Clinical trials: Mild Traumatic Injury
Sports Concussion
Use of Resveratrol to Decrease Acute Secondary Brain Injury Following Sports-Related Concussions in Boxers
Sports-related concussions are a serious problem in football, boxing, and other full contact sports. After experiencing consecutive concussions, there is an increase in neurological deficits that can lead to long-term cognitive…
- Trial name
- REPAIR (NCT01321151)
- Testing
- Resveratrol
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Dementia, Mixed, Dementia Mild
An Innovative Supportive Care Model for Dementia and Traumatic Brain Injury
There are an increasing number of people in the U.S. with Alzheimer's disease and other dementias. Traumatic brain injuries (TBIs) are also common among both civilians and military personnel, and TBIs increase a person's risk for…
- Conditions
- Dementia, Mixed, Dementia Mild, Dementia Moderate, Traumatic Brain Injury
- Trial name
- NCT04495686
- Testing
- Telehealth-delivered Care Coordination Program
- Where
- United States
- Volunteers
- 171 people
- Sponsor
- University of Virginia
Brain Injuries, Traumatic, Concussion, Mild
Validation of Brain Function Assessment Algorithm for mTBI/Concussion
This study is Part 2 of data collection from 13-25 years old subject population for validation of previously derived algorithms.
- Conditions
- Brain Injuries, Traumatic, Concussion, Mild, Concussion, Severe, Concussion, Intermediate
- Trial name
- CAS13-25V (NCT03671083)
- Testing
- BrainScope Ahead 300iP
- Where
- 5 sites in United States
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- BrainScope Company, Inc.
Mild Traumatic Brain Injury (mTBI), Concussion, Mild Traumatic Brain Injury
Postural Motor Activation Deficits After mTBI; Translating Laboratory Findings to Clinical Care
This work will address an important gap in physical therapy rehabilitation after concussion. Physical therapy usually focuses on how the brain processes sensory information such as inner ear and vision for balance rehabilitation…
- Trial name
- NCT07549529
- Testing
- Motor Activation Physical Therapy for mTBI, Standard of Care Physical Therapy for mTBI
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- Oregon Health and Science University
Healthy
Normative Oculomotor and Vestibular Data in Pediatric Population
The purpose of this study is to use a device called I-Portal® Portable Assessment System (I-PAS) to record eye movements in response to a number of visual and auditory stimuli designed to evaluate neural brain pathways related to…
- Trial name
- NCT04107610
- Testing
- I-PAS
- Where
- 2 sites in United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Neurolign
Head Injury
Broad Validation Study of a Management Algorithm Mild Head Injury in Children
Head injury is a frequent reason for consultation with pediatric emergencies, over 95% are mild head injury defined by a Glasgow score greater than or equal to 13.
- Trial name
- EVEACE (NCT02357186)
- Where
- 9 sites in France
- Volunteers
- 7,871 people
- Sponsor
- Nantes University Hospital
Mild Traumatic Brain Injury
Recovery Among Older Adults Following Mild TBI
Among fall related injuries in older adults, head injuries are the most common, yet almost nothing is known about recovery from head injury, also known as traumatic brain injury or TBI, in this population.
- Trial name
- NCT07569354
- Where
- United States
- Volunteers
- 250 people
- Sponsor
- University of Maryland, Baltimore
Traumatic Brain Injury (TBI); Concussion, Initial Encounter
Wearable Device-Based Analysis of the Relationship Between Sleep Patterns and Clinical Prognosis in Patients With Traumatic Brain Injury
In patients with traumatic brain injury, post-traumatic sleep patterns have the potential to impact clinical prognosis. While some progress has been made in the study of sleep and prognosis in patients with traumatic brain…
- Trial name
- NCT06790979
- Where
- China
- Volunteers
- 50 people
- Sponsor
- General Hospital of Ningxia Medical University
Sprain, Strain
Ketoprofen 10% Cream for Treatment of Pain Associated With Mild to Moderate Acute Soft Tissue Injury
Imprimis Pharmaceuticals is investigating a proprietary, topical cream formulation consisting of 10% ketoprofen (containing 100 mg of ketoprofen in 1gram of cream) for the local treatment of acute musculoskeletal pain.
- Conditions
- Sprain, Strain, Acute Soft Tissue Injury
- Trial name
- NCT00765700
- Testing
- Topical Ketoprofen 10% Cream
- Where
- United States
- Volunteers
- 364 people
- Sponsor
- Imprimis Pharmaceuticals, Inc.
Concussion, Brain, Concussion, Mild
BCAAs in Concussion 2.0
This study is a randomized, placebo-controlled, double-blinded, therapeutic exploratory clinical trial of branched chain amino acids (BCAAs) in the treatment of concussion.
- Conditions
- Concussion, Brain, Concussion, Mild, Concussion
- Trial name
- NCT06829498
- Testing
- BCAA
- Where
- United States
- Volunteers
- 17 people
- Sponsor
- Akiva Cohen
Mild Traumatic Brain Injury, Concussion, Brain
The Effect of Creatine Monohydrate on Persistent Post-concussive Symptoms
The purpose of this study, is to investigate whether creatine monohydrate as a supplement reduces the number and severity of symptoms in patients with persistent post-concussive symptoms through self-reported post-concussion…
- Trial name
- NCT05562232
- Testing
- Creatine Monohydrate
- Where
- Denmark
- Volunteers
- 45 people
- Sponsor
- Psychiatric Research Unit, Region Zealand, Denmark
Lateral Ankle Sprain, Ankle Sprain 1St Degree
Therapeutic Low Laser Therapy and Kinesio Taping for Lateral Ankle Sprain
HYPOTHESIS Null Hypothesis (H0): There is no significant effect of therapeutic low laser therapy and kinesio taping in patients with grade 1 \& 2 lateral ankle sprain.
- Conditions
- Lateral Ankle Sprain, Ankle Sprain 1St Degree, Ankle Sprain 2Nd Degree
- Trial name
- NCT07235943
- Testing
- Using Low-Level Laser Therapy, Combined: Low Laser Therapy with Kinesio Taping
- Where
- Pakistan
- Volunteers
- 62 people
- Sponsor
- University of Lahore
Traumatic Brain Injury
Assessing Eye Tracking Features Following Sports-Related Concussion
This proposal aims to describe the oculometric features present during King-Devick (K-D) testing for subjects who experienced sports-related concussion.
- Trial name
- NCT02103803
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Mayo Clinic
Brain Injuries, Brain Concussion
Measuring Head Impacts in Sports
Head impacts in sports can lead to brain injury even when the participant is wearing a helmet. The forces that contribute to brain injury from sports-related head impacts are not well understood.
- Trial name
- NCT00060827
- Testing
- Head Impact Recording Technology (HIRT)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Post-Concussion Syndrome, Traumatic Brain Injury
Hyperbaric Oxygen Treatment to Treat Mild Traumatic Brain Injury (mTBI)/Persistent Post-Concussion Syndrome (PPCS)
Objective/Hypothesis: An eight-week course of forty low-pressure Hyperbaric Oxygen Treatment's (HBOT's) can significantly improve symptoms and cognitive function in subjects with the persistent-post concussion syndrome (PPCS) of…
- Trial name
- NCT02089594
- Testing
- Hyperbaric Oxygen, No Hyperbaric Oxygen
- Where
- United States
- Volunteers
- 59 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Concussion, Mild Traumatic Brain Injury
Clinical Trial of a Rehabilitation Game - SuperBetter
Today's hospitals need innovative solutions to help patients transition from our care to self-management at home. The vast majority of the patients seen in Dodd Rehabilitation Hospital and associated clinics leave our care with…
- Conditions
- Concussion, Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
- Trial name
- SuperBetter (NCT01398566)
- Testing
- SuperBetter play
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Ohio State University
Mild Traumatic Brain Injury
Photobiomodulation for Concussions: the Use of the ImPACT® Test as an Assessment Tool
Brain photobiomodulation (PBM) therapy is an innovative modality for the stimulation of neural activity in order to improve brain function and is currently under investigation as a treatment for several diverse neurological…
- Trial name
- NCT04823507
- Testing
- BIOFLEX DUO+
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- Meditech Rehabilitation Centre
Brain Concussion, Pediatric
Early Exercise to Improve Psychosocial Function After Pediatric Mild Traumatic Brain Injury
The investigators will test the central hypotheses according to the following Specific Aims: Aim 1. Determine if an individually prescribed exercise program initiated within the first week of mild traumatic brain injury can…
- Conditions
- Brain Concussion, Pediatric, Mild Traumatic Brain Injury, Psychological
- Trial name
- NCT04199247
- Testing
- Sub symptom aerobic exercise
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Colorado, Denver
Traumatic Brain Injury
Broad-spectrum Cognitive Remediation: Effects of a Brain Plasticity-based Program in Mild Traumatic Brain Injury
The primary objective of this study is to evaluate the effects of plasticity-based, adaptive cognitive remediation on the cognitive abilities, functional status and quality of life of soldiers and veterans diagnosed with…
- Trial name
- BRAVE (NCT01640158)
- Testing
- Computerized Plasticity-based Adaptive Cognitive Training, Commercially available computerized training
- Where
- United States
- Volunteers
- 86 people
- Sponsor
- Posit Science Corporation
Post-concussion Syndrome, Post-concussive Symptoms
PLAY GAME: Post-concussion Syndrome in Youth - Assessing the GABAergic Effects of Melatonin
PURPOSE: The long-term goal of this line of research is to develop rational, biologically based evidence for the treatment of post-concussion syndrome (PCS) in children.
- Conditions
- Post-concussion Syndrome, Post-concussive Symptoms, Traumatic Brain Injury, Concussion
- Trial name
- PLAYGAME (NCT01874847)
- Testing
- Melatonin, Sugar pill
- Where
- Canada
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Calgary