrillary Acidic Protein (GFAP) biomarker levels in a population of head injured…
- Trial name
- VIGILANT (NCT02541123)
- Testing
- Blood draw
- Where
- 10 sites in United States, Germany and 1 more
- Volunteers
- 194 people
- Sponsor
- Banyan Biomarkers, Inc
Traumatic Brain Injury, Brain Concussion
Comparison of the DANA to the ANAM in the Evaluation of Cognitive Changes After Concussion
The Defense Automated Neurobehavioral Assessment (DANA) was recently developed as a durable, portable, and "field-hardened" NeuroCognitive Assessment Tool.
- Trial name
- NCT01728142
- Testing
- DANA Brief, ANAM
- Where
- Afghanistan
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Traumatic Brain Injury With Brief Loss of Consciousness, Traumatic Brain Injury With No Loss of Consciousness
The Study of Cognitive Rehabilitation Effectiveness for Mild Traumatic Brain Injury
The objective of this trial is to evaluate the effectiveness of cognitive rehabilitation in OIF/OEF service members with a history of mild traumatic brain injury and persistent (3-24 months post injury) cognitive complaints.
- Trial name
- SCORE (NCT01339806)
- Testing
- Cognitive Rehab, Brainworks, Informational Handout/Provider Visits
- Where
- United States
- Volunteers
- 143 people
- Sponsor
- Brooke Army Medical Center
Mild Traumatic Brain Injury, Concussion, Mild
Feasibility of a Cognitive Intervention for Youth Post Concussion
The purpose of this study is to evaluate the feasibility and effects of a cognitive intervention for youth following concussion
- Trial name
- NCT03195738
- Testing
- Cognitive Orientation to Occupational Performance (CO-OP)
- Where
- Canada
- Volunteers
- 3 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Concussion, Mild
The Combined Effect of Chronic Cannabis Use and Subconcussive Head Impacts on Brain Health
The purpose of this pilot study is to better understand the effects of chronic cannabis (THC) use on the neural responses to subconcussive head impacts, as a form of repetitive soccer headings.
- Trial name
- NCT04641832
- Testing
- Soccer heading
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Indiana University
Traumatic Intracranial Hemorrhage, Brain Injuries
Mild Traumatic Brain Injury and the Risk for Traumatic Intracranial Hemorrhage
Management of traumatic brain injuries causes significant efforts on emergency departments (ED) and overall health care. Patients on antithrombotic treatment with even minor trauma to the head, although without significant…
- Trial name
- NCT05609721
- Testing
- no intervention, only observational study
- Where
- Sweden
- Volunteers
- 2,044 people
- Sponsor
- Umeå University
Focus: Healthy Adults Without Brain Injury
Normative Datasets for Assessments Planned for Mild Traumatic Brain Injury (NORMAL)
The purpose of the research study is to collect information about brain function and structure among active duty military personnel or civilians who are healthy.
- Trial name
- NORMAL (NCT01925963)
- Where
- 2 sites in United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Lindell Weaver
Hypoxic-Ischemic Encephalopathy, Brain Injury
Prospective Research in Infants With Mild Encephalopathy
A multicenter observational pilot study will be conducted to determine the natural history of infants with early diagnosis (≤ 6 hrs of age) of mild neonatal encephalopathy (NE) who are not qualified for therapeutic hypothermia.
- Conditions
- Hypoxic-Ischemic Encephalopathy, Brain Injury, Neonatal Seizure
- Trial name
- PRIME (NCT01747863)
- Testing
- Neurologic examination
- Where
- 7 sites in United States, Canada and 2 more
- Volunteers
- 63 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre