Clinical trials: Minimization, Harm
Opioid Use Disorder
Telehealth Treatment for Opioid Use Disorders
This study aims to use an Opioid Use Disorder (OUD) Telehealth Platform to reduce overdose events. This telehealth platform will be pilot tested to evaluate its preliminary efficacy in terms of motivating engagement in…
- Trial name
- NCT05832879
- Testing
- OUD Telehealth Platform
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Yale University
Alcohol Drinking, Social Norms
Implementation of a Web-based Alcohol and Other Drug Prevention Intervention for Collegiate Student-athletes
The broad aim of the proposed study is to use the innovative Multiphase Optimization Strategy to develop a highly effective Internet-delivered intervention, myPlaybook, for the prevention of substance use among college…
- Conditions
- Alcohol Drinking, Social Norms, Expectations, Harm Reduction
- Trial name
- NCT04253158
- Testing
- Educational standard, Educational standard and Harm prevention, Educational standard and Expectancies
- Volunteers
- 3,859 people, healthy volunteers welcome
- Sponsor
- Prevention Strategies, LLC
Tobacco Use
Comparative Tobacco Interventions for Individuals With Severe and Persisting Behavioral Health Disorders
The aim of this pilot intervention is to examine the acceptability of a harm reduction intervention approach to tobacco use for individuals with serious behavioral health disorders and its association with a decrease in smoking.
- Trial name
- THRRP (NCT04523948)
- Testing
- Behavioral and pharmacological support to reduce combustible tobacco use.
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Rose Research Center, LLC
Occupational Health
Adaptation of SFA for HRW
The aim of this study is to pilot and test the feasibility, acceptability, and effectiveness of a Stress First Aid (SFA) intervention adapted for Harm Reduction Workers (HRWs) serving Persons Who Use Drugs.
- Trial name
- NCT07149155
- Testing
- Stress First Aid for Harm Reduction Workers
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Suzannah Creech
Interventions to Enhance Emergency Health Care
EQUIP Emergency: Promoting Health Equity for Indigenous and Non-Indigenous People in Emergency Departments
Emergency Departments (EDs) in Canada often operate over-capacity and are under significant pressures. In this environment, particular groups of people experience inadequate and inequitable treatment in EDs, including Indigenous…
- Trial name
- NCT03369678
- Where
- 3 sites in Canada
- Volunteers
- 5,439 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Alcohol Use, Alcohol Drinking
Young Adult Naturalistic Alcohol Study (YANAS) Using Smartphone Technology in a Simulated Laboratory Environment
It is important to explore use of technology to reduce drinking. The purpose of this research study is to compare different types of mobile technology for their effects on alcohol drinking and ratings of usability among young…
- Conditions
- Alcohol Use, Alcohol Drinking, Drinking Behavior
- Trial name
- NCT02841735
- Testing
- Smartphone breathalyzer device/app use, BAC estimator app use, Text messaging procedure
- Where
- United States
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Florida
Viral Hepatitis C
Serious Game Interventions to Reduce Viral Hepatitis C Among PLWH-MSM
The study is aimed to provide high-risk, HIV-infection, men who have sex with men (MSM) with healthcare education regarding viral hepatitis C, through either serious game intervention or traditional online health education.
- Trial name
- NCT05751889
- Testing
- Serious Game, Traditional Health Education
- Where
- Taiwan
- Volunteers
- 1,320 people
- Sponsor
- National Taiwan University Hospital
Alcohol Abuse
Impact of a Brief Motivational Interview on Drinking Behaviors of At Risk Drinkers Screened in the Emergency Room
Alcohol abuse is associated with injury, chronic illness, absenteeism from work, and social costs to families and communities. The goal of this project is to translate motivational interventions successful in the primary care…
- Trial name
- NCT00183183
- Testing
- Screening and Brief Intervention
- Where
- 15 sites in United States
- Volunteers
- 1,137 people, healthy volunteers welcome
- Sponsor
- UConn Health
E-cigarette Use, Cigarette Smoking
Noncombustible Nicotine Delivery Systems as Potential Harm Reduction Tools for Persistent Cigarette Smokers
This between-subjects study aims to evaluate whether e-cigarettes (ECIGS) versus oral nicotine pouches (ONPS) more readily substitute for combustible cigarettes among 200 cigarette smokers.
- Conditions
- E-cigarette Use, Cigarette Smoking, Harm Reduction, Tobacco Use
- Trial name
- NCT06372899
- Testing
- E-cigarettes, Oral nicotine pouches
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Abramson Cancer Center at Penn Medicine
Opioid Overdose, Drug Overdose
Preventing Overdose Using Information and Data From the Environment
The objectives of this project are to leverage surveillance data to predict future overdose outbreaks, and to evaluate the impact of a randomized, statewide, community-level intervention trial to target overdose prevention…
- Trial name
- PROVIDENT (NCT05096429)
- Testing
- PROVIDENT
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Brown University
Smoking Cessation, Harm Reduction
Combination of E-cigarettes and Varenicline for Tobacco Harm Reduction
This open-label study will explore the impact of varenicline on the process of switching from combustible cigarettes (CC) to an e-cigarette.
- Trial name
- EVAR (NCT04210180)
- Testing
- Varenicline, e-cigarette
- Where
- 2 sites in United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Alcohol Use
Alcohol Related Risk Reduction in Veterans
This project is designed to refine and evaluate the feasibility and preliminary effectiveness of a brief, telephone-administered alcohol risk reduction intervention for Veterans.
- Trial name
- NCT06768684
- Testing
- Brief behavioral counseling
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Iowa City Veterans Affairs Medical Center
Cigarette Smoking Behavior, E-Cigarette Use
Project E-Shift: A Harm Reduction Intervention for Chronically Unhoused Smokers.
This pilot randomized trial tested whether switching to e-cigarettes, compared with standard nicotine replacement therapy (NRT; patch and gum), helped adults with a history of chronic homelessness stop smoking combustible…
- Trial name
- ESHIFT (NCT07897058)
- Testing
- E-cigarette, Nicotine replacement therapy (patch, gum), both arms, CO-contingent financial incentives, both arms
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Thomas Jefferson University
Inflammation, Inflammatory Response
Cannabis Observational Study on Mood, Inflammation, and Cognition
This project examines the effects of cannabis on cognition and other domains of function and whether those effects are dependent upon the ratio of THC to CBD in the product.
- Conditions
- Inflammation, Inflammatory Response, Mood, Cognitive Change
- Trial name
- COSMIC (NCT03522103)
- Where
- United States
- Volunteers
- 421 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Smoking Cessation, Smokeless Tobacco
In-vivo Extraction of Pb, Cd andTSNA From Swedish Snus
In an open label, randomized, two-way cross-over study, 32 male healthy regular snus users will be given repeated doses of four different types of portion snus: "General", "Catch", "Catch Mini" and "Catch Dry Mini".
- Conditions
- Smoking Cessation, Smokeless Tobacco, Harm Reduction
- Trial name
- SMWS03 (NCT01249339)
- Testing
- Buccal Administration of nicotine
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Contract Research Organization el AB
Opioid Use Disorder, Opioid Use
Overdose Recovery and Care Access (ORCA) Qualitative Stakeholder Interviews and County-level Data
The study is a quasi-experimental investigation of a sub-acute stabilization center (SASC) for people who have had or are at risk for having an opioid overdose and have an encounter with Seattle Fire Department emergency medical…
- Trial name
- NCT06768814
- Testing
- Sub-acute stabilization
- Where
- United States
- Volunteers
- 40,000 people
- Sponsor
- University of Washington
HIV, HIV Self-testing
Our Healthbox - Evaluating Interactive Dispensing Systems for Low-Barrier Access to HIV Testing and Harm Reduction.
When REACH Nexus at MAP Centre for Urban Solutions out of St. Michael's Hospital launched its signature program, I'm Ready in 2021, our goal was to democratize access to free HIV self-testing to reach the undiagnosed in Canada.
- Conditions
- HIV, HIV Self-testing, Harm Reduction, Sexually Transmitted Diseases
- Trial name
- NCT05516069
- Testing
- Our Healthbox (smart vending machine or interactive dispensing system)
- Where
- Canada
- Volunteers
- 5,000 people, healthy volunteers welcome
- Sponsor
- Unity Health Toronto
Smoking, Tobacco
A Study to Determine the Effects of ENDS Flavor Availability on Abstinence Within Smokers
The overall purpose of this study will be to assess primary combustible cigarette users' abstinence from smoking their usual brand of combustible cigarettes at the end of the study, when provided with an electronic nicotine…
- Trial name
- NCT07598136
- Testing
- P2613422, P2611222, P2615522
- Where
- 7 sites in United States
- Volunteers
- 1,280 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Tobacco Smoking, Harm Reduction
Smoking Harm Reduction Using E-cigarettes and Cytisine
Smoking remains the leading cause of preventable death globally, with high prevalence in disadvantaged populations despite access to free nicotine replacement therapy (NRT) and counseling through Ontario's STOP Program.
- Conditions
- Tobacco Smoking, Harm Reduction, Nicotine
- Trial name
- SHRECC (NCT07274475)
- Testing
- E-cigarette e-liquid, Cytisine
- Volunteers
- 6,000 people
- Sponsor
- Centre for Addiction and Mental Health
Stress Disorders, Post-Traumatic, Opioid Use Disorder
New Beginnings Following Trauma
Posttraumatic stress disorder (PTSD) is associated with increased rates of prescription opioid misuse, high-risk opioid use, illicit use of substances, and overdose (Meshberg-Cohen et al., 2021) Some research has demonstrated…
- Trial name
- NCT05817344
- Testing
- Written Exposure Therapy - Integrated
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Jesse McCann