Clinical trials: Miscarriage, open to volunteers
Miscarriage in First Trimester
Comprehensive Assessment of First Trimester Pregnancy Loss
The FIRST-CARE Study is a prospective research project conducted at Hospital de la Santa Creu i Sant Pau (Barcelona, Spain), aimed at better understanding the causes and consequences of first-trimester pregnancy loss…
- Trial name
- FIRST-CARE (NCT07293819)
- Where
- 2 sites in Spain
- Volunteers
- 225 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Miscarriage in First Trimester, Prenatal Genetic Diagnosis
GRACE - Genetic Insights Into Early pRegnancy Loss Using Cell-free fEtal DNA
The aim of this study is to assess the impact of non-invasive prenatal testing right after an early isolated miscarriage on mental health and on the patient's subsequent care in the year following the miscarriage
- Trial name
- GRACE (NCT07639333)
- Testing
- Non invasive prenatal test
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Rennes University Hospital
Adverse Pregnancy Outcome
Using Placental Pathology to Prevent Recurrent Adverse Pregnancy Outcomes: A Pilot Project
The goal of this randomized clinical trial is to evaluate if we can use placental pathology in a prior pregnancy which had an adverse outcome, such as early delivery, stillbirth, a baby born smaller than expected, or severe forms…
- Trial name
- NCT06004674
- Testing
- Lovenox 40mg
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Endeavor Health
Miscarriage
Hysteroscopy vs. Endouterine Aspiration in the Management of Trophoblastic Retention
Introduction: Incomplete early miscarriage is defined as early miscarriage with persistent intrauterine material on ultrasound. Intrauterine retention of trophoblastic debris is not an uncommon phenomenon.
- Trial name
- HARET (NCT05789940)
- Testing
- hysteroscopy, Aspiration
- Where
- 4 sites in France
- Volunteers
- 220 people
- Sponsor
- University Hospital, Montpellier
Infertility, Female, Recurrent Miscarriage
Immune Cell Populations in the Endometrium
Specialized immunological studies in the diagnostics of idiopathic infertility and recurrent miscarriages have limited applicability, as the role of the immune system in these conditions is not thoroughly understood.
- Conditions
- Infertility, Female, Recurrent Miscarriage, Gynecologic Disease
- Trial name
- NCT06826365
- Testing
- Percentage distribution of immune system cells in peripheral blood, Percentage distribution of immune system cells in endometrium
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Jagiellonian University
Mannose-Binding Lectin Deficiency, Recurrent Pregnancy Loss
Association Between Plasma Level of Mannose Binding Lectin and Human Reproduction
A low plasma level of mannose binding lectin (p-MBL) is associated with unexplained recurrent pregnancy loss (RPL), but it is not investigated if it is associated with unexplained reproductive failure in general, including…
- Conditions
- Mannose-Binding Lectin Deficiency, Recurrent Pregnancy Loss, Recurrent Implantation Failure, Infertility
- Trial name
- NCT05169541
- Where
- Denmark
- Volunteers
- 500 people
- Sponsor
- Aalborg University Hospital
Retained Products of Conception, Hysteroscopy
Predictors of Successful Office Operative Hysteroscopy Using a Mini-Resectoscope
The goal of this observational study is to identify predictors of successful removal of benign intrauterine pathology using a mini-resectoscope during office operative hysteroscopy without anesthesia in adult women with suspected…
- Conditions
- Retained Products of Conception, Hysteroscopy, Endometrial Polyp Benign, Endometrial Polyp
- Trial name
- NCT07875985
- Testing
- Office Operative Hysteroscopy Using the Karl Storz Mini-Resectoscope Without Anesthesia
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- Shaare Zedek Medical Center
Retained Products of Conception, Miscarriage
A Prospective Study Evaluating the Impact of Conservative Management on Retained Products of Conception and EMV
The goal of this observational study is to learn about the therapeutic effects of the conservative treatment approach on pepole with retained products of conception (RPOC) and Enhanced myometrial vascularity (EMV).
- Conditions
- Retained Products of Conception, Miscarriage, Conservative Management
- Trial name
- NCT06862089
- Where
- China
- Volunteers
- 120 people
- Sponsor
- Fu Xing Hospital, Capital Medical University
Recurrent Miscarriage, Recurrent Pregnancy Loss
Prednisolone Administration in Patients With Unexplained REcurrent MIscarriages
Recurrent miscarriages (RM) affects 3% of all fertile couples, but remains unexplained in most cases, limiting therapeutic options. Possibly the maternal immune system plays a role in recurrent miscarriage.
- Conditions
- Recurrent Miscarriage, Recurrent Pregnancy Loss, Habitual Abortion, Miscarriage
- Trial name
- PREMI (NCT05725512)
- Testing
- Prednisolone
- Where
- Netherlands
- Volunteers
- 490 people
- Sponsor
- Leiden University Medical Center
Miscarriage
Use of Aromatase Inhibitor Before Misoprostol in Medical Termination of Miscarriage
Abortion is one of the most common complications of pregnancy. Missed abortion is a type of abortions, occurs in 15%-20% of clinically diagnosed pregnancies and is defined as the retention of pregnancy products in the uterus for…
- Trial name
- NCT07109947
- Testing
- Letrozole 2.5mg
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Aswan University
Miscarriage in First Trimester
Hysteroscopic Resection Versus Manual Vacuum Aspiration for Early Pregnancy
Early pregnancy loss happens when a pregnancy that is not developing properly is found on an ultrasound before 12 weeks and 6 days. This type of loss occurs in about 10% of pregnancies.
- Trial name
- NCT07088510
- Testing
- Hysteroscopic resection, Manual Vacuum Aspiration
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University Hospitals Cleveland Medical Center
Recurrent Miscarriage
Effect of Prednisolone Treatment on Uterine Natural Killer Cells
This study aims to investigate the role of uNK cells and the association with prednisolone.
- Trial name
- NCT03902912
- Testing
- Prednisolone
- Where
- Hong Kong
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Recurrent Miscarriage
Chronic Endometritis and Benefits of Antibiotics in Women With Recurrent Miscarriage
The aim of the study is to estimate the incidence of CE, evaluate the endometrial microorganism of CE, and investigate the therapeutic benefits of antibiotics for women with unexplained recurrent miscarriage and CE.
- Trial name
- NCT06163092
- Where
- Hong Kong
- Volunteers
- 175 people
- Sponsor
- Chinese University of Hong Kong
Miscarriage, Pregnancy Loss
Cost-utility Analysis of Outpatient Manual Vacuum Aspiration Versus Operating Room Electric Aspiration for the Management of First-trimester Miscarriage
The ASPIR study aims to evaluate the cost-utility of outpatient manual vacuum aspiration compared with operating room electric aspiration for the management of first-trimester miscarriage.
- Conditions
- Miscarriage, Pregnancy Loss, First Trimester Pregnancy
- Trial name
- ASPIR (NCT07732231)
- Testing
- Manual vacuum aspiration (MVA), Electric aspiration (EA)
- Where
- France
- Volunteers
- 860 people
- Sponsor
- Nantes University Hospital
Repeated Embryo Implantation Failure, Recurrent Miscarriage
Immune Profile Analysis and Biomarker Identification in Women With Repeated Implantation Failure or Unexplained Recurrent Spontaneous Miscarriage
Implantation is a determining step in human reproduction which requires the transition from a pro-inflammatory state to an anti-inflammatory state allowing the implantation of a competent embryo within a receptive endometrium…
- Conditions
- Repeated Embryo Implantation Failure, Recurrent Miscarriage, Immune System
- Trial name
- ERIM (NCT05648136)
- Testing
- blood sample
- Where
- France
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Pregnancy-induced Hypertension
Basic and Clinical Research of Pregnancy-Induced Hypertension
Collect blood pressure, blood, amniotic fluid, placenta and other samples from normal pregnant women, patients with pregnancy-induced hypertension and those who have experienced miscarriage, and conduct tests on them.
- Trial name
- BCRPIH (NCT07464379)
- Testing
- no Intervention
- Where
- China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Miscarriage in First Trimester
Non-invasive Monitoring of Miscarriage
cfDNA is extremely useful to ascertain chromosomal causes of miscarriages at the point of miscarriage diagnosis by a simple blood test.
- Trial name
- NCT06581692
- Testing
- This is a routine procedure, no intervention will be provided.
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Pregnancy Related, Pregnancy Complications
The Heartland Study
The Heartland Study is a prospective, observational study that will enroll up to 2,600 pregnant participants across the Heartland States in the U.S..
- Conditions
- Pregnancy Related, Pregnancy Complications, Birth Defect, Gestational Age and Weight Conditions
- Trial name
- NCT05492708
- Where
- 4 sites in United States
- Volunteers
- 2,600 people, healthy volunteers welcome
- Sponsor
- Heartland Health Research Alliance
Spontaneous Abortion
Post-traumatic Stress Disorder in Spontaneous Abortion
The objective of this questionnaire-based study is to prospectively assess the prevalence of post-traumatic stress disorder (PTSD) symptoms in a population of women who have experienced a spontaneous miscarriage during the first…
- Trial name
- NCT07306676
- Testing
- Impact of Event Scale - Revised (IES-R) questionnaire, Posttraumatic Stress Disorder Checklist - Specific (PCL-S) questionnaire, Trauma Recovery Measure (TRM) questionnaire
- Where
- Poland
- Volunteers
- 200 people
- Sponsor
- Jagiellonian University
Pregnancy of Unknown Location
Hysteroscopy for the Diagnosis and Treatment of Pregnancy of Unknown Location
Infertility patients have a higher baseline risk of ectopic pregnancy compared to the general population. If an early pregnancy is not visible by ultrasound, patients with a pregnancy of unknown location (PUL) will undergo…
- Trial name
- NCT07469605
- Testing
- Hysteroscopy for diagnosis and treatment of pregnancy of unknown location
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pennsylvania