Clinical trials: Miscarriage, Recurrent
Cervical Insufficiency
Relation of the Area of Cerclage With Preterm Birth
This study is planned prospectively in pregnancies who applied to Etlik Zübeyde Hanım Women's Health Care, Training and Research Hospital which is a teritiary hospital with 15.000 births anually, between January 2022 and January…
- Trial name
- NCT05220839
- Testing
- Type of cerclage procedure Mc Donald
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Etlik Zubeyde Hanım Women's Health Care, Training and Research Hospital
Cervical Incompetence
Comparison of Anesthesia Type in Patients Undergoing Transabdominal Cervico Isthmic Cerclage (TCIC)
The investigator aimed to compare the effect of anesthesia on overall postoperative outcomes including post-operative pain score and the fetal well-being (heart rate) in patients undergoing transabdominal cervico isthmic…
- Trial name
- NCT03636048
- Testing
- Bupivacaine Hcl 0.5% Inj, Propofol 10 milligram/ML
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
Recurrent Miscarriage
Intralipid Related Effect on NKcells in Patients With Unexplained Recurrent Spontaneous Abortion
Evaluating the effect of intralipid on the natural killer cells
- Trial name
- NCT03132779
- Testing
- Intralipid
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ahmed Mohamed Bahaa Eldin Ahmed
Inflammatory Response, Abortion, Habitual
Explore the Role of NLRP7 in the Regulation of Progestereone Induced Decidualization of Human Endometrial Stroma Cells
The investigators have found that NLRP7 was upregulated and nuclear translocated in an in vitro model of decidualization. Knock-down or overexpression of NLRP7 reduced or enhanced the expression of decidual marker IGFBP-1.
- Trial name
- NCT04148638
- Where
- Taiwan
- Volunteers
- 204 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Recurrent Pregnancy Losses, Positive Anti Phospholipid Syndrome
Preconceptional Thromboprophylaxis in Recurrent PREGNANCY LOSSES Caused by Antiphospholipid Syndrome
Preconceptional use of low molecular weight heparin (enoxaparin) and aspirin in patient with recurrent miscarriages with positive anti phospholipid antibodies increase the implantation rate and the duration of pregnancy with low…
- Trial name
- NCT01661439
- Testing
- low molecular weight heparin (enoxeparine)
- Where
- Egypt
- Volunteers
- 316 people, healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Miscarriage, Recurrent, Infertility
The Role of NLRP Gene Family (NLRP1~14) in Recurrent Miscarriage and Infertility
Development of mole was not associated with segregation of mutated NLRP7 allele in the haploid oocyte. We hypothesize NLRP7 is a maternal factor involved in regulating early embryo development or embryo-uterine interaction.
- Trial name
- NCT04141618
- Where
- Taiwan
- Volunteers
- 143 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Abortion, Spontaneous
Interleukin-10 Promoter-1082A/G Polymorphism and Idiopathic Recurrent Miscarriage Risk
This study aimed to assess the correlation between the interleukin-10 (IL-10)-1082A/G polymorphism and idiopathic recurrent miscarriage (IRM) of Chinese Han.
- Trial name
- NCT02633475
- Testing
- IL-10 polymorphism
- Where
- 2 sites in China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Fourth Affiliated Hospital of Guangxi Medical University
Infertility, Abnormal Uterine and Vaginal Bleeding, Unspecified
Optimum Misoprostol Dose Prior to Office Hysteroscopy
Misoprostol is an effective agent for cervical priming before office hysteroscopy, vaginal route is the best, optimum dose not yet known.
- Conditions
- Infertility, Abnormal Uterine and Vaginal Bleeding, Unspecified, Recurrent Abortion
- Trial name
- NCT01612065
- Testing
- Misoprostol
- Where
- Egypt
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Cairo University
Luteal Phase, Biomarkers
Early Pregnancy Cohort and Preimplantation Factor
Miscarriage is a common event associated with severe psychological and social morbidity, further tormenting in women suffering recurrent pregnancy loss (RPL) by at least three consecutive losses.
- Conditions
- Luteal Phase, Biomarkers, Abortion, Spontaneous, Abortion, Habitual
- Trial name
- PEP-cohort (NCT02761772)
- Volunteers
- 210 people, healthy volunteers welcome
- Sponsor
- Nordsjaellands Hospital
Vitamin D Deficiency, Recurrent Spontaneous Abortion
Study on Clinical Value of Vitamin D in Recurrent Spontaneous Abortion
The observational study is to compare vitamin D deficiency and related indicators among different spontaneous abortions in describe female reproductive health.The main question aim to answer is: the possible pathogenesis of…
- Trial name
- NCT06002035
- Testing
- Binom Vitamin D drops
- Where
- China
- Volunteers
- 1,421 people, healthy volunteers welcome
- Sponsor
- Jianmei Xia
Recurrent Pregnancy Loss
The Epidemiology of Recurrent Spontaneous Abortion Associated With Thrombophilla
RSA is a multifactorial disorder resulting from genetic factors, anatomic factors, autoimmune disorders, endocrine dysfunction, thrombophilia, life style factors, and maternal infections.
- Trial name
- NCT02990390
- Where
- China
- Volunteers
- 45,000 people, healthy volunteers welcome
- Sponsor
- Shanghai First Maternity and Infant Hospital
Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2
Cerclage for Twins With Short Cervix
A prospective randomized control trial that will compare cervical cerclage plus vaginal progesterone to vaginal progesterone along in twin pregnancies complicate by a short cervix (</= 15.0mm) between 16w0d to 25w6d.
- Conditions
- Preterm Birth, Preterm Labor With Preterm Delivery, Unspecified Trimester, Fetus 2, Cervical Incompetence, Cervical Shortening
- Trial name
- NCT03077633
- Testing
- Cervical Cerclage placement, Vaginal Progesterone
- Volunteers
- healthy volunteers welcome
- Sponsor
- Pediatrix
Preterm Labor, Cervical Incompetence
Cervical Cerclage for Singleton Pregnant on Vaginal Progesterone With Progressive Cervical Length Shortening
The aim of this study is to Determine whether cerclage with vaginal progesterone will: 1. Reduce the overall spontaneous preterm birth rate. 2. Prolong pregnancy latency. 3. Improve neonatal outcome.
- Trial name
- NCT03837288
- Testing
- Cerclage
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Helicobacter Pylori Infection, Susceptibility to
Helicobacter Pylori Infection Among Women With Recurrent Abortion of Unknown Cause
Helicobacter pylori (H. pylori) infection affects approximately one half of the world population and it is more prevalent in developing countries. This microorganism colonizes the stomach.
- Trial name
- NCT07293169
- Testing
- H pylori eradication
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Assiut University
Preterm Birth, Cervical Incompetence
Preventing Preterm Birth With a Negative Pressure Cervical Cup: a Feasibility Study
The goal of this Phase I clinical trial is to generate proof-of-concept data to demonstrate that a cervical cup in combination with vacuum application will create negative pressure on uterine cervical tissue, thereby creating…
- Conditions
- Preterm Birth, Cervical Incompetence, Cervical Insufficiency, Short Cervix
- Trial name
- NCT05512052
- Testing
- Hannah Cervical Cup (2 mm Delta), Hannah Cervical Cup (4 mm Delta), Hannah Cervical Cup (6 mm Delta)
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Galena Innovations, LLC
Miscarriage
Mucosal-Associated Invariant T Cells in Cases of Miscarriage
Miscarriage is the most frequently encountered complication of pregnancy ranging from 10% to 30%. The etiology of recurrent spontaneous miscarriage (RSM) in 40%-50% of cases cannot be identified.
- Trial name
- NCT04492098
- Testing
- MAIT cells
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pregnancy; Habitual Aborter, Weeks of Gestation 37 or More
Accuracy and Reliability of Fetal Heart Rate and Uterine Contraction Monitoring Method
Clinical Investigation Protocol for a study designed to determine the equivalence of the Monica AN24 monitor to Philips 50XM for fetal heart rate (FHR) and uterine contraction (UC) monitoring during labor.
- Trial name
- NCT01280357
- Testing
- Monica AN24 (K101081), Philips 50XM
- Where
- 2 sites in United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Monica Healthcare Ltd
Ovarian Reserve, Miscarriage, Recurrent
The Effect of the Ovarian Reserve on the Recurrent Pregnancy Loss
The purpose of this study is to determine whether ovarian reserve is related to recurrent pregnancy loss
- Trial name
- NCT03009370
- Where
- Turkey (Türkiye)
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Abortion in First Trimester
Progesterone and Doppler in Recurrent Abortion
Recurrent pregnancy loss is classically defined as the occurrence of three or more consecutive pregnancy loss. The American Society of Reproductive Medicine has recently redefined recurrent pregnancy loss as two or more pregnancy…
- Trial name
- NCT03267771
- Testing
- Progesterone Suppositories Vaginal, Dydrogesterone Oral Tablet, doppler ultrasound
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Assiut University
Recurrent Miscarriage
The Role of Prothrombin Gene and Methylenetetrahydrofolate Reductase(MTHFR) Gene Polymorphisms as Risk Factors for Recurrent Miscarriage
Recurrent miscarriage is a pregnancy loss before 20 weeks of gestation. The recurrent pregnancy loss(RPL) usually occurring in the first trimester of gestation and its rate is quite high (15-20% even in full reproductive period)…
- Trial name
- NCT03209063
- Testing
- polymerase chain reaction
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Assiut University