Clinical trials: Minimally Conscious State
Disorders of Consciousness
Window On the Brain
Disorders of consciousness (DOC) diagnosis suffers from the difficulty to measure the level of consciousness due to the variability associated with behavioural assessments and the difficulty in detecting the residual level of…
- Trial name
- WOB (NCT06693492)
- Testing
- Ultrasound technique for diagnosis; Focused Ultrasound Stimulation for intervention
- Where
- 4 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Disorder of Consciousness, Comatose
Prognostication of Recovery in Early Disorders of Consciousness Study
The goal of this study is to determine the extent to which neuroimaging metrics (e.g., functional MRI) are associated with the current level of consciousness, and future consciousness recovery, in patients with disorders of…
- Conditions
- Disorder of Consciousness, Comatose, Coma; Prolonged, Vegetative State
- Trial name
- PREDICT (NCT07074678)
- Testing
- Functional MRI (fMRI)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Disorder of Consciousness, Vegetative State
The Use of LIFUP in Chronic Disorders of Consciousness
When patients survive a severe brain injury but fail to fully recover, they often enter a Disorder of Consciousness (DoC) --that is, a set of related conditions of decreased awareness and arousal including the Vegetative State…
- Conditions
- Disorder of Consciousness, Vegetative State, Minimally Conscious State, Minimally Conscious State Plus
- Trial name
- NCT04921683
- Testing
- BX Pulsar 1002 (LIFUP) Low intensity Focused Ultrasound Pulsation
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Casa Colina Hospital and Centers for Healthcare
Disorders of Consciousness, Vegetative State
AI-Assisted Precision Hyperbaric Oxygen Therapy Based on Dynamic BIS-EEG Feedback for Patients With Disorders of Consciousness
Disorders of consciousness (DoC) are severe neurological conditions characterized by impaired awareness and reduced interaction with the environment.
- Conditions
- Disorders of Consciousness, Vegetative State, Minimally Conscious State
- Trial name
- AI-HBOT-DoC (NCT07855848)
- Testing
- AI-Assisted Personalized Hyperbaric Oxygen Therapy, Conventional Hyperbaric Oxygen Therapy
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Boston Intelligent Medical Research Center, Shenzhen United Scheme Technology Co., Ltd.
Disorder of Consciousness, Minimally Conscious State
Diagnostic Accuracy of the Vegetative and Minimally Conscious State
The aim of this study was to investigate diagnostic accuracy of the vegetative and minimally conscious state: Clinical consensus versus standardized neurobehavioral assessment
- Trial name
- NCT04139239
- Testing
- Coma Recovery Scale-revision
- Where
- China
- Volunteers
- 150 people
- Sponsor
- Hangzhou Normal University
Consciousness Disorder
Multimodal Neuroprognostication in Disorders of Consciousness
Disorders of consciousness frequently occur at the acute phase of brain injuries. For the most severe cases, consciousness impairment can be prolonged.
- Trial name
- M-Neuro-DoC (NCT04534777)
- Testing
- repeated neurological, behavioral assessments and conventional, quantitative and functional brain imagery
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Disorder of Consciousness, Minimally Conscious State
Target Behaviours to Identify Minimally Conscious State Patients
To analyse the frequency of the consciousness behaviour response for patients with minimally conscious state of Coma Recovery Scale-Revised items, as well as the necessary items for obtaining higher accuracy.
- Trial name
- NCT04471753
- Testing
- Coma Recovery Scale-Revised
- Where
- China
- Volunteers
- 215 people
- Sponsor
- Hangzhou Normal University
Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State
Assessment of Consciousness With CRS-R and SECONDs
Accurately determining the level of consciousness in patients with severe brain injury is essential for treatment planning, prognosis, and ethical decision-making.
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Minimally Conscious State, Unresponsive Wakefulness Syndrome
- Trial name
- AssessConsc (NCT07456020)
- Testing
- Simplified Evaluation of CONsciousness Disorders (SECONDs), Coma Recovery Scale-Revised (CRS-R)
- Where
- Germany
- Volunteers
- 110 people
- Sponsor
- BDH-Klinik Hessisch Oldendorf
Postcomatose Unawareness State, Minimally Conscious State
Eye Tracking Technology in the Diagnosis of Neurological Patients
Demonstrating that diagnostics of the state of consciousness and cognitive functions of patients with consciousness disorders performed using C-Eye X (based on eye-tracking technology) allows a more objective assessment of state…
- Conditions
- Postcomatose Unawareness State, Minimally Conscious State, Vegetative State, Disorder of Consciousness
- Trial name
- NCT05536921
- Where
- 5 sites in Poland
- Volunteers
- 90 people
- Sponsor
- AssisTech Sp. z o.o.
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Promoting Recovery After Brain Injury Using Focused Ultrasound
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- ReBOUND (NCT07277309)
- Testing
- Low-intensity focused ultrasound
- Where
- 2 sites in United States
- Volunteers
- 36 people
- Sponsor
- Massachusetts General Hospital
Disorders of Consciousness
The Core Body Temperature Rhythms: Distinguishing MCS From UWS
In this study, the core body temperature of 7 disorders of consciousness ( DOC ) patients were measured every 2 hour for 168 h .
- Trial name
- NCT02930213
- Volunteers
- 7 people
- Sponsor
- Jing Wang
Consciousness Disorders
Measuring Brain Complexity to Detect and Predict Recovery of Consciousness in the ICU
Disorders of consciousness (DoC) caused by severe brain injury affect millions of people worldwide each year. A patient's level of consciousness in the intensive care unit (ICU) significantly impacts the recovery from disability…
- Trial name
- COMPASS (NCT06568536)
- Testing
- Repeated behavioral assessments, functional electroencephalography and brain imagery, TMS-EEG
- Where
- 2 sites in United States
- Volunteers
- 120 people
- Sponsor
- Massachusetts General Hospital
Disorders of Consciousness, Severe Brain Injury
Use of Analgesic Treatment to Reduce Signs of Pain in Patients With Disorders of Consciousness.
The purpose of this study is to characterize and improve pain and nociception management in patients with disorders of consciousness (DOC).
- Conditions
- Disorders of Consciousness, Severe Brain Injury, Post-comatose Non-communicative Patients, Vegetative State
- Trial name
- NCT04330547
- Testing
- Analgesic administration
- Where
- Belgium
- Volunteers
- 19 people
- Sponsor
- University of Liege
Coma, Disorder of Consciousness
Development of a Point of Care System for Automated Coma Prognosis
Electroencephalogram/event-related potentials (EEG/ERP) data will be collected from 50 participants in coma or other disorder of consciousness (DOC; i.e., Unresponsive Wakefulness Syndrome [UWS] or Minimally Conscious State…
- Conditions
- Coma, Disorder of Consciousness, Minimally Conscious State, Vegetative State
- Trial name
- NCT03826407
- Where
- Canada
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- McMaster University
Disorder of Consciousness
A Promising Tool for Predicting Consciousness Evolution in Prolonged Disorders of Consciousness
The research contains two parts. Part 1: To explore whether EEG responses to zolpidem can assess consciousness circuit integrity and predict the evolution of consciousness in patients with prolonged disorders of consciousness…
- Trial name
- NCT02948660
- Testing
- Zolpidem Tartrate Tablets
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness
fNIRS for Disorders of Consciousness
The goal of this observational study is to learn whether functional near-infrared spectroscopy (fNIRS) can measure brain activity in healthy adults and in people with disorders of consciousness (DoC) in the neuro-intensive care…
- Conditions
- Disorders of Consciousness Due to Severe Brain Injury, Disorders of Consciousness, Coma, Minimally Conscious State
- Trial name
- NCT07485361
- Testing
- Functional Near-Infrared Spectroscopy Monitoring
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Consciousness Disorders, Disorders of Consciousness Due to Severe Brain Injury
Ultrasound Stimulation for Patients in a Disorder of Consciousness
The overall aim of this study is to develop an intervention that can help recovery in patients surviving severe brain injury but failing to fully recover.
- Trial name
- tFUS (NCT06939348)
- Testing
- The Brainsonix BX Pulsar 1002 was designed to deliver low-intensity focused ultrasound pulsations (LIFUP) to the human brain.
- Where
- 4 sites in United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Chronic and Severe Post-coma Disorders of Consciousness (Permanent Vegetative State, Minimally Conscious State)
Study of Conscious Behavior Under Low-frequency Deep Brain Stimulation in Chronic and Severe Post-coma Disorders of Consciousness
Chronic post-coma consciousness impairment is a severe handicap. Preliminary studies suggest that deep brain stimulation of the thalamic-tegmental reticular system could improve consciousness disorders, and facilitate the…
- Trial name
- Post-coma DBS (NCT01718249)
- Testing
- Implantable neurostimulation system
- Where
- France
- Volunteers
- 5 people
- Sponsor
- University Hospital, Clermont-Ferrand
Disorder of Consciousness
Clinical Validity of the Minimally Conscious State "Plus" and "Minus"
The goal of this observational retrospective study is to investigate and compare the clinical evolution of a sample of patients with the diagnosis of MCS+ versus MCS- according to the CRS-R.
- Trial name
- NCT05954650
- Testing
- Rehabilitation
- Where
- 2 sites in Spain
- Volunteers
- 80 people
- Sponsor
- Hospitales Nisa
Patients in Minimally Conscious State
Personalized Objects Can Improve the Diagnosis of EMCS From MCS
In this study，researchers will use personalized objects to assess patients' level of consciousness in chronic patients in minimally conscious state (MCS).
- Trial name
- NCT02988206
- Testing
- Personalized Objects, non-personalized Objects
- Volunteers
- 21 people
- Sponsor
- Hangzhou Normal University