Clinical trials: Minocycline
Bipolar Depression
Minocycline for Bipolar Depression
The purpose of this study is to evaluate minocycline as a potential treatment for bipolar depression when added to a mood-stabilizing medication.
- Trial name
- NCT01514422
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Pneumonia
The Effect of Nebulization of Alkaline Solution on Treating XDRAB Pneumonia With C/S Plus Minocycline
The mortality of pneumonia with extensively drug resistant Acinetobacter baumannii (XDRAB) is still high, even if these patients received certain strong anti-infection treatment such us the combination of cefoperazone-sulbactam…
- Trial name
- NAEDRAP (NCT02060149)
- Testing
- C/S plus minocycline., nebulization with pH 7.4 solution, nebulization with pH 7.8 solution
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Xijing Hospital
Colorectal Cancer
Phase II Study of Minocycline for Reducing Symptom Burden in Colorectal Patients
The goal of this clinical research study is to learn if minocycline can reduce numbness, pain, and/or loss of motor function in patients with colorectal cancer. In this study, minocycline will be compared to a placebo.
- Trial name
- NCT01906008
- Testing
- Minocycline, Questionnaires, Sensory Test
- Where
- 2 sites in United States
- Volunteers
- 122 people
- Sponsor
- M.D. Anderson Cancer Center
Multiple Sclerosis, Clinically Isolated Syndrome
Minocycline in MS: Confirmation of Benefit
This is an open-label, single-arm clinical trial. Trial participants will include men and women, aged 18-60 years who have had a first demyelinating event within the previous 180 days and who have brain magnetic resonance imaging…
- Trial name
- MS (NCT04291456)
- Testing
- Minocycline 100mg
- Where
- Canada
- Volunteers
- 9 people
- Sponsor
- University of Calgary
Intracerebral Hemorrhage
A Pilot Study of Minocycline in Intracerebral Hemorrhage Patients
The MACH Trial is a pilot study of 400mg minocycline over five days in acute intracerebral hemorrhage patients. The study will evaluation the safety and efficacy of minocycline in intracerebral hemorrhage patients.
- Trial name
- MACH (NCT01805895)
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Augusta University
Acne Vulgaris
To Evaluate the Efficacy and Safety of Minocycline Hydrochloride Foam in the Treatment of Moderate-to-severe Acne Vulgaris
This is a randomized, multicenter, double-blind, vehicle-controlled, 2-arm study to evaluate the safety and efficacy in 12 weeks of FMX101 minocycline foam, 4%, compared to vehicle, in the treatment of subjects with moderate to…
- Trial name
- NCT04960930
- Testing
- FMX101
- Where
- 29 sites in China
- Volunteers
- 372 people
- Sponsor
- Cutia Therapeutics (Shanghai) Co., Ltd
Negative and Cognitive Symptoms in Schizophrenia
Minocycline for the Treatment of Early-Phase Schizophrenia
Current antipsychotics have only a limited effect on two core symptoms of schizophrenia, negative symptoms and cognitive deficits.
- Trial name
- NCT00733057
- Testing
- Minocycline
- Where
- Israel
- Volunteers
- 70 people
- Sponsor
- Shalvata Mental Health Center
Intracerebral Hemorrhage
Use of Minocycline in Intracerebral Hemorrhage
To date, no neuroprotective drugs have demonstrated clinical efficacy in intracerebral hemorrhage (ICH). This study will use intravenous (IV) minocycline in ICH to evaluate for (1) safety/ tolerability and (2) evaluate for…
- Trial name
- NCT03040128
- Testing
- Minocycline, normal saline infusion
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Fasting
Minocycline HCl Extended Release Tablets 135 mg Oral Bioequivalence Study
To determine single-dose oral bioequivalence of Minocycline HCl Extended Release Tablets 135 mg manufactured by Amneal Pharmaceuticals Co.(I)Pvt.
- Trial name
- Minocycline (NCT01067001)
- Where
- India
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Amneal Pharmaceuticals Co. India Private Limited
Periodontitis
Efficacy of Noisome as A Carrier of Locally Delivered Minocycline Hydrochloride Gel
The goal of this clinical trial is to compare the efficacy of Noisome as carrier of minocycline hydrochloride gel to minocycline hydrochloride in Stage II or Stage III Periodontitis .
- Trial name
- NCT06255067
- Testing
- Minocycline hydrochloride with noisome carrier, Minocycline Hydrochloride only
- Where
- 2 sites in Egypt
- Volunteers
- 30 people
- Sponsor
- Ain Shams University
Rosacea
Efficacy of Oral Minocycline (Solodyn) and Oral Minocycline (Solodyn) Plus Azelaic Acid (Finacea) for Acne Rosacea
Rosacea is one of the most commonly occurring dermatoses treated by dermatologist today. Rosacea is an inflammatory condition of the skin presenting as flushing and or blushing along with redness, swelling, telangiectasia, and…
- Trial name
- NCT05014906
- Testing
- Minocycline 45 MG, Azelaic acid
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Dermatology Specialists Research
Major Depressive Disorder
Adjunct Minocyline in Treatment-resistant Depression
This study examines the antidepressant efficacy of minocycline as an adjunct to an antidepressant standard treatment (AD-ST), for patients with unipolar major depressive disorder (MDD).
- Trial name
- Mino-TRD (NCT02456948)
- Testing
- Minocycline
- Where
- 9 sites in Germany
- Volunteers
- 168 people
- Sponsor
- Charite University, Berlin, Germany
Aneurysms, Arteriovenous Malformations
Tetracycline-Derivatives for Treatment of Cerebral Arteriovenous Malformations and Aneurysms
The purpose of this pilot study is to investigate the use of minocycline and doxycycline as medical therapy for inoperable or partially treated arteriovenous malformations (AVMs) and giant aneurysms.
- Trial name
- NCT00243893
- Testing
- minocycline, doxycycline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- University of California, San Francisco
Post-traumatic Stress Disorder, Cocaine Use Disorder
Reconsolidation Blockade of Intrusive Trauma- and Cocaine-related Memories
An investigation of the effect of matrix-metalloproteinase-(MMP)-9 inhibition with minocycline on the reconsolidation of trauma- or cocaine-related memories
- Trial name
- Memocycline (NCT05902819)
- Testing
- Imagery, Minocycline
- Where
- Switzerland
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Psychiatric University Hospital, Zurich
Primary Sclerosing Cholangitis
Minocycline in Primary Sclerosing Cholangitis (PSC)
The purpose of the study is to see how safe and effective minocycline is in the treatment of Primary Sclerosing Cholangitis (PSC).
- Trial name
- NCT00630942
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Mayo Clinic
Oral Lichen Planus
The Efficacy of Topical Minocycline in Managing Symptomatic Oral Lichen Planus
The aim of the present study is to assess the clinical efficacy of topical minocyclin in managing of symptoms associated with oral lichen planus (OLP).
- Trial name
- NCT01083420
- Testing
- Minocycline, Dexamethasone
- Volunteers
- 30 people
- Sponsor
- Sheba Medical Center
Lung Cancer
Minocycline Study in Non Small Cell Lung Cancer (NSCLC) Patients for Chemoradiation Therapy
The goal of this clinical research study is to learn if minocycline can reduce the side effects reported by patients with NSCLC who are receiving chemoradiation therapy. In this study, minocycline will be compared to a placebo.
- Trial name
- NCT01636934
- Testing
- Minocycline, Questionnaires
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- M.D. Anderson Cancer Center
Acute Ischemic Stroke, Endovascular Thrombectomy
Minocycline After Successful Endovascular Thrombectomy Recanalization in Posterior Circulation Arterial Occlusion (ATTRACTION-MINOP)
Acute ischemic stroke (AIS) is a leading cause of mortality and long-term disability worldwide. Among these, stroke caused by large vessel occlusion (LVO) are associated with particularly poor outcomes.
- Conditions
- Acute Ischemic Stroke, Endovascular Thrombectomy, Minocycline, Posterior Circulation
- Trial name
- NCT07594301
- Testing
- Minocycline hydrochloride capsule
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Xiang Luo
Age-Related Macular Degeneration
Evaluation of Oral Minocycline in the Treatment of Geographic Atrophy Associated With Age-Related Macular Degeneration
Background: Age-related macular degeneration (AMD) is the main reason older people lose their vision. It affects the macula, the center of the retina needed for sharp, clear vision.
- Trial name
- NCT02564978
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- National Eye Institute (NEI)
Acne Vulgaris
Comparison of Tazarotene and Minocycline Therapies for Maintenance of Facial Acne Vulgaris
The purpose of the study is to compare the efficacy of three maintenance regimens (topical tazarotene, oral minocycline, or both) in sustaining improvement in acne.
- Trial name
- NCT00145106
- Where
- United States
- Volunteers
- 189 people
- Sponsor
- KGL, Inc.