Clinical trials: Mild to Moderate Depression
Depression, Depression Disorder
GynMDD Add-On to Supportive Psychotherapy in Mild to Moderate Depression
The goal of this clinical trial is to learn whether the dietary supplement GynMDD, when taken as an add-on to supportive psychotherapy, can improve symptoms of mild to moderate depression in adults aged 18 to 65.
- Conditions
- Depression, Depression Disorder, Depression in Adults
- Trial name
- SWING (NCT07416747)
- Testing
- GynMDD
- Where
- France
- Volunteers
- 168 people
- Sponsor
- Fondation FondaMental
Depressive Symptoms
Brief Nursing Advice for University Students With Depressive Symptoms
1. Project title Effectiveness of a Brief Nursing Advice in Promoting the Psychological Well-Being for University Students with Mild to Moderate Depressive Symptoms: A Randomized Controlled Trial 2.
- Trial name
- NCT04966650
- Testing
- 5-mins brief nursing advice incorporating with Social Cognitive Theory (SCT)
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Depressive Disorder, Major
Aerobic Versus Leisure Group for Adolescents With Depression
The aim is to evaluate aerobic group exercise versus leisure group activities in adolescents with mild to moderate depression. Primary outcome is Children's Depression Rating Scale - Revised (CDRS-R).
- Trial name
- NCT05076214
- Testing
- Aerobic exercise in group, Leisure activities in group
- Where
- 4 sites in Sweden
- Volunteers
- 122 people
- Sponsor
- Lund University Hospital
Specific Learning Disorder, Intellectual Disability, Mild to Moderate
SWELE Program: An Unstructured Outdoor Play With Mindfulness-based Interventions to Promote Mental Health Among Students With Special Education Needs
This is an observational study with the aim of SWELE Programme is to raise mental health knowledge and awareness by implementing a play-based approach on Supporting Wellness in E-Child Learning Environments (SWELE) programme…
- Conditions
- Specific Learning Disorder, Intellectual Disability, Mild to Moderate, Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder
- Trial name
- SEN (NCT06112483)
- Testing
- SWELE Programme
- Volunteers
- 1,064 people
- Sponsor
- Chinese University of Hong Kong
Spinal Cord Injury
Treatment of Mild to Moderate Depression Symptoms in Patients With Spinal Cord Injury
This study was initially designed to test the efficacy of Venlafaxine HCl in reducing incidence of the onset of major depression after a new spinal cord injury (SCI).
- Trial name
- NCT00735670
- Testing
- Venlafaxine HCl
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan
Alzheimer's Disease, Dementia
Safety and Efficacy Study of Ladostigil in Mild to Moderate Probable Alzheimer's Disease
For many, Alzheimer's disease is the number one medical issue facing our aging society. It is a late onset neurodegenerative disease, frequently under diagnosed, that impairs memory and cognitive performance.
- Conditions
- Alzheimer's Disease, Dementia, Memory Loss, Cognitive Impairment
- Trial name
- NCT01354691
- Testing
- ladostigil hemitartrate
- Where
- 19 sites in Austria, Croatia and 3 more
- Volunteers
- 200 people
- Sponsor
- Avraham Pharmaceuticals Ltd
Depression, Anxiety
Mediterranean-style Dietary Pattern (MDP), Mood and Anxiety
Observational studies and a limited numbers of RCTs have observed that habitual Mediterranean-style dietary pattern (MDP) consumption is associated with improved mental health and cognition.
- Trial name
- MediMood (NCT05927376)
- Testing
- Mediterranean diet, Western diet
- Where
- United Kingdom
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of East Anglia
Depression and/or Anxiety in the Mild-to-moderate Range, Loneliness
Social Prescribing for a Mindful Lifestyle
The goal of this clinical trial is to evaluate the effectiveness of an 8-week mindfulness lifestyle social prescribing program in community-dwelling older adults aged 55 and older.
- Conditions
- Depression and/or Anxiety in the Mild-to-moderate Range, Loneliness, Social Isolation
- Trial name
- NCT07669805
- Testing
- Mindfulness Lifestyle Social Prescribing Program
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Depression
Efficacy, Safety, and Acceptability of Internet-based Cognitive Behavioral Therapy
This is a prospective, randomized, multicenter, double-blind, placebo-controlled phase III trial evaluating the efficacy and safety of WL-iCBT - a smartphone-based digital therapeutic combining cognitive behavioral therapy and…
- Trial name
- NCT05554289
- Testing
- Depression Auxiliary Intervention Treatment Software (WL-iCBT)
- Where
- 11 sites in China
- Volunteers
- 315 people
- Sponsor
- Adai Technology (Beijing) Co., Ltd.
Mild to Moderate Depression.
Cost-effectiveness of a Non-Pharmacological Treatment (Active Monitoring) vs. a Pharmacological Treatment for Major Depression in Primary Care.
Major Depression (MD) is highly prevalent and has associated a high burden and economic costs. Mild levels of MD could be treated without antidepressants at Primary Care (PC).
- Trial name
- NCT02245373
- Testing
- Antidepressants, Active Monitoring
- Volunteers
- 263 people
- Sponsor
- Fundació Sant Joan de Déu
Depression
Hypericum vs Fluoxetine for Mild to Moderate Adolescent Depression
The study is a pilot study where adolescents 12 - 18 years of age with mild to moderate depression will be randomized to receive either hypericum 250mg twice daily or fluoxetine 10mg daily increased to 20mg daily after 1 week and…
- Trial name
- NCT00557427
- Testing
- hypericum, fluoxetine
- Where
- Israel
- Volunteers
- 30 people
- Sponsor
- Rafa Laboratories
Multiple Sclerosis
Online Mindfulness-Based Cognitive Therapy for People With Multiple Sclerosis With Mild-Moderate Depression
This study will use a waiting list randomized controlled trial design with a mixed-methods research approach, including both quantitative and qualitative methods.
- Trial name
- NCT07742579
- Testing
- Mindfulness-Based Cognitive Therapy
- Volunteers
- 152 people
- Sponsor
- Robert Simpson
Anxiety, Depression - Major Depressive Disorder
Integrative Group Psychotherapy (Terebenin's Method) in Adults With Subclinical and Mild/Moderate Anxiety and Depression
Title Pilot Randomized Controlled Trial of an Integrative Group Psychotherapy (Terebenin's Method) in Adults with Subclinical and Mild/Moderate Anxiety and Depression Summary and Detailed Description (Single Text Block) Anxiety…
- Trial name
- NCT06863948
- Testing
- Teribenin method, Control Interventions
- Where
- Russia
- Volunteers
- 66 people
- Sponsor
- S.LAB (SOLOWAYS)
Cancer
Ketamine Hydrochloride and Best Pain Management in Treating Cancer Patients With Neuropathic Pain
RATIONALE: Ketamine hydrochloride may lessen neuropathic pain in patients with cancer. It is not yet known whether ketamine hydrochloride given together with the best pain management is more effective than a placebo given…
- Trial name
- NCT01316744
- Testing
- ketamine hydrochloride, pharmacogenomic studies, questionnaire administration
- Where
- 3 sites in United Kingdom
- Volunteers
- 214 people
- Sponsor
- University of Glasgow
Depression, Multiple Sclerosis
The Efficacy and Safety of Escitalopram for Depression in Multiple Sclerosis
Emotionally labile, depressed participants with multiple sclerosis treated with escitalopram will have a greater reduction in emotional lability scores and in their psychological distress scores than those who are randomized to…
- Trial name
- NCT00151294
- Testing
- escitalopram oxalate antidepressant
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Weill Medical College of Cornell University
Mild-to-moderate Depression
Treating Depression With Transcutaneous Electrical Cranial-auricular Acupoint Stimulation (TECAS).
One multi-center, randomized controlled clinical trial is designed to examine whether transcutaneous electrical cranial-auricular acupoint stimulation (TECAS) is non-inferior to the antidepressant drug (Escitalopram) in treating…
- Trial name
- TECAS (NCT03909217)
- Testing
- TECAS Procedure, Escitalopram, Insomnia medication
- Where
- 6 sites in China
- Volunteers
- 470 people
- Sponsor
- The University of Hong Kong
Mild-moderate Unipolar Depression; Persistent Negative Affect
Dismantling Mindfulness: Contributions of Attention vs. Acceptance
This study addresses NCCAM's request for research that investigates the neuropsychological mechanisms underlying mind-body therapies, and for precise criteria and better delineation of meditation practices.
- Trial name
- NCT01831362
- Testing
- Mindfulness-Based Cognitive Therapy, Focused Attention (FA), Open- Monitoring
- Where
- United States
- Volunteers
- 104 people
- Sponsor
- Brown University
Mild to Moderate Depressive Symptoms
Effectiveness of Internet-based Depression Treatment
Care for people suffering from depressive symptoms should be given in a step-wise approach. One first step can be the provision of self-help material. Online self-help is an innovative way of providing self-help.
- Trial name
- EVIDENT (NCT01636752)
- Testing
- Deprexis
- Where
- 4 sites in Germany
- Volunteers
- 1,013 people
- Sponsor
- University of Luebeck
Depression
Effects of Saffron and Chamomile in Mild to Moderate Depression
Diabetes characterized by decreased production, or resistance to the action of insulin or both. The reduced production or action alters many important body functions namely glucose absorption and utilization in the body.
- Trial name
- NCT04935671
- Testing
- chamomile tea n saffron
- Where
- Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Dr Saara (Ahmad) Muddasir Khan
Hepatic Impairment
Pharmacokinetics of AGO178 in Participants With Liver Impairment
AGO178 was developed for the treatment of depression. A new formulation is being tested in the present study: a tablet to be placed and dissolved under the tongue (sublingual tablet).
- Trial name
- NCT01531309
- Testing
- AGO178
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Novartis Pharmaceuticals