Clinical trials: Minocycline
Liver Disease
Minocycline Administration During Human Liver Transplantation
Liver transplantation is the sole therapy for end-stage liver diseases and acute liver failure in children and adults. However, use of this life-saving technique is limited due to a severe shortage of donor livers.
- Trial name
- NCT02712775
- Testing
- Minocycline (yes/no)
- Where
- United States
- Sponsor
- Medical University of South Carolina
Periodontitis
Clinical Study of Minocycline Hydrochloride Injectable Hydrogel for the Treatment of Periodontitis
This study aims to construct and systematically evaluate a multifunctional synergistic drug delivery system based on a hyaluronic acid-nanoclay composite hydrogel to achieve integrated treatment of periodontitis encompassing…
- Trial name
- NCT07611630
- Testing
- treatment group
- Volunteers
- 80 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Pneumothorax
Pleural Abrasion Plus Minocycline Versus Apical Pleurectomy for Primary Spontaneous Pneumothorax
Optimal surgical management of primary spontaneous pneumothorax has been a matter of devate, especially regarding the method of pleurodesis.
- Trial name
- NCT00270751
- Testing
- 1 apical pleurectomy, 2 pleural abrasion + minocycline pleurodesis
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Hypertension, Resistant to Conventional Therapy
Antihypertensive Mechanisms of Minocycline in Resistant Hypertension
The goal of this clinical trial is to learn about the mechanisms by which minocycline effect blood pressure in individuals with treatment-resistant hypertension.
- Trial name
- NCT06246396
- Testing
- Minocycline Hydrochloride
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of Florida
Major Depressive Disorder (MDD), Treatment-resistant Depression (TRD)
Comparison of Efficacy of Minocyclin and Celecoxib as Adjunctive Treatment in Treatment Resistant Cases of Major Depressive Disorder
This randomized controlled study was conducted to compare the effectiveness of minocycline and celecoxib as add-on treatments in patients with treatment-resistant major depressive disorder.
- Trial name
- NCT07804979
- Testing
- Minocycline, Celecoxib
- Where
- Pakistan
- Volunteers
- 78 people
- Sponsor
- Lahore General Hospital
Memory Impairment
The Effects of Minocycline in Humans
To determine minocycline's effects on cognitive performance and measures of mood in abstinent cocaine users. Minocycline is a tetracycline derivative antibiotic that also inhibits microglia activation and the release of…
- Trial name
- NCT02193269
- Testing
- Sugar pill, Minocycline
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Yale University
Multiple Sclerosis, Relapsing-Remitting
Minocycline as add-on to Interferon Beta-1a [IFN Beta-1a] (Rebif®) in Relapsing-Remitting Multiple Sclerosis [RRMS]
This is a multicentric, double-blind, placebo-controlled, randomized, parallel group study to estimate the effect of minocycline as add-on to interferon beta-1a (IFN beta-1a) in subjects with relapsing-remitting multiple…
- Trial name
- RECYCLINE (NCT01134627)
- Testing
- Minocycline
- Where
- Denmark
- Volunteers
- 305 people
- Sponsor
- Merck KGaA, Darmstadt, Germany
Obesity, Major Depressive Disorder
Comorbid Obesity and Depression With an Anti-inflammatory Medication
Research suggests that only a subset of individuals with major depressive disorder (MDD) may benefit from anti-inflammatory treatments: those who have C-reactive protein (CRP) ≥3 mg/L, a commonly used threshold for "low-grade"…
- Conditions
- Obesity, Major Depressive Disorder, Inflammation
- Trial name
- CODA (NCT06537921)
- Testing
- Minocycline 200mg
- Where
- United Kingdom
- Volunteers
- 35 people
- Sponsor
- King's College London
Periodontitis
Locally Delivered Antibiotics for the Treatment of Periodontitis
The sample consists of patients with moderate to severe periodontitis who will be subjected to machanical therapy in combination to local antibiotics.
- Trial name
- NCT04125706
- Testing
- Minocycline Topical, Metronidazole Topical Gel
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Angelman Syndrome
Study to Evaluate the Efficacy and Safety of Minocycline in Angelman Syndrome
RANDOMIZED CLINICAL TRIAL, PLACEBO COMPARED TO EVALUATE THE EFFICACY AND SAFETY OF MINOCYCLINE IN ANGELMAN SYNDROME (A-MANECE STUDY)
- Trial name
- A-MANECE (NCT02056665)
- Testing
- MINOCYCLINE
- Where
- Spain
- Volunteers
- 32 people
- Sponsor
- Puerta de Hierro University Hospital
Retinal Vein Occlusion
Minocycline to Treat Branch Retinal Vein Occlusion
Background: Branch retinal vein occlusion (BRVO) is a blockage of the small veins that carry blood away from the retina in the back of the eye.
- Trial name
- NCT01468831
- Testing
- Minocycline, Bevacizumab
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 9 people
- Sponsor
- National Eye Institute (NEI)
Spinal Tumors, Trauma Patients, Minocycline.
Prevention of Imminent Paralysis Following Spinal Cord Trauma or Ischemia by Minocycline: A Multi-center Study in Israel With IDF Primary Care Involvement
Spinal cord trauma and the consequent paraplegia are possibly among the most devastating injuries in soldiers and during spine surgery, and are significant in the medical, social and financial aspects.
- Trial name
- NCT01813240
- Testing
- Minocycline
- Where
- Israel
- Volunteers
- 444 people
- Sponsor
- Hadassah Medical Organization
Alcohol Drinking, Alcohol-Related Disorders
Neuroimmune Dysfunction in Alcohol Use Disorder
The objective of this proposal is to advance medication development for alcohol use disorder by examining the efficacy and mechanisms of action of minocycline, a neuroimmune modulator, as a potential treatment.
- Conditions
- Alcohol Drinking, Alcohol-Related Disorders, Disease, Inflammation
- Trial name
- NCT04210713
- Testing
- Minocycline, Sugar pill
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Schizophrenia and Disorders With Psychotic Features
The Benefit of Minocycline on Negative Symptoms in Schizophrenia: Extent and Mechanisms
The purpose of this study is to investigate if minocycline limits the development of negative symptoms in early psychosis and to test via what mechanism of action this change occurs.
- Trial name
- BeneMin (NCT02928965)
- Testing
- Minocycline
- Volunteers
- 207 people
- Sponsor
- University of Manchester
Ischemic Stroke, Acute
Effects of Minocycline on Patients With Ischemic Stroke Undergoing Intravenous Thrombectomy
Minocycline is the second generation of tetracycline. Because of its lipophilicity, it has high penetrance of blood-brain barrier.
- Trial name
- MIST-A (NCT05487417)
- Testing
- Minocycline
- Where
- China
- Volunteers
- 189 people
- Sponsor
- Xijing Hospital
Lung Cancer
A Study for Reducing Symptom Burden Produced by Chemoradiation Treatment for Non Small Cell Lung Cancer by Minocycline and Armodafinil
The goal of this clinical research study is to compare armodafinil and minocycline when given alone or in combination to learn which is better for controlling symptoms, such as the side effects of chemoradiation, when given to…
- Trial name
- NCT01317550
- Testing
- Armodafinil, Minocycline, Questionnaires
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- M.D. Anderson Cancer Center
Cystic Fibrosis
DPI-Tobra-Kind Cyclops® in Children With Cystic Fibrosis
The goal is to investigate the pharmacokinetic properties of dry powder tobramycin via the Cyclops® at different dosages in children with cystic fibrosis, together with the local tolerability.
- Trial name
- NCT03485456
- Testing
- Tobramycin
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- University Medical Center Groningen
Recurrent Glioma
Repeat Radiation, Minocycline and Bevacizumab in Patients With Recurrent Glioma
The primary objective of step 1 is the rate of adverse events of minocycline and bevacizumab during reirradiation and of step 2 is the response rate to bevacizumab, reirradiation, and minocycline.
- Trial name
- RAMBO (NCT01580969)
- Testing
- Bevacizumab, Minocycline, Radiation
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- University of Utah
Minocycline, Cystoid Macular Edema
Minocycline Treatment for Cystoid Macular Edema
Cystoid macular edema (CME) is one of sight-threatening, immune-related ocular diseases. The efficacy of current treatments for CME (anti-VEGF, glucocorticoids and other agents) are limiting.
- Trial name
- MINOCME (NCT05474950)
- Testing
- minocycline
- Where
- China
- Volunteers
- 5 people
- Sponsor
- Sun Yat-sen University
Healthy
Bioequivalence Study of Minocycline HCl 135 mg ER Tablet Sunder Fed Conditions
The study was conducted as an open-label, balanced, randomized, two-treatment, two-period, two-sequence, single-dose, crossover, bioequivalence study comparing Minocycline hydrochloride extended release tablets 135 mg…
- Trial name
- NCT02312609
- Testing
- Minocycline hydrochloride
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Ranbaxy Laboratories Limited