Clinical trials: Mild Traumatic Injury
MTBI - Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury
Rapid Diagnosis and Prognosis Recognition of Imaging and Biomarkers in Mild to Moderate Traumatic Brain Injury
The investigators will carry out multi-center and large sample research based on the Chinese population, screen the optimal diagnostic and prognosis recognition biomarkers and analyze the diagnostic critical cutoff values in…
- Trial name
- NCT05108909
- Testing
- MRI, CT, and serum biomarkers
- Where
- China
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Brain Concussion, Posttraumatic Stress Disorder
Brain Injury Outcomes (BIO) Study
Many active duty military, national guard, and reserves personnel who served in the recent conflicts in Afghanistan and Iraq were exposed to blasts and other mechanisms of traumatic brain injury (TBI).1,2 Although physical trauma…
- Conditions
- Brain Concussion, Posttraumatic Stress Disorder, Dementia
- Trial name
- BIO (NCT00724607)
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Traumatic Brain Injury, Chronic Traumatic Encephalopathy
Amyloid and Tauopathy PET Imaging in Acute and Chronic Traumatic Brain Injury
The potential long-term effects of Traumatic Brain Injury (TBI) are poorly understood. Repeated concussions have been associated with an elevated incidence of Alzheimer's disease (AD) along with a reduced age of onset.
- Conditions
- Traumatic Brain Injury, Chronic Traumatic Encephalopathy, Mild Cognitive Impairment
- Trial name
- NCT02266563
- Testing
- Amyvid PET Scan, T807 PET scan
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Samuel Gandy
Post-concussive Symptoms, Traumatic Brain Injury
Hyperbaric Oxygen Therapy (HBO2) for Persistent Post-concussive Symptoms After Mild Traumatic Brain Injury (mTBI)
This is a Phase II randomized trial designed to describe the magnitude of change between baseline and follow-up outcomes for symptom surveys and a battery of neuropsychological tests administered at time points corresponding…
- Trial name
- HOPPS (NCT01306968)
- Testing
- hyperbaric oxygen
- Where
- 5 sites in United States
- Volunteers
- 79 people
- Sponsor
- U.S. Army Medical Research and Development Command
Brain Injury Traumatic Mild, Concussion, Brain
Dual-task Assessment and Rehabilitation for Individuals With Residual Symptoms After mTBI
This research aims to develop an intervention that combines mTBI-specific motor and cognitive challenges into a progressive and challenging rehabilitation program.
- Trial name
- NCT03478059
- Testing
- Cognitive and Motor Dual-task Intervention
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Allina Health System
Vestibular Hypofunction
Improving Psychological and Vestibular Health: MINDGAPS
The purpose of this study is twofold: 1) Develop norms for measures of inner ear function and psychological health, and 2) Examine the feasibility of using the MINDGAPS system (a remote monitoring system) to track progress during…
- Trial name
- MINDGAPS (NCT05986279)
- Testing
- Rehab
- Where
- 2 sites in United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Montana
Brain Injuries, Concussion, Mild
Evaluation and Validation of a Multimodal Brain Function Biomarker With NPC
This study is designed to collect data which will be used to associate changes in EEG, neurocognitive performance, eNPC and clinical symptoms in concussion subtypes.
- Conditions
- Brain Injuries, Concussion, Mild, Concussion, Brain, Near Point Convergence
- Trial name
- BSC-CI-NPC (NCT04074486)
- Testing
- BrainScope Ahead 300iP-O, SCAT5, Near Point Convergence
- Where
- 6 sites in United States
- Volunteers
- 1,318 people, healthy volunteers welcome
- Sponsor
- BrainScope Company, Inc.
Mild Traumatic Brain Injury, Moderate Traumatic Brain Injury (TBI)
Memantine as an Additive Therapy in Patients With Traumatic Brain Injury
Memantine has shown promise in mitigating secondary brain injury in previous studies. One study demonstrated that early memantine administration in moderate TBI patients resulted in lower serum neuron-specific enolase levels and…
- Trial name
- NCT06914310
- Testing
- Memantine, Mannitol
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Mansoura University
Post-Traumatic Stress Disorders, Brain Injuries
Identifying Biomarkers That Distinguish PTSD and mTBI Using Advanced Magnetic Resonance Spectroscopy
The purpose of this study is to develop a new test to help diagnose mild traumatic brain injury (mTBI) and post-traumatic stress disorder (PTSD) in soldiers.
- Trial name
- NCT02927288
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Concussion, Mild
Pro-2-Cool Pivotal Trial II
This study is being conducted to determine the clinical safety and efficacy of Pro-2-Cool mediated head and neck cooling when applied after concussion and improved symptomatology among adolescent athletes as quantified by…
- Trial name
- NCT06929923
- Testing
- Pro2Cool Device
- Where
- 3 sites in United States
- Volunteers
- 66 people
- Sponsor
- TecTraum Inc.
Brain Concussion, Mild Traumatic Brain Injury
A Study on the Effect of Mindfulness-based Yoga on Youth With Persistent Concussion Symptoms
Mild traumatic brain injury (mTBI), also known as concussion, is of great concern in the youth population, with incidences of injury steadily increasing within the past few years.
- Trial name
- NCT03217695
- Testing
- Mindfulness-based Yoga Arm
- Where
- Canada
- Volunteers
- 6 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Mild Traumatic Brain Injury (mTBI), Post-traumatic Stress Disorder
Transcranial Electrical Stimulation for mTBI
mTBI is a leading cause of sustained physical, cognitive, emotional, and behavioral deficits in OEF/OIF/OND Veterans and the general public.
- Trial name
- TESmTBI (NCT03244475)
- Testing
- TES
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Concussion, Mild, Diagnoses, Syndromes, and Conditions
Diagnosis of Sport-related Concussion Using Urine Metabolites
Millions of sport related concussions (SRC) occur yearly in the United States, and current diagnosis of concussion is based upon largely subjective clinical evaluations.
- Trial name
- NCT03653195
- Testing
- urine metabolomics
- Where
- Canada
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Calgary
Post-Concussive Syndrome, Chronic, Post-Concussion Syndrome
Impact of Photobiomodulation on Objective, Physiological Measures of Brain Function in Individuals With Post-Concussion Syndrome
Photobiomodulation therapy (PBMT) uses light to influence the mitochondria of cells. PBMT of the brain enhances the metabolic capacity of neurons and stimulates anti-inflammatory, anti-apoptotic, and antioxidant responses, as…
- Conditions
- Post-Concussive Syndrome, Chronic, Post-Concussion Syndrome, Mild Traumatic Brain Injury
- Trial name
- NCT05097222
- Testing
- BioFlex Dualport System
- Where
- 2 sites in Canada
- Volunteers
- 19 people
- Sponsor
- Dr George Medvedev
Post-operative Cognitive Dysfunction
Target Hemodynamics and Brain Injury During General Anesthesia in the Elderly
BACKGROUND: Post-operative cognitive dysfunction (POCD) is a potentially irreversible loss of brain functions observed in elderly patients after surgical operations under general anaesthesia.
- Trial name
- THE BRIDGE (NCT02428062)
- Testing
- Hemodynamic target, Phenylephrine, Intravenous fluids
- Where
- Italy
- Volunteers
- 1,812 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Head Injury, Minor, Concussion, Mild
Heading in Football: Impact on Neural Blood Biomarkers
The goal of this observational study is to evaluate the safety of heading in football. We will study the release of biomarkers in blood that reflect microscopic neural damage.
- Conditions
- Head Injury, Minor, Concussion, Mild, CTE - Chronic Traumatic Encephalopathy, Neurodegeneration
- Trial name
- HEADLINE (NCT06147596)
- Testing
- Head impact exposure
- Where
- Netherlands
- Volunteers
- 335 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Brain Concussion
Examination of Balance, Vestibular, and Ocular Functions and Activity Following Concussion
Previous research and position statements have outlined the necessity of balance and gait testing in the post-concussion evaluation of athletes.
- Trial name
- NCT02317107
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Complication of Surgical Procedure, Acute Respiratory Failure, Adult
Prospective Evaluation of a RIsk Score for Postoperative Pulmonary COmPlications in Europe
Prospective Evaluation of a RIsk Score for postoperative pulmonary COmPlications in Europe (PERISCOPE) is a multi-centre, international observational study of a random-sample cohort of patients undergoing a nonobstetric…
- Conditions
- Complication of Surgical Procedure, Acute Respiratory Failure, Adult, Postoperative Respiratory Complications, Pulmonary Failure
- Trial name
- PERISCOPE (NCT01346709)
- Where
- 63 sites in Albania, Belgium and 19 more
- Volunteers
- 5,450 people
- Sponsor
- European Society of Anaesthesiology
Mild Traumatic Brain Injury, Concussion, Chronic Dizziness
Repetitive Transcranial Magnetic Stimulation Paired with Augmented Reality to Alter Concussion Symptoms
This study aims to determine whether the delivery of brain stimulation paired with a balance training task can improve symptoms of dizziness for individuals experiencing these symptoms due to concussion.
- Conditions
- Mild Traumatic Brain Injury, Concussion, Chronic Dizziness, Vestibular Problem
- Trial name
- NCT06735157
- Testing
- Repetitive transcranial magnetic stimulation, Augmented reality vestibular rehabilitation therapy
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- McMaster University
Concussion, Mild, Sport Injury
Sensorimotor Training for Injury Prevention in Collegiate Soccer Players II
The purpose of this project is to evaluate the effectiveness of an injury prevention intervention delivered primarily using headset virtual reality for collegiate soccer players.
- Trial name
- NCT04036916
- Testing
- Virtual Reality Sensorimotor Training
- Where
- United States
- Volunteers
- 130 people
- Sponsor
- University of Mississippi Medical Center