Clinical trials: Miscarriage
Recurrent Early Pregnancy Loss
PGT-A in Screening of Embryos in the Treatment of Unexplained Recurrent Miscarriage
uRM patients selected PGT-A from 2012 to 2016 were included in this study. Their clinical outcomes were prospectively observed and analyzed to explore the factor influenced the outcomes.
- Trial name
- NCT04643938
- Where
- China
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Pregnancy Related, Pregnancy Complications
The Heartland Study
The Heartland Study is a prospective, observational study that will enroll up to 2,600 pregnant participants across the Heartland States in the U.S..
- Conditions
- Pregnancy Related, Pregnancy Complications, Birth Defect, Gestational Age and Weight Conditions
- Trial name
- NCT05492708
- Where
- 4 sites in United States
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- Heartland Health Research Alliance
Infertility, Implantation Rate
Hyaluronan-enriched Medium and Euploid Blastocyst Transfers
It has been proposed that enriching transfer media with hyaluronan (EmbryoGlue medium) improves pregnancy outcomes compared with media containing lower concentrations of this molecule.
- Conditions
- Infertility, Implantation Rate, Clinical Pregnancy Rate, Live Birth Rate
- Trial name
- GluePloid (NCT06165367)
- Testing
- EmbryoGlue Medium
- Where
- United Arab Emirates
- Volunteers
- 783 people, healthy volunteers welcome
- Sponsor
- ART Fertility Clinics LLC
Recurrent Spontaneous Abortion
Prospective Study of BMD and Ca-P Metabolism in RSA Patients: LMWH Use Versus Control
The goal of this prospective observational study is to learn about the effect of low molecular weight heparin (LMWH) application on bone mineral density (BMD) and on calcium-phosphorus metabolism in patients with recurrent…
- Trial name
- NCT05878574
- Testing
- Low molecular weight heparin
- Where
- China
- Volunteers
- 344 people, healthy volunteers welcome
- Sponsor
- Aimin Zhao
Recurrent Miscarriage
The Role of Prothrombin Gene and Methylenetetrahydrofolate Reductase(MTHFR) Gene Polymorphisms as Risk Factors for Recurrent Miscarriage
Recurrent miscarriage is a pregnancy loss before 20 weeks of gestation. The recurrent pregnancy loss(RPL) usually occurring in the first trimester of gestation and its rate is quite high (15-20% even in full reproductive period)…
- Trial name
- NCT03209063
- Testing
- polymerase chain reaction
- Volunteers
- 285 people, healthy volunteers welcome
- Sponsor
- Assiut University
Miscarriage, Stillbirth
Follow-up of Pregnant Women After a Mass Vaccination of Oral Cholera Vaccine (ShancholTM) in Nsanje Malawi
This study, to be carried out immediately following an emergency, reactive cholera vaccination campaign in Nsanje District, Malawi, will be a cohort study to estimate the safety of killed oral cholera vaccine (OCV), in pregnant…
- Conditions
- Miscarriage, Stillbirth, Cholera
- Trial name
- NCT02499172
- Testing
- Shanchol
- Where
- United States
- Volunteers
- 2,758 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Spontaneous Abortion, Fetal Death
Environmental Factors and Embryonic Development Project
The Environmental Factors and Embryonic Development Project was set up to investigate environmental exposures and behavioral factors responsible for embryonic dysplasia and gestational complications in pregnant women.
- Conditions
- Spontaneous Abortion, Fetal Death, Stillbirth, Birth Defects
- Trial name
- EFED (NCT04182503)
- Testing
- No intervention
- Where
- 19 sites in China
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Jinling Hospital, China
Recurrent Pregnancy Loss(RPL), Recurrent Miscarriage
Low Dose Prednisone Therapy in Women With Recurrent Pregnancy Loss
For many years there is a lack of large randomized controlled trials that study the effect of low dose prednisone in women with RPL and thus the evidence of a probable efficacy of prednisone in RPL women remains limited and…
- Trial name
- NCT04558268
- Testing
- Prednisone, Progesterone, vit D
- Where
- Israel
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Soroka University Medical Center
IVF, Embryo Loss
The Use of High Concentration Hyaluronic Acid (HA) Transfer Medium in Repeated Implantation Failure (RIF) Patients
This is a pilot study with the aim to investigate the beneficial effect of bicarbonate buffered medium containing hyaluronan and recombinant human albumin (EmbryoGlue®, Vitrolife) in patients with documented repeated implantation…
- Conditions
- IVF, Embryo Loss, Miscarriage, Recurrent
- Trial name
- RIFLE (NCT04709796)
- Testing
- EmbryoGlue®, Vitrolife, Conventional Transfer
- Where
- Belgium
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- University Hospital, Ghent
Repeated Embryo Implantation Failure, Recurrent Miscarriage
Immune Profile Analysis and Biomarker Identification in Women With Repeated Implantation Failure or Unexplained Recurrent Spontaneous Miscarriage
Implantation is a determining step in human reproduction which requires the transition from a pro-inflammatory state to an anti-inflammatory state allowing the implantation of a competent embryo within a receptive endometrium…
- Conditions
- Repeated Embryo Implantation Failure, Recurrent Miscarriage, Immune System
- Trial name
- ERIM (NCT05648136)
- Testing
- blood sample
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Recurrent Miscarriage, Infertility
Iron Status in Female Infertility and Recurrent Miscarriage
Multiple studies suggest a link between the iron status and the development of the endometrium. Therefore, a sufficient iron supply seems to relevant for female fertility and reproduction.
- Conditions
- Recurrent Miscarriage, Infertility, Iron-deficiency
- Trial name
- NCT05034250
- Testing
- Blood sample
- Where
- Austria
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Pregnancy Complicated by Low Implantation
Intralipid Therapy for Recurrent Implantation Failure and Recurrent Miscarriages: Is it a Hope or Myth?A Randomized Clinical Trial
Both organ-specific and systemic autoimmunity are associated with an increased prevalence of recurrent miscarriage and reproductive failure, rendering the role of the maternal immunological system in fertility a key concept.
- Trial name
- ILRIFRM (NCT01679561)
- Testing
- intralipid
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Medical; Abortion, Fetus
Fertility and Obstetric Outcomes After Medical Management Versus Surgical Treatment for First-trimester Miscarriage First-trimester Miscarriage
Study Objective: To compare the time to new pregnancy and pregnancy outcomes in women who received Misoprostol for uterus evacuation versus those treated surgically with dilatation and curettage.
- Trial name
- NCT03570307
- Testing
- medical VS surgical evacuation of the uterus
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Asherman Syndrome, Abortion Late
Prevalence of Intrauterine Adhesions After D&C With or Without Antiadhesion Gel After Abortion in Second Trimester.
Only patients who sign an informed consent will be included. Patients after a miscarriage in the 2nd trimester of pregnancy who need to perform an instrumental revision of the uterine cavity (RCUI, revisio cavi uteri…
- Trial name
- ADAB (NCT04671914)
- Testing
- Hyaluronic Acid 20 MG/ML Injectable Solution, Dilation and curretage
- Where
- 3 sites in Czechia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Institute for the Care of Mother and Child, Prague, Czech Republic
Early Miscarriage
Identification of Histories of Pregnancy Termination, Particularly Early Miscarriage, in General Medical Records
Early miscarriage (EM) is defined as the spontaneous expulsion of an intrauterine pregnancy of less than 14 weeks' duration. Early miscarriage is a very common complication, affecting more than 10% of pregnancies.
- Trial name
- NCT07406776
- Where
- France
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Université de Reims Champagne-Ardenne
Vitamin D Deficiency, Recurrent Spontaneous Abortion
Study on Clinical Value of Vitamin D in Recurrent Spontaneous Abortion
The observational study is to compare vitamin D deficiency and related indicators among different spontaneous abortions in describe female reproductive health.The main question aim to answer is: the possible pathogenesis of…
- Trial name
- NCT06002035
- Testing
- Binom Vitamin D drops
- Where
- China
- Volunteers
- 1,421 people, healthy volunteers welcome
- Sponsor
- Jianmei Xia
Obesity, Inflammation
Inflammasome Activation and Cortisol Metabolism in Obese Women With Recurrent Miscarriage
The prevalence of obesity among women of reproductive age is increasing. Obesity represents a chronic low-grade inflammatory state and NLRP3 inflammasome plays a pivotal role in obesity-induced inflammation.
- Trial name
- NCT04275674
- Where
- Taiwan
- Volunteers
- 57 people, healthy volunteers welcome
- Sponsor
- National Cheng-Kung University Hospital
Abortion, Habitual
Effectiveness of Metformin in Recurrent Miscarriage in a Woman With Hyperinsulinaemia
The prevalence of insulin resistance is increased in women with recurrent miscarriage compared with matched fertile controls,Insulin resistance (IR) in this syndrome is not only implicated toward early pregnancy loss (EPL) but…
- Trial name
- MetRPL (NCT01718340)
- Testing
- Metformin
- Where
- Egypt
- Volunteers
- healthy volunteers welcome
- Sponsor
- Woman's Health University Hospital, Egypt
Infertility Female, Recurrent Miscarriage
Study on the Association Between SXCI and RM and the Possible Genetic Mechanism
To determine whether there is higher incidence of skewed X chromosome inactivation(SXCI) in the recurrent miscarriage(RM) population compared with normal population, and verify the existing hypothesis of the possible genetic…
- Trial name
- NCT02504281
- Where
- China
- Volunteers
- 257 people, healthy volunteers welcome
- Sponsor
- ShangHai Ji Ai Genetics & IVF Institute
Infertility, Aneuploidy
The Effect of Acupuncture on Pregnancy Rates in Women Undergoing in Vitro Fertilization With Preimplantation Genetic Screening
While IVF offers an effective treatment for infertility, a significant proportion of IVF cycles still result in failed implantation and early miscarriage.
- Trial name
- NCT03981120
- Testing
- Laser and Traditional Acupuncture
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of British Columbia