Clinical trials: Minimal Hepatic Encephalopathy
Minimal Hepatic Encephalopathy
Transcranial Doppler Ultrasound and Minimal Hepatic Encephalopathy
Minimal hepatic encephalopathy (MHE) is a subclinical complication of liver cirrhosis with a relevant social impact. Thus, there is urgent need to implement easy to use diagnostic tools for the early identification of affected…
- Trial name
- NCT04077125
- Testing
- Rifaximin
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Hepatic Encephalopathy, Cirrhosis, Liver
Rifamycin in Minimal Hepatic Encephalopathy
This is a randomized double-blind placebo-controlled trial of MHE in patients with cirrhosis using rifamycin SV-MMX 600mg BID vs placebo for 30 days with PK, safety, microbiota, brain function and brain MRI endpoints.
- Trial name
- RIVET (NCT04082780)
- Testing
- Rifamycin SV MMX
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Liver Cirrhoses, Hepatic Encephalopathy
Role of MRI in Detection of Minimal Hepatic Encephalopathy
Introduction Liver cirrhosis (LC) is irreversible fibrosis of the liver (1) and it remains a public health problem. One of the complications of the cirrhosis is hepatic encephalopathy (HE) which is defined as brain dysfunction…
- Trial name
- NCT04131205
- Testing
- Magnetic Resonance Imaging
- Where
- Slovenia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Hepatic Pathology (Fibrosis, Cirrhosis, Porto Systemic Shunts)
Development of a Cognitive Tool for Rapid and Reliable Screening of Minimal Hepatic Encephalopathy: Pilot Study
The aim of this project is to evaluate the sensitivity and specificity of a cognitive test toward the presence of minimal hepatic encephalopathy (MHE).
- Trial name
- BLOCK-HE (NCT06619106)
- Testing
- Cognitive test
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Hepatic Encephalopathy, Cirrhosis
Early Diagnosis and Timely Treatment of Cirrhotic Patients With Minimal Hepatic Encephalopathy (CHESS-NCRCID 2106)
Hepatic encephalopathy (HE) is a common complication of cirrhosis, which seriously damages the life quality of patients. As the disease progresses, 50-80% of patients with cirrhosis develop HE.
- Trial name
- NCT05140837
- Testing
- Psychometric hepatic encephalopathy score & Stroop test, Drug therapy
- Where
- 31 sites in China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Hepatopancreatobiliary Surgery Institute of Gansu Province
Cirrhosis
EYE-Mobile TRACKer IN the Diagnosis of Minimal Hepatic Encephalopathy
Hepatic encephalopathy (HE) corresponds to the neurological or the neuropsychological symptoms caused by an acute or chronic liver disease and/or porto-systemic shunt.
- Trial name
- EyeMTRACKIN-HE (NCT03732118)
- Testing
- Eye-tracker Mobile EBT
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Liver Cirrhosis, Hepatic Encephalopathy
Diagnosis of Covert/Minimal Hepatic Encephalopathy by Means of Continuous Reaction Time Measurement
The investigators wish to investigate how the Continuous Reaction Time (CRT) method can be used in the diagnosis and monitoring of covert hepatic encephalopathy (cHE)in patients with cirrhosis of the liver.
- Trial name
- NCT01773538
- Testing
- Lactulose and rifaximin, Branched Chain amino acids
- Where
- 2 sites in Denmark
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Mette Munk Lauridsen
Liver Cirrhosis
High Protein Diet Versus Normal Protein Diet in Treating Patients With Minimal Hepatic Encephalopathy
A total of 80 patients diagnosed with liver cirrhosis and minimal hepatic encephalopathy will be recruited. They will be randomized to receive high protein diet ( n = 40) and a normal protein diet ( n = 40 ) during one month.
- Trial name
- NCT02418039
- Testing
- High protein diet, Normal protein
- Where
- Mexico
- Volunteers
- 42 people
- Sponsor
- Coordinación de Investigación en Salud, Mexico
Minimal Hepatic Encephalopathy
Study of Lactulose in Children With Chronic Liver Disease
Pediatric patients with chronic liver disease may have Minimal Hepatic Encephalopathy(MHE)which can cause changes in behavior,intelligence and neurological function.By utilizing cognitive and developmental testing we will…
- Trial name
- MHE (NCT00811434)
- Testing
- Lactulose
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Indiana University
Minimal Hepatic Encephalopathy
Antioxidants and Zinc Improving Minimal Hepatic Encephalopathy In Truck Drivers; a Pilot Study
Minimal hepatic encephalopathy (MHE) can have a far-reaching impact on quality and ability to function in daily life and may progress to overt Hepatic Encephalopathy.
- Trial name
- NCT02520817
- Testing
- 175 mg zinc gluconate, 50000 IU vitamin A, 500 mg vitamin C and 100 mg vitamin E once daily plus lactulose; dose 30-60 ml/day for 3 months, Lactulose
- Where
- Egypt
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Hepatic Encephalopathy, Minimal Hepatic Encephalopathy
A Prospective Cohort Study on the Epidemiological Investigation, Diagnosis, and Treatment of Hepatic Encephalopathy
Purpose Hepatic encephalopathy (HE) is a serious complication of liver cirrhosis that can cause memory loss, slow reaction, and even coma.
- Conditions
- Hepatic Encephalopathy, Minimal Hepatic Encephalopathy, Liver Cirrhosis
- Trial name
- NCT07612670
- Testing
- wechat mini-program
- Where
- China
- Volunteers
- 700 people, healthy volunteers welcome
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Minimal Hepatic Encephalopathy
Acetyl-L-Carnitine Reduces Depression and Improves Quality of Life in Patients With Minimal Hepatic Encephalopathy
Minimal hepatic encephalopathy represents a common complication present in well-compensated cirrhotic patients that impairs patients daily functioning and health-related quality of life.
- Trial name
- NCT01223729
- Testing
- Acetyl-L-Carnitine
- Where
- Italy
- Volunteers
- 67 people
- Sponsor
- University of Catania
Hepatic Encephalopathy
Minimal HePatic Encephalopathy Among CiRrhotics. A Cross SEctional, Clinico-EpidEmiological, Multi-Centre, Study in Patients of PakisTan
The Preempt study is likely to help determine the frequency of patients suffering from Minimal Hepatic Encephalopathy (MHE) and are cirrhotics. It will also enable us to know about the Quality of life of these patients.
- Trial name
- Preempt (NCT02613858)
- Where
- 6 sites in Pakistan
- Volunteers
- 550 people
- Sponsor
- Abbott
Chronic Liver Disease, Hepatic Encephalopathy
Effect of Probiotics in Treatment of Minimal Hepatic Encephalopathy (MHE) and Health Related Quality of Life
This study is a randomized, open, parallel group, active comparator, single center trial. Objectives of the study are hereby given below: To study the health related quality of life (HRQOL) in patients with chronic liver disease.
- Trial name
- MHE (NCT01008293)
- Testing
- VSL#3, Lactulose
- Where
- India
- Volunteers
- 120 people
- Sponsor
- CD Pharma India Pvt. Ltd.
Liver Cirrhosis, Hepatic Encephalopathy
Metformin Experience on Minimal Hepatic Encephalopathy
Primary aim: -To assess the effect of metformin use on the treatment of minimal hepatic encephalopathy in patients with liver cirrhosis.
- Trial name
- EME (NCT02470546)
- Testing
- Metformin
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Fundación Pública Andaluza para la gestión de la Investigación en Sevilla
Hepatic Encephalopathy, Minimal Hepatic Encephalopathy
A Study of MHE in Patients With Liver Diseases
The study analyzes the diagnostic efficacy of neurophysiological tests and blood biomarkers on MHE, predicts risk factors on the development of OHE and investigate the mortality of MHE in patients with cirrhosis and acute on…
- Conditions
- Hepatic Encephalopathy, Minimal Hepatic Encephalopathy, Overt Hepatic Encephalopathy
- Trial name
- NCT04058327
- Testing
- neurophysiological tests, blood biomarkers.
- Where
- China
- Volunteers
- 252 people, healthy volunteers welcome
- Sponsor
- Qin Ning
Minimal Hepatic Encephalopathy, Hepatic Encephalopathy
Effect of Lactulose on Minimal Hepatic Encephalopathy and Health-Related Quality of Life
Minimal hepatic encephalopathy (MHE) has a negative effect on patients' daily functioning. No study has so far investigated the effect of treatment related improvement in cognitive functions on health related quality-of-life…
- Trial name
- NCT00375375
- Testing
- Lactulose
- Where
- India
- Volunteers
- 80 people
- Sponsor
- Post Graduate Institute of Medical Education and Research, Chandigarh
Hepatic Cirrhosis, Minimal Hepatic Encephalopathy
Hyperproteic Diet Plus Lactobacillus Reuteri and Nitazoxanide in Minimal Hepatic Encephalopathy
Hepatic encephalopathy is a serious complication of cirrhosis which relays under the burden of diseases with therapeutical difficulties for its given morbidity and mortality and the high recurrence it poses.
- Trial name
- NCT01135628
- Testing
- Auxiliary Treatment, Hyperproteic and fiber-rich diet, Nitazoxanide
- Where
- Mexico
- Volunteers
- 60 people
- Sponsor
- Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran
Minimal Hepatic Encephalopathy
Study of Rifaximin in Minimal Hepatic Encephalopathy
Rifaximin therapy will improve brain functioning on MRI scanning and change the microbiome and metabolome.
- Trial name
- NCT01069133
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center
Hepatic Encephalopathy
Rifaximin in Minimal Hepatic Encephalopathy
The purpose of this study is to determine whether alteration of gut flora with rifaximin can lead to improvement in driving performance, psychometric test performance, and quality of life in patients with minimal hepatic…
- Trial name
- NCT00533910
- Testing
- Rifaximin
- Where
- United States
- Volunteers
- 42 people
- Sponsor
- Hunter Holmes Mcguire Veteran Affairs Medical Center