Clinical trials: Mild Traumatic Injury
Traumatic Brain Injury, Degeneration
Offsetting Hippocampal Degeneration in m-sTBI
The goal of this study is to establish the feasibility of an intervention designed to improve memory in patients who have experienced a moderate or severe traumatic brain injury (m-sTBI) and to examine its effect on brain…
- Conditions
- Traumatic Brain Injury, Degeneration, Memory; Loss, Mild, Following Organic Brain Damage
- Trial name
- m-sTBI (NCT03727334)
- Testing
- Online Spatial Navigation Training
- Where
- 2 sites in Canada
- Volunteers
- 25 people
- Sponsor
- University of British Columbia
TBI-Traumatic Brain Injury
Simvastatin for mTBI
Study of simvastatin in Iraq/Afghanistan Veterans with multiple blast exposure and mTBI. The study will measure substances in cerebrospinal fluid (CSF) that are related to dementing disorders.
- Trial name
- NCT01952288
- Testing
- simvastatin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- VA Office of Research and Development
Mild Traumatic Brain Injury
Remediation of Impaired Self-Regulation in Patients With Mild TBI
The ability to regulate impulses enables us to plan for the future, to maintain focus in the face of distractions (i.e. to encode memories), and to manage emotions.
- Trial name
- NCT02260570
- Testing
- Tolcapone
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Headache Disorders, Post-Concussion Syndrome
Can Targeted Education Impact the Current Standard of Care in Patients With Mild Traumatic Brain Injury?
The study will ask the question as to whether or not it is possible to deliver education material to patients with a mild traumatic brain injury in a consistent matter.
- Conditions
- Headache Disorders, Post-Concussion Syndrome, Mild Traumatic Brain Injury
- Trial name
- NCT03391583
- Testing
- Education
- Where
- Canada
- Volunteers
- 70 people
- Sponsor
- Unity Health Toronto
Acupuncture, Mild Traumatic Brain Injury
Acupuncture for Mild Traumatic Brain Injury：A Functional Magnetic Resonance Imaging Study
The overall goal of this study is to examine if acupuncture intervention can reduce the post-concussion symptom (PCS), and affective and cognitive complaints among mild traumatic brain injury (TBI).
- Conditions
- Acupuncture, Mild Traumatic Brain Injury, MRI
- Trial name
- NCT02868671
- Testing
- acupuncture
- Where
- China
- Volunteers
- 66 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Mild Cognitive Impairment, Alzheimer's Disease
Behavioral and Neuroimaging Changes After Cognitive Rehab in Traumatic Brain Injuries (TBI) and Mild Cognitive Impairment (MCI)
Memory deficits are common after traumatic brain injuries (TBI) and are characteristic of various forms of dementia, such as Alzheimer's disease and its common precursor mild cognitive impairment (MCI).
- Conditions
- Mild Cognitive Impairment, Alzheimer's Disease, Traumatic Brain Injury
- Trial name
- NCT00714571
- Testing
- Mnemonic strategy training (MST), Repeated exposure (XP), Subtracting Cues training
- Where
- United States
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Brain Concussion, mTBI - Mild Traumatic Brain Injury
Screening Instruments for Measuring Visual Symptoms in Victims of Concussion
Visual dysfunction after mild traumatic brain injury (mTBI) is common but often remain undiscovered during longer periods of time. No valid, reliable and easy-to-use screening instrument for uncovering visual dysfunction exists.
- Trial name
- VisCom (NCT05862571)
- Where
- Denmark
- Volunteers
- 197 people, healthy volunteers welcome
- Sponsor
- Bispebjerg Hospital
Traumatic Brain Injury, Chronic Balance Disorder
Study of Safety and Effectiveness of PoNS Device to Treat Chronic Balance Deficit Due to Traumatic Brain Injury (TBI)
The purpose of this study is to determine if clinic and home training with a study device will improve a balance deficit. The study device is called Portable Neuromodulation Stimulator (PoNS).
- Trial name
- NCT02429167
- Testing
- Cranial nerve non-invasive neuromodulation via PoNS device
- Where
- 3 sites in United States, Canada
- Volunteers
- 122 people
- Sponsor
- Helius Medical Inc
Concussion, Mild, Vestibular Impairment
Association of History of Concussion With Vestibular Impairment and Cognitive Function in Sports Athletes
This study investigates the potential relationship between prior concussions and their impact on both vestibular function and cognitive abilities in athletes participating in sports.
- Conditions
- Concussion, Mild, Vestibular Impairment, Cognitive Impairment
- Trial name
- NCT06340100
- Testing
- find association between vestibular impairment , cognitive fiunction with concussin
- Where
- Pakistan
- Volunteers
- 115 people
- Sponsor
- Riphah International University
Mild Traumatic Brain Injury, Suicide Prevention
Crisis Response Planning in Military Personnel With Mild Traumatic Brain Injury
The study purpose is to test the effect of Crisis Response Planning (CRP) when used as the second method of suicide prevention in military service members who are at risk for suicide due to mild traumatic brain injury (mTBI).
- Conditions
- Mild Traumatic Brain Injury, Suicide Prevention, Suicide Risk | Patient, Suicide Risk
- Trial name
- NCT07327567
- Testing
- Crisis Response Planning
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Concussion, Mild
Interdisciplinary Interventions After mTBI
The investigators aim to investigate the impact of interdisciplinary and individually tailored programs for mTBI (concussion) on quality of life and work capacity, both at the conclusion of the program and after 1 and 3 years.
- Trial name
- NCT06815692
- Testing
- Psychoeducation, Physiotherapy, Treatment of tinnitus and increased sound sensitivity
- Volunteers
- 140 people
- Sponsor
- Rune Skovgaard Rasmussen
Brain Injuries, Traumatic
Therapeutic Hypothermia for Severe Traumatic Brain Injury in Japan
The purpose of this trial is to determine if mild hypothermia therapy, for severe head trauma patients, improves neurological outcome.
- Trial name
- NCT00134472
- Testing
- Therapeutic mild hypothermia
- Where
- 43 sites in Japan
- Volunteers
- 150 people
- Sponsor
- Yamaguchi University Hospital
Brain Concussion, Mild Cognitive Impairment
Development of a Neurocognitive Screening Test
This research study will evaluate a standalone software application and is designed to standardize and validate new neurocognitive screening testing for children aged 6 through 11, and adolescents and adults ages 12 through 75.
- Trial name
- NCT02597504
- Testing
- Pen and paper neuropsychological test, Quick Test
- Where
- 4 sites in United States
- Volunteers
- 1,600 people, healthy volunteers welcome
- Sponsor
- ImPACT Applications, Inc.
Traumatic Brain Injury (TBI)
Managing Mild Traumatic Brain Injury Related Headaches With Repetitive Transcranial Magnetic Stimulation
Persistent headache is one of the most common debilitating symptoms in military personnel suffering from mild traumatic brain injury (MTBI).
- Trial name
- NCT03314584
- Testing
- Transcranial Magnetic Stimulation, Magnetic resonance imaging (MRI)
- Where
- United States
- Volunteers
- 179 people
- Sponsor
- VA Office of Research and Development
Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder
Pathways Relating Amnestic MCI to a Mild Traumatic Brain Injury History
This study will probe if the biological changes in amnestic mild cognitive impairment (aMCI) are related to a history of mild traumatic brain injury (mTBI) using high definition transcranial direct current stimulation (HD-tDCS)…
- Conditions
- Mild Cognitive Impairment, Amnestic Mild Cognitive Disorder, Amnestic Mild Cognitive Impairment, Mild Traumatic Brain Injury
- Trial name
- PATH (NCT05446584)
- Testing
- High Definition Transcranial Direct Current Stimulation
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- University of Texas Southwestern Medical Center
Mild Traumatic Brain Injury
Olfactory Function in Patients With Acute Mild Traumatic Brain Injury
In this project the investigators aim to evaluate olfactory and non-olfactory function in patients within the first 24h following a mild traumatic brain injury (acute mTBI) and compare their results to a group of age and sex…
- Trial name
- NCT02977728
- Testing
- Olfactory Evaluation
- Volunteers
- 42 people
- Sponsor
- Hôpital de Viege
Traumatic Brain Injury
Effect of Namenda on Short Term Memory and Attention in Patients With Mild to Moderate Traumatic Brain Injury
The purpose of this study is to determine whether memantine (Namenda) improves memory and attention in patients with mild to moderate traumatic brain injury.
- Trial name
- NCT00462228
- Testing
- Memantine
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- University of Missouri-Columbia
Traumatic Brain Injury
Glial Fibrillary Acidic Protein (GFAP) and Ubiquitin Carboxy-terminal Hydrolase L1 (UCH-L1) to Exclude Lesions Linked to Significant Traumatic Brain Injuries
The goal of this observational study is to evaluate the performance of UCH-L1 and GFAP combined in patients with a mild traumatic brain injury.
- Trial name
- GUEST (NCT05885529)
- Testing
- UCH-L1 GFAP
- Where
- 15 sites in France, Monaco
- Volunteers
- 1,500 people
- Sponsor
- Centre Hospitalier Princesse Grace
Concussion, Mild
Reliability of Self-reported Concussion History in Current Rugby Union Players
Perhaps no issue in sports medicine has attracted so much media attention and academic interest in recent years as the potential long-term neurodegenerative sequelae of sports-related concussion on athlete's brain health.
- Trial name
- NCT03544372
- Testing
- Assessment of Concussion History using NIH Concussion History Tool
- Where
- Ireland
- Volunteers
- 63 people
- Sponsor
- University of Dublin, Trinity College
Spinal Cord Injury
Treatment of Mild to Moderate Depression Symptoms in Patients With Spinal Cord Injury
This study was initially designed to test the efficacy of Venlafaxine HCl in reducing incidence of the onset of major depression after a new spinal cord injury (SCI).
- Trial name
- NCT00735670
- Testing
- Venlafaxine HCl
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan