Clinical trials: Minimally Conscious State
Minimally Conscious State, Vegetative State
The Initiation of Swallowing Can Indicate the Prognosis of DOC
This study is aimed to detect the initiation of swallowing act in DOC patients, to find if it is a good item as a stimulus and to detect the relationship between the initiation of swallowing act and the prognosis of DOC patients.
- Trial name
- NCT03508336
- Testing
- Coma Recovery Scale-Revised
- Where
- China
- Volunteers
- 24 people
- Sponsor
- Hangzhou Normal University
Consciousness Disorder
Multimodal Neuroprognostication in Disorders of Consciousness
Disorders of consciousness frequently occur at the acute phase of brain injuries. For the most severe cases, consciousness impairment can be prolonged.
- Trial name
- M-Neuro-DoC (NCT04534777)
- Testing
- repeated neurological, behavioral assessments and conventional, quantitative and functional brain imagery
- Where
- France
- Volunteers
- 500 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Patients in Minimally Conscious State
Personalized Objects Can Improve the Diagnosis of EMCS From MCS
In this study，researchers will use personalized objects to assess patients' level of consciousness in chronic patients in minimally conscious state (MCS).
- Trial name
- NCT02988206
- Testing
- Personalized Objects, non-personalized Objects
- Volunteers
- 21 people
- Sponsor
- Hangzhou Normal University
Brain Injury
A Study of IBRF Disorders of Consciousness Advanced Care/MultiModal Care Protocol in Severe Disorders of Consciousness
This is a study to evaluate the safety and efficacy of the IBRF ACP/MCP intervention protocol in patients with severe disorders of consciousness (SDOC).
- Trial name
- NCT02696512
- Testing
- Polypharmacy using FDA-approved products, Median Nerve Stimulation (MNS), Nutraceutical Supplementation
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- International Brain Research Foundation
Disorder of Consciousness, Unresponsive Wakefulness Syndrome
Behavioral Assessment of Nociception on NCS-R
The aim of this study was to investigate the relationship between behaviorally assessed consciousness levels and responsiveness to nociception in patients with disorders of consciousness (DOC)
- Conditions
- Disorder of Consciousness, Unresponsive Wakefulness Syndrome, Minimally Conscious State
- Trial name
- NCT04137497
- Testing
- The Coma Recovery Scale-Revised and the Nociception Coma Scale-Revised (NCS-R)
- Where
- China
- Volunteers
- 140 people
- Sponsor
- Hangzhou Normal University
Minimally Conscious State, Vegetative State
Validation of the Chinese Version of the SECONDs
The aim of this study was to translate the SECONDs from English into Chinese and determine the validity of this Chinese version
- Trial name
- NCT04687553
- Testing
- Simplified Evaluation of CONsciousness Disorders (SECONDs)
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Hangzhou Normal University
Postcomatose Unawareness State, Minimally Conscious State
Eye Tracking Technology in the Diagnosis of Neurological Patients
Demonstrating that diagnostics of the state of consciousness and cognitive functions of patients with consciousness disorders performed using C-Eye X (based on eye-tracking technology) allows a more objective assessment of state…
- Conditions
- Postcomatose Unawareness State, Minimally Conscious State, Vegetative State, Disorder of Consciousness
- Trial name
- NCT05536921
- Where
- 5 sites in Poland
- Volunteers
- 90 people
- Sponsor
- AssisTech Sp. z o.o.
Traumatic Brain Injury
Amantadine + rTMS as a Neurotherapeutic for Disordered Consciousness
The purpose of this study is to examine the safety and efficacy of repetitive transcranial magnetic stimulation (rTMS) combined with Amantadine relative to rTMS Alone and Amantadine Alone for persons in chronic states of…
- Trial name
- NCT02025439
- Testing
- rTMS, Amantadine
- Where
- 2 sites in United States
- Volunteers
- 4 people
- Sponsor
- Edward Hines Jr. VA Hospital
Minimally Conscious State, Vegetative State
The Effects of Olfactory Stimulation on Diagnosis and Prognosis of DOC Patients
Analyze the behavioral response of patients with disorders of consciousness through olfactory stimulation, compare the response of olfactory stimulation in patients with different consciousness, and analyze the impact of…
- Trial name
- NCT03732092
- Testing
- Coma Recovery Scale-Revised
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Jing Wang
Disorder of Consciousness
Information of the Coma Recovery Scale-Revised for Neurobehavioral State and Recovery of Consciousness Prediction
Background: The Coma Recovery Scale-Revised (CRS-R) is the most recommended instrument to examine the neurobehavioral condition of individuals with disorders of consciousness (DOCs).
- Trial name
- CRS-R_Info (NCT05819177)
- Testing
- Rehabilitation program
- Where
- 2 sites in Spain
- Volunteers
- 171 people
- Sponsor
- Hospitales Nisa
Consciousness Disorder
Detection of Arousal With Facial Micro-expression in Severe Brain-damaged Patient
Severe brain injuries lead to disorders of consciousness after coma. During this awakening period, detection of arousal is critical to the adaptation of medical strategy, but global paralysis, including facial expression, make…
- Trial name
- DAME (NCT03023657)
- Testing
- Detection of arousal
- Where
- 2 sites in France
- Volunteers
- 3 people
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Persistent Vegetative State
Emotion Assessment to Study Consciousness in Awakening Patients
After a coma, one important challenge is the detection of awareness with patients with disorders of consciousness. For some patients, the only behavioral manifestation indicative of awareness is an appropriate emotional response.
- Trial name
- EmotiCones (NCT03706170)
- Testing
- Physiological recording in response to different types of stimuli, EEG recording in response to different types of stimuli
- Where
- France
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Failed Moderate Sedation During Procedure, Minimally Conscious State
Dexmedetomidine vs Midazolam for Intraoperative Sedation
This randomized, open clinical trial sought to compare the use of Midazolam and Dexmedetomidine during surgery in patients under regional anesthesia.
- Trial name
- NCT02878837
- Testing
- Dexmedetomidine, Midazolam
- Where
- Brazil
- Volunteers
- 120 people
- Sponsor
- Instituto de Assistencia Medica ao Servidor Publico Estadual, Sao Paulo
Minimally Conscious States Due to Traumatic Brain Injury, Persistently Vegetative States Due to Traumatic Brain Injury
Vagus Nerve Stimulation to Augment Recovery From Minimally Conscious or Persistently Vegetative States After Traumatic Brain Injury
Traumatic brain injury has a high morbidity and mortality in both civilian and military populations. Blast and other mechanisms of traumatic brain injury damage the brain by causing neurons to disconnect and atrophy.
- Trial name
- NCT01260090
- Testing
- Vagus nerve stimulation;, No stimulation
- Where
- United States
- Sponsor
- VA New York Harbor Healthcare System
Disorders of Consciousness
Window On the Brain
Disorders of consciousness (DOC) diagnosis suffers from the difficulty to measure the level of consciousness due to the variability associated with behavioural assessments and the difficulty in detecting the residual level of…
- Trial name
- WOB (NCT06693492)
- Testing
- Ultrasound technique for diagnosis; Focused Ultrasound Stimulation for intervention
- Where
- 4 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Consciousness Disorder, Brain Injuries
Neural, Behavioural, and Clinical Effects of tDCS in PDOC; Feasibility Study
This study evaluates the feasibility of an experimental protocol that combines advanced multi-modal imaging of the brain with clinical and behavioural scales to characterise the neural, behavioural, and clinical effects of…
- Conditions
- Consciousness Disorder, Brain Injuries, Vegetative State, Minimally Conscious State
- Trial name
- RAINDROP (NCT04248946)
- Testing
- Transcranial direct current stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 15 people
- Sponsor
- University of Birmingham
Vegetative State, Minimally Conscious State
Fronto-parietal tDCS in Severely Brain Injured Patients With Disorders of Consciousness
Previous studies showed that anodal transcranial direct current stimulation (tDCS) transiently improves performance of memory and attention.
- Conditions
- Vegetative State, Minimally Conscious State, Disorders of Consciousness
- Trial name
- NCT02626403
- Testing
- Anodal tDCS
- Where
- Belgium
- Volunteers
- 46 people
- Sponsor
- University of Liege
Brain Injuries, Minimally Conscious State
Effects of Whole-body Vibration Exercise in Brain Injury Patients With Minimally Conscious State
The purpose of this study is to investigate the effect of the whole body vibration exercise on cortical activity and consciousness Level in brain injury patients with minimally conscious state.
- Trial name
- NCT03389113
- Testing
- Whole body vibration, Exersice
- Where
- South Korea
- Volunteers
- 10 people
- Sponsor
- Samsung Medical Center