Clinical trials: Minocycline
Prostate Cancer, Carcinoma of the Rectum
Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium
Postoperative cognitive dysfunction (POCD) and postoperative delirium occurs mainly in aged patients. POCD and POD may increase the mortality and morbidity.
- Conditions
- Prostate Cancer, Carcinoma of the Rectum, Colon Cancer, Renal Carcinoma
- Trial name
- MAPOCD (NCT02928692)
- Testing
- Minocycline
- Where
- 5 sites in China
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Healthy
Bioequivalecne Study of Minocycline 100mg Tablets Under Fed Conditions
The purpose of this study was to determine the bioequivalence of Minocycline formulations after administration of single doses to normal healthy subjects under fed conditions.
- Trial name
- NCT00777413
- Testing
- Minocycline 100mg Tablets
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Mood, Cognitive Change
The Effect of Acute Minocycline Administration on Emotional Processing and Cognition in Healthy Volunteers
There is growing interest in the possibility of producing more effective antidepressant treatments that target a wider range of pathways involved in depression, including anti-inflammatory and anti-glutamatergic systems.
- Trial name
- NCT03768557
- Testing
- Minocycline
- Where
- United Kingdom
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Healthy
Dermal Photo Allergic Skin Reaction
A 6-Week, Randomized Study to Evaluate the Potential of FMX-101, 4% And Vehicle to Induce a Photo Allergic Skin Reaction in Healthy Volunteers, Using a Controlled Photo Patch Test Design
- Trial name
- NCT04070755
- Testing
- FMX-101
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Vyne Therapeutics Inc.
Normal Healthy Volunteers
Study to Evaluate Safety, Tolerability, and Pharmacokinetics of Minocin (Minocycline) for Injection in Healthy Adults
This was a Phase 1, randomized, double-blind, placebo-controlled, single and multiple ascending dose study of the safety, tolerability, and pharmacokinetics of Minocin (minocycline) for injection in healthy adult participants.
- Trial name
- NCT02802631
- Testing
- Minocin (minocycline) for Injection
- Where
- Netherlands
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Rempex (a wholly owned subsidiary of Melinta Therapeutics, Inc.)
Intracerebral Hemorrhage
Use of Minocycline in Intracerebral Hemorrhage
To date, no neuroprotective drugs have demonstrated clinical efficacy in intracerebral hemorrhage (ICH). This study will use intravenous (IV) minocycline in ICH to evaluate for (1) safety/ tolerability and (2) evaluate for…
- Trial name
- NCT03040128
- Testing
- Minocycline, normal saline infusion
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Pharmacokinetics
A Comparative Bioavailability Study of DFD-29 Capsules 40 mg Versus SOLODYN® Tablets 105 mg, Under Fasting & Fed Conditions in Healthy Adult Human Subjects
Single-center, randomized, open-label, laboratory-blinded, 3-treatment, 3-period, 6-sequence, single-dose, crossover study.
- Trial name
- NCT05452785
- Testing
- DFD-29 (Minocycline) Fasting, DFD-29 (Minocycline) Fed, Solodyn (Minocycline) Fasting
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Journey Medical Corporation
Acne
Combination Treatment for Moderate to Severe Acne
To determine if a combination of three currently approved acne products are safe and effective for the treatment of moderate to severe acne
- Trial name
- NCT01206348
- Testing
- Minocycline, Clindamycin, Tretinoin, Benzoyl Peroxide
- Where
- 10 sites in United States
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Medicis Global Service Corporation
Skin Diseases
Minocycline Bioequivalence Study
This study compared the bioavailability of two formulations 100 mg (one capsule or other respectively) of each one of the products, of Minocycline, under fasting conditions, in healthy Mexican volunteers of both sexes.
- Trial name
- NCT01938508
- Testing
- Minocycline
- Where
- Mexico
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Periodontitis, Adult
Locally Delivered Minocycline in Advanced Periodontitis
Local drug delivery provides higher concentrations in the availability of the drug at the specific infected sites with the advantage of sustained release.
- Trial name
- NCT04076098
- Testing
- Minocycline Hydrochloride
- Where
- Malaysia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mahsa University
Healthy
Bioequivalence Study of Minocycline HCl 135 mg ER Tablet Sunder Fed Conditions
The study was conducted as an open-label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioequivalence study comparing Minocycline hydrochloride extended release tablets 135 mg…
- Trial name
- NCT02312609
- Testing
- Minocycline hydrochloride
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Alcohol Drinking, Alcohol-Related Disorders
Neuroimmune Dysfunction in Alcohol Use Disorder
The objective of this proposal is to advance medication development for alcohol use disorder by examining the efficacy and mechanisms of action of minocycline, a neuroimmune modulator, as a potential treatment.
- Conditions
- Alcohol Drinking, Alcohol-Related Disorders, Disease, Inflammation
- Trial name
- NCT04210713
- Testing
- Minocycline, Sugar pill
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Schizophrenia
The Study of Minocycline for Negative and Cognitive Symptoms in Schizophrenia
The purpose of this study is to determine whether minocycline are effective in the treatment of negative and cognitive symptoms in schizophrenia.
- Trial name
- NCT01493622
- Testing
- minocycline
- Where
- China
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- Central South University
HIV Infection
A Pilot Study of the Effect of Minocycline on Cerebrospinal Fluid HIV-1 Infection
This will be an uncontrolled, open-labelled pilot study exploring whether minocycline has a measurable and selective effect on HIV infection of the central nervous system.
- Trial name
- NCT01064752
- Testing
- Minocycline
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Human Volunteer
A Study to Examine the Effects of Minocycline Extended-Release Tablets on Sperm Production in Human Males.
Researchers want to find out how Minocycline Extended-Release Tablets affect sperm-production in healthy males. The study will include Minocycline Extended-Release Tablets, a new once-daily formulation of minocycline, compared…
- Trial name
- NCT00765336
- Testing
- minocycline extended release
- Where
- 10 sites in United States
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Medicis Pharmaceutical Corporation
Normal Healthy Volunteers
Safety and PK Trial Evaluating the Plasma, Epithelial Lining Fluid, and Alveolar Macrophage Concentrations of Minocin IV
This is a phase 1, safety and PK Open-Label trial evaluating the plasma, epithelial lining fluid, and alveolar macrophage concentrations of intravenous Minocin® (Minocycline) for injection in healthy adult subjects.
- Trial name
- NCT03291158
- Testing
- Minocycline
- Where
- Austria
- Volunteers
- healthy volunteers welcome
- Sponsor
- Rempex Pharmaceuticals (a wholly owned subsidiary of The Medicines Company)
Post-traumatic Stress Disorder, Cocaine Use Disorder
Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories
An investigation of the effect of matrix-metalloproteinase-(MMP)-9 inhibition with minocycline on the reconsolidation of trauma- or cocaine-related memories
- Trial name
- Memocycline (NCT05902819)
- Testing
- Imagery, Minocycline
- Where
- Switzerland
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Psychiatric University Hospital, Zurich
Healthy
Bioequivalence Study of Minocycline 100mg Tablets Under Fasting Conditions
The purpose of this study was to determine the bioequivalence of Minocycline formulations after administration of single doses to normal healthy subjects under fasted conditions.
- Trial name
- NCT00776542
- Testing
- Minocycline 100mg Tablets
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Healthy
Bioequivalence Study of Minocycline HCl 135 mg ER Tablet Sunder Fasting Conditions
The study was conducted as an open-label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioequivalence study comparing Minocycline hydrochloride extended release tablets 135 mg…
- Trial name
- NCT02312297
- Testing
- Minocycline hydrochloride
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited
Fragile X Syndrome
Add-on Pilot Trial of Minocycline to Treat Fragile X Syndrome
Fragile X Syndrome (FXS) is the most common known inherited form of mental impairment, developmental disability and autism. Minocycline is an antibiotic that has recently been used to treat the mouse model for Fragile X, and was…
- Trial name
- NCT00858689
- Testing
- Minocycline
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- FRAXA Research Foundation