Clinical trials: Mild-to-moderate Depression
Mental Health, Depression and/or Anxiety in the Mild-to-moderate Range
Effect of a Programme Including an AI-enhanced Mobile Application on the Mental Well- Being of Young Adolescents in Hong Kong
Study Aim and Methods (≈250 words) It aims to evaluate the effectiveness, user perceptions, and applicability of the e-CAMP intervention in improving mental well-being and reducing depressive symptoms among adolescents aged 11-15…
- Trial name
- AI-eCAMP_RCT (NCT07704996)
- Testing
- Control Group :health talk and usual care by school, mobile app group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Tung Wah College
Dementia, Alzheimer Disease
Effectiveness of a 3-month Individual Reminiscence Therapy Program in Older Adults With Alzheimer's Disease
This research aims to evaluate the effectiveness of individual Reminiscence Therapy (RT) program, using a simple reminiscence format, to improve the overall cognitive function, mood, and quality of life (QoL) of older adults with…
- Conditions
- Dementia, Alzheimer Disease, Cognitive Impairment
- Trial name
- NCT06812442
- Testing
- Reminiscence therapy
- Where
- 4 sites in Portugal
- Volunteers
- 40 people
- Sponsor
- Rsocialform - Geriatria, Lda
Depression
Clinical Study of Cang Ai Volatile Oil (CAVO) on Mild to Moderate Depression in Children and Adolescents
A randomized controlled trial was conducted to observe the improvement of mild to moderate depressive symptoms in children and adolescents with the aromatic herbal compound Cang Ai Volatile Oil (CAVO) and to evaluate the…
- Trial name
- NCT05789186
- Testing
- CAVO aromatherapy patch at 3% concentration+Fluoxetine hydrochloride mimetic, Fluoxetine hydrochloride tablet+CAVO aromatherapy patch at 0.1% concentration, Fluoxetine hydrochloride mimetic+CAVO aromatherapy patch at 0.1% concentration
- Where
- China
- Volunteers
- 108 people
- Sponsor
- Chen Qian
Depression, Depressive Symptom
Auricular Concha Electro-acupuncture for the Treatment of Depression
The objective of this study was to compare the therapeutic effects of Auricular Concha Electro-acupuncture and Citalopram on patients with major depressive disorder (MDD).
- Conditions
- Depression, Depressive Symptom, Depressive Disorder
- Trial name
- NCT03607331
- Testing
- Auricular vagus nerve stimulation, Citalopram
- Where
- China
- Volunteers
- 106 people
- Sponsor
- China Academy of Chinese Medical Sciences
Depression
Effect of Electroacupuncture on Treating the First-episode Depression
Depression is a disease that endangers the physical and mental health of all human beings. Only 30-40% of patients with initial episode depression are cured after treatment with antidepressants.
- Trial name
- NCT05818735
- Testing
- electroacupuncture (EA) treatment, Escitalopram 10mg
- Where
- China
- Volunteers
- 204 people
- Sponsor
- Shanghai Municipal Hospital of Traditional Chinese Medicine
Depression and/or Anxiety in the Mild-to-moderate Range, Cognitive Behavioral Therapy
Internet-Based Cognitive Behavioural Therapy (iCBT) for Anxiety and Depression in Singapore
Cognitive-behavioural therapy (CBT) has a robust evidence base for treating anxiety disorders and depression, including transdiagnostic CBT. Internet-based CBT (iCBT) offers a new approach to delivering these therapies.
- Trial name
- NCT07532551
- Testing
- Internet-delivered cognitive behavioural therapy (iCBT)
- Where
- 3 sites in Singapore
- Volunteers
- 390 people
- Sponsor
- National University of Singapore
Spinal Cord Injury
Treatment of Mild to Moderate Depression Symptoms in Patients With Spinal Cord Injury
This study was initially designed to test the efficacy of Venlafaxine HCl in reducing incidence of the onset of major depression after a new spinal cord injury (SCI).
- Trial name
- NCT00735670
- Testing
- Venlafaxine HCl
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University of Michigan
Mild-to-moderate Depression
Treating Depression With Transcutaneous Electrical Cranial-auricular Acupoint Stimulation (TECAS).
One multi-center, randomized controlled clinical trial is designed to examine whether transcutaneous electrical cranial-auricular acupoint stimulation (TECAS) is non-inferior to the antidepressant drug (Escitalopram) in treating…
- Trial name
- TECAS (NCT03909217)
- Testing
- TECAS Procedure, Escitalopram, Insomnia medication
- Where
- 6 sites in China
- Volunteers
- 470 people
- Sponsor
- The University of Hong Kong
Working Memory, Mild to Moderate Depression
Cross-over Study on the Influence of Fampridine on Working Memory in Mild to Moderate Depression
Cognitive deficits, including working memory deficits, are often present in depression and there are currently no effective pharmacological treatments targeting working memory deficits. Papassotiropoulos et al.
- Trial name
- FamD_2025 (NCT06751784)
- Testing
- Fampridine SR
- Where
- Switzerland
- Volunteers
- 38 people
- Sponsor
- University of Basel
Depressive Symptoms Mild to Moderate in Severity
A Pilot Study of Synbiotics in Adults With Depressive Symptoms
This study aims to explore the efficacy and safety of a synbiotic formula (MQU10) in improving mood and well-being in adults with mild to moderate depressive symptoms.
- Trial name
- NCT06905223
- Testing
- MQU10
- Where
- 2 sites in Hong Kong
- Volunteers
- 30 people
- Sponsor
- GenieBiome Limited
Mild to Moderate Depression.
Cost-effectiveness of a Non-Pharmacological Treatment (Active Monitoring) vs. a Pharmacological Treatment for Major Depression in Primary Care.
Major Depression (MD) is highly prevalent and has associated a high burden and economic costs. Mild levels of MD could be treated without antidepressants at Primary Care (PC).
- Trial name
- NCT02245373
- Testing
- Antidepressants, Active Monitoring
- Volunteers
- 263 people
- Sponsor
- Fundació Sant Joan de Déu
Major Depressive Disorder
Efficacy and Cost-effectiveness of Internet-delivered CBT for Adolescents With Depression
Adolescent depression is a prevalent and impairing condition that can be effectively treated with Cognitive Behavior Therapy (CBT). However, a majority of adolescents do not have access to CBT.
- Trial name
- IDA (NCT04977856)
- Testing
- Behavioral activation (BA), Regular care within primary or secondary mental health care for children
- Where
- Sweden
- Volunteers
- 219 people
- Sponsor
- Region Stockholm
Depression, Unspecified Adult Solid Tumor, Protocol Specific
Sertraline Compared With Hypericum Perforatum (St.John's Wort) in Treating Depression
RATIONALE: Antidepressants such as sertraline and the herb hypericum perforatum (St. John's wort) may be effective in treating mild to moderate depression.
- Trial name
- NCT00066859
- Testing
- Zoloft 50 mg, St. John's Wort 600 mg
- Where
- 6 sites in United States
- Volunteers
- 2 people
- Sponsor
- Wake Forest University Health Sciences
Mild to Moderate Depressive Symptoms
Online Self-healing Program
Background. Almost two thirds of adolescents experience a mental disorder before the age of 25. Among mental disorders, depression is one of the most common among young people aged between 15 to 24, with a prevalence of 13.5% to…
- Trial name
- iCBT-A (NCT07374653)
- Testing
- Online Cognitive Behaviural Therapy, Online Relaxation
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- City University of Hong Kong
Crohn Disease, Depression
The Effects of Intraoperative Esketamine on Postoperative Pain and Mood in Patients With Inflammatory Bowel Disease
Crohn's disease (CD) is a chronic inflammatory disease of the gastrointestinal tract with symptoms evolving in a relapsing and remitting manner.
- Conditions
- Crohn Disease, Depression, Esketamine
- Trial name
- NCT05506787
- Testing
- Esketamine
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Jinling Hospital, China
Anxiety-depressive Patients Mild to Moderate
Anxiety-depressive Disorder in Primary Care and Cognitive-behavioral Treatment
OBJECTIVE: Evaluate the effectiveness of quality of life score, a cognitive-behavioral intervention by psychologists in the field of primary care in anxiety-depressive patients, mild to moderate, compared with usual care.
- Trial name
- PSICCAPAD (NCT01907035)
- Testing
- A cognitive-behavioral intervention, Usual care
- Where
- 3 sites in Spain
- Volunteers
- 246 people
- Sponsor
- Basque Health Service
Depression
The Efficacy and Safety of tDCS in Patients With Mild to Moderate Major Depressive Disorder
This study evaluated the effectiveness and safety of improving depressive symptoms by applying tDCS for 6 weeks to patients with mild to moderate depression.
- Trial name
- NCT04720040
- Testing
- Mind STIM
- Where
- South Korea
- Volunteers
- 65 people
- Sponsor
- Ybrain Inc.
Depression and/or Anxiety in the Mild-to-moderate Range, Loneliness
Social Prescribing for a Mindful Lifestyle
The goal of this clinical trial is to evaluate the effectiveness of an 8-week mindfulness lifestyle social prescribing program in community-dwelling older adults aged 55 and older.
- Conditions
- Depression and/or Anxiety in the Mild-to-moderate Range, Loneliness, Social Isolation
- Trial name
- NCT07669805
- Testing
- Mindfulness Lifestyle Social Prescribing Program
- Where
- Taiwan
- Volunteers
- 50 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Depression
Evaluation of the Bounce Back Program
Lifetime prevalence rates of Major Depressive Disorder (MDD) in Canada are between 10-12% with approximately 1.5 million Canadians reporting depression in any given year.
- Trial name
- NCT01324648
- Testing
- Telephone-supported self-help and GP treatment as usual, Unsupported self-help and GP treatment as usual, General practitioner treatment as usual
- Where
- 3 sites in Canada
- Volunteers
- 20 people
- Sponsor
- University of British Columbia
Major Depressive Disorder (MDD)
Group Acceptance and Commitment Therapy (ACT) Among Depressive Patients in Kelantan, Malaysia
The goal of this clinical trial is to learn if group acceptance and commitment therapy works to improve depressive symptoms, psychological flexibility and quality of life in adults. The main questions it aims to answer are: 1.
- Trial name
- Group ACT (NCT06710912)
- Testing
- Group acceptance and commitment therapy (ACT), Treatment as usual
- Where
- Malaysia
- Volunteers
- 44 people
- Sponsor
- Universiti Sains Malaysia