Clinical trials: Minocycline
Stroke, Acute, Ischemic Stroke
Maimonides Minocycline in Stroke Study
The goal of this study is to determine if oral Minocycline's proposed neuroprotective effects further improve the clinical outcomes, including mortality, of acute stroke patients beyond the current standard stroke care in a large…
- Conditions
- Stroke, Acute, Ischemic Stroke, Hemorrhagic Stroke, Mortality
- Trial name
- NCT06107725
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Maimonides Medical Center
Retinitis Pigmentosa, Inherited Retinal Dystrophy
Minocycline Treatment in Retinitis Pigmentosa
The aim of this study is to evaluate the efficacy and safety of oral minocycline (100mg/d), administered for 6 months, for the treatment of patients with retinitis pigments(RP).
- Conditions
- Retinitis Pigmentosa, Inherited Retinal Dystrophy, Retina Disorder
- Trial name
- NCT04068207
- Testing
- Minocycline
- Where
- China
- Volunteers
- 35 people
- Sponsor
- Sun Yat-sen University
Acute Ischemic Stroke
Minocycline Efficacy in Improving Neurological Outcome of Patients Who Undergo Endovascular Revascularization for Acute Ischemic Stroke
The study will be a prospective, randomized, double- blinded placebo, single center pilot clinical trial. Patients with acute ischemic stroke due to large vessel occlusion undergoing endovascular thrombectomy will be included.
- Trial name
- NCT05367362
- Testing
- Minocyclin
- Sponsor
- State University of New York at Buffalo
Bipolar Depression
Minocycline for Bipolar Depression
The purpose of this study is to evaluate minocycline as a potential treatment for bipolar depression when added to a mood-stabilizing medication.
- Trial name
- NCT01514422
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Intracerebral Hemorrhage
Use of Minocycline in Intracerebral Hemorrhage
To date, no neuroprotective drugs have demonstrated clinical efficacy in intracerebral hemorrhage (ICH). This study will use intravenous (IV) minocycline in ICH to evaluate for (1) safety/ tolerability and (2) evaluate for…
- Trial name
- NCT03040128
- Testing
- Minocycline, normal saline infusion
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Tennessee
Pneumothorax
Pleural Abrasion Plus Minocycline Versus Apical Pleurectomy for Primary Spontaneous Pneumothorax
Optimal surgical management of primary spontaneous pneumothorax has been a matter of devate, especially regarding the method of pleurodesis.
- Trial name
- NCT00270751
- Testing
- 1 apical pleurectomy, 2 pleural abrasion + minocycline pleurodesis
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Periodontitis, Diabetes Mellitus
Comparing the Efficacy of Metronidazole and Minocycline Gels for the Treatment of Diabetic Periodontitis Patients
This clinical study randomized 380 diabetic chronic periodontitis patients into 4 groups: scaling and root planning alone (group I), scaling and root planning plus metronidazole gel (group II), scaling and root planning plus…
- Trial name
- NCT06027151
- Testing
- 1ml of 1% metronidazole gel, 1ml of 2% minocycline gel, 1ml of combination of 1% metronidazole gel and 2% minocycline
- Where
- Pakistan
- Volunteers
- 380 people
- Sponsor
- Riphah International University
At Risk Mental State (ARMS), Psychosis
Minocycline and/or Omega-3 Fatty Acids Added to Treatment as Usual for At Risk Mental States
This is a randomized double-blind placebo controlled trial which aims to evaluate the efficacy and tolerability of minocycline and Omega-3 fatty acids for patients with ARMS.
- Trial name
- NAYAB (NCT02569307)
- Testing
- Minocycline, Omega-3 fatty acids, Minocycline Plus Omega-3 fatty acids
- Where
- 7 sites in Pakistan
- Volunteers
- 326 people
- Sponsor
- Pakistan Institute of Living and Learning
Tuberculosis
Pharmacokinetic Evaluation and Local Tolerability of Dry Powder Amikacin Via the Cyclops™
Rationale: Multidrug-resistant tuberculosis (MDR-TB) is defined as tuberculosis resistant to isoniazid and rifampicin. The incidence of MDR-TB worldwide is 3.9% for new cases and 21% for previously treated cases.
- Trial name
- NCT04249531
- Testing
- Amikacin Inhalation Dry Powder, Amikacin Injectable Product
- Where
- Netherlands
- Volunteers
- 8 people
- Sponsor
- University Medical Center Groningen
Asthma
Evaluation of the Utility of Minocycline as an Anti-Inflammatory Agent in the Treatment of Asthma
Trial of effects of minocycline as "add-on" therapy to adults with asthma with a history of requiring at least one episode of oral steroid therapy to control the disease.
- Trial name
- Mino (NCT00456677)
- Testing
- minocycline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- State University of New York - Downstate Medical Center
Retinitis Pigmentosa
Study of Oral Minocycline in Treating Bilateral Cystoid Macular Edema Associated With Retinitis Pigmentosa
Background: Some people with retinitis pigmentosa (RP) have macular edema (swelling) in the central retina. This can cause decreased central vision. The cause of macular edema is unknown, but may involve inflammation.
- Trial name
- NCT02140164
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- National Eye Institute (NEI)
Rosacea, Papulopustular Rosacea
Safety and Efficacy Study of a Topical Minocycline Foam in Patients With Papulopustular Rosacea
The purpose of this study is to see if the study drug, FMX-103, is safe to give and if it helps people with moderate-to-severe papulopustular rosacea. The investigational product is FMX-103 minocycline foam.
- Trial name
- EMIRA (NCT02601963)
- Testing
- FMX-103 1.5%, FMX-103 3%, Vehicle foam (0%)
- Where
- 20 sites in Germany
- Volunteers
- 233 people
- Sponsor
- Vyne Therapeutics Inc.
Depression, Bipolar Disorder
Minocycline and Celecoxib as Adjunctive Treatments of Bipolar Depression
Bipolar disorder is a leading cause of disability worldwide. A high proportion of patients with bipolar disorder experience persistent depressive symptoms that do not respond to standard drug treatments.
- Conditions
- Depression, Bipolar Disorder, Bipolar Depression, Mood Disorders
- Trial name
- NCT02703363
- Testing
- Minocycline, Celecoxib
- Where
- 4 sites in Pakistan
- Volunteers
- 265 people
- Sponsor
- Pakistan Institute of Living and Learning
Oropharynx Cancer
Minocycline for Reduction of Radiation Therapy Treatment-Related Symptom Burden in Oropharynx Cancer: A Randomized Study.
The goal of this clinical research study is to learn if minocycline can reduce the symptoms reported by patients with oropharynx cancer, nasopharynx cancer, or unknown primary cancer of head and neck, who receive treatment with…
- Trial name
- NCT01173692
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 47 people
- Sponsor
- M.D. Anderson Cancer Center
Pneumothorax
Intrapleural Minocycline After Simple Aspiration for the Prevention of Primary Spontaneous Pneumothorax
The estimated recurrence rate of primary spontaneous pneumothorax is 23-50% after the first episode, and the optimal treatment remains unknown.
- Trial name
- NCT00418392
- Testing
- Simple aspiration with minocycline pleurodesis, simple aspiration
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- National Taiwan University Hospital
Acne Vulgaris
A Study to Compare the Efficacy and Safety of Topical Administration of FMX-101 for Treatment of Moderate-to-Severe Acne
This is a Phase 3 study to evaluate the efficacy, safety and long-term safety of the topical administration of FMX-101, 4% minocycline foam for the treatment of moderate-to-severe acne vulgaris.
- Trial name
- NCT02815267
- Testing
- FMX-101, 4% minocycline foam, Vehicle Foam
- Where
- 31 sites in United States, Dominican Republic
- Volunteers
- 466 people
- Sponsor
- Vyne Therapeutics Inc.
Pharmacokinetics
A Comparative Bioavailability Study of DFD-29 Capsules 40 mg Versus SOLODYN® Tablets 105 mg, Under Fasting & Fed Conditions in Healthy Adult Human Subjects
Single-center, randomized, open-label, laboratory-blinded, 3-treatment, 3-period, 6-sequence, single-dose, crossover study.
- Trial name
- NCT05452785
- Testing
- DFD-29 (Minocycline) Fasting, DFD-29 (Minocycline) Fed, Solodyn (Minocycline) Fasting
- Where
- Canada
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Journey Medical Corporation
Fragile X Syndrome
Trial of Minocycline to Treat Children With Fragile X Syndrome
This is a single center study at the UC Davis MIND Institute in patients age 3.5-16 years of age with fragile X syndrome (FXS), funded by a National Fragile X Foundation Grant.
- Trial name
- NCT01053156
- Testing
- minocycline hydrochloride
- Where
- United States
- Volunteers
- 66 people
- Sponsor
- University of California, Davis
Spinal Tumors, Trauma Patients, Minocycline.
Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement
Spinal cord trauma and the consequent paraplegia are possibly among the most devastating injuries in soldiers and during spine surgery, and are significant in the medical, social and financial aspects.
- Trial name
- NCT01813240
- Testing
- Minocycline
- Where
- Israel
- Volunteers
- 444 people
- Sponsor
- Hadassah Medical Organization
Ischemic Stroke, Acute
Efficacy and Safety of Minocycline in Patients With Moderate to Severe Acute Ischemic Stroke
The aim of this study was to evaluate the efficacy and safety of Minocycline versus placebo in the treatment of patients with moderate to severe acute ischemic stroke.
- Trial name
- EMPHASIS (NCT05836740)
- Testing
- Minocycline hydrochloride capsule
- Where
- 58 sites in China
- Volunteers
- 1,724 people
- Sponsor
- Beijing Tiantan Hospital