Clinical trials: Mild Traumatic Injury
Brain Injury, Head Injury
S100 Biomarker in the Acute Management of Mild Head Injuries
A prospective validation study of the "Scandinavian guidelines for initial management of minimal, mild and moderate head injuries in adults".
- Trial name
- S100 (NCT02650765)
- Testing
- Indications for head CT imaging after acute head injury
- Where
- Finland
- Volunteers
- 295 people
- Sponsor
- Tampere University Hospital
Alzheimer Disease, Stroke
Assessment of Social-emotional Functioning in Neurological Diseases
Empathy, defined as the ability to understand others emotions, is a fundamental concept in social interactions. It is a psychological phenomenon involving various separable components : (i) the ability to feel and imagine the…
- Conditions
- Alzheimer Disease, Stroke, Parkinson's Disease, Lewy Body Dementia
- Trial name
- Emotion (NCT01339130)
- Testing
- Computerized tests and Electrophysiological measurements
- Where
- France
- Volunteers
- 177 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Osteoarthritis, Knee
A Telehealth Study of a Wearable Electroceutical & Sports Sleeve for Knee Osteoarthritis Pain Relief & Improved Function
The purpose of this telemedicine 24-person open-label study is to evaluate the safety and usability of a proprietary wearable microcurrent electroceutical (a device that delivers micro-ampere electronic pulses) made by Healables…
- Trial name
- HEAL01WMCOA1 (NCT04938271)
- Testing
- HEAL-122 microcurrent electroceutical with e-textile sports knee sleeve
- Where
- Israel
- Volunteers
- 24 people
- Sponsor
- Healables Ltd.
Traumatic Brain Injury
Effects of Usage of Simvastatin in Mild to Moderate Traumatic Brain Injury (TBI) Patients. Could it Make a Difference?
Traumatic brain injury (TBI) is a common cause of long-term neurological morbidity, with devastating personal and societal consequences.
- Trial name
- NCT05551871
- Testing
- Simvastatin
- Volunteers
- 60 people
- Sponsor
- Assiut University
Traumatic Brain Injury, Degeneration
Offsetting Hippocampal Degeneration in m-sTBI
The goal of this study is to establish the feasibility of an intervention designed to improve memory in patients who have experienced a moderate or severe traumatic brain injury (m-sTBI) and to examine its effect on brain…
- Conditions
- Traumatic Brain Injury, Degeneration, Memory; Loss, Mild, Following Organic Brain Damage
- Trial name
- m-sTBI (NCT03727334)
- Testing
- Online Spatial Navigation Training
- Where
- 2 sites in Canada
- Volunteers
- 25 people
- Sponsor
- University of British Columbia
Mild Traumatic Brain Injury
Transcranial Ultrasonography for the Management of Patients With Mild TBI
The investigators hypothesize that patients with mild TBI and normal TCD can be safely discharged home immediately after the ED.
- Trial name
- TRUST (NCT03989999)
- Testing
- Transcranial Doppler (TCD)
- Where
- 12 sites in France
- Volunteers
- 550 people
- Sponsor
- University Hospital, Grenoble
Brain Injuries, Head Injury
Biomarker Role in Assessing Imaging Needs for Mild Cranial Trauma
This study aims to determine whether a blood test can help doctors decide when to use a head CT scan for patients with a mild head injury.
- Trial name
- BRAIN-CT (NCT06932588)
- Testing
- Biomarker Testing using the Alinity Whole-blood TBI biomarker i-STAT
- Where
- United States
- Volunteers
- 351 people
- Sponsor
- Emory University
Stress Disorders, Stress
Measuring the Effectiveness of Forest Therapy to Alleviate Stress Among International Students
International students often face high levels of stress, leading to mental health conditions, from factors including cultural and social change, educational system, financial insecurity and family responsibilities.
- Conditions
- Stress Disorders, Stress, Anxiety, Anxiety Depression (Mild or Not Persistent)
- Trial name
- FTIS-2024 (NCT06792656)
- Testing
- standardized Forest Therapy session (120 min)
- Where
- Australia
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- International Nature and Forest Therapy Alliance
Concussion, Mild, Post-Concussion Symptoms
Effects of Bright Light Therapy in Mild Traumatic Brain Injury
Mild traumatic brain injuries (mTBI) or "concussions" are an increasingly prevalent injury in our society. Patients with post-concussion syndrome have been shown to have deficits on tests of short term memory, divided attention…
- Conditions
- Concussion, Mild, Post-Concussion Symptoms, Sleep Problems
- Trial name
- NCT01747811
- Testing
- wavelength-1 bright light, wavelength-2 bright light
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Mild to Moderate Traumatic Brain Injury
PoNS Clinical Experience Program (TBI)
Brief Summary: Prospective, cohort, open-label study. The cohort consists of people who have a chronic balance dysfunction due to a mild to moderate traumatic brain injury (TBI).
- Trial name
- NCT03881202
- Testing
- PoNS Treatment
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Helius Medical Inc
MTBI - Mild Traumatic Brain Injury, Dysfunction of Vestibular System
Use of Virtual and Augmented Reality Devices in Vestibular Physical Therapy for mTBI
Rapidly evolving virtual reality (VR) and augmented reality (AR) technologies are being incorporated by many large-scale industries, and the medical field is no exception.
- Trial name
- VR4VPT (NCT05326100)
- Testing
- Conventional Therapy (CPT), CAREN Therapy, Augmented Reality (AR) Therapy
- Where
- 3 sites in United States
- Volunteers
- 36 people
- Sponsor
- Naval Health Research Center
Tetraplegia, Hypothermia
Thermoregulation and Cognition During Cool Ambient Exposure in Tetraplegia
The ability to maintain normal core body temperature (Tcore = 98.6°F) is impaired in persons with a cervical spinal cord injury (tetraplegia).
- Conditions
- Tetraplegia, Hypothermia, Mild Cognitive Impairment
- Trial name
- NCT02379156
- Testing
- Midodrine Hydrochloride, Cool Temperature
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Alcohol Use Disorder, Mild-Moderate Traumatic Brain Injury
Personalized Approach Bias Modification in Heavy Drinking Veterans With Mild to Moderate Traumatic Brain Injury
The project will examine the neural associations of alcohol approach-bias and investigate the extent to which a neuroscience-based personalized cognitive training program will remediate alcohol approach-bias and improve recovery…
- Trial name
- TABM (NCT06380985)
- Testing
- Personalized VR Alcohol Approach Bias Modification (ApBM) Condition
- Where
- United States
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury
Transcranial Doppler on Admission of Patients With Mild to Moderate Traumatic Brain Injury
Patients with mild to moderate traumatic brain injury (TBI) are at risk for secondary neurological deterioration. Their outcome within the first week after injury could be predicted by clinical signs, brain CT scan and…
- Trial name
- TCD (NCT01291706)
- Testing
- Transcranial Doppler
- Where
- 21 sites in France
- Volunteers
- 369 people
- Sponsor
- University Hospital, Grenoble
Brain Injuries, Traumatic, Concussion, Mild
Objective Brain Function Assessment of mTBI/Concussion
This study (Part 3) is designed to build a database including EEG, neurocognitive performance, clinical symptoms, history and other relevant data, which will be used to derive a multimodal EEG based algorithm for the…
- Conditions
- Brain Injuries, Traumatic, Concussion, Mild, Concussion, Intermediate, Concussion, Severe
- Trial name
- CAS13-25 (NCT03963804)
- Testing
- BrainScope Ahead 300iP
- Where
- 4 sites in United States
- Volunteers
- 268 people, healthy volunteers welcome
- Sponsor
- BrainScope Company, Inc.
Right Hemispheric Stroke, Left Hemispheric Stroke
Neural and Cognitive Correlates of Pragmatic Abilities
Pragmatics of language refers to the set of abilities that allow one to use and interpret language according to context and, in general, to communicate effectively.
- Conditions
- Right Hemispheric Stroke, Left Hemispheric Stroke, Traumatic Brain Injury, Right Hemispheric Brain Tumor
- Trial name
- APACS_Neuro (NCT06297044)
- Testing
- Neuropsychological assessment
- Where
- Italy
- Volunteers
- 324 people, healthy volunteers welcome
- Sponsor
- IRCCS San Camillo, Venezia, Italy
Mild Traumatic Brain Injury
The Use of Anti-oxidants to Reduce Sequela of Mild Traumatic Brain Injury (mTBI) After Blast Exposure
The administration of N-acetyl-cysteine (an anti-oxidant) for seven days along with observation will result in improved hearing and balance function in individuals who demonstrate these disorders after blast exposure when…
- Trial name
- NCT00822263
- Testing
- N-acetyl-cysteine (NAC)
- Where
- Iraq
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Mild Traumatic Brain Injury
High-Definition Transcranial Direct Current Stimulation (HD-tDCS) for Sensory Deficits in Complex Traumatic Brain Injury
Aim 1: To use magnetoencephalography (MEG) and magnetic resonance imaging (MRI) in Veterans and civilians with mild traumatic brain injury (mTBI) and sensory postconcussive symptoms (PCS) to demonstrate the mechanism of…
- Trial name
- NAVIGATE-TBI (NCT03799458)
- Testing
- Active High-definition transcranial direct current stimulation (HD-tDCS)
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Brain Concussion, Mild Traumatic Brain Injury
The Role of Mechanical Diagnosis and Therapy in the Management of Concussion
The purpose of this study is to examine the role of a Mechanical Diagnosis and Therapy (MDT) examination in identifying participants diagnosed with concussion who display a directional preference compared to who don't display a…
- Trial name
- NCT05859815
- Testing
- Physical Therapy
- Where
- 2 sites in United States
- Volunteers
- 13 people
- Sponsor
- State University of New York at Buffalo
Combat Posttraumatic Stess Disorder, Mild Traumatic Brain Injury
Lithium Augmentation for Hyperarousal Symptoms of Post Traumatic Stress Disorder: Pilot Study
The purpose of this study is to explore the effectiveness of adding lithium carbonate (lithium) to treatment for combat-related post traumatic stress disorder in combat veterans.
- Trial name
- NCT01754883
- Testing
- Lithium Carbonate
- Where
- United States
- Sponsor
- VA Eastern Colorado Health Care System